NSTL国家科技图书文献中心

1. Discovery of p-Trifuoromethylbenzohydrazide Derivatives as Potent Antiviral Agents against Monkeypox Virus NSTL国家科技图书文献中心

Sara Rossi | Luca Pozzetti ... - 《ACS medicinal chemistry letters》 - 2025,16(5) - 837～843 - 共7页

摘要： occurred,Monkeypox virus(MPXV)is nowadays the most | discovery of new antivirals with optimized synthetic | abolished extracellular virus* production,and in silico* | After the global eradication of smallpox has | signifcant pathogen afecting humans among

关键词： Monkeypox | emerging viruses | tecovirimat | p37 | antiviral agents | drug discovery

2. Computational exploration of Zika virus RNA-dependent RNA polymerase inhibitors: a promising antiviral drug discovery approach NSTL国家科技图书文献中心

Mishra, Prabhu Chand... | Alanazi, Amer M.... - 《Journal of Biomolecular Structure and Dynamics》 - 2025,43(4) - 1689～1700 - 共12页

摘要：The emergence of the Zika virus, which belongs | (RdRp) of the Zika virus* plays a significant part in* | the replication of the virus* and is considered a* | this study, we employed computer-based drug discovery | the Zika virus. A comprehensive virtual screening

关键词： Zika virus | RNA-dependent RNA polymerase (RdRp) | natural compounds | MTiOpenScreen | MD simulation

3. Viral metagenome analysis uncovers hidden RNA virome diversity in juvenile largemouth bass ( Micropterus salmoides) NSTL国家科技图书文献中心

Zhang, Xing | Yu, Wenbin ... - 《Aquaculture》 - 2025,595(Pt.1) - 共7页

摘要：, such as bovine viral diarrhea virus* 1 and 2, porcine* | endogenous retrovirus, feline sarcoma virus, avian sarcoma | virus 16, mouse mammary tumor virus, and mammalian | RNA viruses. The discovery* of this hidden diversity* | The largemouth bass (Micropterus salmoides) is

关键词： Viral metagenome | Largemouth bass | RNA virome | Virus discovery

4. Recent advances in screening methods enabling the discovery of novel anti-hepatitis B virus drug candidates NSTL国家科技图书文献中心

Jin, Yu | Wang, Shuo ... - 《European Journal of Medicinal Chemistry》 - 2025,282 - 117093～117093 - 共11页 - 被引量：1

摘要： virus (HBV) is approximately 296 million, but few | The global population affected by Hepatitis B | drugs have been able to completely eradicate HBV and | the range of effective treatments remains limited | . Recent advancements in molecular biology and artificial

关键词： HBV | Antiviral agents | Small molecules | Screening methods | Drug discovery

5. Discovery of small molecules against porcine reproductive and respiratory syndrome virus replication by targeting NendoU activity NSTL国家科技图书文献中心

Zhu, Jiaqi | Lai, Yunqiang ... - 《Journal of Virology》 - 2025,99(2) - e02034-24～e02034-24 - 共20页

摘要： virus (PRRSV), contains a highly conserved nidoviral | infectious bronchitis virus, a coronavirus in the order | respiratory syndrome virus* (PRRSV) causes significant* | Porcine reproductive and respiratory syndrome | (PRRS) remains a major threat to animal health and

关键词： PRRSV | NendoU | nidovirus | antiviral agents

6. Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization NSTL国家科技图书文献中心

Lanning, Sarah | Aguilar-Hernandez, N...... - 《Journal of Virology》 - 2025,99(2) - e01619-24～e01619-24 - 共22页

摘要：Human astroviruses (HAstVs) are a leading | cause of viral childhood diarrhea that infects nearly | every individual during their lifetime. Although human | astroviruses are highly prevalent, no approved vaccine | currently exists. Antibody responses appear to play an

关键词： human astrovirus | capsid | surface antigens | monoclonal antibodies | protein structure-function | X-ray crystallography | cryo-EM | neutralization

7. ~1H, ~(15)N and ~(13)C backbone resonance assignment of the N-terminal region of Zika virus NS4B protein in detergent micelles NSTL国家科技图书文献中心

Yan Li | Ying Ru Loh ... - 《Biomolecular NMR assignments》 - 2025,19(1) - 1～6 - 共6页 - 被引量：1

摘要：Zika virus* has raised global concerns due to* | its link to microcephaly and Guillain-Barré syndrome | in adults. One of viral nonstructural proteins-NS4B | , an integral membrane protein, plays crucial roles | in viral replication by interacting with both viral

关键词： Zika virus | Membrane protein | NMR | Drug discovery | NS4B

8. Functional characterization and structural prediction of hypothetical proteins in monkeypox virus and identification of potential inhibitors NSTL国家科技图书文献中心

Raen, Reana | Islam, Muhammad Muin...... - 《Molecular diversity》 - 2025,29(2) - 1589～1617 - 共29页

摘要： virus (MPXV-Congo_8-156) is linked to various skin and | The excessive activation of the monkeypox | respiratory disorders such as rashes, fluid-filled blisters | , swollen lymph nodes and encephalitis (inflammation of | the brain), highlighting MPXV-Congo_8-156 as a

关键词： Monkeypox virus (MPXV) | Drug discovery | Hypothetical protein (HP) | Homology modeling | Molecular docking | Molecular dynamics simulations

9. Regulation of miRNA in Cytokine Storm (CS) of COVID-19 and Other Viral Infection: An Exhaustive Review NSTL国家科技图书文献中心

Chakraborty, Chiranj... | Bhattacharya, Manoji...... - 《Reviews in medical virology.》 - 2025,35(2) - e70026～e70026 - 共19页

摘要：) or cytokine storm syndrome (CSS). Sometimes, virus | caused by SARS-CoV-2 and other viruses (influenza virus | , MERS-CoV, SARS-CoV, dengue virus). Targeting those | miRNAs might help in the discovery* of novel* | virus infections.

关键词： COVID-19 | cytokine storm | miRNAs | SARS-CoV-2

10. Revisiting the concept of giant viruses NSTL国家科技图书文献中心

Abrahao, Jonatas San... - 《Microbes and infection》 - 2025,27(3) - 105467～105467 - 共3页

摘要： the discovery* of mimiviruses, the first amoeba* | -infecting viruses described. However, with the discovery | foundations of the term "giant virus" and explores its | Giant viruses have fascinated the scientific | community due to their immense particles and extensive

摘要： occurred,Monkeypox virus(MPXV)is nowadays the most | discovery of new antivirals with optimized synthetic | abolished extracellular virus* production,and in silico* | After the global eradication of smallpox has | signifcant pathogen afecting humans among

关键词： Monkeypox | emerging viruses | tecovirimat | p37 | antiviral agents | drug discovery

摘要：The emergence of the Zika virus, which belongs | (RdRp) of the Zika virus* plays a significant part in* | the replication of the virus* and is considered a* | this study, we employed computer-based drug discovery | the Zika virus. A comprehensive virtual screening

关键词： Zika virus | RNA-dependent RNA polymerase (RdRp) | natural compounds | MTiOpenScreen | MD simulation

摘要：, such as bovine viral diarrhea virus* 1 and 2, porcine* | endogenous retrovirus, feline sarcoma virus, avian sarcoma | virus 16, mouse mammary tumor virus, and mammalian | RNA viruses. The discovery* of this hidden diversity* | The largemouth bass (Micropterus salmoides) is

关键词： Viral metagenome | Largemouth bass | RNA virome | Virus discovery

摘要： virus (HBV) is approximately 296 million, but few | The global population affected by Hepatitis B | drugs have been able to completely eradicate HBV and | the range of effective treatments remains limited | . Recent advancements in molecular biology and artificial

关键词： HBV | Antiviral agents | Small molecules | Screening methods | Drug discovery

摘要： virus (PRRSV), contains a highly conserved nidoviral | infectious bronchitis virus, a coronavirus in the order | respiratory syndrome virus* (PRRSV) causes significant* | Porcine reproductive and respiratory syndrome | (PRRS) remains a major threat to animal health and

关键词： PRRSV | NendoU | nidovirus | antiviral agents

摘要：Human astroviruses (HAstVs) are a leading | cause of viral childhood diarrhea that infects nearly | every individual during their lifetime. Although human | astroviruses are highly prevalent, no approved vaccine | currently exists. Antibody responses appear to play an

关键词： human astrovirus | capsid | surface antigens | monoclonal antibodies | protein structure-function | X-ray crystallography | cryo-EM | neutralization

摘要：Zika virus* has raised global concerns due to* | its link to microcephaly and Guillain-Barré syndrome | in adults. One of viral nonstructural proteins-NS4B | , an integral membrane protein, plays crucial roles | in viral replication by interacting with both viral

关键词： Zika virus | Membrane protein | NMR | Drug discovery | NS4B

摘要： virus (MPXV-Congo_8-156) is linked to various skin and | The excessive activation of the monkeypox | respiratory disorders such as rashes, fluid-filled blisters | , swollen lymph nodes and encephalitis (inflammation of | the brain), highlighting MPXV-Congo_8-156 as a

关键词： Monkeypox virus (MPXV) | Drug discovery | Hypothetical protein (HP) | Homology modeling | Molecular docking | Molecular dynamics simulations

摘要：) or cytokine storm syndrome (CSS). Sometimes, virus | caused by SARS-CoV-2 and other viruses (influenza virus | , MERS-CoV, SARS-CoV, dengue virus). Targeting those | miRNAs might help in the discovery* of novel* | virus infections.

关键词： COVID-19 | cytokine storm | miRNAs | SARS-CoV-2

摘要： the discovery* of mimiviruses, the first amoeba* | -infecting viruses described. However, with the discovery | foundations of the term "giant virus" and explores its | Giant viruses have fascinated the scientific | community due to their immense particles and extensive

关键词： Giant virus | Nucleocytoviricota | Particle | Genome | Classification

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： occurred,Monkeypox virus(MPXV)is nowadays the most | discovery of new antivirals with optimized synthetic | abolished extracellular virus production,and in silico | After the global eradication of smallpox has | signifcant pathogen afecting humans among

关键词： Monkeypox | emerging viruses | tecovirimat | p37 | antiviral agents | drug discovery

摘要：The emergence of the Zika virus, which belongs | (RdRp) of the Zika virus plays a significant part in | the replication of the virus and is considered a | this study, we employed computer-based drug discovery | the Zika virus. A comprehensive virtual screening

关键词： Zika virus | RNA-dependent RNA polymerase (RdRp) | natural compounds | MTiOpenScreen | MD simulation

摘要：, such as bovine viral diarrhea virus 1 and 2, porcine | endogenous retrovirus, feline sarcoma virus, avian sarcoma | virus 16, mouse mammary tumor virus, and mammalian | RNA viruses. The discovery of this hidden diversity | The largemouth bass (Micropterus salmoides) is

关键词： Viral metagenome | Largemouth bass | RNA virome | Virus discovery

摘要： virus (HBV) is approximately 296 million, but few | The global population affected by Hepatitis B | drugs have been able to completely eradicate HBV and | the range of effective treatments remains limited | . Recent advancements in molecular biology and artificial

关键词： HBV | Antiviral agents | Small molecules | Screening methods | Drug discovery

摘要： virus (PRRSV), contains a highly conserved nidoviral | infectious bronchitis virus, a coronavirus in the order | respiratory syndrome virus (PRRSV) causes significant | Porcine reproductive and respiratory syndrome | (PRRS) remains a major threat to animal health and

关键词： PRRSV | NendoU | nidovirus | antiviral agents

摘要：Human astroviruses (HAstVs) are a leading | cause of viral childhood diarrhea that infects nearly | every individual during their lifetime. Although human | astroviruses are highly prevalent, no approved vaccine | currently exists. Antibody responses appear to play an

关键词： human astrovirus | capsid | surface antigens | monoclonal antibodies | protein structure-function | X-ray crystallography | cryo-EM | neutralization

摘要：Zika virus has raised global concerns due to | its link to microcephaly and Guillain-Barré syndrome | in adults. One of viral nonstructural proteins-NS4B | , an integral membrane protein, plays crucial roles | in viral replication by interacting with both viral

关键词： Zika virus | Membrane protein | NMR | Drug discovery | NS4B

摘要： virus (MPXV-Congo_8-156) is linked to various skin and | The excessive activation of the monkeypox | respiratory disorders such as rashes, fluid-filled blisters | , swollen lymph nodes and encephalitis (inflammation of | the brain), highlighting MPXV-Congo_8-156 as a

关键词： Monkeypox virus (MPXV) | Drug discovery | Hypothetical protein (HP) | Homology modeling | Molecular docking | Molecular dynamics simulations

摘要：) or cytokine storm syndrome (CSS). Sometimes, virus | caused by SARS-CoV-2 and other viruses (influenza virus | , MERS-CoV, SARS-CoV, dengue virus). Targeting those | miRNAs might help in the discovery of novel | virus infections.

关键词： COVID-19 | cytokine storm | miRNAs | SARS-CoV-2

摘要： the discovery of mimiviruses, the first amoeba | -infecting viruses described. However, with the discovery | foundations of the term "giant virus" and explores its | Giant viruses have fascinated the scientific | community due to their immense particles and extensive

关键词： Giant virus | Nucleocytoviricota | Particle | Genome | Classification

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： occurred,Monkeypox virus(MPXV)is nowadays the most | discovery of new antivirals with optimized synthetic | abolished extracellular virus* production,and in silico* | After the global eradication of smallpox has | signifcant pathogen afecting humans among

摘要：The emergence of the Zika virus, which belongs | (RdRp) of the Zika virus* plays a significant part in* | the replication of the virus* and is considered a* | this study, we employed computer-based drug discovery | the Zika virus. A comprehensive virtual screening

摘要：, such as bovine viral diarrhea virus* 1 and 2, porcine* | endogenous retrovirus, feline sarcoma virus, avian sarcoma | virus 16, mouse mammary tumor virus, and mammalian | RNA viruses. The discovery* of this hidden diversity* | The largemouth bass (Micropterus salmoides) is

摘要： virus (PRRSV), contains a highly conserved nidoviral | infectious bronchitis virus, a coronavirus in the order | respiratory syndrome virus* (PRRSV) causes significant* | Porcine reproductive and respiratory syndrome | (PRRS) remains a major threat to animal health and

摘要：Zika virus* has raised global concerns due to* | its link to microcephaly and Guillain-Barré syndrome | in adults. One of viral nonstructural proteins-NS4B | , an integral membrane protein, plays crucial roles | in viral replication by interacting with both viral

摘要：) or cytokine storm syndrome (CSS). Sometimes, virus | caused by SARS-CoV-2 and other viruses (influenza virus | , MERS-CoV, SARS-CoV, dengue virus). Targeting those | miRNAs might help in the discovery* of novel* | virus infections.

摘要： the discovery* of mimiviruses, the first amoeba* | -infecting viruses described. However, with the discovery | foundations of the term "giant virus" and explores its | Giant viruses have fascinated the scientific | community due to their immense particles and extensive