NSTL国家科技图书文献中心

1. Antipsychotic polypharmacy and high-dose antipsychotic therapy compared to antipsychotic monotherapy at standard doses in schizophrenia - a systematic review NSTL国家科技图书文献中心

Lawrence, Christophe... | Roberts, Chloe ... - 《Journal of psychopharmacology》 - 2025,39(2) - 132～140 - 共9页

摘要：Background: Schizophrenia is considered to | have a lifetime prevalence of around 1%. Up to 30% of | patients diagnosed with schizophrenia are subsequently | categorised as treatment resistant. Current guidelines | advise against the use of antipsychotic polypharmacy

关键词： Schizophrenia | treatment-resistant schizophrenia | high-dose antipsychotic therapy | antipsychotic polypharmacy | dopamine receptor antagonists | dopamine receptor partial agonists | drugs for psychosis

2. Trace amine-associated receptor 1 agonists reduce alcohol drinking and differentially modulate dopamine release in the nucleus accumbens of alcohol preferring mice NSTL国家科技图书文献中心

Houdant, Charles | Lamarche, Mandy ... - 《Neuropharmacology》 - 2025,274 - Article 110460～Article 110460 - 共10页

摘要： of full and partial* TAAR1 agonists in reducing* | differences between full and partial* agonists. Further* | therapeutic targets. Trace amine-associated receptor* 1* | the partial* agonist RO5263397 on alcohol consumption* | investigated the effects of these agonists* on presynaptic*

关键词： Alcohol addiction | Trace amine-associated receptor 1 | Partial agonist | Full agonist | Drinking | Dopamine | Nucleus accumbens

3. Update Lessons from Positron Emission Tomography Imaging Part I: A Systematic Critical Review on Therapeutic Plasma Concentrations of Antipsychotics NSTL国家科技图书文献中心

Hart, Xenia M. | Spangemacher, Moritz ... - 《Therapeutic Drug Monitoring》 - 2024,46(1) - 16～32 - 共17页 - 被引量：1

摘要： and partial* agonists, as well as their proposed* | review particularly focused on dopamine* D2-like and 5* | estimated based on receptor* occupancy ranges that relate* | relevant receptor* systems were included to further enrich* | Supplemental Digital Content is Available in

关键词： molecular Imaging | dopamine partial agonists | dopamine antagonists | PET | therapeutic reference ranges | DOPAMINE-D-2 RECEPTOR OCCUPANCY | NOREPINEPHRINE TRANSPORTER OCCUPANCY | CLINICAL-RESPONSE | TIME-COURSE | HUMAN BRAIN...

4. Differentiating the third generation of antipsychotics: a focus on lumateperone's similarities and differences NSTL国家科技图书文献中心

Maldonado, Gloria M.... | Schwartz, Thomas L. - 《International clinical psychopharmacology》 - 2024,39(1) - 4～16 - 共13页 - 被引量：3

摘要： are all dopamine-2 receptor* partial agonists with* | varying receptor* affinities. This review aims to compare* | agents reviewed have a variety of receptor* affinities* | The development of atypical antipsychotics has | evolved to include newer pharmacodynamic properties

关键词： adverse drug reaction | antipsychotic agents | aripiprazole | brexpiprazole | cariprazine | dopamine D2 receptor agonists | lumateperone | receptor affinity | therapeutic comparative study | POSTTRAUMATIC-STRESS-DISORDER...

5. The dopamine 3 receptor as a candidate biomarker and therapeutic for opioid use disorder NSTL国家科技图书文献中心

Matthew L. Banks | Jon E. Sprague - 《Addiction biology》 - 2024,29(2) - e13369～e13369 - 共6页 - 被引量：1

摘要： dopamine 3 receptor (D3R) partial agonists and | Abstract Here, we present recent studies | suggesting that specific DRD3 single nucleotide | polymorphisms (SNPs, e.g. rs324029 and rs2654754) might serve | as prognostic biomarkers for opioid use disorder

关键词： genetic risk | opioid | opioid use disorder | pharmacogenetics

6. Rationale for Adjunctive Treatment Targeting Multiple Mechanisms in Schizophrenia NSTL国家科技图书文献中心

Kinon, Bruce J. | Leucht, Stefan ... - 《The journal of clinical psychiatry》 - 2024,85(3) - 23nr15240～23nr15240 - 共6页 - 被引量：1

摘要： act as dopamine D2 receptor antagonists or partial | challenges remain. Current dopamine* D2 receptor-blocking* | tolerance to dopamine* D2 receptor-blocking antipsychotics.* | agonists. While antipsychotics primarily relieve positive | Importance: Schizophrenia is a complex

关键词： MUSCARINIC RECEPTOR AGONIST | KARXT XANOMELINE-TROSPIUM | PLACEBO-CONTROLLED TRIAL | DOUBLE-BLIND | NEGATIVE SYMPTOMS | COGNITIVE IMPAIRMENT | D-2 RECEPTORS | D-SERINE | CLOZAPINE | EFFICACY

7. Examination of the mechanisms underlying the discriminative stimulus properties of the atypical antipsychotic amisulpride NSTL国家科技图书文献中心

Donahue, Timothy J. | Hillhouse, Todd M.... - 《Behavioural pharmacology》 - 2024,35(1) - 47～54 - 共8页

摘要： thought to depend mainly on dopamine D2/3 receptor | discriminative stimulus. Selective agonists* and antagonists of* | of partial* substitution for the amisulpride* | discriminative cue that involves mainly mixed D2/3 receptor | -HT7 receptor* agonist/antagonist and perhaps 5-HT2B*

关键词： benzamide | dopamine | drug discrimination | LP-44 | quinpirole | raclopride | rat | SB-204741 | SB-269970 | serotonin...

8. Muscarinic Receptor Activators as Novel Treatments for Schizophrenia NSTL国家科技图书文献中心

Paul S.M. | Yohn S.E.... - 《Biological psychiatry》 - 2024,96(8) - 627～637 - 共11页 - 被引量：8

摘要： schizophrenia act as antagonists or partial* agonists at the* | dopamine D2 receptor. With only a few possible exceptions | receptor binding and activation properties of xanomeline | ? 2024 Society of Biological | PsychiatryAchieving optimal treatment outcomes for individuals

关键词： Acetylcholine | Antipsychotic | KarXT | Muscarinic | Schizophrenia | Xanomeline

9. Cariprazine and Cognition in Patients with Schizophrenia and Bipolar Disorder: A Systematic Review NSTL国家科技图书文献中心

Garcia-Fernandez, Lo... | Romero-Ferreiro, Ver...... - 《Harvard review of psychiatry.》 - 2024,32(6) - 207～217 - 共11页

摘要： with partial* agonism at the D3 receptor and higher* | affinity than dopamine, has shown significant | compared to PBO and other D2 antagonists or partial | agonists in RCTs, especially in patients with greater | BackgroundCariprazine (CAR), an antipsychotic

关键词： bipolar depression | bipolar mania | cariprazine | cognition | schizophrenia | systematic review | NEGATIVE SYNDROME SCALE | DOUBLE-BLIND | ACUTE EXACERBATION | I DISORDER...

10. SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress NSTL国家科技图书文献中心

Wang, Yaping | Wang, Min ... - 《Free Radical Biology and Medicine》 - 2024,212 - 284～294 - 共11页

摘要： protein expression of dopamine* D1 receptor, and reduced* | partial C674 oxidation. In renal proximal tubule (RPT | agonists CDN1163 and [6]-Gingerol, or the redox modulator | Background and aim: Sarcoplasmic/endoplasmic | reticulum Ca2+ ATPase 2 (SERCA2) is critical in

摘要：Background: Schizophrenia is considered to | have a lifetime prevalence of around 1%. Up to 30% of | patients diagnosed with schizophrenia are subsequently | categorised as treatment resistant. Current guidelines | advise against the use of antipsychotic polypharmacy

关键词： Schizophrenia | treatment-resistant schizophrenia | high-dose antipsychotic therapy | antipsychotic polypharmacy | dopamine receptor antagonists | dopamine receptor partial agonists | drugs for psychosis

摘要： of full and partial* TAAR1 agonists in reducing* | differences between full and partial* agonists. Further* | therapeutic targets. Trace amine-associated receptor* 1* | the partial* agonist RO5263397 on alcohol consumption* | investigated the effects of these agonists* on presynaptic*

关键词： Alcohol addiction | Trace amine-associated receptor 1 | Partial agonist | Full agonist | Drinking | Dopamine | Nucleus accumbens

摘要： and partial* agonists, as well as their proposed* | review particularly focused on dopamine* D2-like and 5* | estimated based on receptor* occupancy ranges that relate* | relevant receptor* systems were included to further enrich* | Supplemental Digital Content is Available in

关键词： molecular Imaging | dopamine partial agonists | dopamine antagonists | PET | therapeutic reference ranges | DOPAMINE-D-2 RECEPTOR OCCUPANCY | NOREPINEPHRINE TRANSPORTER OCCUPANCY | CLINICAL-RESPONSE | TIME-COURSE | HUMAN BRAIN...

摘要： are all dopamine-2 receptor* partial agonists with* | varying receptor* affinities. This review aims to compare* | agents reviewed have a variety of receptor* affinities* | The development of atypical antipsychotics has | evolved to include newer pharmacodynamic properties

关键词： adverse drug reaction | antipsychotic agents | aripiprazole | brexpiprazole | cariprazine | dopamine D2 receptor agonists | lumateperone | receptor affinity | therapeutic comparative study | POSTTRAUMATIC-STRESS-DISORDER...

摘要： dopamine 3 receptor (D3R) partial agonists and | Abstract Here, we present recent studies | suggesting that specific DRD3 single nucleotide | polymorphisms (SNPs, e.g. rs324029 and rs2654754) might serve | as prognostic biomarkers for opioid use disorder

关键词： genetic risk | opioid | opioid use disorder | pharmacogenetics

摘要： act as dopamine D2 receptor antagonists or partial | challenges remain. Current dopamine* D2 receptor-blocking* | tolerance to dopamine* D2 receptor-blocking antipsychotics.* | agonists. While antipsychotics primarily relieve positive | Importance: Schizophrenia is a complex

关键词： MUSCARINIC RECEPTOR AGONIST | KARXT XANOMELINE-TROSPIUM | PLACEBO-CONTROLLED TRIAL | DOUBLE-BLIND | NEGATIVE SYMPTOMS | COGNITIVE IMPAIRMENT | D-2 RECEPTORS | D-SERINE | CLOZAPINE | EFFICACY

摘要： thought to depend mainly on dopamine D2/3 receptor | discriminative stimulus. Selective agonists* and antagonists of* | of partial* substitution for the amisulpride* | discriminative cue that involves mainly mixed D2/3 receptor | -HT7 receptor* agonist/antagonist and perhaps 5-HT2B*

关键词： benzamide | dopamine | drug discrimination | LP-44 | quinpirole | raclopride | rat | SB-204741 | SB-269970 | serotonin...

摘要： schizophrenia act as antagonists or partial* agonists at the* | dopamine D2 receptor. With only a few possible exceptions | receptor binding and activation properties of xanomeline | ? 2024 Society of Biological | PsychiatryAchieving optimal treatment outcomes for individuals

关键词： Acetylcholine | Antipsychotic | KarXT | Muscarinic | Schizophrenia | Xanomeline

摘要： with partial* agonism at the D3 receptor and higher* | affinity than dopamine, has shown significant | compared to PBO and other D2 antagonists or partial | agonists in RCTs, especially in patients with greater | BackgroundCariprazine (CAR), an antipsychotic

关键词： bipolar depression | bipolar mania | cariprazine | cognition | schizophrenia | systematic review | NEGATIVE SYNDROME SCALE | DOUBLE-BLIND | ACUTE EXACERBATION | I DISORDER...

摘要： protein expression of dopamine* D1 receptor, and reduced* | partial C674 oxidation. In renal proximal tubule (RPT | agonists CDN1163 and [6]-Gingerol, or the redox modulator | Background and aim: Sarcoplasmic/endoplasmic | reticulum Ca2+ ATPase 2 (SERCA2) is critical in

关键词： SERCA2 | Hypertension | Oxidant stress | Mitochondrial dysfunction | Water-sodium retention

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：Background: Schizophrenia is considered to | have a lifetime prevalence of around 1%. Up to 30% of | patients diagnosed with schizophrenia are subsequently | categorised as treatment resistant. Current guidelines | advise against the use of antipsychotic polypharmacy

关键词： Schizophrenia | treatment-resistant schizophrenia | high-dose antipsychotic therapy | antipsychotic polypharmacy | dopamine receptor antagonists | dopamine receptor partial agonists | drugs for psychosis

摘要： of full and partial TAAR1 agonists in reducing | differences between full and partial agonists. Further | therapeutic targets. Trace amine-associated receptor 1 | the partial agonist RO5263397 on alcohol consumption | investigated the effects of these agonists on presynaptic

关键词： Alcohol addiction | Trace amine-associated receptor 1 | Partial agonist | Full agonist | Drinking | Dopamine | Nucleus accumbens

摘要： and partial agonists, as well as their proposed | review particularly focused on dopamine D2-like and 5 | estimated based on receptor occupancy ranges that relate | relevant receptor systems were included to further enrich | Supplemental Digital Content is Available in

关键词： molecular Imaging | dopamine partial agonists | dopamine antagonists | PET | therapeutic reference ranges | DOPAMINE-D-2 RECEPTOR OCCUPANCY | NOREPINEPHRINE TRANSPORTER OCCUPANCY | CLINICAL-RESPONSE | TIME-COURSE | HUMAN BRAIN...

摘要： are all dopamine-2 receptor partial agonists with | varying receptor affinities. This review aims to compare | agents reviewed have a variety of receptor affinities | The development of atypical antipsychotics has | evolved to include newer pharmacodynamic properties

关键词： adverse drug reaction | antipsychotic agents | aripiprazole | brexpiprazole | cariprazine | dopamine D2 receptor agonists | lumateperone | receptor affinity | therapeutic comparative study | POSTTRAUMATIC-STRESS-DISORDER...

摘要： dopamine 3 receptor (D3R) partial agonists and | Abstract Here, we present recent studies | suggesting that specific DRD3 single nucleotide | polymorphisms (SNPs, e.g. rs324029 and rs2654754) might serve | as prognostic biomarkers for opioid use disorder

关键词： genetic risk | opioid | opioid use disorder | pharmacogenetics

摘要： act as dopamine D2 receptor antagonists or partial | challenges remain. Current dopamine D2 receptor-blocking | tolerance to dopamine D2 receptor-blocking antipsychotics. | agonists. While antipsychotics primarily relieve positive | Importance: Schizophrenia is a complex

关键词： MUSCARINIC RECEPTOR AGONIST | KARXT XANOMELINE-TROSPIUM | PLACEBO-CONTROLLED TRIAL | DOUBLE-BLIND | NEGATIVE SYMPTOMS | COGNITIVE IMPAIRMENT | D-2 RECEPTORS | D-SERINE | CLOZAPINE | EFFICACY

摘要： thought to depend mainly on dopamine D2/3 receptor | discriminative stimulus. Selective agonists and antagonists of | of partial substitution for the amisulpride | discriminative cue that involves mainly mixed D2/3 receptor | -HT7 receptor agonist/antagonist and perhaps 5-HT2B

关键词： benzamide | dopamine | drug discrimination | LP-44 | quinpirole | raclopride | rat | SB-204741 | SB-269970 | serotonin...

摘要： schizophrenia act as antagonists or partial agonists at the | dopamine D2 receptor. With only a few possible exceptions | receptor binding and activation properties of xanomeline | ? 2024 Society of Biological | PsychiatryAchieving optimal treatment outcomes for individuals

关键词： Acetylcholine | Antipsychotic | KarXT | Muscarinic | Schizophrenia | Xanomeline

摘要： with partial agonism at the D3 receptor and higher | affinity than dopamine, has shown significant | compared to PBO and other D2 antagonists or partial | agonists in RCTs, especially in patients with greater | BackgroundCariprazine (CAR), an antipsychotic

关键词： bipolar depression | bipolar mania | cariprazine | cognition | schizophrenia | systematic review | NEGATIVE SYNDROME SCALE | DOUBLE-BLIND | ACUTE EXACERBATION | I DISORDER...

摘要： protein expression of dopamine D1 receptor, and reduced | partial C674 oxidation. In renal proximal tubule (RPT | agonists CDN1163 and [6]-Gingerol, or the redox modulator | Background and aim: Sarcoplasmic/endoplasmic | reticulum Ca2+ ATPase 2 (SERCA2) is critical in

关键词： SERCA2 | Hypertension | Oxidant stress | Mitochondrial dysfunction | Water-sodium retention

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： of full and partial* TAAR1 agonists in reducing* | differences between full and partial* agonists. Further* | therapeutic targets. Trace amine-associated receptor* 1* | the partial* agonist RO5263397 on alcohol consumption* | investigated the effects of these agonists* on presynaptic*

摘要： and partial* agonists, as well as their proposed* | review particularly focused on dopamine* D2-like and 5* | estimated based on receptor* occupancy ranges that relate* | relevant receptor* systems were included to further enrich* | Supplemental Digital Content is Available in

摘要： are all dopamine-2 receptor* partial agonists with* | varying receptor* affinities. This review aims to compare* | agents reviewed have a variety of receptor* affinities* | The development of atypical antipsychotics has | evolved to include newer pharmacodynamic properties

摘要： act as dopamine D2 receptor antagonists or partial | challenges remain. Current dopamine* D2 receptor-blocking* | tolerance to dopamine* D2 receptor-blocking antipsychotics.* | agonists. While antipsychotics primarily relieve positive | Importance: Schizophrenia is a complex

摘要： thought to depend mainly on dopamine D2/3 receptor | discriminative stimulus. Selective agonists* and antagonists of* | of partial* substitution for the amisulpride* | discriminative cue that involves mainly mixed D2/3 receptor | -HT7 receptor* agonist/antagonist and perhaps 5-HT2B*

摘要： schizophrenia act as antagonists or partial* agonists at the* | dopamine D2 receptor. With only a few possible exceptions | receptor binding and activation properties of xanomeline | ? 2024 Society of Biological | PsychiatryAchieving optimal treatment outcomes for individuals

摘要： with partial* agonism at the D3 receptor and higher* | affinity than dopamine, has shown significant | compared to PBO and other D2 antagonists or partial | agonists in RCTs, especially in patients with greater | BackgroundCariprazine (CAR), an antipsychotic

摘要： protein expression of dopamine* D1 receptor, and reduced* | partial C674 oxidation. In renal proximal tubule (RPT | agonists CDN1163 and [6]-Gingerol, or the redox modulator | Background and aim: Sarcoplasmic/endoplasmic | reticulum Ca2+ ATPase 2 (SERCA2) is critical in