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1. TMCO1 promotes ferroptosis and ECM deposition in glaucomatous trabecular meshwork via ERK1/2 signaling NSTL国家科技图书文献中心

Zhang, Yang |  Han, Ruiqi... -  《Biochimica et biophysica acta.Molecular basis of disease》 - 2025,1871(1) - 167530~167530 - 共15页

摘要: ferroptosis in human trabecular meshwork cells (HTMCs |  extracellular matrix (ECM) deposition in the trabecular |  meshwork (TM). Transmembrane and coiled-coil domain | Glaucoma, a leading cause of global blindness | , is marked by irreversible retinal ganglion cells
关键词: glaucoam |  trabecular meshwork |  ferroptosis |  ECM deposition |  ERK/MAPK

2. Autophagy activation ameliorates the fibrosis of trabecular meshwork cells induced by TGFβ2 through the promotion of fibrotic proteins degradation NSTL国家科技图书文献中心

Gang,Wang |  Rumeng,Zhao... -  《Human cell》 - 2025,38(1) - Article 4~Article 4 - 共12页

摘要: partial glaucoma patients, and induced trabecular |  meshwork (TM) fibrosis, which could cause TM cells | Abstract The level of transforming growth |  factor-beta2 (TGFβ2) is elevated in aqueous humor of |  dysfunction and lead to intraocular pressure (IOP) elevation
关键词: Autophagy |  Trabecular meshwork cells |  Fibrosis |  TGFβ2 |  Smad3 |  Rapamycin

3. Silencing miR-126-5p protects trabecular meshwork cells against chronic oxidative injury by upregulating HSPB8 to activate PI3K/AKT pathway NSTL国家科技图书文献中心

Jia, Tianqi |  Guo, Yujia... -  《Journal of molecular histology》 - 2025,56(1) - Article: 58~Article: 58 - 共11页

摘要: the pathophysiology of the trabecular meshwork (TM |  investigated the function of miR-126-5p in human trabecular |  meshwork cells (TMCs) under chronic oxidative stress (COS | Chronic oxidative stress (COS) is related to | ) in glaucoma. MicroRNAs (miRNAs) have a key role in
关键词: Glaucoma |  miR-126-5p |  PI3K/AKT pathway |  HSPB8

4. Identification of a chromatin regulator signature and potential candidate drugs for primary open-angle glaucoma NSTL国家科技图书文献中心

Zhang, Xinyue |  Xiao, Lulu... -  《Epigenomics》 - 2025,17(5/6) - 377~387 - 共11页

摘要: expression profile of CRs in trabecular meshwork (TM |  human trabecular meshwork cell (HTMC) oxidative stress | AimsThis research aims to establish a |  chromatin regulator (CR) signature to provide new |  epigenetic insights into the pathogenesis of primary open
关键词: Glaucoma |  POAG |  chromatin regulators |  trabecular meshwork |  oxidative stress

5. Preliminary antifibrotic and vasoconstrictor effects of adrenaline in Schlemm's canal and suprachoroidal minimally invasive glaucoma surgery in primary open-angle glaucoma NSTL国家科技图书文献中心

Luo, Jinyuan |  Fajardo-Sanchez, Jul...... -  《Graefe's archive for clinical and experimental ophthalmology》 - 2025,263(2) - 489~500 - 共12页

摘要:). Methods Human trabecular meshwork (TM) cells were |  risk of bleeding from the trabecular meshwork and | Purpose To investigate the antifibrotic and |  vasoconstrictor effects of adrenaline in Schlemm's canal and |  suprachoroidal minimally invasive glaucoma surgery (MIGS
关键词: Glaucoma |  Adrenaline |  Fibrosis |  MIGS

6. Glaucoma Surgery SOS: Emergency Department Utilization Greater among Younger and First-Time Surgical Patients with Glaucoma NSTL国家科技图书文献中心

Gross, Andrew W. |  Aggarwal, Sahil... -  《Ophthalmology..Glaucoma.》 - 2025,8(1) - 37~45 - 共9页

摘要: trabecular meshwork bypass stent to present to the ED with |  glaucoma surgery. Trabecular meshwork bypass stent, but |  not trabecular meshwork excision and/or Schlemm | Purpose: To describe the frequency, findings | , and interventions of patients' emergency department
关键词: Emergency department |  Glaucoma surgery |  Postoperative

7. Manufacturing and characterisation of 3D-printed sustained-release Timolol implants for glaucoma treatment NSTL国家科技图书文献中心

Paleel, Fathima |  Qin, Mengqi... -  《Drug delivery and translational research》 - 2025,15(1) - 242~252 - 共11页

摘要: implants on cell viability in human trabecular meshwork |  trabecular cells. This study shows proof of concept that | Timolol maleate (TML) is a beta-blocker drug |  that is commonly used to lower the intraocular |  pressure in glaucoma. This study focused on using a 3D
关键词: Glaucoma |  Timolol |  3D printing |  Drug-eluting implants |  Sustained-release

8. Investigational drugs for glaucoma: novel mechanistic approaches of preclinical agents NSTL国家科技图书文献中心

Irkec, Murat |  Konstas, Anastasios ...... -  《Expert opinion on investigational drugs.》 - 2025,34(3) - 231~243 - 共13页

摘要: targeting trabecular meshwork function, neuroprotection | IntroductionGlaucoma is a neurodegenerative |  disease that causes irreversible blindness worldwide. It |  results from retinal ganglion cell (RGC) loss and |  progressive optic nerve damage, mainly associated with
关键词: Adenosine |  brimonidine |  glaucoma |  nanoformulation |  neuroprotection |  nutrients

9. Physiological activation of liver X receptor provides protection against ocular inflammation in uveitic glaucoma NSTL国家科技图书文献中心

Ju, Hyun Hee |  Lee, Jiyoung... -  《Biochimica et biophysica acta.Molecular basis of disease》 - 2025,1871(1) - 167573~167573 - 共13页

摘要: human trabecular meshwork cells in response to CMV | Virus-induced trabeculitis is considered a |  significant cause of uveitic glaucoma, being marked by a |  sudden increase in intraocular pressure and relatively |  mild inflammation in the anterior chamber of the eye
关键词: Liver X receptor |  Cytomegalovirus |  Uveitic glaucoma

10. 3D Finite Element Modeling of Femtosecond Laser Trabeculotomy NSTL国家科技图书文献中心

Djotyan, Gagik P. |  Mikula, Eric R.... -  《Lasers in surgery and medicine.》 - 2025,57(2) - 219~228 - 共10页

摘要: trabecular meshwork (TM) to decrease intraocular pressure | ObjectivesFemtosecond laser image guided high |  precision trabeculotomy (FLigHT) is a novel open-angle |  glaucoma treatment. The procedure non-invasively creates |  aqueous humor (AH) drainage channel from the anterior
关键词: aqueous humor |  femtosecond laser trabeculotomy |  finite element modeling |  intraocular pressure |  open-angle glaucoma
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