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1. Azole Derivatives as Quorum Sensing Inhibitors: An In Silico Strategy against Bacterial Biofilms NSTL国家科技图书文献中心

Mishra, Siddharth |  Kumar, Mukesh... -  《Chemistry Select》 - 2025,10(22) - n/a~n/a - 共17页

摘要:Antimicrobial resistance is a global threat |  with Pseudomonas aeruginosa emerging as a virulent |  pathogen due to its ability to form biofilm and regulate |  virulence through pqsD-mediated quorum sensing (QS | ). Biofilms enable bacterial survival in hostile
关键词: Biofilm |  Contact Lens |  Docking |  Drug Discovery |  Molecular Dynamics |  PqsD Inhibitor |  Quorum Sensing

2. Synthesis, antifungal evaluation, two‐dimensional quantitative structure–activity relationship and molecular docking studies of isoxazole derivatives as potential fungicides NSTL国家科技图书文献中心

Kailashpati Tripathi |  Parshant Kaushik... -  《Pest Management Science》 - 2025,81(5) - 2579~2597 - 共19页

摘要: strains. RESULTS A series of 20 isoxazole derivatives |  potential of these isoxazole derivatives as novel | Abstract BACKGROUND Sheath blight and bakanae |  disease, prominent among emerging rice ailments, exert a |  profound impact on rice productivity, causing severe
关键词: azole derivatives |  antifungal activity |  Rhizoctonia solani |  Fusarium fujikuroi |  QSAR

3. Divergent Synthesis of Novel 3(5)‐Aminoazole–Benzopyrone Hybrids and their Evaluation as α‐Glucosidase Inhibitors NSTL国家科技图书文献中心

Andrii S. Myshko |  Galyna P. Mrug... -  《ChemMedChem》 - 2025,20(5) - n/a~n/a - 共5页

摘要: formation of C‐4 or 3‐NH substituted azole derivatives |  the azole and flavonoid, namely, coumarin, chromone | Abstract An efficient approach has been |  developed for the trapping in situ generated benzopyrone | ‐based ortho‐quinone methide intermediates by 3‐ and 5
关键词: Pyrazole |  Isoxazole |  ortho-quinone methide |  Alkylation |  α-glucosidase

4. A Sustainable Catalyst-Free Approach to Bipyrazoles Under Batch and Flow Chemistry Techniques NSTL国家科技图书文献中心

Akanksha Kumari |  Anshul Jain... -  《Asian Journal of Organic Chemistry》 - 2025,14(2) - e202400583~6 - 共6页

摘要:’-and 1,4’-bipyr-azole derivatives,while C C bond |  approach for the synthesis of 4,4’-bipyrazole derivatives |  bipyrazole derivatives for medical sciences and |  derivatives.[12]Among them,most of the reports are metal | We have developed an efficient and sustainable
关键词: Bipyrazole |  cascade synthesis |  continuous flow |  catalyst free |  hydrazine

5. Diverse Synthesis of Azoles: Construction of ortho -Azidotetrazoles/Triazoletetrazoles through N-N Cleavage of 2 H -Indazoles NSTL国家科技图书文献中心

Laru, Sudip |  Bhattacharjee, Suvam... -  《Advanced synthesis & catalysis》 - 2025,367(4) - n/a~n/a - 共9页

摘要: synthesis of ortho-triazoletetrazole derivatives mainly |  via PIDA mediated N-N cleavage of the azole ring of |  and ortho-triazoletetrazole derivatives with wide | Herein, we report a conceptually new, general | , and efficient approach for the synthesis of valuable
关键词: Hypervalent iodine |  N-N bond cleavage |  synthesis of azidotetrazoles |  One-pot synthesis of triazoletetrazoles |  N−N bond cleavage

6. Synthesis and in vitro antitumor activity of 3(4)-alkyl-substituted [1,2,4]triazolo[1,5- a ]pyrimidin-7-amines NSTL国家科技图书文献中心

Ushakova, A. A. |  Fedotov, V. V.... -  《Russian Chemical Bulletin》 - 2025,74(2) - 461~468 - 共8页

摘要:-aminotriazoles with morpholinoacrylonitrile derivatives, and |  substituents in the azole and pyrimidine moieties of the | A series of [1,2,4]triazolo[1,5-a]pyrimidin-7 | -amines was synthesized by cyclocondensation of 5 |  alkylation of the products was studied. The alkylation gave
关键词: nitrogen-containing heterocycles |  [1,2,4]triazolo[1,5-a]pyrimidines |  cyclocondensation |  alkylation |  antitumor activity |  cytotoxicity

7. In Vitro Assessment of Immunobiological Effectivity of Synthetic Non-Ionic Glycolipids NSTL国家科技图书文献中心

Paulovicova, Ema |  Paulovicova, Lucia... -  《Chemistry & biodiversity》 - 2025,22(2) - n/a~n/a - 共13页

摘要: derivatives (GalOC12 > GlcOC12 approximate to ManOC12 |  > GlcNAcOC12) against the C. albicans azole-sensitive | Immunobiological activity of selected decyl |  and (thio)dodecyl hexopyranosides based on d-glucose | , d-galactose, N-acetyl d-glucosamine and d-mannose
关键词: Alkyl glycosides |  Candida biofilm |  Cytokines |  Glycolipids |  Immunomodulation

8. Antibacterial and antifungal pyrazoles based on different construction strategies NSTL国家科技图书文献中心

Rehman, Muneeb Ur |  He, Fang... -  《European Journal of Medicinal Chemistry》 - 2025,282 - 117081~117081 - 共36页

摘要: heterocyclic compound belonging to the azole family, is a |  relationships of these pyrazole derivatives, i.e., how | The growing prevalence of microbial infections | , and antimicrobial resistance (AMR) stemming from the |  overuse and misuse of antibiotics, call for novel
关键词: Antimicrobial resistance |  Pyrazole |  Antibacterial agents |  Antifungal agents |  Pharmacophores |  Construction strategies |  Structure-activity relationship

9. Azole Derivatives: Cutting‐Edge Agents in Cancer Therapy NSTL国家科技图书文献中心

Anuradha Mehra |  Amit Mittal... -  《Chemistry Select》 - 2024,9(43) - n/a~n/a - 共39页

摘要: pathways. Interestingly, several azole derivatives have |  molecules in the azole class with improved selectivity and |  future‐generation azole compounds. In light of these |  overview of the current state of monocyclic azole‐based | Abstract Monocyclic 5‐membered heterocycles
关键词: Azoles |  Cancer |  Drug design |  Heterocyclic derivatives |  SAR

10. Novel Ferrocenyl‐azole Derivatives: Synthesis, DFT Calculation and Unlocking the Anticancer Potential NSTL国家科技图书文献中心

Vijesh Tomar |  Parveen Kumar... -  《European journal of organic chemistry》 - 2024,27(21) - n/a~n/a - 共11页

摘要: Csp2‐Cl with azole derivatives was fully established |  the selected ferrocenated azole derivatives were | Abstract Herein, a series of novel ferrocenyl | /phenyl/thiophenyl‐azoles was disclosed by vinylic |  amination of ferrocenyl/phenyl/thiophenyl substituted β
关键词: Amination |  DFT |  Fe3Se2(CO)9 |  Ferrocenyl-azoles |  Prostate anti-cancer drug
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