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1. FOXA3: A Novel Tumor Suppressor in Esophageal Squamous Cell Carcinoma NSTL国家科技图书文献中心

Zhang, Siang |  Jin, Yuxiang... -  《The journal of gene medicine》 - 2025,27(2) - n/a~n/a - 共9页

摘要: indicate that FOXA3 acts as a tumor suppressor in ESCC |  FOXA3 overexpression on tumor growth. Statistical |  tumor growth in mice.ConclusionsThese findings | BackgroundThe forkhead box A (FOXA) family has |  been extensively studied in cancer research; however
关键词: biomarker |  esophageal squamous cell carcinoma |  FOXA3 |  tumor suppressor

2. CRISPR–Cas9 screening identifies the role of FER as a tumor suppressor NSTL国家科技图书文献中心

Jiaqi Wang |  Ran Yang... -  《Journal of Pathology》 - 2025,265(2) - 158~171 - 共14页

摘要: identify tumor suppressor genes (TSGs) to improve our |  into the essential role of FER as a tumor suppressor |  role of FER in tumor initiation and progression |  in tumor initiation and progression but also | Abstract It is important to systematically
关键词: bioinformatic analysis |  CRISPR screen |  tumor suppressor gene |  FER |  tumorigenesis |  oncogenic transformation

3. Positive Selection Shapes Breast Cancer Tumor Suppressor Genes: Unveiling Insights into BRCA1, BRCA2, and MDC1 Stability NSTL国家科技图书文献中心

Fadel, Youssef M. |  Khaled, Marwan... -  《Journal of Molecular Evolution》 - 2025,93(1) - 100~110 - 共11页

摘要:. Tumor Suppressor Genes (TSGs) defects play a crucial |  role in tumor development, and recent studies propose | Worldwide, breast cancer is the leading cause |  of death in women with cancers. Given this |  situation, new approaches to treatment are urgently needed
关键词: Evolutionary analysis |  Positive selection |  Breast cancer |  Drug targeting |  Tumor suppressor genes

4. DNA hypermethylation of tumor suppressor genes among oral squamous cell carcinoma patients: a prominent diagnostic biomarker NSTL国家科技图书文献中心

Agarwal, Nistha |  Jha, Abhimanyu Kumar -  《Molecular biology reports》 - 2025,52(1) - 共13页

摘要:. Aberrant methylation of DNA of tumor suppressor genes | Oral Squamous Cell Carcinoma is a globally |  revealing form of oral malignancy. Epigenetics, which |  studies genetic modifications in gene expression without |  altering the sequence of DNA, is crucial for
关键词: Oral squamous cell carcinoma |  Tumor suppressor genes |  DNA hypermethylation |  Diagnostic marker

5. Astaxanthin Increases Tumor Suppressor Gene Expression and Affects Cellular Biological Behavior in Oral Dysplastic Keratinocytes by Regulating DNA Methylation NSTL国家科技图书文献中心

Wang, Peiyan |  Yu, Xiaofei... -  《Journal of oral pathology and medicine》 - 2025,54(1) - 39~48 - 共10页

摘要:BackgroundThe inactivation of tumor suppressor |  genes (TSGs) caused by abnormal DNA methylation is |  confirmed to be widely present in oral potential malignant |  diseases (OPMDs). Carotenoids like lycopene and |  astaxanthin can regulate DNA methylation and exert
关键词: astaxanthin |  DNA methylation |  oral potential malignant diseases |  tumor suppressor gene

6. Unveiling the hidden gem: A review of long non-coding RNA NBAT-1 as an emerging tumor suppressor and prognostic biomarker in cancer NSTL国家科技图书文献中心

Sethi, Subhash Chand... |  Singh, Ragini... -  《Cellular Signalling》 - 2025,126 - 共15页

摘要: a dedicated tumor suppressor in many cancers. NBAT |  discovered a decade ago as a risk-associated tumor |  suppressor lncRNA in neuroblastoma (NB). Subsequent studies |  literature, elucidating the tumor-suppressive roles of NBAT | Previously considered junk or non-functional
关键词: LncRNA |  Cancer |  NBAT-1 |  Neuroblastoma |  Prognostic biomarker |  Tumor suppressor

7. Oncoproteins E6/E7 of the human papillomavirus types 16 & 18 synergize in modulating oncogenes and tumor suppressor proteins in colorectal cancer NSTL国家科技图书文献中心

Fernandes, Queenie |  Therachiyil, Lubna... -  《Expert review of proteomics》 - 2025,22(2) - 71~84 - 共14页

摘要: of the oncogenes and tumor suppressor proteins |  modulation of oncogenes and tumor suppressor proteins in |  in CRC. HPV modulates different oncogenes/tumor |  suppressor proteins in CRC of varying mutational | ObjectiveOur study presents a novel analysis
关键词: Human papillomavirus |  colorectal cancer |  oncogenes |  tumor suppressor proteins |  proteomics |  KRAS mutation |  p53 mutation

8. Challenging Conventional Perceptions of Oncogenes and Tumor Suppressor Genes: A Comprehensive Analysis of Gene Expression Patterns in Cancer NSTL国家科技图书文献中心

Mingyuan Zou |  Li Qiu... -  《Genes, chromosomes & cancer.》 - 2025,64(2) - e70030~e70030 - 共13页

摘要:Identifying genes involved in cancer is |  crucial for understanding the underlying molecular |  mechanisms of the disease and developing effective |  treatment strategies. Differential expression analysis |  (DEA) is the predominant method used to identify
关键词: biomarker; differential expression analysis; machine learning; oncogenes; tumor suppressor

9. Somatic genetic alterations of oncogenes and tumor suppressor genes in cholesteatoma NSTL国家科技图书文献中心

Simsek, Levent |  Yildirim, M. Selman... -  《Acta Oto-Laryngologica》 - 2025,145(1/2) - 16~22 - 共7页

摘要: alterations in known proto-oncogenes and tumor suppressor |  different known proto-oncogenes and tumor suppressor genes | Background Cholesteatoma is a proliferative |  disease that affects the tympanic cavity and temporal |  bone. Despite many studies and various theories, the
关键词: Cholesteatoma |  neoplasia |  JAK3 |  TP53 |  KRAS

10. Discovery of a Series of Covalent Ligands That Bind to Cys77 of the Von Hippel-Lindau Tumor Suppressor Protein(VHL) NSTL国家科技图书文献中心

Simon C.C.Lucas |  Yong Xu... -  《ACS medicinal chemistry letters》 - 2025,16(4) - 693~699 - 共7页

摘要:Most ligands for the Von Hippel-Lindau tumor |  suppressor(VHL)bind at the HIF-1α binding site.Ligands that |  bind to allosteric sites on VHL could be highly |  valuable for the feld of protein degradation,therefore,a |  covalent hit identifcation campaign was run targeting
关键词: VHL |  covalent |  mass spectrometry |  cysteine |  E3 ligase |  hit identifcation
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