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1. Kat7 accelerates osteoarthritis disease progression through the TLR4/NF-κB signaling pathway NSTL国家科技图书文献中心

Liu, Zhen |  Qiu, Lijie... -  《Journal of molecular medicine》 - 2025,103(3) - 273~284 - 共12页

摘要: the TLR4/NF-kappa B signaling pathway, and |  inhibition of this pathway reverses the catabolic effects | Osteoarthritis (OA) is a common degenerative |  bone and joint disease with an unclear pathogenesis | . Our study identified that the histone
关键词: Osteoarthritis |  Histone acetyl transferase |  Kat7 |  TLR4/NF-kappa B signaling pathway |  Cartilage metabolism

2. Exosomes derived from human umbilical cord mesenchymal stem cells decrease neuroinflammation and facilitate the restoration of nerve function in rats suffering from intracerebral hemorrhage NSTL国家科技图书文献中心

Nan, Chengrui |  Zhang, Yan... -  《Molecular and Cellular Biochemistry》 - 2025,480(1) - 309~323 - 共15页

摘要: the TLR4/NF-kappa B signaling pathway. This study |  model. The expression of TLR4/NF-kappa B signaling |  of TLR4, NF-kappa B/P65, and p-P65, reduced the |  transcription, thereby suppressing the TLR4/NF-kappa B |  signaling pathway. We can conclude that hUCMSC-ex
关键词: Intracerebral hemorrhage |  Human umbilical cord mesenchymal stem cells |  Exosomes |  Inflammation |  TLR4/NF-kappa B

3. Engeletin attenuates the inflammatory response via inhibiting TLR4-NFκB signaling pathway in Crohn's disease-like colitis NSTL国家科技图书文献中心

Wei, Ziyun |  Ni, Xiao... -  《Journal of Ethnopharmacology》 - 2025,336 - 118733~118733 - 共11页

摘要:, as well as the TLR4-NF kappa B signaling pathway |  inflammatory cytokines. TLR4-NF kappa B signaling pathway |  gene expression and TLR4-NF kappa B pathway. Flow |  ENG and TLR4. Conclusion: ENG has been proven to | , especially TLR4, may be the target of ENG. These data offer
关键词: Engeletin |  CD-Like colitis |  Macrophages |  M1 polarization |  NF-kappa B signaling

4. Epimedium polysaccharides ameliorate ulcerative colitis by inhibiting oxidative stress and regulating autophagy NSTL国家科技图书文献中心

Zhao, Linxian |  Jiang, Tao... -  《Journal of the Science of Food and Agriculture》 - 2025,105(4) - 2655~2670 - 共16页

摘要: receptor 4/nuclear factor-kappa B (TLR4/NF-kappa B | -induced UC through the inhibition of the TLR4/NF-kappa B | ) signaling pathway and to alleviate oxidative stress |  signaling pathway, regulation of the Keap1/Nrf2 pathway |  (Keap1/Nrf2) pathway. Notably, EPS failed to exert
关键词: ulcerative colitis |  Epimedium polysaccharides |  TLR4/NF-kappa B |  oxidative stress |  autophagy |  TLR4/NF‐κB

5. Targeting TLR4/NF-κB signaling, oxidative stress, and apoptosis by farnesol mitigates cadmium-induced testicular toxicity in rats NSTL国家科技图书文献中心

Hassanein, Emad H. M... |  Alotaibi, Mohammed F...... -  《Tissue and Cell》 - 2025,94 - 102813~102813 - 共11页

摘要: TLR4/NF-kappa B signaling and diminished antioxidants | , suppression of TLR4/NF kappa B signaling, and inhibition of | , and IL-6) and suppression of the TLR4/NF-kappa B |  signaling pathway. FAR inhibited testicular apoptosis by | Cadmium (Cd) is a highly toxic heavy metal
关键词: Farnesol |  Cadmium |  Testis |  Oxidative stress |  Inflammation

6. Ameliorating immune-dependent inflammation and apoptosis by targeting TLR4/MYD88/NF-κB pathway by celastrol mitigates the diabetic reproductive dysfunction NSTL国家科技图书文献中心

Faheem, Heba |  Alawadhi, Rana... -  《Physiological genomics》 - 2025,57(3) - 103~114 - 共12页

摘要: TLR4/MyD88/NF-kappa B signaling cascade pathways |  kappa B (NF-kappa B), and myeloid differentiation |  celastrol significantly reduced TLR4, MyD88, and NF-kappa |  relative toll-like receptor 4 (TLR4), nuclear factor |  B expressions, and the levels of inflammatory
关键词: celastrol |  diabetic testicular dysfunction |  TLR4/MYD88/NF-kappa B signaling pathway

7. Bioassay-guided and DeepSAT plus SMART-driven identification of hepatoprotective phenolics from the fruits of Phyllanthus emblica NSTL国家科技图书文献中心

Liang, Zhenzhen |  Li, Sheng... -  《Fitoterapia》 - 2025,182 - 共10页

摘要:-alcoholic liver injury effect via the TLR4/NF-kappa B |  signaling pathway. | To explore potential protective effects of |  natural products against alcohol-induced liver disease | , a bioactivitydriven approach and HSQC-based
关键词: Phenolics constituents |  Targeted isolation |  Alcohol liver injury |  Network pharmacology

8. Involvement of circ_0029407 in Caerulein-Evoked Cytotoxicity in Human Pancreatic Cells via the miR-579-3p/TLR4/NF-κB Pathway NSTL国家科技图书文献中心

Lu, Xingwen |  Shi, Caiyan... -  《Molecular biotechnology》 - 2025,67(5) - 1978~1990 - 共13页

摘要: regulated the TLR4/nuclear factor NF-kappaB (NF-kappa B |  pancreatic cells at least in part via the TLR4/NF-kappa B |  signaling pathway by functioning as a ceRNA for miR-579-3p. |  (miR)-579-3p, and toll-like receptor 4 (TLR4) were | -3p and circ_0029407 or TLR4. Our results indicated
关键词: Acute pancreatitis (AP) |  circ_0029407 |  miR-579-3p |  ceRNA |  TLR4/NF-kappa B signaling

9. Anti-inflammatory, anti-colitis, and antioxidant effects of columbianadin against DSS-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and TLR4-NF-κB signaling pathway NSTL国家科技图书文献中心

Zhang, Yanping |  Cao, Ping... -  《Inflammopharmacology》 - 2025,33(1) - 341~352 - 共12页

摘要: TLR4-NF-kappa B signaling pathway. | /Nrf2 and TLR4-NF-kappa B signaling pathways. Material |  (NF-kappa B), transforming growth factor (TGF-beta | -gamma, IL-6, IL-1 beta, IL-8, TNF-alpha, NF-kappa B |  nitric oxide synthetase (iNOS), nuclear factor kappa B
关键词: Columbianadin |  Ulcerative colitis |  Apoptosis |  Inflammation |  Oxidative stress

10. Signaling Pathways (TNF-α-NF-κB, TLR2-TLR4 as well as ROS-MDA) and Cardiac Damages during Cardiac Surgeries (Coronary stenting, Permanent Pacemaker Implantations, Radiofrequency Ablations) NSTL国家科技图书文献中心

Li, Xia |  Zhao, Yongjuan... -  《Current topics in medicinal chemistry》 - 2025,25(2) - 196~208 - 共13页

摘要:-inflammatory response (TNF-alpha/NF-kappa B signaling pathway |  mutual activation of TNF-alpha/NF-kappa B, TLR2/TLR4 |  receptor 4 (TLR4), nuclear factor kappa B (NF-kappa B | , MDA, TLR2, TLR4, NF-kappa B, TNF-alpha, and hs-cTnT | , MDA, TLR2, TLR4, NF-kappa B, and TNF-alpha predicted
关键词: Inflammatory signaling |  oxidative stress signaling |  immune signaling |  myocardial cell injury |  elderly
检索条件TLR4/NF-kappa B signaling pathway
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