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1. Gene therapy for β-thalassemia: current and future options NSTL国家科技图书文献中心

Giulia Hardouin |  Annarita Miccio... -  《Trends in molecular medicine》 - 2025,31(4) - 344~358 - 共15页

摘要: development of lentiviral vectors and genome-editing tools | Beta-thalassemia is a severe, hereditary blood |  disorder characterized by anemia, transfusion dependence | , reduced life expectancy, and poor quality of life | . Allogeneic transplantation of hematopoietic stem cells
关键词: base editing; gene therapy; genome editing; lentiviral vectors; β-thalassemia.

2. Multiple gene therapy as a tool for regulating the expression of molecules involved in neovascular age-related macular degeneration NSTL国家科技图书文献中心

Corydon, Thomas J. |  Bek, Toke -  《Progress in retinal and eye research》 - 2025,104 - 101323~101323 - 共17页

摘要:) using adeno-associated virus (AAV) vectors. It is | Anti-vascular endothelial growth factor (VEGF | ) therapies have revolutionized the treatment of neovascular |  age- related macular degeneration (nAMD) and other |  retinal diseases. However, the necessity for repeated
关键词: Age-related macular degeneration |  Multiple gene therapy |  VEGF |  Angiogenesis |  RNA interference |  Adeno-associated virus |  Lentiviral vectors

3. Therapeutic potential of anti-ErbB3 chimeric antigen receptor natural killer cells against breast cancer NSTL国家科技图书文献中心

Lee, Juheon |  Song, Jinhoo... -  《Cancer immunology,immunotherapy》 - 2025,74(2) - Article: 73~Article: 73 - 共15页

摘要:-pseudotyped lentiviral vectors. Transduced cells displayed | ErbB3 is markedly overexpressed in breast |  cancer cells and is associated with resistance and |  metastasis. Additionally, ErbB3 expression levels are |  positively correlated with low densities of tumor
关键词: Chimeric antigen receptor (CAR) |  Natural killer (NK) cells |  Breast cancer |  ErbB3

4. Purification of plasmid DNA using a novel two stage chromatography process NSTL国家科技图书文献中心

Yu, Minglei |  Yu, Mengran... -  《Journal of chromatography,B.Analytical technologies in the biomedical and life sciences》 - 2025,1250 - 共8页

摘要: below 5 EU/mg. Lentiviral vectors packaged using these |  lentiviral packaging plasmids (pLP1, pLP2 and pLP/VSVG) and | The chromatography process of large-scale |  plasmid purification with high efficiency and low cost |  has always been a major challenge. We established a
关键词: Plasmid DNA |  Purification |  Core-shell particles |  Thiophilic interaction chromatography |  Design of Experiments

5. Anti-tembusu virus of capsid-targeted viral inactivation delivered by lentiviral vector in vivo NSTL国家科技图书文献中心

Zhang, Xingcui |  Luo, Ning... -  《Veterinary Microbiology》 - 2025,300 - 共8页

摘要:. This study combines lentiviral vectors with CTVI |  viral DNA or RNA. Lentivirus vectors are an effective | Tembusu virus (TMUV) is a member of genus |  flavivirus, which mainly causes decrease in production in |  egg ducks and neurological symptom in meatducks
关键词: Tembusu virus |  Antivirus |  Lentivirus vector

6. Study on the role and mechanism of TMED2 in oral squamous cell carcinoma NSTL国家科技图书文献中心

Wu, Xuechen |  Liu, Boxin... -  《International Journal of Biological Macromolecules》 - 2025,289 - 共14页

摘要: with lentiviral vectors, and RT-PCR and Western | Purpose: This study investigated TMED2 |  expression in oral squamous cell carcinoma (OSCC) and its |  effects on SCC9 cell behaviors, including proliferation | , migration, invasion, and autophagy, to support OSCC
关键词: Oral squamous cell carcinoma |  TMED2 |  Prognosis

7. FoxO1 regulates human haematopoietic stem cells self-renewal and engraftment NSTL国家科技图书文献中心

Chen, Lieguang |  Ge, Qunfang... -  《Molecular biology reports》 - 2025,52(1) - 共11页

摘要: the development of HSCs, lentiviral vectors | BackgroundHematopoietic stem cell |  transplantation (HSCT) is one of the most effective ways to |  treat hematological malignant diseases, but the |  traditional culture of hematopoietic stem cells (HSCs) in
关键词: Hematological malignant diseases |  Self-renewal |  Differentiation |  FoxO1 |  Engraftment

8. YAP1 overexpression aggravates the progress of diabetic retinopathy by activating the TUG1/miR-144-3p/VEGFA signaling pathway in the hypoxia-induced DR MRMECs model NSTL国家科技图书文献中心

Yang, Ying -  《Tissue and Cell》 - 2025,92 - 102620~102620 - 共7页

摘要: taurine-upregulated gene 1 (TUG1) silencing lentiviral |  vectors, both of which were used to infect the DR MRMECs | Diabetic retinopathy (DR) has been proven to |  be a leading cause of blindness. This study aimed |  to investigate the effect of Yes-associated protein
关键词: Diabetic retinopathy |  YAP1 |  TUG1 |  MiR-144-3 P |  VEGFA

9. Stable expression of SARS-CoV-2 envelope viroporin promotes intracellular calcium depletion in human cells: relevance for endoplasmic reticulum stress, cell proliferation, pluripotency and lineage differentiation NSTL国家科技图书文献中心

Sala, Cesare |  Ninu, Andrea... -  《Cell Calcium》 - 2025,128 - 103032~103032 - 共13页

摘要: poorly investigated. Using lentiviral vectors, we | SARS-CoV-2 infection affects the respiratory |  system but also many tissues and organs that may be |  adversely compromised. Accordingly, recent evidence has |  assessed virus ability to infect different cell
关键词: SARS-CoV-2 1 |  Envelope 2 |  hiPS cells |  Ca 2+handling 4 |  ER stress 5 |  Dysfunctional mitochondria 6 |  Tri-lineage differentiation 7

10. GSTA2 overexpression alleviates bis (2-ethylhexyl) phthalate (DEHP)-induced male reproductive disorders by inhibiting oxidative stress-mediated cell apoptosis via the activated PI3K/AKT signaling pathway NSTL国家科技图书文献中心

Wei, Lei |  Feng, Zonggang... -  《Molecular and Cellular Endocrinology》 - 2025,599 - 112462~112462 - 共12页

摘要: GSTA2 in DEHP exposure, lentiviral vectors carrying | Male reproductive disorders are responsible |  for approximately 50% of infertility cases. Bis (2 | -ethylhexyl) phthalate (DEHP) is a common environmental |  pollutant known for its reproductive toxicity. Oxidative
关键词: Male reproductive disorders |  Bis (2-ethylhexyl) phthalate (DEHP) |  Cell apoptosis |  Oxidative stress |  PI3K/AKT signaling pathway
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