NSTL国家科技图书文献中心

1. Canagliflozin differentially modulates carfilzomib-induced endoplasmic reticulum stress in multiple myeloma and endothelial cells NSTL国家科技图书文献中心

Dabour, Mohamed S. | George, Mina Y.... - 《Archives of Toxicology》 - 2025,99(2) - 729～744 - 共16页

摘要： and that canagliflozin* protects against CFZ-induced* | of canagliflozin* on these processes and its impact* | , either alone or in combination with canagliflozin* (5-20* | , canagliflozin* mitigated CFZ-induced markers of ER stress* | . Whereas, in MM cells, canagliflozin* did not alter CFZ*

关键词： ER stress | Autophagy | Multiple myeloma | Endothelial Cells | Carfilzomib | Canagliflozin

2. The alleviative effects of canagliflozin on imiquimod-induced mouse model of psoriasis-like inflammation NSTL国家科技图书文献中心

Ridha-Salman, Hayder | Al-Zubaidy, Adeeb Ah...... - 《Naunyn-Schmiedeberg's Archives of Pharmacology》 - 2025,398(3) - 2695～2715 - 共21页

摘要：. Canagliflozin* is a gliflozin antidiabetic with non-classical* | canagliflozin on a mouse model of imiquimod-provoked psoriasis | ointment (clobetasol group), or 4% canagliflozin* emulgel* | (canagliflozin* 4% group) on exactly the same day as imiquimod* | cream was administered. Topical canagliflozin* markedly*

关键词： Imiquimod-induced psoriasis | Immune-mediated dermatoses | Autoinflammatory diseases | Anti-psoriatic therapy | Gliflozins | SGL2 inhibitors | Canagliflozin

3. Cardiovascular, kidney and safety outcomes with canagliflozin in older adults: A combined analysis from the CANVAS Program and CREDENCE trial NSTL国家科技图书文献中心

Siriwardana, Amanda | Buizen, Luke ... - 《Diabetes, obesity & metabolism.》 - 2025,27(4) - 1972～1979 - 共8页

摘要： and safety of canagliflozin* according to age* | cardiovascular and kidney outcomes with canagliflozin* were* | age, effects of canagliflozin* on safety outcomes* | , canagliflozin* reduced cardiovascular and kidney outcomes* | AimSGLT2 inhibitors may be underused in older

关键词： canagliflozin | clinical trial | elderly | SGLT2 inhibitor

4. Effects of canagliflozin preconditioning on post-resuscitation myocardial function in a diabetic rat model of cardiac arrest and cardiopulmonary resuscitation NSTL国家科技图书文献中心

Wang, Minjie | Hua, Tianfeng ... - 《European Journal of Pharmacology》 - 2025,988 - 177212～177212 - 共9页

摘要：Background: Canagliflozin* can reduce the risk* | remains unknown whether canagliflozin* alleviates the* | effects and potential mechanisms of canagliflozin* on* | randomized into four groups: (1) sham + canagliflozin, (2 | + canagliflozin. Except for the sham + canagliflozin* and placebo*

关键词： Type 2 diabetes mellitus | Cardiopulmonary resuscitation | Myocardial function | Post-resuscitation | Canagliflozin

5. Canagliflozin Delays Aortic Valve Calcification by Enhancing the AMPK/Nrf2/HO‐1 Antioxidant Signaling Pathway in Valvular Interstitial Cells NSTL国家科技图书文献中心

Quangong Zhao | Boyao Zhang ... - 《The FASEB Journal》 - 2025,39(10) - e70630～e70630 - 共14页

摘要： cotransporter 2 inhibitors, such as canagliflozin* (CANA), have* | ABSTRACT Aortic valve calcification is a | significant contributor to the development of aortic valve | stenosis, a condition for which effective pharmacological | treatments are currently limited. Sodium‐glucose

关键词： aortic valve calcification | canagliflozin | Nrf2/HO‐1 pathway | oxidative stress | valvular interstitial cells

6. Role of gliflozins on hepatocellular carcinoma progression: a systematic synthesis of preclinical and clinical evidence NSTL国家科技图书文献中心

Basile, Livia | Cannarella, Rossella ... - 《Expert opinion on drug safety》 - 2025,24(4) - 413～426 - 共14页

摘要：. Preclinical studies were mainly focused on canagliflozin | drugs.ConclusionsOverall, canagliflozin* had a negative effect on HCC cell* | IntroductionThe risk of HCC is twice as high | in diabetic patients compared to non-diabetic ones | , suggesting that diabetes advances carcinogenesis in the

关键词： Canagliflozin | hepatocellular carcinoma | HCC | Sodium-glucose cotransporter 2 inhibitors | SGLT2is

7. Hypouricemic effect of sodium glucose transporter-2 inhibitors: a network meta-analysis and meta-regression of randomized clinical trials NSTL国家科技图书文献中心

Sridharan, Kannan | Alkhidir, Maya Moham... - 《Expert review of endocrinology & metabolism》 - 2025,20(2) - 139～146 - 共8页

摘要：), empagliflozin (-46.75 mu mol/L), canagliflozin* (-35.55 mu mol* | BackgroundSodium-glucose cotransporter-2 | inhibitors (SGLT2is) are known for their cardiovascular | benefits, but their impact on serum uric acid levels is | not well understood. This study evaluates the

关键词： SGLT2is | dapagliflozin | empagliflozin | ertugliflozin | canagliflozin | uric acid

8. Horse owner experiences and observations with the use of SGLT2i for the management of equine metabolic syndrome and hyperinsulinaemia‐associated laminitis NSTL国家科技图书文献中心

Tania Sundra | Erin Kelty ... - 《Equine Veterinary Education》 - 2025,37(4) - 202～209 - 共8页

摘要：Summary Background Sodium‐glucose | cotransporter 2 inhibitors (SGLT2i) are being used | increasingly in equine practice. While there is emerging | clinical evidence of the safety and efficacy of these | drugs, there are currently no reports to document

关键词： canagliflozin | endocrine | ertugliflozin | insulin | SGLT2 inhibitor

9. Identification of approved drugs with ALDH1A1 inhibitory potential aimed at enhancing chemotherapy sensitivity in cancer cells: an in-silico drug repurposing approach NSTL国家科技图书文献中心

Paul, Sanjay Kumar | Guendouzi, Abdelmadj...... - 《Journal of Biomolecular Structure and Dynamics》 - 2025,43(8) - 3830～3844 - 共15页

摘要：The aldehyde dehydrogenase 1A1 (ALDH1A1) also | known as retinal dehydrogenase, is an enzyme normally | involved in the cellular metabolism, development and | detoxification processes in healthy cells. However, it's also | considered a cancer stem cell marker and its high levels of

关键词： ALDH1A | drug repurposing | in-silico | cancer | telmisartan | irbesartan | canagliflozin

10. Recent Advancements in Glycosylation Reactions: An Access to Privileged C - and S -glycosides NSTL国家科技图书文献中心

Pandey, Ram Pratap | Tiwari, Bindu ... - 《Current organic chemistry》 - 2025,29(5) - 343～358 - 共16页

摘要：Glycosylation reactions are central to | carbohydrate chemistry due to their broad applications in | drug development and biological probes. Despite | presenting significant challenges and often requiring | substantial amounts of promoters, these reactions yield

关键词： ER stress | Autophagy | Multiple myeloma | Endothelial Cells | Carfilzomib | Canagliflozin

关键词： Imiquimod-induced psoriasis | Immune-mediated dermatoses | Autoinflammatory diseases | Anti-psoriatic therapy | Gliflozins | SGL2 inhibitors | Canagliflozin

摘要： and safety of canagliflozin* according to age* | cardiovascular and kidney outcomes with canagliflozin* were* | age, effects of canagliflozin* on safety outcomes* | , canagliflozin* reduced cardiovascular and kidney outcomes* | AimSGLT2 inhibitors may be underused in older

关键词： canagliflozin | clinical trial | elderly | SGLT2 inhibitor

摘要：Background: Canagliflozin* can reduce the risk* | remains unknown whether canagliflozin* alleviates the* | effects and potential mechanisms of canagliflozin* on* | randomized into four groups: (1) sham + canagliflozin, (2 | + canagliflozin. Except for the sham + canagliflozin* and placebo*

关键词： Type 2 diabetes mellitus | Cardiopulmonary resuscitation | Myocardial function | Post-resuscitation | Canagliflozin

摘要： cotransporter 2 inhibitors, such as canagliflozin* (CANA), have* | ABSTRACT Aortic valve calcification is a | significant contributor to the development of aortic valve | stenosis, a condition for which effective pharmacological | treatments are currently limited. Sodium‐glucose

关键词： aortic valve calcification | canagliflozin | Nrf2/HO‐1 pathway | oxidative stress | valvular interstitial cells

关键词： Canagliflozin | hepatocellular carcinoma | HCC | Sodium-glucose cotransporter 2 inhibitors | SGLT2is

摘要：), empagliflozin (-46.75 mu mol/L), canagliflozin* (-35.55 mu mol* | BackgroundSodium-glucose cotransporter-2 | inhibitors (SGLT2is) are known for their cardiovascular | benefits, but their impact on serum uric acid levels is | not well understood. This study evaluates the

关键词： SGLT2is | dapagliflozin | empagliflozin | ertugliflozin | canagliflozin | uric acid

摘要：Summary Background Sodium‐glucose | cotransporter 2 inhibitors (SGLT2i) are being used | increasingly in equine practice. While there is emerging | clinical evidence of the safety and efficacy of these | drugs, there are currently no reports to document

关键词： canagliflozin | endocrine | ertugliflozin | insulin | SGLT2 inhibitor

摘要：The aldehyde dehydrogenase 1A1 (ALDH1A1) also | known as retinal dehydrogenase, is an enzyme normally | involved in the cellular metabolism, development and | detoxification processes in healthy cells. However, it's also | considered a cancer stem cell marker and its high levels of

关键词： ALDH1A | drug repurposing | in-silico | cancer | telmisartan | irbesartan | canagliflozin

摘要：Glycosylation reactions are central to | carbohydrate chemistry due to their broad applications in | drug development and biological probes. Despite | presenting significant challenges and often requiring | substantial amounts of promoters, these reactions yield

关键词： Glycosylation reactions | O-glycosides | vitexin | dapagliflozin | canagliflozin | empagliflozin

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： and that canagliflozin protects against CFZ-induced | of canagliflozin on these processes and its impact | , either alone or in combination with canagliflozin (5-20 | , canagliflozin mitigated CFZ-induced markers of ER stress | . Whereas, in MM cells, canagliflozin did not alter CFZ

关键词： ER stress | Autophagy | Multiple myeloma | Endothelial Cells | Carfilzomib | Canagliflozin

关键词： Imiquimod-induced psoriasis | Immune-mediated dermatoses | Autoinflammatory diseases | Anti-psoriatic therapy | Gliflozins | SGL2 inhibitors | Canagliflozin

摘要： and safety of canagliflozin according to age | cardiovascular and kidney outcomes with canagliflozin were | age, effects of canagliflozin on safety outcomes | , canagliflozin reduced cardiovascular and kidney outcomes | AimSGLT2 inhibitors may be underused in older

关键词： canagliflozin | clinical trial | elderly | SGLT2 inhibitor

摘要：Background: Canagliflozin can reduce the risk | remains unknown whether canagliflozin alleviates the | effects and potential mechanisms of canagliflozin on | randomized into four groups: (1) sham + canagliflozin, (2 | + canagliflozin. Except for the sham + canagliflozin and placebo

关键词： Type 2 diabetes mellitus | Cardiopulmonary resuscitation | Myocardial function | Post-resuscitation | Canagliflozin

摘要： cotransporter 2 inhibitors, such as canagliflozin (CANA), have | ABSTRACT Aortic valve calcification is a | significant contributor to the development of aortic valve | stenosis, a condition for which effective pharmacological | treatments are currently limited. Sodium‐glucose

关键词： aortic valve calcification | canagliflozin | Nrf2/HO‐1 pathway | oxidative stress | valvular interstitial cells

关键词： Canagliflozin | hepatocellular carcinoma | HCC | Sodium-glucose cotransporter 2 inhibitors | SGLT2is

摘要：), empagliflozin (-46.75 mu mol/L), canagliflozin (-35.55 mu mol | BackgroundSodium-glucose cotransporter-2 | inhibitors (SGLT2is) are known for their cardiovascular | benefits, but their impact on serum uric acid levels is | not well understood. This study evaluates the

关键词： SGLT2is | dapagliflozin | empagliflozin | ertugliflozin | canagliflozin | uric acid

摘要：Summary Background Sodium‐glucose | cotransporter 2 inhibitors (SGLT2i) are being used | increasingly in equine practice. While there is emerging | clinical evidence of the safety and efficacy of these | drugs, there are currently no reports to document

关键词： canagliflozin | endocrine | ertugliflozin | insulin | SGLT2 inhibitor

摘要：The aldehyde dehydrogenase 1A1 (ALDH1A1) also | known as retinal dehydrogenase, is an enzyme normally | involved in the cellular metabolism, development and | detoxification processes in healthy cells. However, it's also | considered a cancer stem cell marker and its high levels of

关键词： ALDH1A | drug repurposing | in-silico | cancer | telmisartan | irbesartan | canagliflozin

摘要：Glycosylation reactions are central to | carbohydrate chemistry due to their broad applications in | drug development and biological probes. Despite | presenting significant challenges and often requiring | substantial amounts of promoters, these reactions yield

关键词： Glycosylation reactions | O-glycosides | vitexin | dapagliflozin | canagliflozin | empagliflozin

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： and safety of canagliflozin* according to age* | cardiovascular and kidney outcomes with canagliflozin* were* | age, effects of canagliflozin* on safety outcomes* | , canagliflozin* reduced cardiovascular and kidney outcomes* | AimSGLT2 inhibitors may be underused in older

摘要：Background: Canagliflozin* can reduce the risk* | remains unknown whether canagliflozin* alleviates the* | effects and potential mechanisms of canagliflozin* on* | randomized into four groups: (1) sham + canagliflozin, (2 | + canagliflozin. Except for the sham + canagliflozin* and placebo*

摘要： cotransporter 2 inhibitors, such as canagliflozin* (CANA), have* | ABSTRACT Aortic valve calcification is a | significant contributor to the development of aortic valve | stenosis, a condition for which effective pharmacological | treatments are currently limited. Sodium‐glucose

摘要：), empagliflozin (-46.75 mu mol/L), canagliflozin* (-35.55 mu mol* | BackgroundSodium-glucose cotransporter-2 | inhibitors (SGLT2is) are known for their cardiovascular | benefits, but their impact on serum uric acid levels is | not well understood. This study evaluates the