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1. Targeted therapy of multiple myeloma by IL21-NKG2D CAR-T cells NSTL国家科技图书文献中心

Han, Kunkun |  Wang, Xuan... -  《Journal of investigative medicine》 - 2025,73(1) - 45～53 - 共9页

摘要：NKG2D chimeric antigen receptor (CAR)-modified |  T cells (NKG2D CAR-T cells) have been reported to |  little is known whether NKG2D CAR-T cells co-expressing |  IL21 (IL21-NKG2D CAR-T cells) display greater |  the IL21 sequence linked to the extracellular NKG2D
关键词： Multiple myeloma |  IL21 |  NKG2D |  CAR-T cells |  dexamethasone
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2. HCMV Variants Expressing ULBP2 Enhance the Function of Human NK Cells via its Receptor NKG2D NSTL国家科技图书文献中心

Greta Meyer |  Anna Rebecca Siemes... -  《European journal of immunology.》 - 2025,55(2) - e202451266～e202451266 - 共13页

摘要： responses. We tested the concept of expressing the NKG2D |  ligand (NKG2D-L) ULBP2 by HCMV vaccine candidates to |  additional triggering of the activating receptor NKG2D | . Engagement of NKG2D was also confirmed by its |  well as the presence of T cells. This NKG2D-L-based
关键词： HCMV vaccine; NK cells; NKG2D; ULBP2; attenuation
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3. Xylooligosaccharide and Akkermansia muciniphila synergistically ameliorate insulin resistance by reshaping gut microbiota, improving intestinal barrier and regulating NKG2D/NKG2DL signaling in gestational diabetes mellitus mice NSTL国家科技图书文献中心

Wang, Jiexian |  Wu, Yanhua... -  《Food Research International》 - 2025,201(Feb.) - 1.1～1.17 - 共17页

摘要： group 2 member D (NKG2D) on intestinal epithelial |  lymphocytes (IELs) and NKG2D ligands (NKG2DL) on intestinal | ) NKG2D on IELs and NKG2DLs (H60, MULT-1, Rae-1 epsilon | , improving intestinal barrier and regulating NKG2D/NKG2DL | Xylooligosaccharides (XOS) ameliorate insulin
关键词： Xylooligosaccharide |  Akkermansia. muciniphila |  Natural killer group 2 member D |  Insulin resistance |  Gestational diabetes mellitus |  GLUCOSE-TOLERANCE TEST |  LONGITUDINAL CHANGES |  OLIGOSACCHARIDES |  INFLAMMATION |  ENDOTOXEMIA...
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4. IKZF1 and Ikaros Overexpression Results in Alopecia Areata-Like Phenotype in Mice NSTL国家科技图书文献中心

Arakawa, Yukiyasu |  Tamagawa-Mineoka, Ri...... -  《Experimental dermatology.》 - 2025,34(3) - e70074～e70074 - 共10页

摘要： high levels of the NKG2D ligand H60 and contained |  infiltrating CD8+NKG2D+ T cells. Interleukin 15, tumour | Ikaros, which is encoded by the Ikaros family |  zinc finger 1 (IKZF1) gene, is a zinc finger |  transcription factor. We have previously generated K5-Ikzf1
关键词： alopecia areata |  CD4 |  CD8 |  Ikaros |  IKZF1 |  NKG2D
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5. Recognition of Self and Viral Ligands by NK Cell Receptors NSTL国家科技图书文献中心

Roy A. Mariuzza |  Pragya Singh... -  《Immunological reviews.》 - 2025,329(1) - e13435～e13435 - 共16页

摘要：) molecules, and NKG2D, which binds MHC‐I paralogs such MICA | ABSTRACT Natural killer (NK) cells are |  essential elements of the innate immune response against |  tumors and viral infections. NK cell activation is |  governed by NK cell receptors that recognize both
关键词： KIR |  Ly49 |  MHC |  NK receptor |  structure |  virus
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6. The Effect of Gender on the Intestinal Flora of Colorectal Cancer Under Different Stages NSTL国家科技图书文献中心

He, Fuhai |  Huang, Xiaoliang... -  《Molecular Carcinogenesis》 - 2025,64(3) - 526～542 - 共17页

摘要： genes TNFSF13B, LTA, KLRK1, and CXCL12. In the CRC | This study aims to determine whether gender is |  a factor in the interplay between the human |  intestinal flora and colorectal cancer (CRC), ultimately |  providing new evidence for the clinical prediction and
关键词： 16S rRNA |  colorectal cancer |  gender |  intestinal flora |  stage
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7. Identification of key immune-related genes and potential therapeutic targets in immune checkpoint inhibitor-associated myocarditis NSTL国家科技图书文献中心

Qu, Shenglin |  Zhang, Junyi... -  《Postgraduate Medical Journal》 - 2025,101(1192) - 137～146 - 共10页

摘要：, PRF1, GNLY, CD3G, NKG7, GZMH, GZMB, KLRB1, KLRK1, and | Background Immune checkpoint inhibitors (ICIs | ) are widely used in cancer treatment; however, the |  emergence of ICI-associated myocarditis (ICI-MC) presents |  a severe and potentially fatal complication with
关键词： immune checkpoint inhibitor-associated myocarditis (ICI-MC) |  immune-related genes (IRGs) |  optimal feature genes (OFGs) |  ceRNA network |  bioinformatics analysis
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8. NKG2D-bispecific enhances NK and CD8+T cell antitumor immunity NSTL国家科技图书文献中心

Herault, Aurelie |  Mak, Judy... -  《Cancer immunology, immunotherapy》 - 2024,73(10) - Article: 209～Article: 209 - 共6页 - 被引量：1

摘要：-stimulatory receptor NKG2D as a target based on its |  and murine surrogate NKG2D co-stimulatory receptor | -bispecifics (CRB) that bind NKG2D on NK and CD8+ T cells as |  differentiation.ConclusionWe demonstrate that targeting NKG2D with bispecific |  leveraging NK and T cells for cancer immunotherapy, NKG2D
关键词： NKG2D |  NK cells |  CD8+T cells |  Bispecifics |  Synthetic immunity |  NATURAL-KILLER-CELLS |  REGULATORY T-CELLS |  MONOCLONAL-ANTIBODY |  NKG2D RECEPTOR |  BISPECIFIC ANTIBODY...
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9. NKG2D receptor signaling shapes T cell thymic education NSTL国家科技图书文献中心

Cynthia Perez |  Lourdes Plaza-Rojas... -  《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 - 2024,115(2) - 306～321 - 共16页

摘要：The role of natural killer group 2D (NKG2D) in |  cells from mice lacking NKG2D signaling. In C57BL/6 |  (B6) and OT-I mice, we found that NKG2D deficiency |  thymocytes from NKG2D deficient mice were reduced | , indicating a direct influence of NKG2D on the strength of T
关键词： CD45 |  CD5 |  NKG2D |  OT-I |  TCR threshold |  T cell thymic education |  thymus
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10. Lower NKG2D expression in hepatic natural killer cells predicts poorer prognosis for chronic hepatitis B patients with cirrhosis NSTL国家科技图书文献中心

Ma Y. |  Ping D.... -  《Human Immunology: Official Journal of the American Society for Histocompatibility and Immunogenetics》 - 2024,85(3) - 110775～110775 - 共6页

摘要： group 2D (NKG2D) in patients with chronic hepatitis B |  (CHB) and analyzed the correlation between NKG2D |  were included. The primary outcome was the NKG2D | . Subsequently, the correlation of expression of NKG2D and |  collagen deposition and lower NKG2D expression in hepatic
关键词： CHB-cirrhosis |  Liver fibrosis |  NK cells |  NKG2D
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