NSTL国家科技图书文献中心

1. Targeting the hypothalamic MC4 receptor: A novel approach to senolytic therapy? NSTL国家科技图书文献中心

Kim, Youn Ju | Lim, Joo Hyun ... - 《Medical hypotheses》 - 2025,195 - 111551～111551 - 共5页

摘要： senolytic therapeutics for correcting neuronal dysfunction | senolytic approach could provide valuable insights into | The hypothalamus is a center of whole-body | energy metabolism. With aging, its function decreases | , leading to a higher chance of metabolic disorders

关键词： MC4R | Senescence | Senolysis | Hypothalamus | Aging | Hyperglycemia

2. Uncovering cellular senescence as a therapeutic target in NF2-related vestibular schwannoma NSTL国家科技图书文献中心

Franco-Caspuenas, Sa... | Garcia-Montoya, Carm...... - 《Hearing Research》 - 2025,455 - 109165～109165 - 共12页

摘要： senolytic therapy represents a new paradigm for the | only effective treatments. Cancer therapy* based in* | VS cells as druggable targets for senolytic | therapy induced by chemotherapy treatment followed by | Background: Vestibular schwannomas (VS) are

关键词： Genotoxic drugs | p21 | DNA damage | SASP | Senolysis | Apoptosis

3. Nanodevice-Mediated Immune Cell Recruitment: Targeting Senescent Cells via MMP-3-Responsive CXCL12-Coated Nanoparticles NSTL国家科技图书文献中心

Escriche-Navarro, Bl... | Garrido, Eva ... - 《ACS applied materials & interfaces》 - 2025,17(4) - 5880～5892 - 共13页

摘要： a nanoparticle for immune cell-mediated senolytic | therapy designed to recruit immune cells in response to | Senescent cells are involved in age-related | disorders in different organs and are therapeutic targets | for fibrotic and chronic pathologies. Immune

关键词： CXCL12 | matrix metalloproteinase-3 | mesoporoussilica nanoparticles | senescence, immune cells

4. Inhibition of PERK-mediated unfolded protein response acts as a switch for reversal of residual senescence and as senolytic therapy in glioblastoma NSTL国家科技图书文献中心

Ketkar, Madhura | Desai, Sanket ... - 《Neuro-oncology》 - 2024,26(11) - 2027～2043 - 共17页

摘要：. Previously we showed that therapy-induced senescence (TIS | without SASP. PERKi in RS functioned as senolytic* via* | Background Glioblastoma due to recurrence is | clinically challenging with 10-15 months overall survival | ) in glioblastoma reverses causing recurrence. Here

关键词： ER stress | glioblastoma | PERK | TIS reversal | unfolded protein response

5. Can tissue-specific PD-1/PD-L1 targeting combined with other immune checkpoint blockades enhance immune clearance? NSTL国家科技图书文献中心

Ahmad S. | Rehman A.... - 《Medical hypotheses》 - 2024,192 - 111491～111491 - 共6页

摘要： approach to improve the efficacy of senolytic* therapy.* | ? 2024 Elsevier LtdAge-related disorders are | exacerbated by senescent cells (SnCs) due to their secretion | of proinflammatory molecules, yet current | therapeutic strategies have limited success in preclinical

关键词： Chronic inflammation | Immune checkpoint blockade | Immune clearance | Immune surveillance | Senescence

6. Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax NSTL国家科技图书文献中心

Faakye, Janet | Nyul-Toth, Adam ... - 《GeroScience.》 - 2024,46(1) - 21～37 - 共17页

摘要： with the senolytic* agent ABT263/Navitoclax, and young* | senolytic pre-treatment wielded considerable | senolytic interventions as a viable therapeutic avenue to | Emerging evidence from both clinical and | preclinical studies underscores the role of aging in

关键词： Cellular senescence | ABT263/Navitoclax | Cerebral microcirculation | Capillary | Senolytic therapy | Hypertension | VASCULAR OXIDATIVE STRESS | SMALL VESSEL DISEASE | COGNITIVE DECLINE | AUTOREGULATORY DYSFUNCTION...

7. Cellular senescence imaging and senolysis monitoring in cancer therapy based on a fi-galactosidase-activated aggregation-induced emission luminogen NSTL国家科技图书文献中心

Cen, Peili | Cui, Chunyi ... - 《Acta biomaterialia》 - 2024,179 - 340～353 - 共14页

摘要： therapy followed by senolytic therapy. However, there is | cancer cell clearance during senolytic therapy* with* | monitoring senolysis in cancer therapy. Aggregation | senescence and monitoring senolysis in cancer therapy* when* | senolysis monitoring in cancer therapy. QMfi -gal

关键词： Cellular senescence | Cancer | fi -galactosidase | AIE | Senolysis | Fluorescence imaging | BETA-GALACTOSIDASE | CELLS

8. The role of cellular senescence in profibrillatory atrial remodelling associated with cardiac pathology NSTL国家科技图书文献中心

Mehdizadeh, Mozhdeh | Naud, Patrice ... - 《Cardiovascular Research》 - 2024,120(5) - 506～518 - 共13页

摘要： reducing senescent-cell burden with senolytic* therapy on* | each). Senolytic* therapy reduced AF inducibility in* | senolytic combination, dasatinib and quercetin, (D+Q; or | Aims Cellular senescence is a stress-related | or aging response believed to contribute to many

关键词： AF susceptibility | Myocardial infarction | Cellular senescence | Fibrosis | Senolytic drugs | HEART-FAILURE | FIBRILLATION | AGE | MECHANISMS | CELLS

9. Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury NSTL国家科技图书文献中心

Gregory H. Tesch | Frank Y. Ma ... - 《Clinical Science》 - 2024,138(5) - 309～326 - 共18页

摘要：, and renal function impairment. Senolytic* therapy can* | targeting senescence with a senolytic* drug (HSP90* | Senescence of kidney tubules leads to | tubulointerstitial fibrosis (TIF). Proximal tubular epithelial | cells undergo stress-induced senescence during

关键词： ASK1 inhibitor | HSP90 inhibitor | acute kidney injury | cellular senescence | diabetic kidney disease | tubulointerstitial fibrosis

10. A navitoclax-loaded nanodevice targeting matrix metalloproteinase-3 for the selective elimination of senescent cells NSTL国家科技图书文献中心

Escriche-Navarro, Bl... | Garrido, Eva ... - 《Acta biomaterialia》 - 2024,176 - 405～416 - 共12页

摘要： senolytic therapy. In this study, we have developed an | senescence biomarker that limits the effective of senolytic | (MSNs) were loaded with the senolytic* navitoclax (Nav* | use of NPs to develop enhanced senolytic* therapies* | senolytic therapies. (c) 2024 The Author(s). Published by

关键词： Matrix metalloproteinase-3 | Mesoporous silica nanoparticles | Senescence | Navitoclax | BETA-GALACTOSIDASE ACTIVITY | CELLULAR SENESCENCE | IONIZING-RADIATION | IN-VITRO | DIFFERENTIATION | INHIBITORS...

摘要： senolytic therapeutics for correcting neuronal dysfunction | senolytic approach could provide valuable insights into | The hypothalamus is a center of whole-body | energy metabolism. With aging, its function decreases | , leading to a higher chance of metabolic disorders

关键词： MC4R | Senescence | Senolysis | Hypothalamus | Aging | Hyperglycemia

摘要： senolytic therapy represents a new paradigm for the | only effective treatments. Cancer therapy based in | VS cells as druggable targets for senolytic | therapy induced by chemotherapy treatment followed by | Background: Vestibular schwannomas (VS) are

关键词： Genotoxic drugs | p21 | DNA damage | SASP | Senolysis | Apoptosis

摘要： a nanoparticle for immune cell-mediated senolytic | therapy designed to recruit immune cells in response to | Senescent cells are involved in age-related | disorders in different organs and are therapeutic targets | for fibrotic and chronic pathologies. Immune

关键词： CXCL12 | matrix metalloproteinase-3 | mesoporoussilica nanoparticles | senescence, immune cells

摘要：. Previously we showed that therapy-induced senescence (TIS | without SASP. PERKi in RS functioned as senolytic via | Background Glioblastoma due to recurrence is | clinically challenging with 10-15 months overall survival | ) in glioblastoma reverses causing recurrence. Here

关键词： ER stress | glioblastoma | PERK | TIS reversal | unfolded protein response

摘要： approach to improve the efficacy of senolytic therapy. | ? 2024 Elsevier LtdAge-related disorders are | exacerbated by senescent cells (SnCs) due to their secretion | of proinflammatory molecules, yet current | therapeutic strategies have limited success in preclinical

关键词： Chronic inflammation | Immune checkpoint blockade | Immune clearance | Immune surveillance | Senescence

摘要： with the senolytic agent ABT263/Navitoclax, and young | senolytic pre-treatment wielded considerable | senolytic interventions as a viable therapeutic avenue to | Emerging evidence from both clinical and | preclinical studies underscores the role of aging in

关键词： Cellular senescence | ABT263/Navitoclax | Cerebral microcirculation | Capillary | Senolytic therapy | Hypertension | VASCULAR OXIDATIVE STRESS | SMALL VESSEL DISEASE | COGNITIVE DECLINE | AUTOREGULATORY DYSFUNCTION...

摘要： therapy followed by senolytic therapy. However, there is | cancer cell clearance during senolytic therapy with | monitoring senolysis in cancer therapy. Aggregation | senescence and monitoring senolysis in cancer therapy when | senolysis monitoring in cancer therapy. QMfi -gal