NSTL国家科技图书文献中心

1. Protein stability models fail to capture epistatic interactions of double point mutations NSTL国家科技图书文献中心

Dieckhaus, Henry | Kuhlman, Brian - 《Protein science :》 - 2025,34(1) - e70003～e70003 - 共13页

摘要： for predicting changes in protein stability | advancements in predicting changes in protein* stability when* | protein stability models on this and other datasets. We | find that additive models of protein stability | physics-based protein* stability models consistently*

关键词： deep learning | epistasis | point mutations | protein design | protein stability

2. Amino acid sequence encodes protein abundance shaped by protein stability at reduced synthesis cost NSTL国家科技图书文献中心

Buric, Filip | Viknander, Sandra ... - 《Protein science :》 - 2025,34(1) - e5239～e5239 - 共25页

摘要： stability and metabolic costs related to protein synthesis | Understanding what drives protein* abundance is* | sequence alone encodes over half of protein* abundance* | to interpret latent factors predictive of protein | for guiding protein* abundance through sequence*

关键词： deep learning | explainable machine learning | language models | molecular dynamics | protein engineering | protein expression | protein sequence | protein stability | proteome

3. Loss-of-function SLC25A20 variant causes carnitine-acylcarnitine translocase deficiency by reducing SLC25A20 protein stability NSTL国家科技图书文献中心

Gan, Zhongzhi | Wei, Xiaofeng ... - 《Gene》 - 2025,940 - Article 149201～Article 149201 - 共9页

摘要： decreased the protein* stability of SLC25A20, reduced CPT1A* | mRNA levels. The expression and stability* of the* | variant protein* were assessed via Western blot* | protein was observed using immunofluorescence. Results | and CPT2 mRNA expression, and caused protein

关键词： CACTD | Compound heterozygous variants | c.199-10T> | G and c.476T> | C variants | Loss-of-function | Protein stability

4. Mass balance approximation of unfolding boosts potential‐based protein stability predictions NSTL国家科技图书文献中心

Ivan Rossi | Guido Barducci ... - 《Protein science :》 - 2025,34(5) - e70134～e70134 - 共8页

摘要：Abstract Predicting protein* stability changes* | estimating stability* changes. However, most of them* | enhance stability* change predictions.* | upon single‐point mutations is crucial in | computational biology, with applications in drug design

关键词： deep learning models | Gibbs free energy | mass‐balance correction | potential‐like methods | protein stability prediction | single‐point mutations

5. Pepper RING-Type E3 Ligase CaFIRF1 Negatively Regulates the Protein Stability of Pepper Stress-Associated Protein, CaSAP14, in the Dehydration Stress Response NSTL国家科技图书文献中心

Bae, Yeongil | Lim, Chae Woo ... - 《Plant, Cell & Environment》 - 2025,48(1) - 435～450 - 共16页

摘要： crucial role in regulating the protein* stability of* | CaSAP14 protein* degradation, implicating CaFIRF1 in the* | regulation of CaSAP14 protein* via the 26S proteasomal* | previously reported that pepper stress-associated protein | stability.

关键词： dehydration | protein stability | stress-associated protein | ubiquitin-proteasome system

6. Predicting absolute protein folding stability using generative models NSTL国家科技图书文献中心

Cagiada, Matteo | Ovchinnikov, Sergey ... - 《Protein science :》 - 2025,34(1) - e5233～e5233 - 共12页

摘要： our ability to predict changes in protein stability | absolute protein* stability. We benchmark our predictions* | slower in methods to predict the absolute stability* of* | a protein. Here, we show how a generative model | for protein* sequence can be leveraged to predict*

关键词： machine learning | protein folding | protein stability | thermodynamics

7. HOS15 impacts DIL9 protein stability during drought stress in Arabidopsis NSTL国家科技图书文献中心

Shah Zareen | Akhtar Ali ... - 《The New Phytologist》 - 2025,245(6) - 2553～2568 - 共16页

摘要： DROUGHT-INDUCED LIKE 19 (DIL9) protein stability | HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE | 15 (HOS15) acts as a substrate receptor of E3 | ligase complex, which plays a negative role in drought | stress tolerance. However, whether and how HOS15

关键词： ABA and drought stress | ABFsTFs | Arabidopsis | DIL9 | HOS15 | proteasomaldegradation

8. Unsymmetric Triazine-Based Triglucoside Detergents for Membrane Protein Stability NSTL国家科技图书文献中心

Ehsan, Muhammad | Ghani, Lubna ... - 《Chembiochem》 - 2025,26(5) - n/a～n/a - 共8页

摘要： relied on solubilization of the target protein* using* | maintain the stability* of challenging membrane proteins* | novel detergents with enhanced protein* stabilization* | G protein-coupled receptor, TTG-8,12 demonstrated | significant potential for advancing membrane protein

关键词： Glucoside detergent | Detergent design | 1,3,5-Triazine | Membrane proteins | Protein stabilization

9. Intrinsic Differential Scanning Fluorimetry for Protein Stability Assessment in Microwell Plates NSTL国家科技图书文献中心

Cohrs, Michaela | Davy, Alastair ... - 《Molecular pharmaceutics》 - 2025,22(3) - 1697～1706 - 共10页

摘要： characterizing protein* stability and ranking protein drug* | (DSF) is essential for analyzing protein* thermal* | stability. Until now, intrinsic DSF was characterized by | powerful tool for the early stability* analysis of various* | protein samples and drug candidates.

关键词： differential scanning fluorimetry | modulated scanningfluorimetry | biotherapeutics | monoclonal antibodies | intrinsic fluorescence | thermal stability

10. Death associated protein like 1 acts as a novel tumor suppressor in melanoma by increasing the stability of P21 protein NSTL国家科技图书文献中心

Liu, Xiaoyan | Hu, Xiaojuan ... - 《Molecular and Cellular Biochemistry》 - 2025,480(3) - 1595～1610 - 共16页

摘要：-associated protein-like 1 (DAPL1) expression is lower in | proliferation of melanoma cells by increasing the protein | degradation of P21 and promoting its stability. Conversely | Melanoma is a primary malignant tumor with | high lethality, which occurs in the skin and eye

摘要： for predicting changes in protein stability | advancements in predicting changes in protein* stability when* | protein stability models on this and other datasets. We | find that additive models of protein stability | physics-based protein* stability models consistently*

关键词： deep learning | epistasis | point mutations | protein design | protein stability

摘要： stability and metabolic costs related to protein synthesis | Understanding what drives protein* abundance is* | sequence alone encodes over half of protein* abundance* | to interpret latent factors predictive of protein | for guiding protein* abundance through sequence*

关键词： deep learning | explainable machine learning | language models | molecular dynamics | protein engineering | protein expression | protein sequence | protein stability | proteome

摘要： decreased the protein* stability of SLC25A20, reduced CPT1A* | mRNA levels. The expression and stability* of the* | variant protein* were assessed via Western blot* | protein was observed using immunofluorescence. Results | and CPT2 mRNA expression, and caused protein

关键词： CACTD | Compound heterozygous variants | c.199-10T> | G and c.476T> | C variants | Loss-of-function | Protein stability

摘要：Abstract Predicting protein* stability changes* | estimating stability* changes. However, most of them* | enhance stability* change predictions.* | upon single‐point mutations is crucial in | computational biology, with applications in drug design

关键词： deep learning models | Gibbs free energy | mass‐balance correction | potential‐like methods | protein stability prediction | single‐point mutations

摘要： crucial role in regulating the protein* stability of* | CaSAP14 protein* degradation, implicating CaFIRF1 in the* | regulation of CaSAP14 protein* via the 26S proteasomal* | previously reported that pepper stress-associated protein | stability.

关键词： dehydration | protein stability | stress-associated protein | ubiquitin-proteasome system

摘要： our ability to predict changes in protein stability | absolute protein* stability. We benchmark our predictions* | slower in methods to predict the absolute stability* of* | a protein. Here, we show how a generative model | for protein* sequence can be leveraged to predict*

关键词： machine learning | protein folding | protein stability | thermodynamics

摘要： DROUGHT-INDUCED LIKE 19 (DIL9) protein stability | HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE | 15 (HOS15) acts as a substrate receptor of E3 | ligase complex, which plays a negative role in drought | stress tolerance. However, whether and how HOS15

关键词： ABA and drought stress | ABFsTFs | Arabidopsis | DIL9 | HOS15 | proteasomaldegradation

摘要： relied on solubilization of the target protein* using* | maintain the stability* of challenging membrane proteins* | novel detergents with enhanced protein* stabilization* | G protein-coupled receptor, TTG-8,12 demonstrated | significant potential for advancing membrane protein

关键词： Glucoside detergent | Detergent design | 1,3,5-Triazine | Membrane proteins | Protein stabilization

摘要： characterizing protein* stability and ranking protein drug* | (DSF) is essential for analyzing protein* thermal* | stability. Until now, intrinsic DSF was characterized by | powerful tool for the early stability* analysis of various* | protein samples and drug candidates.

关键词： differential scanning fluorimetry | modulated scanningfluorimetry | biotherapeutics | monoclonal antibodies | intrinsic fluorescence | thermal stability

摘要：-associated protein-like 1 (DAPL1) expression is lower in | proliferation of melanoma cells by increasing the protein | degradation of P21 and promoting its stability. Conversely | Melanoma is a primary malignant tumor with | high lethality, which occurs in the skin and eye

关键词： Melanoma | Cell proliferation | DAPL1 | P21 | Protein stability

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： for predicting changes in protein stability | advancements in predicting changes in protein stability when | protein stability models on this and other datasets. We | find that additive models of protein stability | physics-based protein stability models consistently

关键词： deep learning | epistasis | point mutations | protein design | protein stability

摘要： stability and metabolic costs related to protein synthesis | Understanding what drives protein abundance is | sequence alone encodes over half of protein abundance | to interpret latent factors predictive of protein | for guiding protein abundance through sequence

关键词： deep learning | explainable machine learning | language models | molecular dynamics | protein engineering | protein expression | protein sequence | protein stability | proteome

摘要： decreased the protein stability of SLC25A20, reduced CPT1A | mRNA levels. The expression and stability of the | variant protein were assessed via Western blot | protein was observed using immunofluorescence. Results | and CPT2 mRNA expression, and caused protein

关键词： CACTD | Compound heterozygous variants | c.199-10T> | G and c.476T> | C variants | Loss-of-function | Protein stability

摘要：Abstract Predicting protein stability changes | estimating stability changes. However, most of them | enhance stability change predictions. | upon single‐point mutations is crucial in | computational biology, with applications in drug design

关键词： deep learning models | Gibbs free energy | mass‐balance correction | potential‐like methods | protein stability prediction | single‐point mutations

摘要： crucial role in regulating the protein stability of | CaSAP14 protein degradation, implicating CaFIRF1 in the | regulation of CaSAP14 protein via the 26S proteasomal | previously reported that pepper stress-associated protein | stability.

关键词： dehydration | protein stability | stress-associated protein | ubiquitin-proteasome system

摘要： our ability to predict changes in protein stability | absolute protein stability. We benchmark our predictions | slower in methods to predict the absolute stability of | a protein. Here, we show how a generative model | for protein sequence can be leveraged to predict

关键词： machine learning | protein folding | protein stability | thermodynamics

摘要： DROUGHT-INDUCED LIKE 19 (DIL9) protein stability | HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE | 15 (HOS15) acts as a substrate receptor of E3 | ligase complex, which plays a negative role in drought | stress tolerance. However, whether and how HOS15

关键词： ABA and drought stress | ABFsTFs | Arabidopsis | DIL9 | HOS15 | proteasomaldegradation

摘要： relied on solubilization of the target protein using | maintain the stability of challenging membrane proteins | novel detergents with enhanced protein stabilization | G protein-coupled receptor, TTG-8,12 demonstrated | significant potential for advancing membrane protein

关键词： Glucoside detergent | Detergent design | 1,3,5-Triazine | Membrane proteins | Protein stabilization

摘要： characterizing protein stability and ranking protein drug | (DSF) is essential for analyzing protein thermal | stability. Until now, intrinsic DSF was characterized by | powerful tool for the early stability analysis of various | protein samples and drug candidates.

关键词： differential scanning fluorimetry | modulated scanningfluorimetry | biotherapeutics | monoclonal antibodies | intrinsic fluorescence | thermal stability

摘要：-associated protein-like 1 (DAPL1) expression is lower in | proliferation of melanoma cells by increasing the protein | degradation of P21 and promoting its stability. Conversely | Melanoma is a primary malignant tumor with | high lethality, which occurs in the skin and eye

关键词： Melanoma | Cell proliferation | DAPL1 | P21 | Protein stability

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： for predicting changes in protein stability | advancements in predicting changes in protein* stability when* | protein stability models on this and other datasets. We | find that additive models of protein stability | physics-based protein* stability models consistently*

摘要： stability and metabolic costs related to protein synthesis | Understanding what drives protein* abundance is* | sequence alone encodes over half of protein* abundance* | to interpret latent factors predictive of protein | for guiding protein* abundance through sequence*

摘要： decreased the protein* stability of SLC25A20, reduced CPT1A* | mRNA levels. The expression and stability* of the* | variant protein* were assessed via Western blot* | protein was observed using immunofluorescence. Results | and CPT2 mRNA expression, and caused protein

摘要：Abstract Predicting protein* stability changes* | estimating stability* changes. However, most of them* | enhance stability* change predictions.* | upon single‐point mutations is crucial in | computational biology, with applications in drug design

摘要： crucial role in regulating the protein* stability of* | CaSAP14 protein* degradation, implicating CaFIRF1 in the* | regulation of CaSAP14 protein* via the 26S proteasomal* | previously reported that pepper stress-associated protein | stability.

摘要： our ability to predict changes in protein stability | absolute protein* stability. We benchmark our predictions* | slower in methods to predict the absolute stability* of* | a protein. Here, we show how a generative model | for protein* sequence can be leveraged to predict*

摘要： relied on solubilization of the target protein* using* | maintain the stability* of challenging membrane proteins* | novel detergents with enhanced protein* stabilization* | G protein-coupled receptor, TTG-8,12 demonstrated | significant potential for advancing membrane protein

摘要： characterizing protein* stability and ranking protein drug* | (DSF) is essential for analyzing protein* thermal* | stability. Until now, intrinsic DSF was characterized by | powerful tool for the early stability* analysis of various* | protein samples and drug candidates.