NSTL国家科技图书文献中心

1. Microneedle-Loaded Gene-Editable Nanohybrids Engineer Cancer Cells by Telomere Stress Induction and Metabolic Interference for Enhanced Cuproptosis and Immunotherapy NSTL国家科技图书文献中心

Xiaowei Luan | Shiyu Du ... - 《Advanced functional materials》 - 2025,35(9) - 2416285.1～2416285.15 - 共15页

摘要： telomere stress and metabolic interference is developed | suppression. Moreover, 6-Thio-dG-induced telomere* stress not* | through telomere* stress induction and CRISPR/Cas9* | Cuproptosis, a novel copper-driven cell death | , offers potential for cancer therapy, yet challenges

关键词： CRISPR/Cas9 | cuproptosis | immunotherapy | metabolic interference | microneedle patch | telomere stress | treatment resistance

2. The relationship between neuropsychiatric disorders and aging: A review on telomere length, oxidative stress, and inflammation NSTL国家科技图书文献中心

Solh, Tala | Cevher, Sule Coskum - 《Behavioural Brain Research》 - 2025,485 - Article 115528～Article 115528 - 共26页

摘要： of accelerated biological aging. Oxidative stress | , inflammation and telomere* length are factors commonly used to* | the effects of treatment on telomere* length in* | focus, however, is on telomere* length seeing the* | telomere length, thus further research is needed where

关键词： Accelerated aging | Telomere length | Oxidation | Inflammation | Neuropsychiatric disorders | Stress

3. Telomere- and oxidative stress dynamics in Psittacidae species with different longevity trajectories NSTL国家科技图书文献中心

Dominguez-de-Barros,... | Sifaoui, Ines ... - 《GeroScience.》 - 2025,47(1) - 121～134 - 共14页

摘要： erythrocyte telomere length (TL) and oxidative stress | correlation was found between the telomere* length shortening* | oxidative stress* (r = 0.426, p = 0.069) in short-lived* | stress dynamics over time, revealing distinct patterns | Telomeres, conserved DNA sequences at

关键词： Aging | Longevity | Psittacidae | Telomere dynamics | Oxidative stress | Breeding

4. The telomere connection between aging and cancer: The burden of replication stress and dysfunction NSTL国家科技图书文献中心

Boccardi, Virginia | Marano, Luigi - 《Mechanisms of Ageing and Development》 - 2025,223 - 112026～112026 - 共7页

摘要： excessively short and long telomere* lengths may contribute* | abnormalities and replication stress, may provide novel | to intense replicative stress, may represent a key | Aging is a complex process that affects | individuals at the molecular, cellular, tissue, and systemic

关键词： Aging | Cancer | Telomeres

5. Locking the gates of immortality: targeting alternative lengthening of telomeres (ALT) pathways NSTL国家科技图书文献中心

Mishra, Apurwa | Patel, Trupti N. - 《Medical oncology.》 - 2025,42(3) - Article: 78～Article: 78 - 共19页

摘要：Telomere maintenance is essential for the | characterized by hallmarks such as heterogeneous telomere | replication stress. This review has a threefold aim: (1) to | replication stress* proteins such as FANCM and SMARCAL1* | interactions in telomere* recombination provides a novel*

关键词： Telomere | Replication stress | ALT | Recombination | Cancer | Targeted therapy

6. Diet-induced plasticity modifies relationships between larval growth rate and post-metamorphic behavior and physiology in spadefoot toads NSTL国家科技图书文献中心

Shephard, Alexander ... | Jacobsen, Sydney ... - 《The Journal of Experimental Biology》 - 2025,228(2) - 共8页 - 被引量：1

摘要： reactivity (an indicator of stress* responsiveness) and* | It has frequently been hypothesized that among | -individual variation in behavior and physiology will | correlate with life history traits, yet the nature of | these correlations can vary. Such variability may

关键词： Trait correlation | Stress | Carryover effect | Corticosterone | Life history | Telomere

7. Novel immunoinformatics-guided activation of CISD1 with compound 4'-methoxy-3',5,7-trihydroxyflavanone for the prevention of age-related cardiomyopathy NSTL国家科技图书文献中心

Munir, Abdur-Rehman | Wattoo, Javed Iqbal ... - 《Biogerontology》 - 2025,26(2) - 共18页

摘要：, characterized by mitochondrial dysfunction, oxidative stress | , and progressive telomere* shortening in* | mitochondrial bioenergetics, reducing oxidative stress, and | preserving telomere* integrity. Our Immunoinformatic* | telomere attrition, thereby sustaining cardiomyocyte

关键词： CISD1 activation | Cardiomyopathy | Telomere preservation | Mitochondrial bioenergetics | Age-related cardiovascular disease

8. Serum Nutrients, Periodontitis and Biological Ageing NSTL国家科技图书文献中心

Nguyen, L. M. | Tran, A. V.... - 《Journal of clinical periodontology》 - 2025,52(6) - 868～876 - 共9页

摘要： ageing, oxidative stress* and malnutrition. Shorter* | -cryptoxanthin are associated with telomere* lengths and* | ), vitamin levels (low, medium, high), telomere* lengths* | , vitamin E and cis-beta-carotene. Telomere* length was* | telomere length: folate and sex, vitamin D and

关键词： age | dietary vitamins | inflammation | periodontal disease | senescence

9. The Role and Molecular Pathways of SIRT6 in Senescence and Age-related Diseases NSTL国家科技图书文献中心

Lu, Yi | Yang, Junye ... - 《Advanced Biology》 - 2025,9(4) - 共12页

摘要：, telomere* homeostasis, oxidative stress, autophagy, and* | mechanisms. Second, SIRT6 preserves telomere* integrity and* | mitigates cellular senescence by reducing oxidative stress | SIRT6 is a NAD+-dependent histone deacetylase | with crucial roles in controlling DNA damage repair

关键词： mechanisms of senescence | senescence | senescence-related diseases | signaling pathway | SIRT6 | senescence‐related diseases

10. Alternative lengthening of telomere-based immortalization renders H3G34R-mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens NSTL国家科技图书文献中心

Anna Laemmerer | Christian Lehmann ... - 《Neuro-oncology》 - 2025,27(3) - 811～827 - 共17页

摘要：, investigate the impact on telomere* stabilization, and* | glioma (pHGG) models for telomere-maintenance | mechanisms, DNA damage stress* (including protein expression* | with increased basal DNA damage stress, mediating | development of PARPi together with DNA damage stress

摘要： telomere stress and metabolic interference is developed | suppression. Moreover, 6-Thio-dG-induced telomere* stress not* | through telomere* stress induction and CRISPR/Cas9* | Cuproptosis, a novel copper-driven cell death | , offers potential for cancer therapy, yet challenges

关键词： CRISPR/Cas9 | cuproptosis | immunotherapy | metabolic interference | microneedle patch | telomere stress | treatment resistance

摘要： of accelerated biological aging. Oxidative stress | , inflammation and telomere* length are factors commonly used to* | the effects of treatment on telomere* length in* | focus, however, is on telomere* length seeing the* | telomere length, thus further research is needed where

关键词： Accelerated aging | Telomere length | Oxidation | Inflammation | Neuropsychiatric disorders | Stress

摘要： erythrocyte telomere length (TL) and oxidative stress | correlation was found between the telomere* length shortening* | oxidative stress* (r = 0.426, p = 0.069) in short-lived* | stress dynamics over time, revealing distinct patterns | Telomeres, conserved DNA sequences at

关键词： Aging | Longevity | Psittacidae | Telomere dynamics | Oxidative stress | Breeding

摘要： excessively short and long telomere* lengths may contribute* | abnormalities and replication stress, may provide novel | to intense replicative stress, may represent a key | Aging is a complex process that affects | individuals at the molecular, cellular, tissue, and systemic

关键词： Aging | Cancer | Telomeres

摘要：Telomere maintenance is essential for the | characterized by hallmarks such as heterogeneous telomere | replication stress. This review has a threefold aim: (1) to | replication stress* proteins such as FANCM and SMARCAL1* | interactions in telomere* recombination provides a novel*

关键词： Telomere | Replication stress | ALT | Recombination | Cancer | Targeted therapy

摘要： reactivity (an indicator of stress* responsiveness) and* | It has frequently been hypothesized that among | -individual variation in behavior and physiology will | correlate with life history traits, yet the nature of | these correlations can vary. Such variability may

关键词： Trait correlation | Stress | Carryover effect | Corticosterone | Life history | Telomere

摘要：, characterized by mitochondrial dysfunction, oxidative stress | , and progressive telomere* shortening in* | mitochondrial bioenergetics, reducing oxidative stress, and | preserving telomere* integrity. Our Immunoinformatic* | telomere attrition, thereby sustaining cardiomyocyte

关键词： CISD1 activation | Cardiomyopathy | Telomere preservation | Mitochondrial bioenergetics | Age-related cardiovascular disease

摘要： ageing, oxidative stress* and malnutrition. Shorter* | -cryptoxanthin are associated with telomere* lengths and* | ), vitamin levels (low, medium, high), telomere* lengths* | , vitamin E and cis-beta-carotene. Telomere* length was* | telomere length: folate and sex, vitamin D and

关键词： age | dietary vitamins | inflammation | periodontal disease | senescence

摘要：, telomere* homeostasis, oxidative stress, autophagy, and* | mechanisms. Second, SIRT6 preserves telomere* integrity and* | mitigates cellular senescence by reducing oxidative stress | SIRT6 is a NAD+-dependent histone deacetylase | with crucial roles in controlling DNA damage repair

关键词： mechanisms of senescence | senescence | senescence-related diseases | signaling pathway | SIRT6 | senescence‐related diseases

摘要：, investigate the impact on telomere* stabilization, and* | glioma (pHGG) models for telomere-maintenance | mechanisms, DNA damage stress* (including protein expression* | with increased basal DNA damage stress, mediating | development of PARPi together with DNA damage stress

关键词： ATRX | DNA damage | diffuse hemispheric glioma | H3G34R | PARP inhibitor

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： telomere stress and metabolic interference is developed | suppression. Moreover, 6-Thio-dG-induced telomere stress not | through telomere stress induction and CRISPR/Cas9 | Cuproptosis, a novel copper-driven cell death | , offers potential for cancer therapy, yet challenges

关键词： CRISPR/Cas9 | cuproptosis | immunotherapy | metabolic interference | microneedle patch | telomere stress | treatment resistance

摘要： of accelerated biological aging. Oxidative stress | , inflammation and telomere length are factors commonly used to | the effects of treatment on telomere length in | focus, however, is on telomere length seeing the | telomere length, thus further research is needed where

关键词： Accelerated aging | Telomere length | Oxidation | Inflammation | Neuropsychiatric disorders | Stress

摘要： erythrocyte telomere length (TL) and oxidative stress | correlation was found between the telomere length shortening | oxidative stress (r = 0.426, p = 0.069) in short-lived | stress dynamics over time, revealing distinct patterns | Telomeres, conserved DNA sequences at

关键词： Aging | Longevity | Psittacidae | Telomere dynamics | Oxidative stress | Breeding

摘要： excessively short and long telomere lengths may contribute | abnormalities and replication stress, may provide novel | to intense replicative stress, may represent a key | Aging is a complex process that affects | individuals at the molecular, cellular, tissue, and systemic

关键词： Aging | Cancer | Telomeres

摘要：Telomere maintenance is essential for the | characterized by hallmarks such as heterogeneous telomere | replication stress. This review has a threefold aim: (1) to | replication stress proteins such as FANCM and SMARCAL1 | interactions in telomere recombination provides a novel

关键词： Telomere | Replication stress | ALT | Recombination | Cancer | Targeted therapy

摘要： reactivity (an indicator of stress responsiveness) and | It has frequently been hypothesized that among | -individual variation in behavior and physiology will | correlate with life history traits, yet the nature of | these correlations can vary. Such variability may

关键词： Trait correlation | Stress | Carryover effect | Corticosterone | Life history | Telomere

摘要：, characterized by mitochondrial dysfunction, oxidative stress | , and progressive telomere shortening in | mitochondrial bioenergetics, reducing oxidative stress, and | preserving telomere integrity. Our Immunoinformatic | telomere attrition, thereby sustaining cardiomyocyte

关键词： CISD1 activation | Cardiomyopathy | Telomere preservation | Mitochondrial bioenergetics | Age-related cardiovascular disease

摘要： ageing, oxidative stress and malnutrition. Shorter | -cryptoxanthin are associated with telomere lengths and | ), vitamin levels (low, medium, high), telomere lengths | , vitamin E and cis-beta-carotene. Telomere length was | telomere length: folate and sex, vitamin D and

关键词： age | dietary vitamins | inflammation | periodontal disease | senescence

摘要：, telomere homeostasis, oxidative stress, autophagy, and | mechanisms. Second, SIRT6 preserves telomere integrity and | mitigates cellular senescence by reducing oxidative stress | SIRT6 is a NAD+-dependent histone deacetylase | with crucial roles in controlling DNA damage repair

关键词： mechanisms of senescence | senescence | senescence-related diseases | signaling pathway | SIRT6 | senescence‐related diseases

摘要：, investigate the impact on telomere stabilization, and | glioma (pHGG) models for telomere-maintenance | mechanisms, DNA damage stress (including protein expression | with increased basal DNA damage stress, mediating | development of PARPi together with DNA damage stress

关键词： ATRX | DNA damage | diffuse hemispheric glioma | H3G34R | PARP inhibitor

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： telomere stress and metabolic interference is developed | suppression. Moreover, 6-Thio-dG-induced telomere* stress not* | through telomere* stress induction and CRISPR/Cas9* | Cuproptosis, a novel copper-driven cell death | , offers potential for cancer therapy, yet challenges

摘要： of accelerated biological aging. Oxidative stress | , inflammation and telomere* length are factors commonly used to* | the effects of treatment on telomere* length in* | focus, however, is on telomere* length seeing the* | telomere length, thus further research is needed where

摘要： erythrocyte telomere length (TL) and oxidative stress | correlation was found between the telomere* length shortening* | oxidative stress* (r = 0.426, p = 0.069) in short-lived* | stress dynamics over time, revealing distinct patterns | Telomeres, conserved DNA sequences at

摘要： excessively short and long telomere* lengths may contribute* | abnormalities and replication stress, may provide novel | to intense replicative stress, may represent a key | Aging is a complex process that affects | individuals at the molecular, cellular, tissue, and systemic

摘要：Telomere maintenance is essential for the | characterized by hallmarks such as heterogeneous telomere | replication stress. This review has a threefold aim: (1) to | replication stress* proteins such as FANCM and SMARCAL1* | interactions in telomere* recombination provides a novel*

摘要： reactivity (an indicator of stress* responsiveness) and* | It has frequently been hypothesized that among | -individual variation in behavior and physiology will | correlate with life history traits, yet the nature of | these correlations can vary. Such variability may

摘要：, characterized by mitochondrial dysfunction, oxidative stress | , and progressive telomere* shortening in* | mitochondrial bioenergetics, reducing oxidative stress, and | preserving telomere* integrity. Our Immunoinformatic* | telomere attrition, thereby sustaining cardiomyocyte

摘要： ageing, oxidative stress* and malnutrition. Shorter* | -cryptoxanthin are associated with telomere* lengths and* | ), vitamin levels (low, medium, high), telomere* lengths* | , vitamin E and cis-beta-carotene. Telomere* length was* | telomere length: folate and sex, vitamin D and

摘要：, telomere* homeostasis, oxidative stress, autophagy, and* | mechanisms. Second, SIRT6 preserves telomere* integrity and* | mitigates cellular senescence by reducing oxidative stress | SIRT6 is a NAD+-dependent histone deacetylase | with crucial roles in controlling DNA damage repair

摘要：, investigate the impact on telomere* stabilization, and* | glioma (pHGG) models for telomere-maintenance | mechanisms, DNA damage stress* (including protein expression* | with increased basal DNA damage stress, mediating | development of PARPi together with DNA damage stress