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1. Decongestion and Outcomes in Patients Hospitalized for Acute Heart Failure Insights From the RELAX-AHF-2 Trial NSTL国家科技图书文献中心

Pagnesi, Matteo | Staal, Laura ... - 《JACC..Heart failure.》 - 2025,13(3) - 414～429 - 共16页 - 被引量：1

摘要： RELAX-AHF-2 (Efficacy, Safety and Tolerability of | Therapy in AHF [RELAX-AHF-2]; NCT01870778) (JACC Heart | residual congestion after acute heart failure (AHF | large cohort of patients with AHF* enrolled in the* | Serelaxin When Added to Standard Therapy in AHF) trial

关键词： acute heart failure | congestion | decongestion | heart failure | hospitalization | mortality

2. Distinct Comorbidity Clusters in Patients With Acute Heart Failure: Data From RELAX-AHF-2 NSTL国家科技图书文献中心

Karla Arevalo Gomez | Jasper Tromp ... - 《JACC. Heart failure.》 - 2024,12(10) - 1762～1774 - 共13页 - 被引量：2

摘要： outcomes.Methods: From the prospective RELAX-AHF-2 (Relaxin for | groups in RELAX-AHF-2, showing variations in clinical | the RELAX-AHF* trial, which comprised 1,161* | the RELAX-AHF* trial clustered in 5 multimorbidity* | in patients with acute heart failure (AHF). The co

关键词： RELAX-AHF-2 | acute heart failure | cluster | multimorbidity | poLCA.

3. Impact of age on clinical outcomes and response to serelaxin in patients with acute heart failure: An analysis from the RELAX-AHF-2 trial NSTL国家科技图书文献中心

Inciardi, Riccardo M... | Staal, Laura ... - 《European journal of heart failure》 - 2024,26(11) - 2431～2439 - 共9页

摘要： (RELAX-AHF-2), a study that included older patients | RELAX-AHF-2 randomized patients admitted for AHF to | patients enrolled in RELAX-AHF-2 was 73.0 +/- 11 years | Aims Acute heart failure (AHF) is a major | than in previous AHF* trials. Methods and results The*

关键词： Acute heart failure | Age | Comorbidities | Serelaxin

4. Impact of mitral regurgitation in patients with acute heart failure: insights from the RELAX‐AHF‐2 trial NSTL国家科技图书文献中心

Matteo Pagnesi | Marianna Adamo ... - 《European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology》 - 2023,25(4) - 541～552 - 共12页 - 被引量：6

摘要： Acute Heart Failure 2 (RELAX‐AHF‐2) trial. Methods and | results Patients enrolled in RELAX‐AHF‐2 with available | failure (AHF) is not well established. We assessed the | . Among 6420 AHF* patients with known MR status, 1810* | with AHF, moderate/severe MR was associated with a

关键词： Acute heart failure | Hospitalization | Mitral regurgitation | Mortality | Outcomes | Valvular heart disease

5. Mineralocorticoid receptor antagonist initiation during admission is associated with improved outcomes irrespective of ejection fraction in patients with acute heart failure NSTL国家科技图书文献中心

Iris E. Beldhuis | Kevin Damman ... - 《European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology》 - 2023,25(9) - 1584～1592 - 共9页 - 被引量：4

摘要： analysis of 6197 patients enrolled in the RELAX‐AHF‐2 | Aims Heart failure (HF) guidelines recommend | initiation and optimization of guideline‐directed medical | therapy, including mineralocorticoid receptor | antagonists (MRAs), before hospital discharge. However

关键词： Acute heart failure | Mineralocorticoid receptor antagonist | Post‐discharge outcome

6. Characteristics and clinical outcomes of patients with acute heart failure with a supranormal left ventricular ejection fraction NSTL国家科技图书文献中心

Bart J. Essen | Jasper Tromp ... - 《European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology》 - 2023,25(1) - 35～42 - 共8页 - 被引量：22

摘要： distinctive group of patients. Methods and results RELAX‐AHF | ‐2 was a multicentre, placebo‐controlled trial on | Abstract Aim Recent data suggest that | guideline‐directed medical therapy of patients with heart | failure (HF) with reduced ejection fraction (HFrEF

关键词： Acute heart failure | Heart failure with supranormal ejection fraction | Clinical outcome | Serelaxin

7. Disconnect between the effects of serelaxin on renal function and outcome in acute heart failure NSTL国家科技图书文献中心

I. E. Beldhuis | J. M. ter Maaten ... - 《Clinical research in cardiology :》 - 2023,112(7) - 901～910 - 共10页 - 被引量：2

摘要： AHF-2 (RELAX-AHF2) study. Improvement in renal | day 2. Worsening renal function (WRF) was defined as | Background We aimed to study whether | improvement in renal function by serelaxin in patients who | were hospitalized for acute heart failure (HF) might

关键词： Acute heart failure | Renal function change | Serelaxin | Mediation analysis

8. Worsening renal function in acute heart failure in the context of diuretic response SCIE Web of Science核心 NSTL国家科技图书文献中心

Johanna E. Emmens | Jozine M. Maaten ... - 《European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology》 - 2022,24(2) - 365～374 - 共10页

摘要： (PROTECT, n?=?1698 and RELAX‐AHF‐2, n?=?5586 in current | ‐AHF‐2, respectively. Patients with WRF had higher | failure (AHF), substantial diuresis after administration | patients with AHF. Methods and results In two AHF* cohorts* | (16.8%) and 1031 (18.5%) patients in PROTECT and RELAX

关键词： Acute heart failure | Worsening renal function | Diuretic response | Decongestion | Outcomes

9. Neutrophil-to-Lymphocyte Ratio and Outcomes in Patients Admitted for Acute Heart Failure (As Seen in the BLAST-AHF, Pre-RELAX-AHF, and RELAX-AHF Studies) SCIE Web of Science核心 NSTL国家科技图书文献中心

Davison, Beth A. | Takagi, Koji ... - 《The American Journal of Cardiology》 - 2022,180 - 72～80 - 共9页 - 被引量：12

摘要： angiotensin 2 type 1 receptor, TRV027), Pre-RELAX-AHF* (phase* | ), and RELAX-AHF* (phase 3 study of serelaxin) ran* | -AHF* (phase 2b study of the biased ligand of the* | 2b study of recombi-nant human relaxin-2, serelaxin | Previous studies have suggested that the

关键词： MYELOPEROXIDASE LEVELS | PREDICTION | SERELAXIN | PRESSURE | SURVIVAL

10. Association of Early Blood Pressure Decrease and Renal Function With Prognosis in Acute Heart Failure SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Matsue, Yuya | Sama, Iziah E.... - 《JACC. Heart failure.》 - 2021,9(12) - 890～903 - 共14页 - 被引量：7

摘要： RELAX-AHF-2 (Relaxin in Acute Heart Failure-2) trial | Standard Therapy in AHF [RELAX-AHF-2]; NCT01870778) (J Am | prognosis in patients with acute heart failure (AHF | admission for AHF* might be associated with increased risk* | analysis among 6,544 patients with AHF* enrolled in the*

关键词： | acute heart failure | blood pressure | renal dysfunction | DIURETIC RESPONSE | EJECTION FRACTION | SERUM CREATININE | REDUCTION | SERELAXIN | INSIGHTS...

摘要： RELAX-AHF-2 (Efficacy, Safety and Tolerability of | Therapy in AHF [RELAX-AHF-2]; NCT01870778) (JACC Heart | residual congestion after acute heart failure (AHF | large cohort of patients with AHF enrolled in the | Serelaxin When Added to Standard Therapy in AHF) trial