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1. The nuclear condensates of ESE3/EHF induce cellular senescence without the associated inflammatory secretory phenotype in pancreatic ductal adenocarcinoma NSTL国家科技图书文献中心

Zhou, Tianxing |  Yan, Jingrui... -  《Cancer letters》 - 2025,611 - 217408~217408 - 共15页

摘要: factors, termed the senescence-associated secretory |  phenotype (SASP), paradoxically contributing to pro | Senescent cells are in a stable state of cell |  cycle arrest, leading to a natural barrier to |  tumorigenesis. Senescent cells secrete a pool of molecules
关键词: PDAC |  Senescence |  EHF |  SASP |  Phase separation

2. Resistance training suppresses accumulation of senescent fibro-adipogenic progenitors and senescence-associated secretory phenotype in aging rat skeletal muscle NSTL国家科技图书文献中心

Yung-Li,Hung |  Ayami,Sato... -  《GeroScience.》 - 2025,47(2) - 1669~1683 - 共15页

摘要:-associated secretory phenotype (SASP). The killer T cell | Abstract Accumulation of senescent cells in |  tissues contributes to multiple aging-related |  pathologies. Senescent fibro-adipogenic progenitors (FAPs | ) contribute to aging-related muscle atrophy. Resistance
关键词: Sarcopenia |  Senescent cells |  Resistance training |  Fibro-adipogenic progenitors

3. Inhibition of OLR1 Reduces SASP of Nucleus Pulposus Cells by Targeting Autophagy-GATA4 Axis NSTL国家科技图书文献中心

Jia-Wei,Gao |  Hang,Shi... -  《The journals of gerontology.Series A.Biological sciences and medical sciences》 -  PhD |  MD - 2025,80(2) - glae204~glae204 - 共12页

摘要: senescence associated secretory phenotype (SASP) through | Abstract Targeting cellular senescence and |  autophagy has emerged as a promising intervertebral disc |  (IVD) degeneration (IDD) treatment strategy in recent |  years. This study aimed to clarify the role and
关键词: Autophagy |  GATA4 |  Nucleus pulposus cells |  OLR1 |  Senescence-associated secretory phenotype

4. Unveiling the role of GATA4 in endothelial cell senescence and atherosclerosis development NSTL国家科技图书文献中心

Kang, Chun-Min |  Zhao, Jing-Jing... -  《Atherosclerosis》 - 2025,404 - Article 119183~Article 119183 - 共15页

摘要: induces senescence-associated secretory phenotype (SASP | Background and aims: Cellular senescence is |  intimately linked to atherosclerosis development and |  progression. However, the mechanism is not well known. GATA4 |  is a classical regulator in human fibroblast
关键词: Atherosclerosis |  Endothelial cell senescence |  GATA4 |  Senescence-associated secretory phenotype

5. Brain inflammaging in the pathogenesis of late-life depression NSTL国家科技图书文献中心

Toshiaki,Ishizuka |  Wataru,Nagata... -  《Human cell》 - 2025,38(1) - Article 7~Article 7 - 共9页

摘要: senescence-associated secretory phenotype (SASP) and |  transition to M1-phenotype, cause neuroinflammation, and | Abstract Late-life depression (LLD) is a |  prevalent mental disorder among older adults. Previous |  studies revealed that many pathologic factors are
关键词: Late-life depression |  Senescence-associated secretory phenotype (SASP) |  BBB breakdown |  Inflammasome activation |  Metabolic reprogramming

6. Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis NSTL国家科技图书文献中心

Almalki, Waleed Hass... |  Almujri, Salem Salma... -  《Biogerontology》 - 2025,26(1) - 共21页

摘要:-associated secretory phenotype (SASP). The presence of | Ageing is an inevitable and multifaceted |  biological process that impacts a wide range of cellular |  and molecular mechanisms, leading to the development |  of various diseases, such as liver fibrosis. Liver
关键词: Aging |  Liver fibrosis |  Reactive oxygen species |  Cellular senescence |  Oxidative stress |  Senescence-associated secretory phenotype

7. Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation NSTL国家科技图书文献中心

Wijayasiri, Pramudi |  Astbury, Stuart... -  《Human cell》 - 2025,38(3) - Article 70~Article 70 - 共12页

摘要: senescence-associated secretory phenotype (SASP) factors | Accumulation of senescent hepatocytes is |  universal in chronic liver disease (CLD). This study |  investigates an association between hepatocyte senescence and |  hepatocellular carcinoma (HCC) and explores the therapeutic
关键词: Hepatocyte senescence |  Hepatocellular carcinoma |  Mammalian target of rapamycin |  Senescence-associated secretory phenotype |  Chemoprophylaxis

8. Identification of Key Genes and Immune Characteristics of SASP in Acute Ischemic Stroke NSTL国家科技图书文献中心

Hanlu,Cai |  Huixue,Zhang... -  《Journal of Molecular Neuroscience》 - 2025,75(1) - Article: 22~Article: 22 - 共21页

摘要:Abstract The senescence-associated secretory |  phenotype (SASP) is a key mechanism through which |  senescent cardiovascular cells contribute to plaque |  formation, instability, and vascular remodeling. However | , the correlation between SASP and acute ischemic
关键词: Senescence-associated secretory phenotype |  Acute ischemic stroke |  Immune inflammation characteristics |  Machine learning |  Diagnostic model

9. Targeting senescence to prevent diabetic kidney disease: Exploring molecular mechanisms and potential therapeutic targets for disease management NSTL国家科技图书文献中心

Paige Charlotte Alis... |  Mafalda de Sousa Lor...... -  《Diabetic medicine :》 - 2025,42(2) - e15408~e15408 - 共18页

摘要:, fibrosis, senescence‐associated secretory phenotype (SASP | Abstract Background/Aims As a microvascular |  complication, diabetic kidney disease is the leading cause of |  chronic kidney disease and end‐stage renal disease |  worldwide. While the underlying pathophysiology driving
关键词: diabetes |  diabetic kidney disease |  diabetic nephropathy |  senescence |  senescence‐associated secretory phenotype |  SGLT2i |  inflammation

10. The Influence of Body Mass Index on Biomarkers of Cellular Senescence in Older Adults NSTL国家科技图书文献中心

Allyson K,Palmer |  Jennifer,St. Sauver... -  《The journals of gerontology.Series A.Biological sciences and medical sciences》 -  MD, PhD |  PhD |  MS |  BS |  PhD, MS - 2025,80(4) - glae251~glae251 - 共5页

摘要:Abstract Obesity accelerates the onset and |  progression of age-related conditions. In preclinical models | , obesity drives cellular senescence, a cell fate that |  compromises tissue health and function, in part through a |  robust and diverse secretome. In humans, components of
关键词: Body mass index |  Cellular senescence |  Obesity |  Senescence-associated secretory phenotype
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