NSTL国家科技图书文献中心

1. Shear force-ROS sequential responsive drug delivery system for improving cerebral thrombosis microcirculation and neurological function NSTL国家科技图书文献中心

Zhang, Huijuan | Wang, Jingjing ... - 《Journal of Controlled Release》 - 2025,378 - 195～208 - 共14页

摘要： system (UK@Fuc/CDPC-PTPCS) for sequential targeted | delivery of thrombolytic agent urokinase (UK) and | neuroprotective drug* cytosolic choline (CDPC). Results proved* | The ischemic strokes seriously threaten human | health with high incidence and disability rates

关键词： Ischemic stroke | Sequential targeted drug delivery | Shear force-ROS dual-responsive | Thrombolysis | Neuroprotection

2. Nanoscale Investigation of Elasticity Changes and Augmented Rigidity of Block Copolymer Micelles Induced by Reversible Core-Cross-Linking NSTL国家科技图书文献中心

Wang, Xinyue | Stihl, Andreas ... - 《ACS applied materials & interfaces》 - 2025,17(18) - 27557～27567 - 共11页

摘要：Drug-delivery systems have attracted | enabling targeted* drug release. Reversibly core-cross* | implementation of strategies for targeted* drug release, which* | furfuryl moieties and sequential* de-cross-linking by* | crucial for improving the efficiency of drug

关键词： atomic force microscopy | nanoindentation | blockcopolymer micelles | reversible cross-linking | nanomechanicalproperties | mechanical stability

3. Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools NSTL国家科技图书文献中心

Martinez-Borrajo, Re... | Diaz-Rodriguez, Patr...... - 《Drug delivery and translational research》 - 2025,15(1) - 343～354 - 共12页

摘要： significant promise as drug* delivery systems (DDS) owing to* | , enabling targeted* cell delivery. Mannosylation has* | their small size and efficient drug-loading | mannosylated drug* loaded NLCs. Artificial neural networks* | proposed sequential* methodology has enabled the design of*

关键词： Nanostructured lipid carriers | Carbohydrate surface functionalization | Artificial intelligence | Quality by design | Mannosylation optimization | Artificial neural networks | Genetic algorithms | Neurofuzzy logic

4. Thrombin-Responsive and Sequential Targeted Nanoplatform for Synergistic Thrombolysis Therapy NSTL国家科技图书文献中心

Zhang, Huijuan | Wang, Chaoqun ... - 《ACS applied materials & interfaces》 - 2025,17(11) - 16696～16707 - 共12页

摘要： sequential targeted nanoplatform (MMSN-UK/TI@pep-Fuco) for | multifunctional drug* carriers MMSN@pep-Fuco. Then, urokinase (UK* | MMSN@pep-Fuco to obtain MMSN-UK/TI@pep-Fuco nano drug | delivery systems (NDDS). In vitro and in vivo results | Traditional thrombolytic therapy is limited by

关键词： thrombin-responsive | sequentialtargeted | differentialrelease drug | UK | TI | synergistic thrombolysistherapy

5. Orally Administrated Precision Nanomedicine for Restoring the Intestinal Barrier and Alleviating Inflammation in Treatment of Inflammatory Bowel Disease NSTL国家科技图书文献中心

Wang, Ding | Jiang, Qi ... - 《ACS applied materials & interfaces》 - 2025,17(7) - 10986～11001 - 共16页

摘要： introduces the development of a targeted sequential | drug delivery, facilitated by degradation by colon | -specific microbiota. Responsive drug release, controlled | Inflammatory bowel disease (IBD) presents a | significant challenge in healthcare, characterized by its

关键词： inflammatory bowel disease | targeted therapy | oral delivery | reactive oxygen species-responsive | controlled release

6. Ultrasound-responsive microbubbles and nanodroplets: A pathway to targeted drug delivery NSTL国家科技图书文献中心

Shakya, Gazendra | Cattaneo, Marco ... - 《Advanced drug delivery reviews》 - 2024,206 - 115178～115178 - 共6页

摘要： potential as targeted* drug delivery agents, effectively* | overview of their drug* delivery process. Particular* | augmenting cell permeability and facilitating drug | , microbubbles and nanodroplets, and provides a sequential | Ultrasound -responsive agents have shown great

关键词： Microbubbles | Nanodroplets | Sonoporation | Cellular permeabilization | Endocytosis | Blood-brain barrier (BBB) | Enhanced Permeability and Retention effect (EPR) | BLOOD-BRAIN-BARRIER | ACOUSTIC DROPLET VAPORIZATION | GUIDED FOCUSED ULTRASOUND...

7. Neutrophil-Based Bionic Delivery System Breaks Through the Capillary Barrier of Liver Sinusoidal Endothelial Cells and Inhibits the Activation of Hepatic Stellate Cells NSTL国家科技图书文献中心

Sun, Dan | Du, Xiao ... - 《Molecular pharmaceutics》 - 2024,21(4) - 2043～2057 - 共15页

摘要： sequential drug delivery approach utilizing neutrophil | barriers and achieving efficient drug* delivery to* | synergistic sequential* delivery system effectively overcomes* | delivery of therapeutic agents to the Disse space for | breach the capillary barrier for targeted* HSC cell*

关键词： aHSC | liver fibrosis | LSEC | PPAR gamma/TGF-beta 1 | STAT1/Smad7 signaling pathways | BAICALIN | FIBROGENESIS | FIBROSIS | GAMMA

8. pH and ROS Dual‐Sensitive Nanocarriers for the Targeted Co‐Delivery and On‐Demand Sequential Release of Tofacitinib and Glucosamine for Synergistic Rheumatoid Arthritis Treatment NSTL国家科技图书文献中心

Guo Chen | Shaohui Deng ... - 《Small》 - 2024,20(24) - n/a～n/a - 共16页

摘要： involves multiple cell types, and sequential* drug action* | targeted delivery and on‐demand release of multiple drugs | (CS) for the co‐delivery* of the cartilage repair* | agent, glucosamine (GlcN), and anti‐inflammatory drug | approach for RA treatment with synergistic drug* effects.*

关键词： glucosamine | on‐demand sequential release | pH and ROS dual‐sensitive release | synergistic treatment of rheumatoid arthritis | targeted codelivery | Tofacitinib

9. Bioinspired molecular communications system for targeted drug delivery with IoBNT-based sustainable biocyber interface NSTL国家科技图书文献中心

Saied M. Abd El-atty | P. Vijayakumar ... - 《Computers and Electrical Engineering》 - 2024,118(Pt.B) - 109452-1～109452-17 - 共17页

摘要： interface approach for an intelligent targeted drug | probability of drug* delivery and the average delay time. The* | delivery system (TDDS). The proposed approach employs a | accomplished by a sequential* multistep FRET, and the* | This paper presents a sustainable biocyber

关键词： Molecular communications | Biocyber interface | FRET | Relay | BER | IoBNT

10. Delivery of PARP inhibitors through 2HG-incorporated liposomes for synergistically targeting DNA repair in cancer NSTL国家科技图书文献中心

Luo, Zhangyi | Huang, Yixian ... - 《Cancer letters》 - 2024,604 - 217268～217268 - 共6页

摘要： kinetics of drug* release, and targeted delivery to the* | of a PARPi can lead to the development of drug | sequential loading protocol was developed such that the | , combination of veliparib and 2HG via liposomal co-delivery | PARP inhibitors (PARPi) benefit only a small

摘要： system (UK@Fuc/CDPC-PTPCS) for sequential targeted | delivery of thrombolytic agent urokinase (UK) and | neuroprotective drug* cytosolic choline (CDPC). Results proved* | The ischemic strokes seriously threaten human | health with high incidence and disability rates

关键词： Ischemic stroke | Sequential targeted drug delivery | Shear force-ROS dual-responsive | Thrombolysis | Neuroprotection

摘要：Drug-delivery systems have attracted | enabling targeted* drug release. Reversibly core-cross* | implementation of strategies for targeted* drug release, which* | furfuryl moieties and sequential* de-cross-linking by* | crucial for improving the efficiency of drug

关键词： atomic force microscopy | nanoindentation | blockcopolymer micelles | reversible cross-linking | nanomechanicalproperties | mechanical stability

摘要： significant promise as drug* delivery systems (DDS) owing to* | , enabling targeted* cell delivery. Mannosylation has* | their small size and efficient drug-loading | mannosylated drug* loaded NLCs. Artificial neural networks* | proposed sequential* methodology has enabled the design of*

关键词： Nanostructured lipid carriers | Carbohydrate surface functionalization | Artificial intelligence | Quality by design | Mannosylation optimization | Artificial neural networks | Genetic algorithms | Neurofuzzy logic

摘要： sequential targeted nanoplatform (MMSN-UK/TI@pep-Fuco) for | multifunctional drug* carriers MMSN@pep-Fuco. Then, urokinase (UK* | MMSN@pep-Fuco to obtain MMSN-UK/TI@pep-Fuco nano drug | delivery systems (NDDS). In vitro and in vivo results | Traditional thrombolytic therapy is limited by

关键词： thrombin-responsive | sequentialtargeted | differentialrelease drug | UK | TI | synergistic thrombolysistherapy

摘要： introduces the development of a targeted sequential | drug delivery, facilitated by degradation by colon | -specific microbiota. Responsive drug release, controlled | Inflammatory bowel disease (IBD) presents a | significant challenge in healthcare, characterized by its

关键词： inflammatory bowel disease | targeted therapy | oral delivery | reactive oxygen species-responsive | controlled release

摘要： potential as targeted* drug delivery agents, effectively* | overview of their drug* delivery process. Particular* | augmenting cell permeability and facilitating drug | , microbubbles and nanodroplets, and provides a sequential | Ultrasound -responsive agents have shown great

关键词： Microbubbles | Nanodroplets | Sonoporation | Cellular permeabilization | Endocytosis | Blood-brain barrier (BBB) | Enhanced Permeability and Retention effect (EPR) | BLOOD-BRAIN-BARRIER | ACOUSTIC DROPLET VAPORIZATION | GUIDED FOCUSED ULTRASOUND...

摘要： sequential drug delivery approach utilizing neutrophil | barriers and achieving efficient drug* delivery to* | synergistic sequential* delivery system effectively overcomes* | delivery of therapeutic agents to the Disse space for | breach the capillary barrier for targeted* HSC cell*

关键词： aHSC | liver fibrosis | LSEC | PPAR gamma/TGF-beta 1 | STAT1/Smad7 signaling pathways | BAICALIN | FIBROGENESIS | FIBROSIS | GAMMA

关键词： glucosamine | on‐demand sequential release | pH and ROS dual‐sensitive release | synergistic treatment of rheumatoid arthritis | targeted codelivery | Tofacitinib

摘要： interface approach for an intelligent targeted drug | probability of drug* delivery and the average delay time. The* | delivery system (TDDS). The proposed approach employs a | accomplished by a sequential* multistep FRET, and the* | This paper presents a sustainable biocyber

关键词： Molecular communications | Biocyber interface | FRET | Relay | BER | IoBNT

摘要： kinetics of drug* release, and targeted delivery to the* | of a PARPi can lead to the development of drug | sequential loading protocol was developed such that the | , combination of veliparib and 2HG via liposomal co-delivery | PARP inhibitors (PARPi) benefit only a small

关键词： IDH2 MUTATIONS | HOMOLOGOUS RECOMBINATION | 2-HYDROXYGLUTARATE | SENSITIVITY | SURVIVAL | EFFICACY | DAMAGE | CELLS

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： system (UK@Fuc/CDPC-PTPCS) for sequential targeted | delivery of thrombolytic agent urokinase (UK) and | neuroprotective drug cytosolic choline (CDPC). Results proved | The ischemic strokes seriously threaten human | health with high incidence and disability rates

关键词： Ischemic stroke | Sequential targeted drug delivery | Shear force-ROS dual-responsive | Thrombolysis | Neuroprotection

摘要：Drug-delivery systems have attracted | enabling targeted drug release. Reversibly core-cross | implementation of strategies for targeted drug release, which | furfuryl moieties and sequential de-cross-linking by | crucial for improving the efficiency of drug

关键词： atomic force microscopy | nanoindentation | blockcopolymer micelles | reversible cross-linking | nanomechanicalproperties | mechanical stability

摘要： significant promise as drug delivery systems (DDS) owing to | , enabling targeted cell delivery. Mannosylation has | their small size and efficient drug-loading | mannosylated drug loaded NLCs. Artificial neural networks | proposed sequential methodology has enabled the design of

关键词： Nanostructured lipid carriers | Carbohydrate surface functionalization | Artificial intelligence | Quality by design | Mannosylation optimization | Artificial neural networks | Genetic algorithms | Neurofuzzy logic

摘要： sequential targeted nanoplatform (MMSN-UK/TI@pep-Fuco) for | multifunctional drug carriers MMSN@pep-Fuco. Then, urokinase (UK | MMSN@pep-Fuco to obtain MMSN-UK/TI@pep-Fuco nano drug | delivery systems (NDDS). In vitro and in vivo results | Traditional thrombolytic therapy is limited by

关键词： thrombin-responsive | sequentialtargeted | differentialrelease drug | UK | TI | synergistic thrombolysistherapy

摘要： introduces the development of a targeted sequential | drug delivery, facilitated by degradation by colon | -specific microbiota. Responsive drug release, controlled | Inflammatory bowel disease (IBD) presents a | significant challenge in healthcare, characterized by its

关键词： inflammatory bowel disease | targeted therapy | oral delivery | reactive oxygen species-responsive | controlled release

摘要： potential as targeted drug delivery agents, effectively | overview of their drug delivery process. Particular | augmenting cell permeability and facilitating drug | , microbubbles and nanodroplets, and provides a sequential | Ultrasound -responsive agents have shown great

关键词： Microbubbles | Nanodroplets | Sonoporation | Cellular permeabilization | Endocytosis | Blood-brain barrier (BBB) | Enhanced Permeability and Retention effect (EPR) | BLOOD-BRAIN-BARRIER | ACOUSTIC DROPLET VAPORIZATION | GUIDED FOCUSED ULTRASOUND...

摘要： sequential drug delivery approach utilizing neutrophil | barriers and achieving efficient drug delivery to | synergistic sequential delivery system effectively overcomes | delivery of therapeutic agents to the Disse space for | breach the capillary barrier for targeted HSC cell

关键词： aHSC | liver fibrosis | LSEC | PPAR gamma/TGF-beta 1 | STAT1/Smad7 signaling pathways | BAICALIN | FIBROGENESIS | FIBROSIS | GAMMA

摘要： involves multiple cell types, and sequential drug action | targeted delivery and on‐demand release of multiple drugs | (CS) for the co‐delivery of the cartilage repair | agent, glucosamine (GlcN), and anti‐inflammatory drug | approach for RA treatment with synergistic drug effects.

关键词： glucosamine | on‐demand sequential release | pH and ROS dual‐sensitive release | synergistic treatment of rheumatoid arthritis | targeted codelivery | Tofacitinib

摘要： interface approach for an intelligent targeted drug | probability of drug delivery and the average delay time. The | delivery system (TDDS). The proposed approach employs a | accomplished by a sequential multistep FRET, and the | This paper presents a sustainable biocyber

关键词： Molecular communications | Biocyber interface | FRET | Relay | BER | IoBNT

摘要： kinetics of drug release, and targeted delivery to the | of a PARPi can lead to the development of drug | sequential loading protocol was developed such that the | , combination of veliparib and 2HG via liposomal co-delivery | PARP inhibitors (PARPi) benefit only a small

关键词： IDH2 MUTATIONS | HOMOLOGOUS RECOMBINATION | 2-HYDROXYGLUTARATE | SENSITIVITY | SURVIVAL | EFFICACY | DAMAGE | CELLS

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： system (UK@Fuc/CDPC-PTPCS) for sequential targeted | delivery of thrombolytic agent urokinase (UK) and | neuroprotective drug* cytosolic choline (CDPC). Results proved* | The ischemic strokes seriously threaten human | health with high incidence and disability rates

摘要：Drug-delivery systems have attracted | enabling targeted* drug release. Reversibly core-cross* | implementation of strategies for targeted* drug release, which* | furfuryl moieties and sequential* de-cross-linking by* | crucial for improving the efficiency of drug

摘要： significant promise as drug* delivery systems (DDS) owing to* | , enabling targeted* cell delivery. Mannosylation has* | their small size and efficient drug-loading | mannosylated drug* loaded NLCs. Artificial neural networks* | proposed sequential* methodology has enabled the design of*

摘要： sequential targeted nanoplatform (MMSN-UK/TI@pep-Fuco) for | multifunctional drug* carriers MMSN@pep-Fuco. Then, urokinase (UK* | MMSN@pep-Fuco to obtain MMSN-UK/TI@pep-Fuco nano drug | delivery systems (NDDS). In vitro and in vivo results | Traditional thrombolytic therapy is limited by

摘要： potential as targeted* drug delivery agents, effectively* | overview of their drug* delivery process. Particular* | augmenting cell permeability and facilitating drug | , microbubbles and nanodroplets, and provides a sequential | Ultrasound -responsive agents have shown great

摘要： sequential drug delivery approach utilizing neutrophil | barriers and achieving efficient drug* delivery to* | synergistic sequential* delivery system effectively overcomes* | delivery of therapeutic agents to the Disse space for | breach the capillary barrier for targeted* HSC cell*

摘要： interface approach for an intelligent targeted drug | probability of drug* delivery and the average delay time. The* | delivery system (TDDS). The proposed approach employs a | accomplished by a sequential* multistep FRET, and the* | This paper presents a sustainable biocyber

摘要： kinetics of drug* release, and targeted delivery to the* | of a PARPi can lead to the development of drug | sequential loading protocol was developed such that the | , combination of veliparib and 2HG via liposomal co-delivery | PARP inhibitors (PARPi) benefit only a small