NSTL国家科技图书文献中心

1. Spatiotemporal Nano-Regulator Unleashes Anti-Tumor Immunity by Overcoming Dendritic Cell Tolerance and T Cell Exhaustion in Tumor-Draining Lymph Nodes NSTL国家科技图书文献中心

Ruonan Wang | Huixin Li ... - 《Advanced Materials》 - 2025,37(5) - 2412141.1～2412141.17 - 共17页

摘要： microenvironment, activating the anti-tumor immunity cascade | anti-tumor* functions of tumor-draining lymph nodes* | the spatiotemporal activation of TLR4 and TLR7/8 | tolerogenic effects induced by tumor-derived factors and TLR | facilitates potent remodeling of TDLNs and the tumor

关键词： dendritic cell tolerance | immune nano-regulator | T cell exhaustion | TLR agonists | tumor-draining lymph nodes

2. Tumor microenvironment immunomodulation by nanoformulated TLR 7/8 agonist and PI3k delta inhibitor enhances therapeutic benefits of radiotherapy NSTL国家科技图书文献中心

Yazdimamaghani, Most... | Kolupaev, Oleg V.... - 《Biomaterials》 - 2025,312 - 共13页

摘要： the breast tumor* microenvironment (TME) is* | , accelerated tumor* growth, and poor clinical outcomes* | orthotopic claudinlow tumor* model, limiting the efficacy of* | drugs activating Toll-like receptors 7 and 8 (TLR7/8 | immunomodulation of the TME by TLR7/8 agonist and PI3K inhibitor

关键词： Cancer immunotherapy | Immunomodulation | Tumor microenvironment | Drug delivery | Nanomedicine | Radioimmunotherapy

3. Tumor-Selective Nano-Dispatcher Enforced Cancer Immunotherapeutic Effects via Regulating Lactate Metabolism and Activating Toll-Like Receptors NSTL国家科技图书文献中心

Liu, Yang | Li, Hui ... - 《Small》 - 2025,21(1) - 共14页

摘要： levels in the tumor* microenvironment (TME) and* | . To address this, a tumor-selective nano-dispatcher | the tumor-targeting properties of c-RGD, the system | efflux in tumor* cells, leading to decreased lactate* | increased accumulation within tumor* cells. The reduction*

关键词： immune therapy | lactate metabolism | monocarboxylate transporters 4 (MCT4) | nano-dispatcher | TLR7/8

4. Nanoengineered Macrophages Armed with TLR7/8 Agonist Enhance Remodeling of Immunosuppressive Tumor Microenvironment NSTL国家科技图书文献中心

Yeon Jeong Yoo | Ryounho Eun ... - 《Small》 - 2024,20(13) - n/a～n/a - 共12页 - 被引量：2

摘要：‐conjugated Toll‐like receptor 7/8 agonist (masked TLR7/8a | the remodeling of the immunosuppressive tumor | microenvironment (TME). The liposome‐anchored macrophages (LAMΦ | phagocytosed tumor* cells for up to 48 h in vitro. Both* | with doxorubicin‐loaded liposomes in 4T1‐tumor

关键词： cancer therapy | cell‐based therapy | click chemistry | immunotherapy | macrophages | tumor microenvironment

5. Heterocyclic-Modified Imidazoquinoline Derivatives: Selective TLR7 Agonist Regulates Tumor Microenvironment against Melanoma NSTL国家科技图书文献中心

Ou, Jiaxin | Zheng, Lu ... - 《Journal of Medicinal Chemistry》 - 2024,67(5) - 3321～3338 - 共18页 - 被引量：3

摘要： 7 (TLR7) is a promising strategy for cancer | a series of imidazoquinoline-based TLR7* agonists* | -molecule TLR7* agonist, SMU-L11 (EC50 = 0.024 +/- 0.002 mu* | specifically activated TLR7, resulting in recruitment of the | using a B16-F10 mouse tumor* model showed that SMU-L11*

关键词： TOLL-LIKE RECEPTORS | ACTIVATE INNATE | CELLS

6. Targeting Tumor-Associated Macrophages with the Immune-Activating Nanomedicine for Achieving Strong Antitumor Activity with Rapid Clearance from the Body NSTL国家科技图书文献中心

Ota, Yosuke | Inagaki, Ryosaku ... - 《ACS nano》 - 2024,18(34) - 23757～23772 - 共16页

摘要： tumor-associated macrophages (TAMs) to deliver the | TLR7 agonist DSP-0509. We used low molecular weight | Toll-like receptors (TLRs) are a class of | pattern recognition receptors (PRRs) crucial for the | detection of infections and activation of downstream

关键词： cancer immunology | tumor associated macrophages | nanomedicine | TLR7. tumor microenvironment | DEXTRAN | ANAPHYLAXIS | CHARGE

7. Radioresponsive Delivery of Toll-like Receptor 7/8 Agonist for Tumor Radioimmunotherapy Enabled by Core-Cross-Linked Diselenide Nanoparticles NSTL国家科技图书文献中心

Wu, Yanxian | Qin, Jianzhong ... - 《ACS nano》 - 2024,18(4) - 2800～2814 - 共15页 - 被引量：2

摘要：The development of a radioresponsive delivery | platform has led to an innovative combination | radioimmunotherapy strategy for treating tumors. However | , controlling the release of immunomodulators by local | radiotherapy in vivo remains a significant challenge in order

关键词： radioresponsiveness | diselenide bonds | core-cross-linked | TLR7/8agonist | tumor radioimmunotherapy | RADIOTHERAPY | MICROENVIRONMENT | IMMUNOTHERAPY | RESISTANCE | MECHANISMS

8. Amplifying cancer chemoimmunotherapy through F4/80+CD11c+DC-like macrophages induced by micellar docetaxel together with a TLR7/ 8 nanoagonist NSTL国家科技图书文献中心

Peng, Jinrong | Yang, Qian ... - 《Nano Today》 - 2024,54 - ARTN 102087～ - 共16页

摘要： reinflame the tumor* immune microenvironment, further* | immunomodulation has been developed to inflame the "cold" tumor | immune microenvironment* (TiME) for enhanced triple* | combined with immunomodulation by TLR7/8 agonists remains | (DTX-m) and a TLR7/8 nanoagonist suitable for

关键词： Chemoimmunotherapy | Tumor immune microenvironment | Triple-negative breast | Cancer | Administration sequence | DC-like macrophage | TUMOR-ASSOCIATED MACROPHAGES | CHEMOTHERAPY

9. A DNA-polymer hybrid nanocomplex based bi-adjuvant vaccine for tumor immunotherapy NSTL国家科技图书文献中心

Li, Feng | Ding, Xiaohui ... - 《Nano Today》 - 2024,54 - ARTN 102061～ - 共9页 - 被引量：4

摘要：The immunosuppressive tumor | microenvironment (TME) seriously impedes the cancer immunotherapy | emerging as vaccine adjuvant in reprogramming tumor | immune microenvironment. Herein, we develop a | vaccine for tumor* immunotherapy. In the nanocomplex, the*

关键词： DNA dynamic assembly | Dynamic boron chemistry | DNA nanotechnology | Cancer immunotherapy | TOLL-LIKE RECEPTORS | CANCER-IMMUNOTHERAPY | DELIVERY | INTERLEUKIN-6 | NANOPARTICLES | POLARIZATION...

10. Apoptotic cell mimics enhance immunogenic cell death and inflame tumor microenvironment by modulating macrophages NSTL国家科技图书文献中心

Su, Jing-Yun | Li, Wen-Hao ... - 《Nano Today》 - 2024,58 - ARTN 102464～ - 共9页

摘要： reverse the suppressive tumor* microenvironment. These* | the efficacy of immunotherapy. However, the tumor | microenvironment (TME) educated macrophages into immune | apoptotic tumor* cells by interacting with various* | macrophages. Uncleared apoptotic tumor* cells undergo*

摘要： microenvironment, activating the anti-tumor immunity cascade | anti-tumor* functions of tumor-draining lymph nodes* | the spatiotemporal activation of TLR4 and TLR7/8 | tolerogenic effects induced by tumor-derived factors and TLR | facilitates potent remodeling of TDLNs and the tumor

关键词： dendritic cell tolerance | immune nano-regulator | T cell exhaustion | TLR agonists | tumor-draining lymph nodes

摘要： the breast tumor* microenvironment (TME) is* | , accelerated tumor* growth, and poor clinical outcomes* | orthotopic claudinlow tumor* model, limiting the efficacy of* | drugs activating Toll-like receptors 7 and 8 (TLR7/8 | immunomodulation of the TME by TLR7/8 agonist and PI3K inhibitor

关键词： Cancer immunotherapy | Immunomodulation | Tumor microenvironment | Drug delivery | Nanomedicine | Radioimmunotherapy

摘要： levels in the tumor* microenvironment (TME) and* | . To address this, a tumor-selective nano-dispatcher | the tumor-targeting properties of c-RGD, the system | efflux in tumor* cells, leading to decreased lactate* | increased accumulation within tumor* cells. The reduction*

关键词： immune therapy | lactate metabolism | monocarboxylate transporters 4 (MCT4) | nano-dispatcher | TLR7/8

摘要：‐conjugated Toll‐like receptor 7/8 agonist (masked TLR7/8a | the remodeling of the immunosuppressive tumor | microenvironment (TME). The liposome‐anchored macrophages (LAMΦ | phagocytosed tumor* cells for up to 48 h in vitro. Both* | with doxorubicin‐loaded liposomes in 4T1‐tumor

关键词： cancer therapy | cell‐based therapy | click chemistry | immunotherapy | macrophages | tumor microenvironment

摘要： 7 (TLR7) is a promising strategy for cancer | a series of imidazoquinoline-based TLR7* agonists* | -molecule TLR7* agonist, SMU-L11 (EC50 = 0.024 +/- 0.002 mu* | specifically activated TLR7, resulting in recruitment of the | using a B16-F10 mouse tumor* model showed that SMU-L11*

关键词： TOLL-LIKE RECEPTORS | ACTIVATE INNATE | CELLS

摘要： tumor-associated macrophages (TAMs) to deliver the | TLR7 agonist DSP-0509. We used low molecular weight | Toll-like receptors (TLRs) are a class of | pattern recognition receptors (PRRs) crucial for the | detection of infections and activation of downstream

关键词： cancer immunology | tumor associated macrophages | nanomedicine | TLR7. tumor microenvironment | DEXTRAN | ANAPHYLAXIS | CHARGE

摘要：The development of a radioresponsive delivery | platform has led to an innovative combination | radioimmunotherapy strategy for treating tumors. However | , controlling the release of immunomodulators by local | radiotherapy in vivo remains a significant challenge in order

关键词： radioresponsiveness | diselenide bonds | core-cross-linked | TLR7/8agonist | tumor radioimmunotherapy | RADIOTHERAPY | MICROENVIRONMENT | IMMUNOTHERAPY | RESISTANCE | MECHANISMS

摘要： reinflame the tumor* immune microenvironment, further* | immunomodulation has been developed to inflame the "cold" tumor | immune microenvironment* (TiME) for enhanced triple* | combined with immunomodulation by TLR7/8 agonists remains | (DTX-m) and a TLR7/8 nanoagonist suitable for

关键词： Chemoimmunotherapy | Tumor immune microenvironment | Triple-negative breast | Cancer | Administration sequence | DC-like macrophage | TUMOR-ASSOCIATED MACROPHAGES | CHEMOTHERAPY

摘要：The immunosuppressive tumor | microenvironment (TME) seriously impedes the cancer immunotherapy | emerging as vaccine adjuvant in reprogramming tumor | immune microenvironment. Herein, we develop a | vaccine for tumor* immunotherapy. In the nanocomplex, the*

关键词： DNA dynamic assembly | Dynamic boron chemistry | DNA nanotechnology | Cancer immunotherapy | TOLL-LIKE RECEPTORS | CANCER-IMMUNOTHERAPY | DELIVERY | INTERLEUKIN-6 | NANOPARTICLES | POLARIZATION...

摘要： reverse the suppressive tumor* microenvironment. These* | the efficacy of immunotherapy. However, the tumor | microenvironment (TME) educated macrophages into immune | apoptotic tumor* cells by interacting with various* | macrophages. Uncleared apoptotic tumor* cells undergo*

关键词： Immunogenic cell death | Phosphatidylserine | Macrophages | Phagocytosis blockade | CANCER | CLEARANCE | RECEPTOR | BIOLOGY

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： microenvironment, activating the anti-tumor immunity cascade | anti-tumor functions of tumor-draining lymph nodes | the spatiotemporal activation of TLR4 and TLR7/8 | tolerogenic effects induced by tumor-derived factors and TLR | facilitates potent remodeling of TDLNs and the tumor

关键词： dendritic cell tolerance | immune nano-regulator | T cell exhaustion | TLR agonists | tumor-draining lymph nodes

摘要： the breast tumor microenvironment (TME) is | , accelerated tumor growth, and poor clinical outcomes | orthotopic claudinlow tumor model, limiting the efficacy of | drugs activating Toll-like receptors 7 and 8 (TLR7/8 | immunomodulation of the TME by TLR7/8 agonist and PI3K inhibitor

关键词： Cancer immunotherapy | Immunomodulation | Tumor microenvironment | Drug delivery | Nanomedicine | Radioimmunotherapy

摘要： levels in the tumor microenvironment (TME) and | . To address this, a tumor-selective nano-dispatcher | the tumor-targeting properties of c-RGD, the system | efflux in tumor cells, leading to decreased lactate | increased accumulation within tumor cells. The reduction

关键词： immune therapy | lactate metabolism | monocarboxylate transporters 4 (MCT4) | nano-dispatcher | TLR7/8

摘要：‐conjugated Toll‐like receptor 7/8 agonist (masked TLR7/8a | the remodeling of the immunosuppressive tumor | microenvironment (TME). The liposome‐anchored macrophages (LAMΦ | phagocytosed tumor cells for up to 48 h in vitro. Both | with doxorubicin‐loaded liposomes in 4T1‐tumor

关键词： cancer therapy | cell‐based therapy | click chemistry | immunotherapy | macrophages | tumor microenvironment

摘要： 7 (TLR7) is a promising strategy for cancer | a series of imidazoquinoline-based TLR7 agonists | -molecule TLR7 agonist, SMU-L11 (EC50 = 0.024 +/- 0.002 mu | specifically activated TLR7, resulting in recruitment of the | using a B16-F10 mouse tumor model showed that SMU-L11

关键词： TOLL-LIKE RECEPTORS | ACTIVATE INNATE | CELLS

摘要： tumor-associated macrophages (TAMs) to deliver the | TLR7 agonist DSP-0509. We used low molecular weight | Toll-like receptors (TLRs) are a class of | pattern recognition receptors (PRRs) crucial for the | detection of infections and activation of downstream

关键词： cancer immunology | tumor associated macrophages | nanomedicine | TLR7. tumor microenvironment | DEXTRAN | ANAPHYLAXIS | CHARGE

摘要：The development of a radioresponsive delivery | platform has led to an innovative combination | radioimmunotherapy strategy for treating tumors. However | , controlling the release of immunomodulators by local | radiotherapy in vivo remains a significant challenge in order

关键词： radioresponsiveness | diselenide bonds | core-cross-linked | TLR7/8agonist | tumor radioimmunotherapy | RADIOTHERAPY | MICROENVIRONMENT | IMMUNOTHERAPY | RESISTANCE | MECHANISMS

摘要： reinflame the tumor immune microenvironment, further | immunomodulation has been developed to inflame the "cold" tumor | immune microenvironment (TiME) for enhanced triple | combined with immunomodulation by TLR7/8 agonists remains | (DTX-m) and a TLR7/8 nanoagonist suitable for

关键词： Chemoimmunotherapy | Tumor immune microenvironment | Triple-negative breast | Cancer | Administration sequence | DC-like macrophage | TUMOR-ASSOCIATED MACROPHAGES | CHEMOTHERAPY

摘要：The immunosuppressive tumor | microenvironment (TME) seriously impedes the cancer immunotherapy | emerging as vaccine adjuvant in reprogramming tumor | immune microenvironment. Herein, we develop a | vaccine for tumor immunotherapy. In the nanocomplex, the

关键词： DNA dynamic assembly | Dynamic boron chemistry | DNA nanotechnology | Cancer immunotherapy | TOLL-LIKE RECEPTORS | CANCER-IMMUNOTHERAPY | DELIVERY | INTERLEUKIN-6 | NANOPARTICLES | POLARIZATION...

摘要： reverse the suppressive tumor microenvironment. These | the efficacy of immunotherapy. However, the tumor | microenvironment (TME) educated macrophages into immune | apoptotic tumor cells by interacting with various | macrophages. Uncleared apoptotic tumor cells undergo

关键词： Immunogenic cell death | Phosphatidylserine | Macrophages | Phagocytosis blockade | CANCER | CLEARANCE | RECEPTOR | BIOLOGY

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： microenvironment, activating the anti-tumor immunity cascade | anti-tumor* functions of tumor-draining lymph nodes* | the spatiotemporal activation of TLR4 and TLR7/8 | tolerogenic effects induced by tumor-derived factors and TLR | facilitates potent remodeling of TDLNs and the tumor

摘要： the breast tumor* microenvironment (TME) is* | , accelerated tumor* growth, and poor clinical outcomes* | orthotopic claudinlow tumor* model, limiting the efficacy of* | drugs activating Toll-like receptors 7 and 8 (TLR7/8 | immunomodulation of the TME by TLR7/8 agonist and PI3K inhibitor

摘要： levels in the tumor* microenvironment (TME) and* | . To address this, a tumor-selective nano-dispatcher | the tumor-targeting properties of c-RGD, the system | efflux in tumor* cells, leading to decreased lactate* | increased accumulation within tumor* cells. The reduction*

摘要： 7 (TLR7) is a promising strategy for cancer | a series of imidazoquinoline-based TLR7* agonists* | -molecule TLR7* agonist, SMU-L11 (EC50 = 0.024 +/- 0.002 mu* | specifically activated TLR7, resulting in recruitment of the | using a B16-F10 mouse tumor* model showed that SMU-L11*

摘要： reinflame the tumor* immune microenvironment, further* | immunomodulation has been developed to inflame the "cold" tumor | immune microenvironment* (TiME) for enhanced triple* | combined with immunomodulation by TLR7/8 agonists remains | (DTX-m) and a TLR7/8 nanoagonist suitable for

摘要：The immunosuppressive tumor | microenvironment (TME) seriously impedes the cancer immunotherapy | emerging as vaccine adjuvant in reprogramming tumor | immune microenvironment. Herein, we develop a | vaccine for tumor* immunotherapy. In the nanocomplex, the*

摘要： reverse the suppressive tumor* microenvironment. These* | the efficacy of immunotherapy. However, the tumor | microenvironment (TME) educated macrophages into immune | apoptotic tumor* cells by interacting with various* | macrophages. Uncleared apoptotic tumor* cells undergo*