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1. Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard NSTL国家科技图书文献中心

Malaviya R. |  Meshanni J.A.... -  《Toxicology and Applied Pharmacology》 - 2024,485 - 116908~116908 - 共6页

摘要:? 2024Nitrogen mustard (NM) is a toxic |  vesicant that causes acute injury to the respiratory |  tract. This is accompanied by an accumulation of |  activated macrophages in the lung and oxidative stress |  which have been implicated in tissue injury. In these
关键词: Antioxidant |  Lung injury |  Macrophages |  Mustard vesicants |  Oxidative stress

2. Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices NSTL国家科技图书文献中心

Bellomo A. |  Herbert J.... -  《Toxicology and Applied Pharmacology》 - 2024,486 - 116941~116941 - 共6页 - 被引量:1

摘要:? 2024 The AuthorsNitrogen mustard (NM | ; mechlorethamine) is a cytotoxic vesicant known to cause acute |  lung injury which can progress to chronic disease | . Due to the complex nature of NM injury, it has been |  difficult to analyze early responses of resident lung
关键词: Lung injury |  Mustard vesicants |  Oxidative stress |  Precision cut lung slices

3. Analytical methods based on liquid chromatography for the analysis of albumin adducts involved in retrospective biomonitoring of exposure to mustard agents NSTL国家科技图书文献中心

Avigo Lorenzo |  Hallez Florine... -  《Analytical and bioanalytical chemistry》 - 2024,416(9) - 2173~2188 - 共16页

摘要: mustard agents, and that can be used as biomarkers of |  of sulfur mustard, its analogues, and nitrogen |  samples exposed to sulfur mustard, its analogues, and | Abstract The objective of the present review |  is to list, describe, compare, and critically
关键词: Albumin adducts |  Biomarkers |  Mustard exposure |  Vesicants |  HPLC–MS/MS

4. HSP90, a Common Therapeutic Target for Suppressing Skin Injury Caused by Exposure to Chemically Diverse Classes of Blistering Agents NSTL国家科技图书文献中心

Srivastava, Ritesh K... |  Muzaffar, Suhail... -  《The Journal of pharmacology and experimental therapeutics.》 - 2024,388(2) - 546~559 - 共14页 - 被引量:3

摘要:Vesicants such as arsenicals and mustards |  mustard surrogates, namely phenylarsine oxide (PAO) and |  action by these two distinct classes of vesicants |  by these two distinct vesicants and provide an |  produce highly painful cutaneous inflammatory and
关键词: SULFUR MUSTARD ANALOG |  I DOSE-ESCALATION |  SHOCK-PROTEIN 90 |  DNA-DAMAGE |  PHASE-I |  HYDROCHLORIDE IPI-504 |  EPIDERMAL-CELLS |  LEWISITE |  INHIBITOR |  VESICANT

5. Targeting Tumor Necrosis Factor Alpha to Mitigate Lung Injury Induced by Mustard Vesicants and Radiation NSTL国家科技图书文献中心

Rama Malaviya |  Jeffrey D Laskin... -  《Disaster medicine and public health preparedness.》 - 2023,17(1) - e553~e553 - 共1页 - 被引量:2

摘要:Pulmonary injury induced by mustard vesicants |  in pathologies associated with exposure to mustard |  vesicants and radiation, with a focus on the therapeutic |  and radiation is characterized by DNA damage | , oxidative stress, and inflammation. This is associated
关键词: lung injury |  mustard vesicants |  radiation |  tumor necrosis factor.

6. Cellular senescence implication in mustard keratopathy NSTL国家科技图书文献中心

Soleimani M. |  Baharnoori S.M.... -  《Experimental Eye Research》 - 2023,233 - 109565~109565 - 共6页 - 被引量:3

摘要: vesicants that were used in warfare multiple times. They |  to mustard exposure with a wide range of ocular |  surface damage. Three main categories of mustard-related |  manifestations. Mustard keratopathy (MK) is a known |  induction as a new pathological mechanism in mustard
关键词: Aging |  Beta-galactosidase |  Mustard gas |  Mustard keratopathy |  Nitrogen mustard |  Ocular surface |  Senescence

7. Cutaneous Exposure to Arsenicals Is Associated with Development of Constrictive Bronchiolitis in Mice NSTL国家科技图书文献中心

Surolia, Ranu |  Li, Fu Jun... -  《American journal of respiratory cell and molecular biology.》 - 2023,68(5) - 485~497 - 共13页 - 被引量:1

摘要: are reported for the organoarsenical sulfur mustard |  vesicants and constrictive bronchiolitis. We developed and | Organoarsenicals, such as lewisite and related |  chloroarsine, diphenylchloroarsine (DPCA), are chemical |  warfare agents developed during World War I. Stockpiles
关键词: chemical warfare agents |  delayed lung injury |  constrictive bronchiolitis |  CHEMICAL WEAPONS |  LUNG |  INHALATION |  DISEASE |  AIRWAYS |  COMPLICATIONS |  INFLAMMATION...

8. Farnesoid X receptor regulates lung macrophage activation and injury following nitrogen mustard exposure NSTL国家科技图书文献中心

Murray, Alexa |  Banota, Tanvi... -  《Toxicology and Applied Pharmacology》 - 2022,454 - 116208~116208 - 共7页 - 被引量:6

摘要:Nitrogen mustard (NM) is a cytotoxic vesicant |  mustard lung toxicity. |  known to cause acute lung injury which progresses to |  fibrosis; this is associated with a sequential |  accumulation of pro- and anti-inflammatory macrophages in the
关键词: FXR |  Mustard vesicants |  Lung toxicity |  Macrophages |  Oxidative stress |  AGONIST OBETICHOLIC ACID |  GENDER-DIFFERENCES |  PULMONARY INJURY |  TISSUE-INJURY |  UNITED-STATES...

9. Research models of sulfur mustard- and nitrogen mustard-induced ocular injuries and potential therapeutics NSTL国家科技图书文献中心

Mishra N. |  Agarwal R. -  《Experimental Eye Research》 - 2022,223 - 109209~109209 - 共8页 - 被引量:5

摘要:? 2022 Elsevier LtdSulfur mustard (SM) is a |  accessible analogue, nitrogen mustard (NM) that mimics SM |  mechanisms underlying mustard-induced ocular injury that |  notorious, bifunctional alkylating vesicant that was first |  used in warfare during World War I in 1917 and since
关键词: Animal models |  Eyes |  Human patients |  Nitrogen mustard |  Pathways |  Sulfur mustard |  Therapeutics |  Vesicants

10. Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes SCIE Web of Science核心 NSTL国家科技图书文献中心

Jan, Yi-Hua |  Heck, Diane E.... -  《Chemical research in toxicology》 - 2022,35(4) - 636~650 - 共15页 - 被引量:1

摘要: for mustard vesicants. Modification of p53 likely |  mustard and nitrogen mustard (HN2) were synthesized for | Cytotoxic blistering agents such as sulfur |  chemical warfare. Toxicity is due to reactive chloroethyl |  side chains that modify and damage cellular
关键词: REACTIVATES MUTANT P53 |  LUNG EPITHELIAL-CELLS |  TUMOR-SUPPRESSOR P53 |  DNA-DAMAGE |  SULFUR MUSTARD |  INHIBITION |  ACTIVATION |  BINDING |  PHARMACOLOGY |  MECHANISMS
检索条件Mustard vesicants

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