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1. The clinical significance of signal regulatory protein alpha expression in the immune environment of gastric cancer NSTL国家科技图书文献中心

Tanaka, Yasushi |  Hu, Qingjiang... -  《International journal of clinical oncology》 - 2025,30(2) - 330~339 - 共10页

摘要: (SIRP alpha) inhibits phagocytosis by macrophages by |  cancers, the clinical significance of SIRP alpha in |  elucidate the clinical implications of SIRP alpha in GC | ). Immunohistochemistry was used to assess SIRP alpha, CD80, CD163, CD8 | ).ResultsIn the gastrectomy cohort, high SIRP alpha
关键词: Signal regulatory protein alpha (SIRP alpha) |  Gastric cancer |  Macrophages |  B7-H1 antigen |  Interferon type 2

2. The relationship between clinical prognostic factors, microvascular density, and tumor-infiltrating lymphocytes with CD47 and SIRPα expression in diffuse large B cell lymphomas NSTL国家科技图书文献中心

Kilicarslan, Aydan |  Polat, Sevdenur Ozdu...... -  《Leukemia Research》 - 2025,149 - Article 107636~Article 107636 - 共6页

摘要: alpha (SIRP alpha) on macrophages to deliver an anti |  CD47 and SIRP alpha expression and key clinical |  the Allred scoring system, and SIRP alpha expression |  (p = 0.021). High SIRP alpha expression (>= 25 |  between CD3 and CD47-SIRP alpha. The study reveals that
关键词: Diffuse Large B Cell Lymphoma |  CD47 |  SIRP alpha |  Microvascular density |  Tumor-infiltrating lymphocytes(TIL)

3. In situ production and precise release of bioactive GM-CSF and siRNA by engineered bacteria for macrophage reprogramming in cancer immunotherapy NSTL国家科技图书文献中心

Wang, Yaxin |  Fan, Yali... -  《Biomaterials》 - 2025,317 - 共14页

摘要: signal regulatory protein alpha (SIRP alpha). The two |  lowest ratio of F4/80+SIRP alpha+TAMs (3.46 %) than |  continuously produce and release bioactive GM-CSF and SIRP |  alpha siRNA, exhibiting significant therapeutic | In the immunosuppressive tumor
关键词: Engineered bacteria |  Macrophage reprograming |  Cancer immunotherapy |  Optogenetics |  Outer membrane vesicles

4. The role of inhibitory immune checkpoint receptors in the pathogenesis of Alzheimer's disease NSTL国家科技图书文献中心

Salminen, Antero -  《Journal of molecular medicine》 - 2025,103(1) - 1~19 - 共19页

摘要:, LILRB2-4, Siglecs, and SIRP alpha receptors, which can |  decrease in the expression of SIRP alpha receptor in | There is mounting evidence that microglial |  cells have a key role in the pathogenesis of |  Alzheimer's disease (AD). In AD pathology, microglial cells
关键词: Ageing |  Alzheimer's disease |  Immune tolerance |  Immunosenescence |  Immunosuppression |  Microglia

5. Design, synthesis, and evaluation of 4-(4-methyl-4H-1,2,4-triazol-3-yl) piperidine derivatives as potential glutaminyl cyclase isoenzyme inhibitors for the treatment of cancer NSTL国家科技图书文献中心

Zhou, Qingqing |  Wu, Zhenxin... -  《European Journal of Medicinal Chemistry》 - 2025,281 - 117019~117019 - 共19页

摘要: pE-CD47 generation and thus enhancing CD47-SIRP |  alpha binding and subsequent "don't eat me" signals | Upregulated glutaminyl cyclase isoenzyme |  (isoQC) contributes to cancer development by catalyzing | . We thus consider that isoQC could represent a novel
关键词: Glutaminyl cyclase isoenzyme |  Selective inhibitor |  A549 |  pE-CD47 |  BALB/C nude mice

6. Reprogramming tumor microenvironment with precise photothermal therapy by calreticulin nanobody-engineered probiotics NSTL国家科技图书文献中心

Zheng, Liuhai |  Wang, Huifang... -  《Biomaterials》 - 2025,314 - 共15页

摘要: is synergistically enhanced by blocking CD47-SIRP |  alpha axis. Collectively, our study provides a proof | Targeted therapies have revolutionized |  traditional cancer treatments by precisely targeting tumor |  cells, enhancing efficacy and safety. Despite this
关键词: Targeted therapies |  Immunogenic cell death |  CALR |  Nanobody |  Photothermal therapy

7. Microglia membrane-mediated trans-blood-brain barrier prodrug micelles enhance phagocytosis for glioblastoma chemo-immunotherapy NSTL国家科技图书文献中心

Li, Sufen |  Zhang, Jingyan... -  《Journal of Controlled Release》 - 2025,378 - 932~948 - 共17页

摘要: blocks the CD47-SIRP alpha axis, disabling the 'don't | Glioblastoma-associated macrophages |  & microglia (GAMs) are critical immune cells within the |  glioblastoma (GBM) microenvironment. Their phagocytosis of |  GBM cells is crucial for initiating both innate and
关键词: Glioblastoma |  Blood-brain tumor barrier |  Glioblastoma-associated macrophages & microglia |  CD47 blockade |  Immunogenic cell death |  Responsive release

8. Construction and characterization of a novel secreted MsC-CAR-T cell in solid tumors NSTL国家科技图书文献中心

Mao, Yuan |  Chen, Yufeng... -  《Cancer letters》 - 2025,611 - 217382~217382 - 共14页

摘要:The CD47-SIRP alpha signaling has been |  acknowledged as a significant immune checkpoint and CD47 |  blocking has been proved as a potential therapeutic |  strategy for the treatment of solid tumor. However, the |  potential application of CAR-T cells secreted antibody
关键词: MAGE-A1 |  CD47 |  CAR-T |  Secreted scFv

9. Triple Hybrid Cellular Nanovesicles Promote Cardiac Repair after Ischemic Reperfusion NSTL国家科技图书文献中心

Lai, Jialin |  Pan, Qi... -  《ACS nano》 - 2024,18(5) - 4443~4455 - 共13页

摘要: overexpressing high-affinity SIRP alpha variants (S alpha V-NVs |  presence of S alpha V-NVs suppresses the CD47-SIRP alpha |  alpha V-NVs and EXOs showed a notable synergistic | The management of myocardial ischemia | /reperfusion (I/R) damage in the context of reperfusion
关键词: biomaterials |  drug delivery |  extracellularvesicles |  myocardial ischemia/reperfusion |  CD47-SIRP alpha |  ALPHA SIRP-ALPHA |  EXTRACELLULAR VESICLES |  INFLAMMATORY RESPONSE |  INJURY |  CD47...

10. Intracellular Magnetic Hyperthermia Enables Concurrent Down-Regulation of CD47 and SIRPα To Potentiate Antitumor Immunity NSTL国家科技图书文献中心

Wang, Siyao |  Jiao, Wangbo... -  《Nano letters》 - 2024,24(9) - 2894~2903 - 共10页

摘要: alpha (SIRP alpha) axis, is crucial for modulating TAM |  cells and SIRP alpha receptor on macrophages, which |  disrupts CD47-SIRP alpha interaction. FVIO-mediated |  of CD47 and SIRP alpha, reshaping the tumor | Harnessing the potential of tumor-associated
关键词: Magnetic hyperthermia |  ferrimagnetic vortex-domainironoxide nanoring |  CD47-SIRP alpha axis inhibition |  enhanced macrophage phagocytosis |  hepatocellular carcinomaimmunotherapy |  CANCER |  MACROPHAGES |  NANORINGS |  ESCAPE |  TARGET
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