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1. Fuzzy-DDI: A robust fuzzy logic query model for complex drug-drug interaction prediction NSTL国家科技图书文献中心

Cheng, Junkai |  Zhang, Yijia... -  《Artificial intelligence in medicine》 - 2025,164(Jun.) - 1.1~1.8 - 共8页

摘要:Drug-drug interactions (DDI) refer to the | , DDI prediction is significant for drug development |  drugs simultaneously, which may reduce the drug |  interactions between drug pairs, cannot contain more | , Fuzzy-DDI, to predict DDI under various complex
关键词: Drug-drug interaction |  Fuzzy logic |  Rough set |  Robust |  Logical query |  NEURAL-NETWORK |  PHARMACOKINETICS |  LORATADINE

2. PBPK modelling for the evaluation of drug-drug interaction between meropenem and valproic acid NSTL国家科技图书文献中心

Liu, Hongrui |  Yu, Yiqun... -  《British Journal of Clinical Pharmacology》 - 2025,91(4) - 1198~1207 - 共10页

摘要: investigate the potential drug-drug interaction (DDI |  quantitatively investigate the potential DDI between MEPM and |  acylpeptide hydrolase (APEH) on DDI was also |  of VPA.ConclusionsThe DDI between MEPM and VPA | AimsThe present study aimed to quantitatively
关键词: acylpeptide hydrolase (APEH) |  drug-drug interaction (DDI) |  meropenem (MEPM) |  physiologically based pharmacokinetic (PBPK) modelling |  polymorphisms |  valproic acid (VPA)

3. Severe Impact of Omeprazole Timing on pH‐Sensitive Dasatinib Absorption: Unveiling Substantial DrugDrug Interaction NSTL国家科技图书文献中心

Per Andersson |  Magnus Brisander... -  《Journal of clinical pharmacology.》 - 2025,65(5) - 588~597 - 共10页

摘要: inhibitors (PPIs) should be avoided. Drugdrug interaction |  (DDI) studies with PPIs report approximately 40%‐80 |  near maximum DDI as timing of PPI dosing was either |  conducted a DDI study of crystalline dasatinib and |  exposure at a time point when the near maximum DDI effect
关键词: acid reducing agent (ARA) |  bioavailability |  chronic myeloid leukemia (CML) |  crystalline dasatinib |  drugdrug interaction (DDI) |  omeprazole |  pharmacokinetics |  proton‐pump inhibitors (PPI)

4. An accurate prediction of drug-drug interactions and side effects by using integrated convolutional and BiLSTM networks NSTL国家科技图书文献中心

Ali, Sabir |  Alam, Waleed... -  《Chemometrics and Intelligent Laboratory Systems》 - 2025,257 - 105304.1~105304.9 - 共9页

摘要: effects. Accurate prediction of drug-drug interactions |  is crucial in drug discovery and safety research |  is necessary for predicting drug-drug interactions |  convolutional and BiLSTM networks to predict the types of drug | -drug interactions. The Morgan fingerprints approach
关键词: drug-drug interaction |  DDI-hybrid model |  Deep learning |  Convolutional neural network |  BiLSTM |  Adverse drug effects

5. Drug-drug interaction prediction based on graph contrastive learning and dual-view fusion NSTL国家科技图书文献中心

Ding, Shanyang |  Niu, Dongjiang... -  《Computational biology and chemistry》 - 2025,117 - 共8页

摘要:Drug-drug interaction (DDI) is important in |  drug research and are one of the major causes of |  automatically extract drug features from molecular graphs or |  drug-related networks, which improves the performance |  of DDI prediction. However, there is noise and
关键词: Knowledge graph |  Drug similarity network |  Graph contrastive learning |  Self-supervised learning |  Dual-view fusion model

6. Clinical Assessment of Drug Transporter Inhibition Using Biomarkers: Review of the Literature (2015-2024) NSTL国家科技图书文献中心

Rodrigues, David |  Wezalis, Stephanie -  《Journal of clinical pharmacology.》 - 2025,65(6) - 688~703 - 共16页

摘要: drug-drug interaction (DDI) perpetrator drugs |  jointly with drug probes to deconvolute DDI mechanisms | -based drug transporter biomarkers, it was determined |  enable DDI predictions and development of multiplexed |  encompassing in vitro transporter inhibition data, DDI risk
关键词: biomarker |  drug interaction |  drug transporter |  solute carrier

7. Addressing Drug-Drug Interaction Knowledge Gaps at the Time of Approval: An Analysis of FDA Postmarketing Requirements and Commitments from 2009 to 2023 NSTL国家科技图书文献中心

Ridge, Sarah |  Yang, Xinning... -  《Journal of clinical pharmacology.》 - 2025,65(3) - 378~388 - 共11页

摘要: potential for interaction with other drugs. Drug-drug |  interaction (DDI) assessments are typically performed in a |  stepwise manner during drug development, though knowledge |  and Drug Administration can establish postmarketing |  pharmacokinetics-based DDIs (i.e., drug metabolizing enzyme- and
关键词: commitments |  drug-drug interactions |  drug metabolizing enzymes |  postmarketing |  requirements |  transporters |  drugdrug interactions

8. Drug-drug interactions potential with the HIV-1 capsid inhibitor lenacapavir NSTL国家科技图书文献中心

Marzolini, Catia |  Gibbons, Sara... -  《Expert opinion on drug metabolism & toxicology》 - 2025,21(2) - 161~172 - 共12页

摘要: emphasis placed on its drug-drug interaction (DDI |  polypharmacy. The effect of lenacapavir on drug metabolizing |  enzymes and transporters as well as findings of DDI |  opinionLenacapavir has a favorable DDI profile with 80% of | IntroductionLenacapavir is the first HIV-1
关键词: Lenacapavir |  capsid inhibitor |  drug-drug interactions |  long-acting |  antiretroviral

9. Preclinical Evidence for a Drug-Drug Interaction Between Cannabinol and Melatonin NSTL国家科技图书文献中心

Anderson, Lyndsey L. |  Hawkins, Nicole A.... -  《Basic & clinical pharmacology & toxicology.》 - 2025,136(1) - e14120~e14120 - 共5页 - 被引量:1

摘要:-drug interaction (DDI) given that cannabinoids are |  melatonin provides potential for a pharmacokinetic drug |  known to inhibit drug-metabolizing enzymes. Indeed, we |  potential DDI involving melatonin. | The worldwide legalization of medicinal
关键词: cannabinoid |  cannabinol |  CYP1A2 |  melatonin |  metabolism

10. Computational Approaches for Predicting Drug Interactions with Human Organic Anion Transporter 4 (OAT4) NSTL国家科技图书文献中心

Martinez-Guerrero, L... |  Vignaux, Patricia A.... -  《Molecular pharmaceutics》 - 2025,22(4) - 1847~1858 - 共12页

摘要: concentration as per the 2020 FDA drug-drug interaction (DDI |  important transporter for drug-drug interactions (DDIs |  values were then compared to the drug plasma | Human Organic Anion Transporter 4 (OAT4) is |  predominantly expressed in the kidneys, particularly in the
关键词: MegaTrans |  Human Organic Anion Transporter 4 (OAT4) |  Organic Anions (OAs) |  Drug-Drug Interactions(DDIs) |  Predictive Modeling |  Drug Screening |  Machine Learning |  Conformal Predictors
检索条件drug-drug interaction (DDI)
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