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1. Gene therapy for β-thalassemia: current and future options NSTL国家科技图书文献中心

Giulia Hardouin |  Annarita Miccio... -  《Trends in molecular medicine》 - 2025,31(4) - 344~358 - 共15页 - 被引量:1

摘要: development of lentiviral vectors and genome-editing tools | Beta-thalassemia is a severe, hereditary blood |  disorder characterized by anemia, transfusion dependence | , reduced life expectancy, and poor quality of life | . Allogeneic transplantation of hematopoietic stem cells
关键词: base editing; gene therapy; genome editing; lentiviral vectors; β-thalassemia.

2. Multiple gene therapy as a tool for regulating the expression of molecules involved in neovascular age-related macular degeneration NSTL国家科技图书文献中心

Corydon, Thomas J. |  Bek, Toke -  《Progress in retinal and eye research》 - 2025,104 - 101323~101323 - 共17页

摘要:) using adeno-associated virus (AAV) vectors. It is | Anti-vascular endothelial growth factor (VEGF | ) therapies have revolutionized the treatment of neovascular |  age- related macular degeneration (nAMD) and other |  retinal diseases. However, the necessity for repeated
关键词: Age-related macular degeneration |  Multiple gene therapy |  VEGF |  Angiogenesis |  RNA interference |  Adeno-associated virus |  Lentiviral vectors

3. Therapeutic potential of anti-ErbB3 chimeric antigen receptor natural killer cells against breast cancer NSTL国家科技图书文献中心

Lee, Juheon |  Song, Jinhoo... -  《Cancer immunology,immunotherapy》 - 2025,74(2) - Article: 73~Article: 73 - 共15页

摘要:-pseudotyped lentiviral vectors. Transduced cells displayed | ErbB3 is markedly overexpressed in breast |  cancer cells and is associated with resistance and |  metastasis. Additionally, ErbB3 expression levels are |  positively correlated with low densities of tumor
关键词: Chimeric antigen receptor (CAR) |  Natural killer (NK) cells |  Breast cancer |  ErbB3

4. Purification of plasmid DNA using a novel two stage chromatography process NSTL国家科技图书文献中心

Yu, Minglei |  Yu, Mengran... -  《Journal of chromatography,B.Analytical technologies in the biomedical and life sciences》 - 2025,1250 - 共8页

摘要: below 5 EU/mg. Lentiviral vectors packaged using these |  lentiviral packaging plasmids (pLP1, pLP2 and pLP/VSVG) and | The chromatography process of large-scale |  plasmid purification with high efficiency and low cost |  has always been a major challenge. We established a
关键词: Plasmid DNA |  Purification |  Core-shell particles |  Thiophilic interaction chromatography |  Design of Experiments

5. Anti-tembusu virus of capsid-targeted viral inactivation delivered by lentiviral vector in vivo NSTL国家科技图书文献中心

Zhang, Xingcui |  Luo, Ning... -  《Veterinary Microbiology》 - 2025,300 - 共8页

摘要:. This study combines lentiviral vectors with CTVI |  viral DNA or RNA. Lentivirus vectors are an effective | Tembusu virus (TMUV) is a member of genus |  flavivirus, which mainly causes decrease in production in |  egg ducks and neurological symptom in meatducks
关键词: Tembusu virus |  Antivirus |  Lentivirus vector

6. Study on the role and mechanism of TMED2 in oral squamous cell carcinoma NSTL国家科技图书文献中心

Wu, Xuechen |  Liu, Boxin... -  《International Journal of Biological Macromolecules》 - 2025,289 - 共14页

摘要: with lentiviral vectors, and RT-PCR and Western | Purpose: This study investigated TMED2 |  expression in oral squamous cell carcinoma (OSCC) and its |  effects on SCC9 cell behaviors, including proliferation | , migration, invasion, and autophagy, to support OSCC
关键词: Oral squamous cell carcinoma |  TMED2 |  Prognosis

7. FoxO1 regulates human haematopoietic stem cells self-renewal and engraftment NSTL国家科技图书文献中心

Chen, Lieguang |  Ge, Qunfang... -  《Molecular biology reports》 - 2025,52(1) - 共11页

摘要: the development of HSCs, lentiviral vectors | BackgroundHematopoietic stem cell |  transplantation (HSCT) is one of the most effective ways to |  treat hematological malignant diseases, but the |  traditional culture of hematopoietic stem cells (HSCs) in
关键词: Hematological malignant diseases |  Self-renewal |  Differentiation |  FoxO1 |  Engraftment

8. Artesunate Enhances Sensitivity of Renal Cancer Cells to Sunitnib by Mediating Tripartite Motif Containing 24-Induced Ubiquitination of Paired Box 6 NSTL国家科技图书文献中心

Cui, Zelin |  Wen, Jianhua... -  《Chemical biology and drug design》 - 2025,105(5) - n/a~n/a - 共15页

摘要: lentiviral vectors, quantified by reverse transcription | This research aims to elucidate the |  mechanistic role of artesunate (ART) in enhancing the |  sensitivity of renal cell carcinoma (RCC) to sunitinib. To |  establish sunitinib-resistant RCC cell lines (786-O R and
关键词: artesunate |  EMT |  PAX6 |  renal cancer |  TRIM24

9. Total saponins from Panax japonicus reduced lipid deposition and inflammation in hepatocyte via PHD2 and hepatic macrophage-derived exosomal miR-463-5p NSTL国家科技图书文献中心

Yang, Jingjie |  Gui, Yibei... -  《Journal of Ethnopharmacology》 - 2025,342 - 119376~119376 - 共18页

摘要: transfecting lentiviral vectors to cause miR-463-5p knockdown | Ethnopharmacological relevance: Panax |  japonicus (T. Nees) C.A. Mey. (PJ) is a traditional |  Chinese herbal medicine revered as the "King of Herbs | " in Tujia and Hmong medical practices. Clinically
关键词: Total saponins |  Panax japonicus (T. Nees) CA Mey. |  Non-alcoholic steatohepatitis |  Lipid metabolism |  Exosomes |  miR-463-5p |  PHD2

10. YAP1 overexpression aggravates the progress of diabetic retinopathy by activating the TUG1/miR-144-3p/VEGFA signaling pathway in the hypoxia-induced DR MRMECs model NSTL国家科技图书文献中心

Yang, Ying -  《Tissue and Cell》 - 2025,92 - 102620~102620 - 共7页

摘要: taurine-upregulated gene 1 (TUG1) silencing lentiviral |  vectors, both of which were used to infect the DR MRMECs | Diabetic retinopathy (DR) has been proven to |  be a leading cause of blindness. This study aimed |  to investigate the effect of Yes-associated protein
关键词: Diabetic retinopathy |  YAP1 |  TUG1 |  MiR-144-3 P |  VEGFA
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