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1. Understanding and overcoming resistance to tyrosine kinase inhibitors (TKIs) in Chronic myeloid leukemia (CML) NSTL国家科技图书文献中心

Lagana, Alessandro |  Scalzulli, Emilia... -  《Expert review of hematology》 - 2025,18(1) - 65~79 - 共15页

摘要:Introduction: Chronic myeloid leukemia (CML |  CML patients and their life expectancy. Nonetheless |  the major challenges in CML management. Areas |  therapeutic arsenal for resistant-CML management and |  revolutionize the management of TKI-resistant CML cases.
关键词: Chronic myeloid leukemia |  tyrosine kinase inhibitors |  TKI resistance |  BCR::ABL1 mutations |  asciminib |  ponatinib |  allogeneic hematopoietic stem cell transplant |  allo-HSCT

2. Real-World Efficacy Profile of Compassionate Use of Asciminib in an Italian, Multi-Resistant Chronic-Phase Chronic Myeloid Leukemia (CML-CP) Patient Population NSTL国家科技图书文献中心

Breccia, Massimo |  Rossi, Antonella Rus...... -  《Hematological oncology》 - 2025,43(3) - e70101~e70101 - 共11页

摘要:Chronic myeloid leukemia (CML) patients who |  chronic phase (CML-CP) within a compassionate use |  outcomes of asciminib in treating 77 CML patients in |  tolerability and efficacy in real-world CML-CP patient |  have experienced failure and/or intolerance to
关键词: asciminib |  chronic myeloid leukemia in chronic phase (CML-CP) |  major molecular response (MMR) |  real-world |  TKI resistance/intolerance |  tyrosine kinase inhibitor (TKI)

3. Treatment‐Free Remissions in Children With Chronic Myeloid Leukemia (CML): A Prospective Study From the Tata Memorial Hospital (TMH) Pediatric CML (pCML) Cohort NSTL国家科技图书文献中心

Nirmalya Roy Moulik |  Swaminathan Keerthiv...... -  《American Journal of Hematology》 - 2025,100(2) - 210~217 - 共8页 - 被引量:1

摘要:ABSTRACT Pediatric chronic myeloid leukemia | %–3% of all childhood leukemia. Tyrosine kinase |  chronic phase on imatinib. Eligibility criteria were as |  (pCML) is a rare childhood malignancy, representing 2 |  inhibitors (TKIs) have greatly improved survival but pose
关键词: imatinib discontinuation |  pediatric CML |  TFR in pediatric CML |  TKI discontinuation

4. Different In Vitro Models of Chronic Myeloid Leukemia Show Different Characteristics: Biological Replicates Are Not Biologically Equivalent NSTL国家科技图书文献中心

Cavalleri, Alessia |  Xhahysa, Besjana... -  《Cell biology international.》 - 2025,49(5) - 570~586 - 共17页 - 被引量:1

摘要:Chronic Myeloid Leukemia (CML) is |  uncontrolled myeloid cell proliferation. Furthermore |  commonly used CML cell lines (K562, LAMA84, KCL22) to |  necessity of considering cellular heterogeneity in CML |  translational relevance in CML research and treatment
关键词: chronic myeloid leukemia (CML) |  digital PCR |  K562 |  KCL22 |  LAMA84 |  STAMP inhibitor |  tyrosine kinase inhibitors (TKIs)

5. Patient-reported toxicity symptoms during tyrosine kinase inhibitor treatment in chronic myeloid leukemia: a systematic review and meta-analysis NSTL国家科技图书文献中心

Smit, Yolba |  Scheuter, Pien... -  《Supportive care in cancer》 - 2025,33(5) - Article: 446~Article: 446 - 共14页

摘要:PurposeOne in five chronic myeloid leukemia |  (CML) patients experiences such intolerability that | -reported symptoms in CML per TKI. This study follows the |  they switch tyrosine kinase inhibitor (TKI) treatment |  within 3 years. Information on tolerability is needed
关键词: Chronic myeloid leukemia |  CML |  Patient-reported outcome measure |  PROM |  Toxicity |  Tyrosine kinase inhibitor |  TKI |  Meta-analysis

6. Choice of Frontline Tyrosine-Kinase Inhibitor and Early Events in Very Elderly Patients With Chronic Myeloid Leukemia in Chronic Phase: A "Campus CML" Study NSTL国家科技图书文献中心

Bucelli, C. |  Capodanno, I.... -  《European Journal of Haematology》 - 2025,114(1) - 37~44 - 共8页

摘要: elderly CP-CML patients. Methods: A retrospective |  analysis was conducted on 332 CP-CML patients aged 75 |  Hematology Centers involved in the "Campus CML" project |  the preferred frontline therapy for older CP-CML | Objectives: The study aimed to evaluate the
关键词: chronic myeloid leukemia |  comorbidities |  dose optimization |  efficacy |  older |  safety |  tyrosine kinase inhibitor |  very elderly

7. Severe Impact of Omeprazole Timing on pH‐Sensitive Dasatinib Absorption: Unveiling Substantial Drug–Drug Interaction NSTL国家科技图书文献中心

Per Andersson |  Magnus Brisander... -  《Journal of clinical pharmacology.》 - 2025,65(5) - 588~597 - 共10页

摘要:Abstract The absorption and bioavailability of |  most tyrosine kinase inhibitors are affected by |  gastrointestinal pH as they are weak basic lipophilic drugs | . Hence, concomitant use of acid reducing agents (ARAs | ) is frequently restricted. Particularly comedication
关键词: acid reducing agent (ARA) |  bioavailability |  chronic myeloid leukemia (CML) |  crystalline dasatinib |  drug–drug interaction (DDI) |  omeprazole |  pharmacokinetics |  proton‐pump inhibitors (PPI)

8. Targeting FLT3 for treating diseases: FLT3 inhibitors NSTL国家科技图书文献中心

Qing-Yun Rong |  Yu Lu... -  《Drug discovery today》 - 2025,30(5) - Article 104367~Article 104367 - 共8页

摘要: chronic myeloid leukemia (CML). A variety of FLT3 |  hematological tumors, such as acute myeloid leukemia (AML) and | FMS-like tyrosine kinase 3 (FLT3) is a |  receptor tyrosine kinase (RTK) expressed mainly in |  hematopoietic stem and progenitor cells and often mutated in
关键词: AML; FLT3 inhibitor; gilteritinib.

9. Quality of Life and Adherence to Tyrosine Kinase Inhibitors Among Pediatric, Adolescent, and Young Adult Chronic Myeloid Leukemia Patients: A Systematic Review NSTL国家科技图书文献中心

Werk, Rachel S. |  Mehrhoff, Casey J.... -  《Pediatric blood & cancer.》 - 2025,72(6) - e31686~e31686 - 共9页

摘要:The chronic nature of chronic myeloid leukemia |  (CML) has a negative impact on patients' health |  adult (AYA) patients with CML. Full-text screening |  improve HRQOL outcomes among AYA patients with CML. | -related quality of life (HRQOL) and the need for
关键词: adolescent and young adult |  chronic myeloid leukemia |  health-related quality of life |  medication adherence |  health‐related quality of life

10. The Prevalence and Characteristics of Anemia Among Newly-Diagnosed Patients with Leukemia in Saudi Arabia NSTL国家科技图书文献中心

Zaini, Rana G. |  Nawwab, Wafa A.... -  《Clinical laboratory》 - 2025,71(4) - 678~683 - 共6页

摘要: myeloid leukemia (CML) and 2% had non-Hodgkin lymphoma | , 36.7% had acute myeloid leukemia (AML), 36.7% had |  chronic lymphocytic leukemia (CLL), 22.5% had acute |  lymphoblastic leukemia (ALL), while only 2% had chronic | Background: Anemia in patients with leukemia
关键词: anemia |  leukemia |  hematological malignancy
检索条件chronic myeloid leukemia (CML)
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