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1. Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs NSTL国家科技图书文献中心

Lin, Hongbing |  Liu, Jinbin... -  《Drug delivery and translational research》 - 2025,15(1) - 216~230 - 共15页

摘要: dissolving MN patch with pure liraglutide at the needle |  of liraglutide in a patch size of 0.9 cm2, which | . Raman imaging confirmed that liraglutide was localized |  to 0.93 +/- 0.04 mg of liraglutide into skin with a |  delivery enabled faster absorption of liraglutide than
关键词: Microneedle patch |  Liraglutide |  Microneedle with pure-drug tips |  Pharmacokinetics

2. High Dose of Liraglutide Impairs Renal Function in Female Hypertensive Rats NSTL国家科技图书文献中心

Tonon Firmino, Felip... |  Peixoto, Pollyana... -  《Journal of cardiovascular pharmacology.》 - 2025,85(2) - 120~128 - 共9页

摘要: renal effects of different doses of liraglutide in an | ) or liraglutide at low (0.06 mg/kg) and high (LH | , and potassium were analyzed. Liraglutide reduced |  low liraglutide. LH augmented collagen and early |  blood pressure and glycemic control. Liraglutide
关键词: GLP-1 |  liraglutide |  hypertension |  kidney |  blood urea nitrogen

3. Liraglutide promotes osteogenic differentiation of mesenchymal stem cells by inhibiting M1 macrophage polarization and CXCL9 release in vitro NSTL国家科技图书文献中心

He, Yilin |  Song, Wenpeng... -  《Molecular and Cellular Endocrinology》 - 2025,597 - Article 112441~Article 112441 - 共10页 - 被引量:1

摘要: treating type 2 diabetes, liraglutide shows potential |  polarization. Results showed that liraglutide significantly | . Additionally, liraglutide markedly inhibited M1 macrophage |  from liraglutide-treated macrophages showed stronger |  demonstrates that liraglutide enhances BMSC osteogenic
关键词: Liraglutide |  Macrophage polarization |  Bone regeneration |  CXCL9

4. Liraglutide effects on epicardial adipose tissue micro-RNAs and intra-operative glucose control NSTL国家科技图书文献中心

Iacobellis G. |  Goldberger J.J.... -  《Nutrition, metabolism, and cardiovascular diseases》 - 2025,35(2) - 103726~103726 - 共9页

摘要: fat (SAT), and liraglutide can modulate EAT miRNAs |  disease (CAD) who were started on either liraglutide or |  LA-EAT than SAT (p < 0.05) in the liraglutide group | . Liraglutide-treated patients had better intra-op glucose |  liraglutide group. Pre-op liraglutide was also associated
关键词: Coronary artery bypass grafting |  Coronary artery disease |  Epicardial fat |  GLP-1RAs |  Liraglutide

5. Nmnat2 deficiency in the arcuate nucleus or paraventricular nucleus induces Sarm 1-independent neuron loss and liraglutide-reversible obesity NSTL国家科技图书文献中心

Yu, Huimin |  Feng, Ning... -  《The FASEB Journal》 - 2025,39(4) - e70400~e70400 - 共18页

摘要: liraglutide, a glucagon-like peptide-1 (GLP-1) analog |  injection of liraglutide activates neurons in PVN and LPBN |  neuron loss, and liraglutide-reversible hyperphagia and | Nicotinamide mononucleotide |  adenylyltransferase 2 (Nmnat2) plays an important role in
关键词: hyperphagia |  liraglutide |  neurons survival |  Nmnat2 |  obesity |  Sarm1

6. Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice NSTL国家科技图书文献中心

Ma, Jun |  Hu, Xiaoyan... -  《Endocrine.》 - 2025,87(1) - 159~169 - 共11页

摘要: efficacy of Liraglutide, Tirzepatide, and Retatrutide in |  injections of Liraglutide (10 nmol/kg), Tirzepatide (10 |  Liraglutide and Tirzepatide. Additionally, it markedly | PurposeTo assess and compare the therapeutic |  treating diabetic kidney disease (DKD) in db/db
关键词: Diabetic kidney disease |  Retatrutide |  Tirzepatide |  Liraglutide |  Glycaemic control |  Weight control

7. Effects of Liraglutide on Leptin Promoter Methylation in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome and Obesity NSTL国家科技图书文献中心

Zhao, Hongli |  Guo, Yanying -  《Gynecologic and obstetric investigation》 - 2025,90(1) - 6~17 - 共12页

摘要: the impacts of liraglutide on leptin (LEP) promoter |  group received a subcutaneous injection of liraglutide | : Liraglutide has a therapeutic effect on patients with | Objective: The aim of the study was to explore |  methylation in ovarian granulosa cells of patients with
关键词: Liraglutide |  Polycystic ovary syndrome |  Obese |  Methylation of leptin promoter |  Ovarian granulosa cells

8. Differential effects of liraglutide naltrexone/bupropion, and caloric restriction on metabolic parameters and beta-cell regeneration in type 2 diabetic rat model: role of beta arrestin 1 NSTL国家科技图书文献中心

Merzeban, Dina H. |  Ali, Amani M. El Ami...... -  《Journal of molecular histology》 - 2025,56(1) - Article: 50~Article: 50 - 共16页

摘要: of Liraglutide, naltrexone/bupropion (NTX + BUP |  + liraglutide (0.3 mg/kg/day, S.C). Body weight, BMI, serum |  compared to liraglutide. Of note, liraglutide | , liraglutide and caloric restriction significantly increased |  promoting beta-cell regeneration compared to liraglutide
关键词: Naltrexone/bupropion |  Liraglutide |  Caloric restriction |  beta-cell regeneration |  Type 2 diabetes

9. An oral liraglutide nanomicelle formulation conferring reduced insulin-resistance and long-term hypoglycemic and lipid metabolic benefits NSTL国家科技图书文献中心

Subedi, Laxman |  Bamjan, Arjun Dhwoj... -  《Journal of Controlled Release》 - 2025,378 - 637~655 - 共19页

摘要: an oral liraglutide (LRG) formulation by | Type 2 diabetes is a chronic disease |  characterized by insulin resistance and often worsened by |  obesity. Effective management involves the use of |  glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to
关键词: Liraglutide |  GLP-1 receptor agonist |  Nanomicelle |  Bile acid transporter-mediated oral absorption |  Type 2 diabetes |  Obesity

10. A comprehensive study on the identification and characterization of major degradation products of synthetic liraglutide using liquid chromatography-high resolution mass spectrometry NSTL国家科技图书文献中心

Badgujar, Devendra |  Bawake, Sanket... -  《Journal of peptide science》 - 2025,31(1) - n/a~n/a - 共12页

摘要:Liraglutide (LGT) is a synthetic glucagon-like |  behavior of liraglutide was studied by exposing the drug |  peptide-1 analogue mainly used for the treatment of type | -2 diabetes or obesity. Comprehensive stability |  testing is essential in the development and routine
关键词: hydrolysis |  isomers |  LC-HRMS |  liraglutide |  stress degradation |  LC‐HRMS
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