NSTL国家科技图书文献中心

1. "Chance and Necessity" on the Molecular Evolution of REV3 (a Catalytic Subunit of DNA Polymerase ζ) - The Dual Roles of Translesion and Neuronal Extension NSTL国家科技图书文献中心

Kajiwara, Kagemasa | Yamada, Kouichi - 《Genes to cells》 - 2025,30(1) - e13189～e13189 - 共12页

摘要：), involved in translesion-replication is evolutionarily | Catalytic subunit of DNA polymerase zeta (REV3 | conserved from yeast and plants to higher eukaryotes | . However, a large intermediate domain is inserted in REV3 | of humans and mice. The domain has "DUF4683" region

关键词： AHDC1 | DNA polymerase ζ (zeta) | DUF4683 | neurite extension | NEXMIF | REV3 | tBLASTn | whole‐genome duplication | DNA polymerase zeta (zeta) | whole-genome duplication

2. Multiple DNA repair pathways prevent acetaldehyde-induced mutagenesis in yeast NSTL国家科技图书文献中心

Porcher, Latarsha | Vijayraghavan, Srira...... - 《Genetics》 - 2025,229(4) - 共10页

摘要： dependent on translesion* synthesis and DNA interstrand* | Acetaldehyde is the primary metabolite of | alcohol and is present in many environmental sources | , including tobacco smoke. Acetaldehyde is genotoxic | , whereby it can form DNA adducts and lead to mutagenesis

关键词： acetaldehyde | nucleotide excision repair | DNA protein crosslink repair | mutagenesis

3. Novel insights into the role of translesion synthesis polymerase in DNA incorporation and bypass of 5-fluorouracil in colorectal cancer NSTL国家科技图书文献中心

Jameson R. Averill | Jackson C. Lin ... - 《Nucleic Acids Research》 - 2024,52(8) - 4295～4312 - 共18页

摘要： showed that one of the translesion* synthesis (TLS) DNA* | 5-Fluorouracil (5-FU) is the first-line | chemotherapeutic agent in colorectal cancer, and resistance to 5 | -FU easily emerges. One of the mechanisms of drug | action and resistance of 5-FU is through DNA

关键词： Novel insights | translesion synthesis | colorectal cancer

4. WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases NSTL国家科技图书文献中心

Yoon, Jung-Hoon | Sellamuthu, Karthi ... - 《Genes and Development》 - 2024,38(5/6) - 213～232 - 共20页 - 被引量：1

摘要： damage to facilitate error-free translesion* DNA* | translesion synthesis (TLS) DNA polymerases (Pols) replicate | In this study, Yoon et al. discover that | Werner syndrome protein (WRN) and WRN-interacting | protein 1 (WRNIP1) assemble with Rev1 and Y family DNA

关键词： DNA repair | DNA lesions | UV damage | Werner syndrome protein WRN | Y family DNA polymerases | fidelity of translesion synthesis

5. Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT -deficient glioblastoma cells NSTL国家科技图书文献中心

Latancia, Marcela Te... | da Silva Leandro, Gi...... - 《DNA repair》 - 2024,141 - 103715～103715 - 共6页 - 被引量：1

摘要： translesion synthesis (TLS) DNA polymerases iota (Pol iota | Glioblastoma (GBM) is a highly aggressive | brain tumor associated with poor patient survival. The | current standard treatment involves invasive surgery | , radiotherapy, and chemotherapy employing temozolomide (TMZ

关键词： Glioma | Temozolomide | Translesion synthesis | Cancer | Chemotherapy resistance | DNA polymerase | PROMOTER METHYLATION | MALIGNANT GLIOMAS | TLS POLYMERASES | RESISTANCE...

6. Role of Translesion DNA Synthesis in the Metabolism of Replication- associated Nascent Strand Gaps NSTL国家科技图书文献中心

Khatib, Jude B. | Nicolae, Claudia M.... - 《Journal of Molecular Biology》 - 2024,436(1) - ARTN 168275～ - 共13页 - 被引量：5

摘要：Translesion DNA synthesis (TLS) is a DNA | damage tolerance pathway utilized by cells to overcome | lesions encountered throughout DNA replication. During | replication stress, cancer cells show increased dependency | on TLS proteins for cellular survival and

关键词： BRCA | translesion synthesis | homologous recombination | replication stress | ssDNA gaps | ERROR-FREE | POLYMERASE-KAPPA | HOMOLOGOUS RECOMBINATION | MONOUBIQUITINATED PCNA | DAMAGE TOLERANCE...

7. Polymerase iota plays a key role during translesion synthesis of UV‐induced lesions in the absence of polymerase eta NSTL国家科技图书文献中心

Davi Jardim Martins | Jenny Kaur Singh ... - 《Photochemistry and Photobiology: An International Journal》 - 2024,100(1) - 4～18 - 共15页 - 被引量：1

摘要： cells are deficient in the translesion* synthesis (TLS* | Abstract Xeroderma pigmentosum (XP) variant | ) DNA polymerase Polη (eta). This protein contributes | to DNA damage tolerance, bypassing unrepaired UV | photoproducts and allowing S‐phase progression with minimal

关键词： DNA replication | lesion bypass | polymerase eta | polymerase iota | pyrimidine dimers | translesion synthesis | ultraviolet light

8. Myxococcus xanthus translesion DNA synthesis protein ImuA is an ATPase enhanced by DNA NSTL国家科技图书文献中心

Lichimo, Kristi | Sowa, Dana J.... - 《Protein science :》 - 2024,33(5) - e4981～e4981 - 共6页 - 被引量：1

摘要：Translesion DNA synthesis pathways are | of DNA damage. Translesion* DNA synthesis carried* | for translesion* DNA synthesis and that ImuC is the* | literature in the field, we suggest a model for translesion | assembly and disassembly of the translesion* DNA synthesis*

关键词： ATPase | DNA binding protein | DNA replication | DNA-protein interaction | RECA PROTEIN | HOMOLOGOUS RECOMBINATION | STRANDED-DNA | MUTAGENESIS | POLYMERASE | MECHANISM...

9. Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases NSTL国家科技图书文献中心

Shilkin, Evgeniy S. | V. Petrova, Daria ... - 《DNA repair》 - 2024,141 - 103712～103712 - 共6页

摘要： translesion synthesis remains unexplored. Here we analyze | the efficiency and fidelity of translesion* Y-family* | and fidelity of translesion* DNA polymerases.* | Epigenetic cytosine methylation covers most of | genomic CpG dinucleotides in human cells. In addition to

关键词： 5-methylcytosine | 5-hydroxymethylcytosine | CpG dinucleotides | 8-oxo-2 ' -deoxyguanosine | DNA polymerases | PYRIMIDINE DIMER FORMATION | ERROR-FREE BYPASS | MUTATIONAL SIGNATURES | INDUCED DEAMINATION | DCMP TRANSFERASE...

10. Cryo-EM structure of the Rev1-Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis NSTL国家科技图书文献中心

Malik, Radhika | Johnson, Robert E.... - 《Nature structural & molecular biology》 - 2024,31(9) - 共26页

摘要：Rev1-Pol zeta-dependent translesion* synthesis* | Rev1 and Pol zeta cooperate in translesion* DNA* | (TLS) of DNA is crucial for maintaining genome | integrity. To elucidate the mechanism by which the two | polymerases cooperate in TLS, we determined the cryogenic

摘要：), involved in translesion-replication is evolutionarily | Catalytic subunit of DNA polymerase zeta (REV3 | conserved from yeast and plants to higher eukaryotes | . However, a large intermediate domain is inserted in REV3 | of humans and mice. The domain has "DUF4683" region

关键词： AHDC1 | DNA polymerase ζ (zeta) | DUF4683 | neurite extension | NEXMIF | REV3 | tBLASTn | whole‐genome duplication | DNA polymerase zeta (zeta) | whole-genome duplication

摘要： dependent on translesion* synthesis and DNA interstrand* | Acetaldehyde is the primary metabolite of | alcohol and is present in many environmental sources | , including tobacco smoke. Acetaldehyde is genotoxic | , whereby it can form DNA adducts and lead to mutagenesis

关键词： acetaldehyde | nucleotide excision repair | DNA protein crosslink repair | mutagenesis

摘要： showed that one of the translesion* synthesis (TLS) DNA* | 5-Fluorouracil (5-FU) is the first-line | chemotherapeutic agent in colorectal cancer, and resistance to 5 | -FU easily emerges. One of the mechanisms of drug | action and resistance of 5-FU is through DNA

关键词： Novel insights | translesion synthesis | colorectal cancer

摘要： damage to facilitate error-free translesion* DNA* | translesion synthesis (TLS) DNA polymerases (Pols) replicate | In this study, Yoon et al. discover that | Werner syndrome protein (WRN) and WRN-interacting | protein 1 (WRNIP1) assemble with Rev1 and Y family DNA

关键词： DNA repair | DNA lesions | UV damage | Werner syndrome protein WRN | Y family DNA polymerases | fidelity of translesion synthesis

摘要： translesion synthesis (TLS) DNA polymerases iota (Pol iota | Glioblastoma (GBM) is a highly aggressive | brain tumor associated with poor patient survival. The | current standard treatment involves invasive surgery | , radiotherapy, and chemotherapy employing temozolomide (TMZ

关键词： Glioma | Temozolomide | Translesion synthesis | Cancer | Chemotherapy resistance | DNA polymerase | PROMOTER METHYLATION | MALIGNANT GLIOMAS | TLS POLYMERASES | RESISTANCE...

摘要：Translesion DNA synthesis (TLS) is a DNA | damage tolerance pathway utilized by cells to overcome | lesions encountered throughout DNA replication. During | replication stress, cancer cells show increased dependency | on TLS proteins for cellular survival and

关键词： BRCA | translesion synthesis | homologous recombination | replication stress | ssDNA gaps | ERROR-FREE | POLYMERASE-KAPPA | HOMOLOGOUS RECOMBINATION | MONOUBIQUITINATED PCNA | DAMAGE TOLERANCE...

摘要： cells are deficient in the translesion* synthesis (TLS* | Abstract Xeroderma pigmentosum (XP) variant | ) DNA polymerase Polη (eta). This protein contributes | to DNA damage tolerance, bypassing unrepaired UV | photoproducts and allowing S‐phase progression with minimal

关键词： DNA replication | lesion bypass | polymerase eta | polymerase iota | pyrimidine dimers | translesion synthesis | ultraviolet light

摘要：Translesion DNA synthesis pathways are | of DNA damage. Translesion* DNA synthesis carried* | for translesion* DNA synthesis and that ImuC is the* | literature in the field, we suggest a model for translesion | assembly and disassembly of the translesion* DNA synthesis*

关键词： ATPase | DNA binding protein | DNA replication | DNA-protein interaction | RECA PROTEIN | HOMOLOGOUS RECOMBINATION | STRANDED-DNA | MUTAGENESIS | POLYMERASE | MECHANISM...

摘要： translesion synthesis remains unexplored. Here we analyze | the efficiency and fidelity of translesion* Y-family* | and fidelity of translesion* DNA polymerases.* | Epigenetic cytosine methylation covers most of | genomic CpG dinucleotides in human cells. In addition to

关键词： 5-methylcytosine | 5-hydroxymethylcytosine | CpG dinucleotides | 8-oxo-2 ' -deoxyguanosine | DNA polymerases | PYRIMIDINE DIMER FORMATION | ERROR-FREE BYPASS | MUTATIONAL SIGNATURES | INDUCED DEAMINATION | DCMP TRANSFERASE...

摘要：Rev1-Pol zeta-dependent translesion* synthesis* | Rev1 and Pol zeta cooperate in translesion* DNA* | (TLS) of DNA is crucial for maintaining genome | integrity. To elucidate the mechanism by which the two | polymerases cooperate in TLS, we determined the cryogenic

关键词： REV1 PROTEIN INTERACTS | FACTOR-C P140 | POLYMERASE-ZETA | BRCT DOMAIN | POL-ZETA | BINDING | COMPLEX | LIGASE | BYPASS | FAMILY

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：), involved in translesion-replication is evolutionarily | Catalytic subunit of DNA polymerase zeta (REV3 | conserved from yeast and plants to higher eukaryotes | . However, a large intermediate domain is inserted in REV3 | of humans and mice. The domain has "DUF4683" region

关键词： AHDC1 | DNA polymerase ζ (zeta) | DUF4683 | neurite extension | NEXMIF | REV3 | tBLASTn | whole‐genome duplication | DNA polymerase zeta (zeta) | whole-genome duplication

摘要： dependent on translesion synthesis and DNA interstrand | Acetaldehyde is the primary metabolite of | alcohol and is present in many environmental sources | , including tobacco smoke. Acetaldehyde is genotoxic | , whereby it can form DNA adducts and lead to mutagenesis

关键词： acetaldehyde | nucleotide excision repair | DNA protein crosslink repair | mutagenesis

摘要： showed that one of the translesion synthesis (TLS) DNA | 5-Fluorouracil (5-FU) is the first-line | chemotherapeutic agent in colorectal cancer, and resistance to 5 | -FU easily emerges. One of the mechanisms of drug | action and resistance of 5-FU is through DNA

关键词： Novel insights | translesion synthesis | colorectal cancer

摘要： damage to facilitate error-free translesion DNA | translesion synthesis (TLS) DNA polymerases (Pols) replicate | In this study, Yoon et al. discover that | Werner syndrome protein (WRN) and WRN-interacting | protein 1 (WRNIP1) assemble with Rev1 and Y family DNA

关键词： DNA repair | DNA lesions | UV damage | Werner syndrome protein WRN | Y family DNA polymerases | fidelity of translesion synthesis

摘要： translesion synthesis (TLS) DNA polymerases iota (Pol iota | Glioblastoma (GBM) is a highly aggressive | brain tumor associated with poor patient survival. The | current standard treatment involves invasive surgery | , radiotherapy, and chemotherapy employing temozolomide (TMZ

关键词： Glioma | Temozolomide | Translesion synthesis | Cancer | Chemotherapy resistance | DNA polymerase | PROMOTER METHYLATION | MALIGNANT GLIOMAS | TLS POLYMERASES | RESISTANCE...

摘要：Translesion DNA synthesis (TLS) is a DNA | damage tolerance pathway utilized by cells to overcome | lesions encountered throughout DNA replication. During | replication stress, cancer cells show increased dependency | on TLS proteins for cellular survival and

关键词： BRCA | translesion synthesis | homologous recombination | replication stress | ssDNA gaps | ERROR-FREE | POLYMERASE-KAPPA | HOMOLOGOUS RECOMBINATION | MONOUBIQUITINATED PCNA | DAMAGE TOLERANCE...

摘要： cells are deficient in the translesion synthesis (TLS | Abstract Xeroderma pigmentosum (XP) variant | ) DNA polymerase Polη (eta). This protein contributes | to DNA damage tolerance, bypassing unrepaired UV | photoproducts and allowing S‐phase progression with minimal

关键词： DNA replication | lesion bypass | polymerase eta | polymerase iota | pyrimidine dimers | translesion synthesis | ultraviolet light

摘要：Translesion DNA synthesis pathways are | of DNA damage. Translesion DNA synthesis carried | for translesion DNA synthesis and that ImuC is the | literature in the field, we suggest a model for translesion | assembly and disassembly of the translesion DNA synthesis

关键词： ATPase | DNA binding protein | DNA replication | DNA-protein interaction | RECA PROTEIN | HOMOLOGOUS RECOMBINATION | STRANDED-DNA | MUTAGENESIS | POLYMERASE | MECHANISM...

摘要： translesion synthesis remains unexplored. Here we analyze | the efficiency and fidelity of translesion Y-family | and fidelity of translesion DNA polymerases. | Epigenetic cytosine methylation covers most of | genomic CpG dinucleotides in human cells. In addition to

关键词： 5-methylcytosine | 5-hydroxymethylcytosine | CpG dinucleotides | 8-oxo-2 ' -deoxyguanosine | DNA polymerases | PYRIMIDINE DIMER FORMATION | ERROR-FREE BYPASS | MUTATIONAL SIGNATURES | INDUCED DEAMINATION | DCMP TRANSFERASE...

摘要：Rev1-Pol zeta-dependent translesion synthesis | Rev1 and Pol zeta cooperate in translesion DNA | (TLS) of DNA is crucial for maintaining genome | integrity. To elucidate the mechanism by which the two | polymerases cooperate in TLS, we determined the cryogenic

关键词： REV1 PROTEIN INTERACTS | FACTOR-C P140 | POLYMERASE-ZETA | BRCT DOMAIN | POL-ZETA | BINDING | COMPLEX | LIGASE | BYPASS | FAMILY

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： dependent on translesion* synthesis and DNA interstrand* | Acetaldehyde is the primary metabolite of | alcohol and is present in many environmental sources | , including tobacco smoke. Acetaldehyde is genotoxic | , whereby it can form DNA adducts and lead to mutagenesis

摘要： showed that one of the translesion* synthesis (TLS) DNA* | 5-Fluorouracil (5-FU) is the first-line | chemotherapeutic agent in colorectal cancer, and resistance to 5 | -FU easily emerges. One of the mechanisms of drug | action and resistance of 5-FU is through DNA

摘要： damage to facilitate error-free translesion* DNA* | translesion synthesis (TLS) DNA polymerases (Pols) replicate | In this study, Yoon et al. discover that | Werner syndrome protein (WRN) and WRN-interacting | protein 1 (WRNIP1) assemble with Rev1 and Y family DNA

摘要： cells are deficient in the translesion* synthesis (TLS* | Abstract Xeroderma pigmentosum (XP) variant | ) DNA polymerase Polη (eta). This protein contributes | to DNA damage tolerance, bypassing unrepaired UV | photoproducts and allowing S‐phase progression with minimal

摘要：Translesion DNA synthesis pathways are | of DNA damage. Translesion* DNA synthesis carried* | for translesion* DNA synthesis and that ImuC is the* | literature in the field, we suggest a model for translesion | assembly and disassembly of the translesion* DNA synthesis*

摘要： translesion synthesis remains unexplored. Here we analyze | the efficiency and fidelity of translesion* Y-family* | and fidelity of translesion* DNA polymerases.* | Epigenetic cytosine methylation covers most of | genomic CpG dinucleotides in human cells. In addition to

摘要：Rev1-Pol zeta-dependent translesion* synthesis* | Rev1 and Pol zeta cooperate in translesion* DNA* | (TLS) of DNA is crucial for maintaining genome | integrity. To elucidate the mechanism by which the two | polymerases cooperate in TLS, we determined the cryogenic