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1. Microneedle-Loaded Gene-Editable Nanohybrids Engineer Cancer Cells by Telomere Stress Induction and Metabolic Interference for Enhanced Cuproptosis and Immunotherapy NSTL国家科技图书文献中心

Xiaowei Luan |  Shiyu Du... -  《Advanced functional materials》 - 2025,35(9) - 2416285.1~2416285.15 - 共15页

摘要: telomere stress and metabolic interference is developed |  suppression. Moreover, 6-Thio-dG-induced telomere stress not |  through telomere stress induction and CRISPR/Cas9 | Cuproptosis, a novel copper-driven cell death | , offers potential for cancer therapy, yet challenges
关键词: CRISPR/Cas9 |  cuproptosis |  immunotherapy |  metabolic interference |  microneedle patch |  telomere stress |  treatment resistance

2. The relationship between neuropsychiatric disorders and aging: A review on telomere length, oxidative stress, and inflammation NSTL国家科技图书文献中心

Solh, Tala |  Cevher, Sule Coskum -  《Behavioural Brain Research》 - 2025,485 - Article 115528~Article 115528 - 共26页

摘要: of accelerated biological aging. Oxidative stress | , inflammation and telomere length are factors commonly used to |  the effects of treatment on telomere length in |  focus, however, is on telomere length seeing the |  telomere length, thus further research is needed where
关键词: Accelerated aging |  Telomere length |  Oxidation |  Inflammation |  Neuropsychiatric disorders |  Stress

3. Telomere- and oxidative stress dynamics in Psittacidae species with different longevity trajectories NSTL国家科技图书文献中心

Dominguez-de-Barros,... |  Sifaoui, Ines... -  《GeroScience.》 - 2025,47(1) - 121~134 - 共14页

摘要: erythrocyte telomere length (TL) and oxidative stress |  correlation was found between the telomere length shortening |  oxidative stress (r = 0.426, p = 0.069) in short-lived |  stress dynamics over time, revealing distinct patterns | Telomeres, conserved DNA sequences at
关键词: Aging |  Longevity |  Psittacidae |  Telomere dynamics |  Oxidative stress |  Breeding

4. The telomere connection between aging and cancer: The burden of replication stress and dysfunction NSTL国家科技图书文献中心

Boccardi, Virginia |  Marano, Luigi -  《Mechanisms of Ageing and Development》 - 2025,223 - 112026~112026 - 共7页

摘要: excessively short and long telomere lengths may contribute |  abnormalities and replication stress, may provide novel |  to intense replicative stress, may represent a key | Aging is a complex process that affects |  individuals at the molecular, cellular, tissue, and systemic
关键词: Aging |  Cancer |  Telomeres

5. Locking the gates of immortality: targeting alternative lengthening of telomeres (ALT) pathways NSTL国家科技图书文献中心

Mishra, Apurwa |  Patel, Trupti N. -  《Medical oncology.》 - 2025,42(3) - Article: 78~Article: 78 - 共19页

摘要:Telomere maintenance is essential for the |  characterized by hallmarks such as heterogeneous telomere |  replication stress. This review has a threefold aim: (1) to |  replication stress proteins such as FANCM and SMARCAL1 |  interactions in telomere recombination provides a novel
关键词: Telomere |  Replication stress |  ALT |  Recombination |  Cancer |  Targeted therapy

6. Diet-induced plasticity modifies relationships between larval growth rate and post-metamorphic behavior and physiology in spadefoot toads NSTL国家科技图书文献中心

Shephard, Alexander ... |  Jacobsen, Sydney... -  《The Journal of Experimental Biology》 - 2025,228(2) - 共8页 - 被引量:1

摘要: reactivity (an indicator of stress responsiveness) and | It has frequently been hypothesized that among | -individual variation in behavior and physiology will |  correlate with life history traits, yet the nature of |  these correlations can vary. Such variability may
关键词: Trait correlation |  Stress |  Carryover effect |  Corticosterone |  Life history |  Telomere

7. Novel immunoinformatics-guided activation of CISD1 with compound 4'-methoxy-3',5,7-trihydroxyflavanone for the prevention of age-related cardiomyopathy NSTL国家科技图书文献中心

Munir, Abdur-Rehman |  Wattoo, Javed Iqbal... -  《Biogerontology》 - 2025,26(2) - 共18页

摘要:, characterized by mitochondrial dysfunction, oxidative stress | , and progressive telomere shortening in |  mitochondrial bioenergetics, reducing oxidative stress, and |  preserving telomere integrity. Our Immunoinformatic |  telomere attrition, thereby sustaining cardiomyocyte
关键词: CISD1 activation |  Cardiomyopathy |  Telomere preservation |  Mitochondrial bioenergetics |  Age-related cardiovascular disease

8. Serum Nutrients, Periodontitis and Biological Ageing NSTL国家科技图书文献中心

Nguyen, L. M. |  Tran, A. V.... -  《Journal of clinical periodontology》 - 2025,52(6) - 868~876 - 共9页

摘要: ageing, oxidative stress and malnutrition. Shorter | -cryptoxanthin are associated with telomere lengths and | ), vitamin levels (low, medium, high), telomere lengths | , vitamin E and cis-beta-carotene. Telomere length was |  telomere length: folate and sex, vitamin D and
关键词: age |  dietary vitamins |  inflammation |  periodontal disease |  senescence

9. The Role and Molecular Pathways of SIRT6 in Senescence and Age-related Diseases NSTL国家科技图书文献中心

Lu, Yi |  Yang, Junye... -  《Advanced Biology》 - 2025,9(4) - 共12页

摘要:, telomere homeostasis, oxidative stress, autophagy, and |  mechanisms. Second, SIRT6 preserves telomere integrity and |  mitigates cellular senescence by reducing oxidative stress | SIRT6 is a NAD+-dependent histone deacetylase |  with crucial roles in controlling DNA damage repair
关键词: mechanisms of senescence |  senescence |  senescence-related diseases |  signaling pathway |  SIRT6 |  senescence‐related diseases

10. Alternative lengthening of telomere-based immortalization renders H3G34R-mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens NSTL国家科技图书文献中心

Anna Laemmerer |  Christian Lehmann... -  《Neuro-oncology》 - 2025,27(3) - 811~827 - 共17页

摘要:, investigate the impact on telomere stabilization, and |  glioma (pHGG) models for telomere-maintenance |  mechanisms, DNA damage stress (including protein expression |  with increased basal DNA damage stress, mediating |  development of PARPi together with DNA damage stress
关键词: ATRX |  DNA damage |  diffuse hemispheric glioma |  H3G34R |  PARP inhibitor
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