NSTL国家科技图书文献中心

1. Insights to Design New Drugs against Human African Trypanosomiasis Targeting Rhodesain using Covalent Docking, Molecular Dynamics Simulations, and MM-PBSA Calculations NSTL国家科技图书文献中心

Nascimento, Igor Jos... | Santos, Mirelly Barb...... - 《Current computer-aided drug design》 - 2025,21(1) - 67～82 - 共16页

摘要： Trypanosomiasis (HAT), known as sleeping sickness, shows | without basic sanitation. Among these, Human African | Background Neglected tropical diseases (NTDs | ) are parasitic and bacterial diseases that affect | approximately 149 countries, mainly the poor population

关键词： Human african trypanosomiasis | sleeping sickness | rhodesain | molecular modeling | molecular docking | molecular dynamics | MM-PBSA calculations

2. Diversity of trypanosomes in tsetse fly caught in two "silent" sleeping sickness foci of Bafia and the Manoka Island in Cameroon NSTL国家科技图书文献中心

Tagueu, Sartrien Kan... | Mbida, Jean Arthur M...... - 《Parasitology International》 - 2025,104 - 共9页

摘要： African Trypanosomiasis (HAT) foci is important for the | Background: Surveillance of "silent" human | achievement of the World Health Organization (WHO) goal of | interrupting the transmission of this disease by 2030. It is | in this context that this study was carried out to

关键词： Trypanosomiasis | "Silent foci" HAT | Trypanosomes | Blood meals | Tsetse flies

3. Retrospective clinical performance evaluation of the Abbott Bioline HAT 2.0, a rapid diagnostic test for human African trypanosomiasis based on recombinant antigens NSTL国家科技图书文献中心

Sara Tablado Alonso | Sylvain Biéler ... - 《Tropical Medicine and International Health》 - 2025,30(2) - 135～142 - 共8页

摘要： the serological detection of gambiense human African | trypanosomiasis (gHAT) have been developed to overcome the | . gambiense. The Abbott Bioline human African | trypanosomiasis (HAT) 2.0 rapid diagnostic test has recently | Abstract Background Rapid diagnostic tests for

关键词： human African trypanosomiasis | rapid diagnostic tests | recombinant rapid diagnostic tests | serology | sleeping sickness | specificity | Trypanosoma brucei gambiense

4. Antileishmanial and Antitrypanosomal Trends of Synthetic Tetralone Derivatives NSTL国家科技图书文献中心

Alkhaldi, Abdulsalam... | de Koning, Harry P.... - 《Drug Development Research》 - 2025,86(1) - e70055～e70055 - 共9页

摘要：Leishmaniasis and trypanosomiasis are | parasitic diseases that are closely linked to poverty | , pose significant local burdens, and are common in | tropical and subtropical regions. Various synthetic | tetralone derivatives were studied as potential scaffolds

关键词： cyclohexanone | protozoan parasites | sleeping sickness | synthesis | zoonotic vector-borne disease

5. The impact of canine African trypanosomiasis in anti-poaching dogs in the Republic of Zambia NSTL国家科技图书文献中心

Sundelin, Freja | Anderson, Neil ... - 《Veterinary Parasitology》 - 2025,59 - 共6页

摘要： being the protozoal, vector-borne canine African | trypanosomiasis (CAT). This report aims to investigate the | Zambia introduced canine units in 2014 as an | anti-poaching tool. Working in challenging | environments, these dogs face several health threats, one

关键词： Canine trypanosomiasis | African trypanosomiasis | Working dogs | Isometamidium | Diminazene

6. Exploring the latest breakthroughs in rhodesain inhibitors for African trypanosomiasis NSTL国家科技图书文献中心

Chiba D.E | dos Santos Fernes G....... - 《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 - 2024,33(3) - 354～369 - 共16页

摘要： in sleeping* sickness, highlighting its relevance in* | Human African* Trypanosomiasis is a serious* | public health concern, and new chemical therapeutic | agents need to be developed to combat this disease | . Rhodesain (RhD) inhibitors have shown promising results in

关键词： Drug discovery | Human African Trypanosomiasis | New compounds | Rhodesian | Sleeping sickness | Trypanosoma brucei

7. 100 years since the publication of the suramin formula NSTL国家科技图书文献中心

Steverding, Dietmar | Troeberg, Linda - 《Parasitology Research》 - 2024,123(1) - Article 11～Article 11 - 共6页 - 被引量：3

摘要： sleeping sickness caused by the two subspecies | , sleeping* sickness caused by Trypanosoma brucei* | company in the 1910s for the treatment of human African | Suramin was the first drug developed using the | approach of medicinal chemistry by the German Bayer

关键词： Suramin | Sleeping sickness | Political instrumentalization | Colonial revisionism | CHEMOTHERAPY

8. The Transmission of Animal African Trypanosomiasis in Two Districts in the Forest Zone of Ghana NSTL国家科技图书文献中心

Tweneboah, Austine | Rosenau, Jana ... - 《The American Journal of Tropical Medicine and Hygiene》 - 2024,110(6) - 1127～1136 - 共10页

摘要：Animal African* trypanosomiasis, also known as* | nagana, is caused by Trypanosoma species, which cause | significant clinical diseases and lead to losses in animal | production. We carried out a cross-sectional survey to | investigate the composition of vectors and parasite

关键词： SLEEPING SICKNESS FOCI | TSETSE-FLIES GLOSSINA | MIXED INFECTIONS | DOMESTIC-ANIMALS | GENERIC PRIMERS | DIPTERA | FLY | CONGOLENSE | BRUCEI | CATTLE

9. The Hidden Hand of Asymptomatic Infection Hinders Control of Neglected Tropical Diseases: A Modeling Analysis NSTL国家科技图书文献中心

Kat S,Rock | Lloyd A C,Chapman ... - 《Clinical infectious diseases》 - 2024,78(Suppl.2) - S175～S182 - 共8页

摘要： sub-continent (VL), gambiense sleeping sickness | Abstract Background Neglected tropical | diseases are responsible for considerable morbidity and | mortality in low-income populations. International efforts | have reduced their global burden, but transmission is

关键词： asymptomatic infection | Chagas disease | gambiense sleeping sickness | visceral leishmaniasis | modeling

10. Mobile Monkeys and Modified Microbes: Medical Experimentation between Metropolitan and Colonial Laboratories, 1880-ca. 1925 NSTL国家科技图书文献中心

Thaddeus Sunseri - 《Bulletin of the history of medicine》 - 2024,98(1) - 26～60 - 共35页

摘要： variety of diseases, notably syphilis, sleeping sickness | Following the medical breakthroughs of Pasteur | and Koch after 1880, the use of simians became | pivotal to laboratory research to develop vaccines and | cultivate microbes through the technique of serial passage

摘要： Trypanosomiasis (HAT), known as sleeping sickness, shows | without basic sanitation. Among these, Human African | Background Neglected tropical diseases (NTDs | ) are parasitic and bacterial diseases that affect | approximately 149 countries, mainly the poor population

关键词： Human african trypanosomiasis | sleeping sickness | rhodesain | molecular modeling | molecular docking | molecular dynamics | MM-PBSA calculations

摘要： African Trypanosomiasis (HAT) foci is important for the | Background: Surveillance of "silent" human | achievement of the World Health Organization (WHO) goal of | interrupting the transmission of this disease by 2030. It is | in this context that this study was carried out to

关键词： Trypanosomiasis | "Silent foci" HAT | Trypanosomes | Blood meals | Tsetse flies

摘要： the serological detection of gambiense human African | trypanosomiasis (gHAT) have been developed to overcome the | . gambiense. The Abbott Bioline human African | trypanosomiasis (HAT) 2.0 rapid diagnostic test has recently | Abstract Background Rapid diagnostic tests for

关键词： human African trypanosomiasis | rapid diagnostic tests | recombinant rapid diagnostic tests | serology | sleeping sickness | specificity | Trypanosoma brucei gambiense

摘要：Leishmaniasis and trypanosomiasis are | parasitic diseases that are closely linked to poverty | , pose significant local burdens, and are common in | tropical and subtropical regions. Various synthetic | tetralone derivatives were studied as potential scaffolds

关键词： cyclohexanone | protozoan parasites | sleeping sickness | synthesis | zoonotic vector-borne disease

摘要： being the protozoal, vector-borne canine African | trypanosomiasis (CAT). This report aims to investigate the | Zambia introduced canine units in 2014 as an | anti-poaching tool. Working in challenging | environments, these dogs face several health threats, one

关键词： Canine trypanosomiasis | African trypanosomiasis | Working dogs | Isometamidium | Diminazene

摘要： in sleeping* sickness, highlighting its relevance in* | Human African* Trypanosomiasis is a serious* | public health concern, and new chemical therapeutic | agents need to be developed to combat this disease | . Rhodesain (RhD) inhibitors have shown promising results in

关键词： Drug discovery | Human African Trypanosomiasis | New compounds | Rhodesian | Sleeping sickness | Trypanosoma brucei

摘要： sleeping sickness caused by the two subspecies | , sleeping* sickness caused by Trypanosoma brucei* | company in the 1910s for the treatment of human African | Suramin was the first drug developed using the | approach of medicinal chemistry by the German Bayer

关键词： Suramin | Sleeping sickness | Political instrumentalization | Colonial revisionism | CHEMOTHERAPY

摘要：Animal African* trypanosomiasis, also known as* | nagana, is caused by Trypanosoma species, which cause | significant clinical diseases and lead to losses in animal | production. We carried out a cross-sectional survey to | investigate the composition of vectors and parasite

关键词： SLEEPING SICKNESS FOCI | TSETSE-FLIES GLOSSINA | MIXED INFECTIONS | DOMESTIC-ANIMALS | GENERIC PRIMERS | DIPTERA | FLY | CONGOLENSE | BRUCEI | CATTLE

摘要： sub-continent (VL), gambiense sleeping sickness | Abstract Background Neglected tropical | diseases are responsible for considerable morbidity and | mortality in low-income populations. International efforts | have reduced their global burden, but transmission is

关键词： asymptomatic infection | Chagas disease | gambiense sleeping sickness | visceral leishmaniasis | modeling

摘要： variety of diseases, notably syphilis, sleeping sickness | Following the medical breakthroughs of Pasteur | and Koch after 1880, the use of simians became | pivotal to laboratory research to develop vaccines and | cultivate microbes through the technique of serial passage

关键词： sleeping sickness | serial passage | syphilis | nonhuman primates | Ajoshohe | colonial laboratories | simians

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： Trypanosomiasis (HAT), known as sleeping sickness, shows | without basic sanitation. Among these, Human African | Background Neglected tropical diseases (NTDs | ) are parasitic and bacterial diseases that affect | approximately 149 countries, mainly the poor population

关键词： Human african trypanosomiasis | sleeping sickness | rhodesain | molecular modeling | molecular docking | molecular dynamics | MM-PBSA calculations

摘要： African Trypanosomiasis (HAT) foci is important for the | Background: Surveillance of "silent" human | achievement of the World Health Organization (WHO) goal of | interrupting the transmission of this disease by 2030. It is | in this context that this study was carried out to

关键词： Trypanosomiasis | "Silent foci" HAT | Trypanosomes | Blood meals | Tsetse flies

摘要： the serological detection of gambiense human African | trypanosomiasis (gHAT) have been developed to overcome the | . gambiense. The Abbott Bioline human African | trypanosomiasis (HAT) 2.0 rapid diagnostic test has recently | Abstract Background Rapid diagnostic tests for

关键词： human African trypanosomiasis | rapid diagnostic tests | recombinant rapid diagnostic tests | serology | sleeping sickness | specificity | Trypanosoma brucei gambiense

摘要：Leishmaniasis and trypanosomiasis are | parasitic diseases that are closely linked to poverty | , pose significant local burdens, and are common in | tropical and subtropical regions. Various synthetic | tetralone derivatives were studied as potential scaffolds

关键词： cyclohexanone | protozoan parasites | sleeping sickness | synthesis | zoonotic vector-borne disease

摘要： being the protozoal, vector-borne canine African | trypanosomiasis (CAT). This report aims to investigate the | Zambia introduced canine units in 2014 as an | anti-poaching tool. Working in challenging | environments, these dogs face several health threats, one

关键词： Canine trypanosomiasis | African trypanosomiasis | Working dogs | Isometamidium | Diminazene

摘要： in sleeping sickness, highlighting its relevance in | Human African Trypanosomiasis is a serious | public health concern, and new chemical therapeutic | agents need to be developed to combat this disease | . Rhodesain (RhD) inhibitors have shown promising results in

关键词： Drug discovery | Human African Trypanosomiasis | New compounds | Rhodesian | Sleeping sickness | Trypanosoma brucei

摘要： sleeping sickness caused by the two subspecies | , sleeping sickness caused by Trypanosoma brucei | company in the 1910s for the treatment of human African | Suramin was the first drug developed using the | approach of medicinal chemistry by the German Bayer

关键词： Suramin | Sleeping sickness | Political instrumentalization | Colonial revisionism | CHEMOTHERAPY

摘要：Animal African trypanosomiasis, also known as | nagana, is caused by Trypanosoma species, which cause | significant clinical diseases and lead to losses in animal | production. We carried out a cross-sectional survey to | investigate the composition of vectors and parasite

关键词： SLEEPING SICKNESS FOCI | TSETSE-FLIES GLOSSINA | MIXED INFECTIONS | DOMESTIC-ANIMALS | GENERIC PRIMERS | DIPTERA | FLY | CONGOLENSE | BRUCEI | CATTLE

摘要： sub-continent (VL), gambiense sleeping sickness | Abstract Background Neglected tropical | diseases are responsible for considerable morbidity and | mortality in low-income populations. International efforts | have reduced their global burden, but transmission is

关键词： asymptomatic infection | Chagas disease | gambiense sleeping sickness | visceral leishmaniasis | modeling

摘要： variety of diseases, notably syphilis, sleeping sickness | Following the medical breakthroughs of Pasteur | and Koch after 1880, the use of simians became | pivotal to laboratory research to develop vaccines and | cultivate microbes through the technique of serial passage

关键词： sleeping sickness | serial passage | syphilis | nonhuman primates | Ajoshohe | colonial laboratories | simians

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： in sleeping* sickness, highlighting its relevance in* | Human African* Trypanosomiasis is a serious* | public health concern, and new chemical therapeutic | agents need to be developed to combat this disease | . Rhodesain (RhD) inhibitors have shown promising results in

摘要： sleeping sickness caused by the two subspecies | , sleeping* sickness caused by Trypanosoma brucei* | company in the 1910s for the treatment of human African | Suramin was the first drug developed using the | approach of medicinal chemistry by the German Bayer

摘要：Animal African* trypanosomiasis, also known as* | nagana, is caused by Trypanosoma species, which cause | significant clinical diseases and lead to losses in animal | production. We carried out a cross-sectional survey to | investigate the composition of vectors and parasite