NSTL国家科技图书文献中心

1. Amelioration of breast cancer therapies through normalization of tumor vessels and microenvironment: paradigm shift to improve drug perfusion and nanocarrier permeation NSTL国家科技图书文献中心

Famta, Paras | Shah, Saurabh ... - 《Drug delivery and translational research》 - 2025,15(2) - 389～406 - 共18页

摘要：, the tumor* microenvironment (TME) prevents free drugs* | as normalization* of tumor vessels, reversal of* | and nanocarriers (NCs) from entering the tumor | inconsistent nature of EPR among different patients and tumor | types. In addition, angiogenesis, high intra-tumor

关键词： Angiogenesis | Tumor microenvironment normalization | Mechanotherapeutics | Chemotherapy | Immunotherapy

2. Mechanisms of Anti-PD Therapy Resistance in Digestive System Neoplasms NSTL国家科技图书文献中心

Wu, Yuxia | Jiang, Xiangyan ... - 《Recent patents on anti-cancer drug discovery》 - 2025,20(1) - 1～25 - 共25页

摘要：) therapies poorly effective. The tumor microenvironment | significance of the tumor* immune microenvironment (TIME* | (TME) plays a pivotal role in tumor* development* | , apart from supplying energy for tumor* proliferation* | and impeding the body's anti-tumor* immune response*

关键词： Immunotherapy resistance | normalization cancer immunotherapy | PD-1/B7-H1 | anti-PD-1/PD-L1 therapy | digestive system neoplasms | pancreatic cancer

3. RadioFlow Cytometry Reveals That [18F]FDG Uptake in K-RAS Lung Cancer Is Driven by Immune Cells: An Analysis on a Single-Cell Level NSTL国家科技图书文献中心

Chrysoula Vraka | Monika Homolya ... - 《The Journal of Nuclear Medicine》 - 2025,66(2) - 215～222 - 共8页

摘要： cellular heterogeneity within the tumor microenvironment | tumor microenvironment. This study aims to investigate | Tumor metabolism is a hallmark of cancer, yet | % ± 6.6%; macrophage, 13.9% ± 4.3%), whereas tumor* cells* | structural cells (CD45-; tumor* cells, 5.0% ± 2.3*

关键词： K-RAS lung cancer; [18F]FDG; immunometabolism; radioFlow; radioactive cell sorting.

4. Tumor microenvironment-modulated nanoparticles with cascade energy transfer as internal light sources for photodynamic therapy of deep-seated tumors NSTL国家科技图书文献中心

Dai, Wenbin | Zhou, Xianchi ... - 《Biomaterials》 - 2025,312 - 共12页

摘要：-activation and tumor* microenvironment modulation overcomes* | . Meanwhile, tumor* hypoxia and intracellular reductive* | microenvironment restrain the generation of reactive oxygen | species (ROS). To overcome these limitations, a tumor | . The high H2O2 level in tumor* can trigger*

关键词： Self-excited photodynamic therapy | Chemiluminescence resonance energy transfer | Tumor microenvironment modulation | Nitric oxide | Antitumor

5. Bioresponsive nanoreactor initiates cascade reactions for tumor vascular normalization and lactate depletion to augment immunotherapy NSTL国家科技图书文献中心

Chen, Jiaoyu | Bu, Changxin ... - 《Biomaterials》 - 2025,317 - 共14页

摘要： revolutionized cancer treatment. However, abnormal tumor | vasculature and excess lactate contribute to tumor | immunosuppression and sensitize ICB therapy. In the tumor | microenvironment, lactate oxidase catalyzes lactate to produce | to generate nitric oxide for vascular normalization

关键词： Nanoreactor | Cascade reactions | Vascular normalization | Lactate depletion | Tumor immunotherapy

6. A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells NSTL国家科技图书文献中心

Xiao, Chen | Wang, Xing ... - 《Biomaterials》 - 2025,313 - 共19页

摘要： often reside in a hypoxic tumor* microenvironment (TME* | @PHF, tumor* hypoxia is overcome via tumor mechanics* | normalization, thereby leading to enhanced cuproptosis and | only significantly suppresses tumor* growth but also* | effectively inhibits tumor* recurrence and distant metastasis*

关键词： Cuproptosis | ROS-Responsiveness | Tumor microenvironment | Cancer stem cells

7. Autophagy inhibition alleviates tumor desmoplasia and improves the efficacy of locally and systemically administered liposomal doxorubicin NSTL国家科技图书文献中心

Sandha, Kamalpreet K... | Kaur, Sukhleen ... - 《Journal of Controlled Release》 - 2025,378 - 1030～1044 - 共15页 - 被引量：1

摘要：The abnormal physiology of the tumor | microenvironment poses a challenge to the drug delivery in the | tumor tissues. The dense tumor stroma hinders the | the autophagy. In the 4T1 tumor* models, HCQ* | the tumor* tissues. The reduction in the ECM*

关键词： Tumor microenvironment | Extracellular matrix | Autophagy | Collagen | Liposomal doxorubicin | Injectable hydrogel

8. Ratiometric surface-enhanced Raman scattering quantification of extracellular matrix metalloproteinase-2 activity for tumor diagnosis NSTL国家科技图书文献中心

Zhu, Dan | Zhong, Hanyan ... - 《Analytical and bioanalytical chemistry》 - 2025,417(10) - 2073～2083 - 共11页

摘要： promoting tumor* invasion. Therefore, the sensitive and* | reliable detection of MMP activity in the tumor | microenvironment is of great importance for the diagnosis and | . Benefitting from the synergistic normalization* by MBN at* | potential in the fields of tumor* biology and accurate*

关键词： Surface-enhanced Raman scattering | Ratiometric detection | Core-satellite nanocomposite | Matrix metalloproteinase

9. Metabolic regulating enhanced immunological activating nanocomposites for tumor microenvironment normalization and immunotherapy NSTL国家科技图书文献中心

Chen Wang | Qiliner Feng ... - 《Materials Today Nano》 - 2024,27 - 100509,2-18～ - 共18页

摘要： tumor microenvironment(TME)intracellularly and | multifunctional nanocomposites realized an effective tumor | The mitochondrial energy metabolic | reprogramming of tumors leads to the hypoxic,acidic,and | immunosup-pressive microenvironment.To regulate the

关键词： Metabolic regulation | Immunological activation | Nanocomposites | Tumor microenvironment | Immunotherapy

10. Investigating the synergistic effects of immunotherapy and normalization treatment in modulating tumor microenvironment and enhancing treatment efficacy NSTL国家科技图书文献中心

Harkos, Constantinos | Stylianopoulos, Tria... - 《Journal of Theoretical Biology》 - 2024,583 - 共15页

摘要：) characteristics of the tumor microenvironment, such as the tumor | variations of the modeled components within the tumor* and* | the tumor-host tissue with convection and diffusion | , and v) modeling of the tumor* draining lymph nodes* | reproduced experimental data from various murine tumor

摘要：, the tumor* microenvironment (TME) prevents free drugs* | as normalization* of tumor vessels, reversal of* | and nanocarriers (NCs) from entering the tumor | inconsistent nature of EPR among different patients and tumor | types. In addition, angiogenesis, high intra-tumor

关键词： Angiogenesis | Tumor microenvironment normalization | Mechanotherapeutics | Chemotherapy | Immunotherapy

摘要：) therapies poorly effective. The tumor microenvironment | significance of the tumor* immune microenvironment (TIME* | (TME) plays a pivotal role in tumor* development* | , apart from supplying energy for tumor* proliferation* | and impeding the body's anti-tumor* immune response*

关键词： Immunotherapy resistance | normalization cancer immunotherapy | PD-1/B7-H1 | anti-PD-1/PD-L1 therapy | digestive system neoplasms | pancreatic cancer

摘要： cellular heterogeneity within the tumor microenvironment | tumor microenvironment. This study aims to investigate | Tumor metabolism is a hallmark of cancer, yet | % ± 6.6%; macrophage, 13.9% ± 4.3%), whereas tumor* cells* | structural cells (CD45-; tumor* cells, 5.0% ± 2.3*

关键词： K-RAS lung cancer; [18F]FDG; immunometabolism; radioFlow; radioactive cell sorting.

摘要：-activation and tumor* microenvironment modulation overcomes* | . Meanwhile, tumor* hypoxia and intracellular reductive* | microenvironment restrain the generation of reactive oxygen | species (ROS). To overcome these limitations, a tumor | . The high H2O2 level in tumor* can trigger*

关键词： Self-excited photodynamic therapy | Chemiluminescence resonance energy transfer | Tumor microenvironment modulation | Nitric oxide | Antitumor

摘要： revolutionized cancer treatment. However, abnormal tumor | vasculature and excess lactate contribute to tumor | immunosuppression and sensitize ICB therapy. In the tumor | microenvironment, lactate oxidase catalyzes lactate to produce | to generate nitric oxide for vascular normalization

关键词： Nanoreactor | Cascade reactions | Vascular normalization | Lactate depletion | Tumor immunotherapy

关键词： Cuproptosis | ROS-Responsiveness | Tumor microenvironment | Cancer stem cells

摘要：The abnormal physiology of the tumor | microenvironment poses a challenge to the drug delivery in the | tumor tissues. The dense tumor stroma hinders the | the autophagy. In the 4T1 tumor* models, HCQ* | the tumor* tissues. The reduction in the ECM*

关键词： Tumor microenvironment | Extracellular matrix | Autophagy | Collagen | Liposomal doxorubicin | Injectable hydrogel

关键词： Surface-enhanced Raman scattering | Ratiometric detection | Core-satellite nanocomposite | Matrix metalloproteinase

摘要： tumor microenvironment(TME)intracellularly and | multifunctional nanocomposites realized an effective tumor | The mitochondrial energy metabolic | reprogramming of tumors leads to the hypoxic,acidic,and | immunosup-pressive microenvironment.To regulate the

关键词： Metabolic regulation | Immunological activation | Nanocomposites | Tumor microenvironment | Immunotherapy

关键词： Cancer immunotherapy | Mathematical model | Tumor microenvironment | Lymph nodes | Tumor vasculature

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：, the tumor microenvironment (TME) prevents free drugs | as normalization of tumor vessels, reversal of | and nanocarriers (NCs) from entering the tumor | inconsistent nature of EPR among different patients and tumor | types. In addition, angiogenesis, high intra-tumor

关键词： Angiogenesis | Tumor microenvironment normalization | Mechanotherapeutics | Chemotherapy | Immunotherapy

摘要：) therapies poorly effective. The tumor microenvironment | significance of the tumor immune microenvironment (TIME | (TME) plays a pivotal role in tumor development | , apart from supplying energy for tumor proliferation | and impeding the body's anti-tumor immune response

关键词： Immunotherapy resistance | normalization cancer immunotherapy | PD-1/B7-H1 | anti-PD-1/PD-L1 therapy | digestive system neoplasms | pancreatic cancer

摘要： cellular heterogeneity within the tumor microenvironment | tumor microenvironment. This study aims to investigate | Tumor metabolism is a hallmark of cancer, yet | % ± 6.6%; macrophage, 13.9% ± 4.3%), whereas tumor cells | structural cells (CD45-; tumor cells, 5.0% ± 2.3

关键词： K-RAS lung cancer; [18F]FDG; immunometabolism; radioFlow; radioactive cell sorting.

摘要：-activation and tumor microenvironment modulation overcomes | . Meanwhile, tumor hypoxia and intracellular reductive | microenvironment restrain the generation of reactive oxygen | species (ROS). To overcome these limitations, a tumor | . The high H2O2 level in tumor can trigger

关键词： Self-excited photodynamic therapy | Chemiluminescence resonance energy transfer | Tumor microenvironment modulation | Nitric oxide | Antitumor

摘要： revolutionized cancer treatment. However, abnormal tumor | vasculature and excess lactate contribute to tumor | immunosuppression and sensitize ICB therapy. In the tumor | microenvironment, lactate oxidase catalyzes lactate to produce | to generate nitric oxide for vascular normalization

关键词： Nanoreactor | Cascade reactions | Vascular normalization | Lactate depletion | Tumor immunotherapy

摘要： often reside in a hypoxic tumor microenvironment (TME | @PHF, tumor hypoxia is overcome via tumor mechanics | normalization, thereby leading to enhanced cuproptosis and | only significantly suppresses tumor growth but also | effectively inhibits tumor recurrence and distant metastasis

关键词： Cuproptosis | ROS-Responsiveness | Tumor microenvironment | Cancer stem cells

摘要：The abnormal physiology of the tumor | microenvironment poses a challenge to the drug delivery in the | tumor tissues. The dense tumor stroma hinders the | the autophagy. In the 4T1 tumor models, HCQ | the tumor tissues. The reduction in the ECM

关键词： Tumor microenvironment | Extracellular matrix | Autophagy | Collagen | Liposomal doxorubicin | Injectable hydrogel

摘要： promoting tumor invasion. Therefore, the sensitive and | reliable detection of MMP activity in the tumor | microenvironment is of great importance for the diagnosis and | . Benefitting from the synergistic normalization by MBN at | potential in the fields of tumor biology and accurate

关键词： Surface-enhanced Raman scattering | Ratiometric detection | Core-satellite nanocomposite | Matrix metalloproteinase

摘要： tumor microenvironment(TME)intracellularly and | multifunctional nanocomposites realized an effective tumor | The mitochondrial energy metabolic | reprogramming of tumors leads to the hypoxic,acidic,and | immunosup-pressive microenvironment.To regulate the

关键词： Metabolic regulation | Immunological activation | Nanocomposites | Tumor microenvironment | Immunotherapy

关键词： Cancer immunotherapy | Mathematical model | Tumor microenvironment | Lymph nodes | Tumor vasculature

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：, the tumor* microenvironment (TME) prevents free drugs* | as normalization* of tumor vessels, reversal of* | and nanocarriers (NCs) from entering the tumor | inconsistent nature of EPR among different patients and tumor | types. In addition, angiogenesis, high intra-tumor

摘要：) therapies poorly effective. The tumor microenvironment | significance of the tumor* immune microenvironment (TIME* | (TME) plays a pivotal role in tumor* development* | , apart from supplying energy for tumor* proliferation* | and impeding the body's anti-tumor* immune response*

摘要： cellular heterogeneity within the tumor microenvironment | tumor microenvironment. This study aims to investigate | Tumor metabolism is a hallmark of cancer, yet | % ± 6.6%; macrophage, 13.9% ± 4.3%), whereas tumor* cells* | structural cells (CD45-; tumor* cells, 5.0% ± 2.3*

摘要：-activation and tumor* microenvironment modulation overcomes* | . Meanwhile, tumor* hypoxia and intracellular reductive* | microenvironment restrain the generation of reactive oxygen | species (ROS). To overcome these limitations, a tumor | . The high H2O2 level in tumor* can trigger*

摘要：The abnormal physiology of the tumor | microenvironment poses a challenge to the drug delivery in the | tumor tissues. The dense tumor stroma hinders the | the autophagy. In the 4T1 tumor* models, HCQ* | the tumor* tissues. The reduction in the ECM*