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1. Understanding and overcoming resistance to tyrosine kinase inhibitors (TKIs) in Chronic myeloid leukemia (CML) NSTL国家科技图书文献中心

Lagana, Alessandro |  Scalzulli, Emilia... -  《Expert review of hematology》 - 2025,18(1) - 65~79 - 共15页

摘要: pathogenesis was successfully unraveled, with tyrosine kinase |  inhibitors (TKIs) representing one of the first-targeted | Introduction: Chronic myeloid leukemia (CML | ) represents one of the first neoplasms whose molecular |  therapies. TKIs have revolutionized long-term outcomes of
关键词: Chronic myeloid leukemia |  tyrosine kinase inhibitors |  TKI resistance |  BCR::ABL1 mutations |  asciminib |  ponatinib |  allogeneic hematopoietic stem cell transplant |  allo-HSCT

2. Head-to-head comparison of tyrosine kinase inhibitors in renal cell carcinoma using patient-derived cell culture NSTL国家科技图书文献中心

Urquhart, Aaron J. |  Glass, Christian H.... -  《Personalized medicine》 - 2025,22(2) - 83~91 - 共9页

摘要: immunotherapy and tyrosine kinase inhibitors (TKIs). Patient | Background Metastatic renal cell carcinoma |  (RCC) is often treated with a combination of | -derived RCC cells were cultured and inter-individual |  differences to treatment with a panel of TKIs were evaluated
关键词: Renal cell carcinoma |  patient-derived cell culture |  tyrosine kinase inhibitors |  sunitinib |  cabozantinib |  pazopanib |  axitinib

3. PD-1 inhibitors improve the efficacy of tyrosine kinase inhibitors combined with transcatheter arterial chemoembolization in advanced hepatocellular carcinoma: a meta-analysis and trial sequential analysis NSTL国家科技图书文献中心

Jiahui Yu |  Yong Li... -  《Scandinavian journal of gastroenterology.》 - 2025,60(5) - 472~484 - 共13页

摘要: and safety of triple therapy with tyrosine kinase |  inhibitors (TKIs) combined with transcatheter arterial |  chemoembolization (TACE) plus programmed death 1 (PD-1) inhibitors |  inhibitors in uHCC was searched using the Embase, PubMed | Background: This meta-analysis and trial
关键词: PD-1 inhibitors; Tyrosine kinase inhibitors; hepatocellular carcinoma; meta-analysis

4. Locally advanced/metastatic non-small-cell lung cancer in Lebanon: focus on ALK tyrosine kinase inhibitors NSTL国家科技图书文献中心

Tfayli, Arafat |  Ghanem, Hady... -  《Future oncology》 - 2025,21(1/2) - 127~137 - 共11页

摘要:-tyrosine kinase inhibitors (ALK-TKIs) have improved | Treatment of non-small-cell lung cancers |  (NSCLC) has evolved over the last decade. According to |  studies, the use of targeted therapies has significantly |  increased the life expectancy of patients. Moreover, ALK
关键词: ALK-rearrangement |  ALK-tyrosine kinase inhibitor |  expert opinion |  lung cancer |  non-small-cell lung cancer

5. Efficacy and Safety of Tyrosine Kinase Inhibitors in Downstaging and Palliation in Patients with Advanced Differentiated Thyroid Cancer - A Multicentre study NSTL国家科技图书文献中心

Bhat, Ganesh |  Chanthar, Vishvak K....... -  《Indian journal of surgical oncology》 - 2025,16(1) - 165~171 - 共7页

摘要: challenging, prompting the exploration of tyrosine kinase |  inhibitors (TKIs) to downstage the disease burden before | Thyroid cancer (TC) is the most common |  endocrine malignancy worldwide, with differentiated |  thyroid cancer (DTC) comprising the majority of cases
关键词: Sorafenib |  Lenvatinib |  Efficacy and safety of Tyrosine kinase inhibitors |  Radioactive refractory differentiated thyroid cancer |  Inoperable differentiated thyroid cancer

6. Efficacy of Second-line Nivolumab Versus Tyrosine Kinase Inhibitors for Renal Cell Carcinoma With Bone Metastases NSTL国家科技图书文献中心

Yamamichi, Gaku |  Kato, Taigo... -  《Anticancer Research》 - 2025,45(2) - 639~650 - 共12页

摘要: options, such as nivolumab or tyrosine kinase inhibitors |  immune checkpoint inhibitors has become the standard | Background/Aim: Combination therapy with |  firstline treatment for metastatic renal cell carcinoma |  (mRCC), leading to changes in second-line treatment
关键词: Key Words: Renal cell carcinoma |  bone metastasis |  second-line |  treatment |  nivolumab |  tyrosine kinase inhibitor |  overall survival.

7. Effect on neutrophil migration and antimicrobial functions by the Bruton's tyrosine kinase inhibitors tolebrutinib, evobrutinib, and fenebrutinib NSTL国家科技图书文献中心

De Bondt, Mirre |  Renders, Janne... -  《Journal of Leukocyte Biology》 - 2025,117(3) - qiae160~qiae160 - 共18页

摘要: these are the inhibitors of Bruton's tyrosine kinase |  BTK inhibitors on neutrophil functions. Although |  overlooked in MS. In this study, we used 3 BTK inhibitors |  inhibitors prolonged neutrophil survival in an inflammatory |  environment. Finally, treatment with BTK inhibitors
关键词: autoimmunity |  Bruton's tyrosine kinase signaling |  innate immunity |  pharmacological inhibitors

8. Catalytic Lysine745 targeting strategy in fourth-generation EGFR tyrosine kinase inhibitors to address C797S mutation resistance NSTL国家科技图书文献中心

Patil, Bhatu R. |  Patel, Harun M. -  《European Journal of Medicinal Chemistry》 - 2025,283 - 117140~117140 - 共29页

摘要: tyrosine kinase inhibitors (TKIs) such as Osimertinib |  inhibitors that specifically target the catalytic Lys745 |  Osimertinib. Both covalent and non-covalent inhibitors | ) for optimizing Lys745-targeting inhibitors. The | Overcoming resistance to third-generation
关键词: Catalytic Lys745 |  Non-small cell lung cancer |  Osimertinib |  C797S |  Brigatinib

9. The Cost-Effectiveness of Frontline Tyrosine Kinase Inhibitors for Patients With Chronic Myeloid Leukemia: In Pursuit of Treatment-Free Remission and Dose Reduction NSTL国家科技图书文献中心

Metsemakers, Sanne J... |  Hermens, Rosella P. ...... -  《Value in health》 - 2025,28(2) - 224~232 - 共9页

摘要:-effectiveness of lifelong-prescribed expensive tyrosine kinase |  inhibitors (TKIs) for CML is crucial. Prior cost | Objectives: The management of chronic myeloid |  leukemia (CML) now includes dose reduction (DR) and |  treatment-free remission (TFR). Evaluating the cost
关键词: chronic myeloid leukemia |  dose reduction |  economic evaluation |  healthcare costs |  treatment-free remission |  tyrosine kinase inhibitors |  quality of life

10. Outcomes of pregnancy in patients with chronic myeloid leukemia in the era of tyrosine kinase inhibitors NSTL国家科技图书文献中心

Kondo, Takeshi |  Matsuki, Eri... -  《Cancer.》 - 2025,131(1) - e35611~e35611 - 共12页

摘要: pregnant due to the teratogenicity of tyrosine kinase |  inhibitors (TKIs). Methods: The authors conducted a | Background: Young female patients with chronic |  myeloid leukemia (CML) often face challenges becoming |  nationwide survey of female patients with CML who
关键词: chronic myeloid leukemia |  interferon-alpha |  pregnancy |  treatment discontinuation |  treatment-free remission |  tyrosine kinase inhibitor
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