NSTL国家科技图书文献中心

1. Wall shear stress modulates metabolic pathways in endothelial cells NSTL国家科技图书文献中心

Simoes-Faria, Rita | Daems, Margo ... - 《Metabolomics》 - 2025,21(1) - Article: 16～Article: 16 - 共13页

摘要： using transcriptomics and tracer metabolomics | related to metabolic pathways. Tracer* metabolomics was* | activity in ECs exposed to WSS. Tracer metabolomics | IntroductionHemodynamic forces play a crucial | role in modulating endothelial cell (EC) behavior

关键词： Shear stress | Endothelial cells | Tracer metabolomics | Glutamine | Glutamate dehydrogenase

2. Tracer-based metabolomics for profiling nitric oxide metabolites in a 3D microvessels-on-chip model NSTL国家科技图书文献中心

Kanchana Pian | Luojiao Huang ... - 《The FASEB Journal》 - 2024,38(16) - e70005～e70005 - 共1页

摘要：. Here we developed a tracer-based metabolomics | Endothelial dysfunction, prevalent in | cardiovascular diseases (CVDs) and linked to conditions like | diabetes, hypertension, obesity, renal failure, or | hypercholesterolemia, is characterized by diminished nitric oxide (NO

关键词： 3D microvessel model | eNOS | endothelial dysfunction | nitric oxide metabolites | shear stress.

3. Metabolic signatures of thymomas: potential biomarkers and treatment targets NSTL国家科技图书文献中心

James W,Miller | Brandon M,Faubert ... - 《European journal of cardio-thoracic surgery :》 - 2024,65(2) - ezad394～ezad394 - 共6页

摘要： unknown. This study utilized metabolomics* and isotope* | stable, non-radioactive tracer* which reports the flow* | Abstract OBJECTIVES A study of tumour | metabolic reprogramming has revealed disease biomarkers | and avenues for therapeutic intervention. Metabolic

关键词： Thymomas | Metabolism | Biomarkers

4. Asparagine Uptake: a Cellular Strategy of Methylocystis to Combat Severe Salt Stress NSTL国家科技图书文献中心

Guo, Kangli | Glatter, Timo ... - 《Applied and Environmental Microbiology》 - 2023,89(6) - 共17页

摘要：Methylocystis spp. play a major role in | reducing methane emissions into the atmosphere from | methanogenic wetlands. In addition, they contribute to | atmospheric methane oxidation in upland soils. Methylocystis | spp. are known to have a low salt tolerance (<= 1.0

关键词： methanotrophs | sodium chloride | asparagine | osmoprotectant | proteomics | metabolomics | C-13 tracer analysis | METHANE-OXIDIZING BACTERIA | METHYLOBACTERIUM-EXTORQUENS AM1 | OXIC-ANOXIC INTERFACE...

5. The Role of Acyl-CoA Pools and Metabolic Adaptations in Response to Altered Lipid Metabolism NSTL国家科技图书文献中心

Pearce, Ryan W. - Chemistry.;Medicine.... - Ph.D. - Sandlers, Yana - 2023, - 1～182 - 共182页

摘要：, Coriell Institute). Stable isotope tracer* analysis of* | substrates. Untargeted metabolomics* revealed a significant* | The integration of acyl-CoAs into multiple | pathways demonstrates their utility as biomarkers for the | study of fatty acid metabolism, particularly in the

关键词： Fabry disease | Lysosomal storage disorder | Acyl-CoAs | Energy production | Mass spectrometry

6. TRACKING AMINO ACID METABOLISM IN CHO CELL CULTURES USING STABLE ISOTOPE LABELING ASSISTED METABOLOMICS NSTL国家科技图书文献中心

Maciek R Antoniewicz | Harnish Mukesh Naik ... - 《Cell Culture Engineering XVIII》 - Cell Culture Engineering Conference - 2023, - 199～199 - 共1页

摘要： assisted metabolomics* and advanced 13C-flux analysis* | universally labeled ~(13)C tracer* of the depleted amino acid* | based global metabolomics* strategies to also identify* | based metabolomics, we were also able to some of these | Chinese Hamster Ovary (CHO) cells are the

关键词： Amino acid metabolism | Inhibitory metabolites | Metabolomics | ~(13)C labeling | Mass spectrometry

7. Multi-omics view of recombinant Yarrowia lipolytica: Enhanced ketogenic amino acid catabolism increases polyketide-synthase-driven docosahexaenoic production to high selectivity at the gram scale NSTL国家科技图书文献中心

Gasovic, Sofija Jova... | Dietrich, Demian ... - 《Metabolic engineering》 - 2023,80 - 45～65 - 共21页

摘要： transcriptomics, metabolomics, and 13C-based metabolic pathway | the DHA titer by almost 40%. Isotopic 13C-tracer | DHA is a marine PUFA of commercial value | , given its multiple health benefits. The worldwide | emerging shortage in DHA supply has increased interest in

关键词： PUFA | Omega-3 fatty acid | Docosahexaenoic acid | DHA | Yarrowia lipolytica | Fatty acid | CoA thioester | Acetyl-CoA | Malonyl-CoA | PKS synthase...

8. Mechanism of the effect of Xiaoyao powder treatment on exercise capacity of depressed rats-A stable isotope tracer metabolomic study EI 工程索引 NSTL国家科技图书文献中心

Ji, Cui | Zhao, Weidi ... - 《Journal of liquid chromatography and related technologies》 - 2022,45(9/12) - 143～155 - 共13页

摘要： the four-week intervention. Stable isotope tracer | metabolomics and molecular biology techniques were utilized | Depression accounts for 10% of the total | global burden of nonfatal disease. Xiaoyao Powder, a | well-known traditional Chinese medicine is commonly

关键词： Depression | exercise capacity | serum | stable isotope tracer metabolomics | GLUCOSE | DISORDER | FEATURES

9. Towards a broader view of the metabolome: untargeted profiling of soluble and bound polyphenols in plants NSTL国家科技图书文献中心

Doppler Maria | Bueschl Christoph ... - 《Analytical and bioanalytical chemistry》 - 2022,414(25) - 7421～7433 - 共13页

摘要： using 13C-labelled Phe as tracer* was extended. The* | method for a typical metabolomics* application, mock* | Abstract Phenylalanine (Phe) is a central | precursor for numerous secondary plant metabolites with a | multitude of biological functions. Recent studies on the

关键词： Hydrolytic release | Triticum aestivum | Stable isotope | Tracer | Metabolomics | LC-HRMS

10. CPExtract, a Software Tool for the Automated Tracer-Based Pathway Specific Screening of Secondary Metabolites in LC-HRMS Data EI 工程索引 SCIE Web of Science核心 NSTL国家科技图书文献中心

Seidl, Bernhard | Schuhmacher, Rainer ... - 《Analytical chemistry》 - 2022,94(8) - 3543～3552 - 共10页

摘要： metabolomics approaches, no software tool is currently | metabolism of labeled tracer* substances. Here, we present* | labeled tracer* compounds in nonlabeled biological* | samples as well as a reversed tracer* approach, employing* | nonlabeled tracer* compounds along with globally labeled*

摘要： using transcriptomics and tracer metabolomics | related to metabolic pathways. Tracer* metabolomics was* | activity in ECs exposed to WSS. Tracer metabolomics | IntroductionHemodynamic forces play a crucial | role in modulating endothelial cell (EC) behavior

关键词： Shear stress | Endothelial cells | Tracer metabolomics | Glutamine | Glutamate dehydrogenase

摘要：. Here we developed a tracer-based metabolomics | Endothelial dysfunction, prevalent in | cardiovascular diseases (CVDs) and linked to conditions like | diabetes, hypertension, obesity, renal failure, or | hypercholesterolemia, is characterized by diminished nitric oxide (NO

关键词： 3D microvessel model | eNOS | endothelial dysfunction | nitric oxide metabolites | shear stress.

摘要： unknown. This study utilized metabolomics* and isotope* | stable, non-radioactive tracer* which reports the flow* | Abstract OBJECTIVES A study of tumour | metabolic reprogramming has revealed disease biomarkers | and avenues for therapeutic intervention. Metabolic

关键词： Thymomas | Metabolism | Biomarkers

摘要：Methylocystis spp. play a major role in | reducing methane emissions into the atmosphere from | methanogenic wetlands. In addition, they contribute to | atmospheric methane oxidation in upland soils. Methylocystis | spp. are known to have a low salt tolerance (<= 1.0

关键词： methanotrophs | sodium chloride | asparagine | osmoprotectant | proteomics | metabolomics | C-13 tracer analysis | METHANE-OXIDIZING BACTERIA | METHYLOBACTERIUM-EXTORQUENS AM1 | OXIC-ANOXIC INTERFACE...

摘要：, Coriell Institute). Stable isotope tracer* analysis of* | substrates. Untargeted metabolomics* revealed a significant* | The integration of acyl-CoAs into multiple | pathways demonstrates their utility as biomarkers for the | study of fatty acid metabolism, particularly in the

关键词： Fabry disease | Lysosomal storage disorder | Acyl-CoAs | Energy production | Mass spectrometry

摘要： assisted metabolomics* and advanced 13C-flux analysis* | universally labeled ~(13)C tracer* of the depleted amino acid* | based global metabolomics* strategies to also identify* | based metabolomics, we were also able to some of these | Chinese Hamster Ovary (CHO) cells are the

关键词： Amino acid metabolism | Inhibitory metabolites | Metabolomics | ~(13)C labeling | Mass spectrometry

摘要： transcriptomics, metabolomics, and 13C-based metabolic pathway | the DHA titer by almost 40%. Isotopic 13C-tracer | DHA is a marine PUFA of commercial value | , given its multiple health benefits. The worldwide | emerging shortage in DHA supply has increased interest in

关键词： PUFA | Omega-3 fatty acid | Docosahexaenoic acid | DHA | Yarrowia lipolytica | Fatty acid | CoA thioester | Acetyl-CoA | Malonyl-CoA | PKS synthase...

摘要： the four-week intervention. Stable isotope tracer | metabolomics and molecular biology techniques were utilized | Depression accounts for 10% of the total | global burden of nonfatal disease. Xiaoyao Powder, a | well-known traditional Chinese medicine is commonly

关键词： Depression | exercise capacity | serum | stable isotope tracer metabolomics | GLUCOSE | DISORDER | FEATURES

摘要： using 13C-labelled Phe as tracer* was extended. The* | method for a typical metabolomics* application, mock* | Abstract Phenylalanine (Phe) is a central | precursor for numerous secondary plant metabolites with a | multitude of biological functions. Recent studies on the

关键词： Hydrolytic release | Triticum aestivum | Stable isotope | Tracer | Metabolomics | LC-HRMS

关键词： METABOLOMICS | FLUX

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： using transcriptomics and tracer metabolomics | related to metabolic pathways. Tracer metabolomics was | activity in ECs exposed to WSS. Tracer metabolomics | IntroductionHemodynamic forces play a crucial | role in modulating endothelial cell (EC) behavior

关键词： Shear stress | Endothelial cells | Tracer metabolomics | Glutamine | Glutamate dehydrogenase

摘要：. Here we developed a tracer-based metabolomics | Endothelial dysfunction, prevalent in | cardiovascular diseases (CVDs) and linked to conditions like | diabetes, hypertension, obesity, renal failure, or | hypercholesterolemia, is characterized by diminished nitric oxide (NO

关键词： 3D microvessel model | eNOS | endothelial dysfunction | nitric oxide metabolites | shear stress.

摘要： unknown. This study utilized metabolomics and isotope | stable, non-radioactive tracer which reports the flow | Abstract OBJECTIVES A study of tumour | metabolic reprogramming has revealed disease biomarkers | and avenues for therapeutic intervention. Metabolic

关键词： Thymomas | Metabolism | Biomarkers

摘要：Methylocystis spp. play a major role in | reducing methane emissions into the atmosphere from | methanogenic wetlands. In addition, they contribute to | atmospheric methane oxidation in upland soils. Methylocystis | spp. are known to have a low salt tolerance (<= 1.0

关键词： methanotrophs | sodium chloride | asparagine | osmoprotectant | proteomics | metabolomics | C-13 tracer analysis | METHANE-OXIDIZING BACTERIA | METHYLOBACTERIUM-EXTORQUENS AM1 | OXIC-ANOXIC INTERFACE...

摘要：, Coriell Institute). Stable isotope tracer analysis of | substrates. Untargeted metabolomics revealed a significant | The integration of acyl-CoAs into multiple | pathways demonstrates their utility as biomarkers for the | study of fatty acid metabolism, particularly in the

关键词： Fabry disease | Lysosomal storage disorder | Acyl-CoAs | Energy production | Mass spectrometry

摘要： assisted metabolomics and advanced 13C-flux analysis | universally labeled ~(13)C tracer of the depleted amino acid | based global metabolomics strategies to also identify | based metabolomics, we were also able to some of these | Chinese Hamster Ovary (CHO) cells are the

关键词： Amino acid metabolism | Inhibitory metabolites | Metabolomics | ~(13)C labeling | Mass spectrometry

摘要： transcriptomics, metabolomics, and 13C-based metabolic pathway | the DHA titer by almost 40%. Isotopic 13C-tracer | DHA is a marine PUFA of commercial value | , given its multiple health benefits. The worldwide | emerging shortage in DHA supply has increased interest in

关键词： PUFA | Omega-3 fatty acid | Docosahexaenoic acid | DHA | Yarrowia lipolytica | Fatty acid | CoA thioester | Acetyl-CoA | Malonyl-CoA | PKS synthase...

摘要： the four-week intervention. Stable isotope tracer | metabolomics and molecular biology techniques were utilized | Depression accounts for 10% of the total | global burden of nonfatal disease. Xiaoyao Powder, a | well-known traditional Chinese medicine is commonly

关键词： Depression | exercise capacity | serum | stable isotope tracer metabolomics | GLUCOSE | DISORDER | FEATURES

摘要： using 13C-labelled Phe as tracer was extended. The | method for a typical metabolomics application, mock | Abstract Phenylalanine (Phe) is a central | precursor for numerous secondary plant metabolites with a | multitude of biological functions. Recent studies on the

关键词： Hydrolytic release | Triticum aestivum | Stable isotope | Tracer | Metabolomics | LC-HRMS

摘要： metabolomics approaches, no software tool is currently | metabolism of labeled tracer substances. Here, we present | labeled tracer compounds in nonlabeled biological | samples as well as a reversed tracer approach, employing | nonlabeled tracer compounds along with globally labeled

关键词： METABOLOMICS | FLUX

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： using transcriptomics and tracer metabolomics | related to metabolic pathways. Tracer* metabolomics was* | activity in ECs exposed to WSS. Tracer metabolomics | IntroductionHemodynamic forces play a crucial | role in modulating endothelial cell (EC) behavior

摘要： unknown. This study utilized metabolomics* and isotope* | stable, non-radioactive tracer* which reports the flow* | Abstract OBJECTIVES A study of tumour | metabolic reprogramming has revealed disease biomarkers | and avenues for therapeutic intervention. Metabolic

摘要：, Coriell Institute). Stable isotope tracer* analysis of* | substrates. Untargeted metabolomics* revealed a significant* | The integration of acyl-CoAs into multiple | pathways demonstrates their utility as biomarkers for the | study of fatty acid metabolism, particularly in the

摘要： assisted metabolomics* and advanced 13C-flux analysis* | universally labeled ~(13)C tracer* of the depleted amino acid* | based global metabolomics* strategies to also identify* | based metabolomics, we were also able to some of these | Chinese Hamster Ovary (CHO) cells are the

摘要： using 13C-labelled Phe as tracer* was extended. The* | method for a typical metabolomics* application, mock* | Abstract Phenylalanine (Phe) is a central | precursor for numerous secondary plant metabolites with a | multitude of biological functions. Recent studies on the