NSTL国家科技图书文献中心

1. Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard NSTL国家科技图书文献中心

Malaviya R. | Meshanni J.A.... - 《Toxicology and Applied Pharmacology》 - 2024,485 - 116908～116908 - 共6页

摘要：? 2024Nitrogen mustard* (NM) is a toxic* | vesicant that causes acute injury to the respiratory | tract. This is accompanied by an accumulation of | activated macrophages in the lung and oxidative stress | which have been implicated in tissue injury. In these

关键词： Antioxidant | Lung injury | Macrophages | Mustard vesicants | Oxidative stress

2. Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices NSTL国家科技图书文献中心

Bellomo A. | Herbert J.... - 《Toxicology and Applied Pharmacology》 - 2024,486 - 116941～116941 - 共6页 - 被引量：1

摘要：? 2024 The AuthorsNitrogen mustard* (NM* | ; mechlorethamine) is a cytotoxic vesicant known to cause acute | lung injury which can progress to chronic disease | . Due to the complex nature of NM injury, it has been | difficult to analyze early responses of resident lung

关键词： Lung injury | Mustard vesicants | Oxidative stress | Precision cut lung slices

3. Analytical methods based on liquid chromatography for the analysis of albumin adducts involved in retrospective biomonitoring of exposure to mustard agents NSTL国家科技图书文献中心

Avigo Lorenzo | Hallez Florine ... - 《Analytical and bioanalytical chemistry》 - 2024,416(9) - 2173～2188 - 共16页

摘要： mustard agents, and that can be used as biomarkers of | of sulfur mustard, its analogues, and nitrogen | samples exposed to sulfur mustard, its analogues, and | Abstract The objective of the present review | is to list, describe, compare, and critically

关键词： Albumin adducts | Biomarkers | Mustard exposure | Vesicants | HPLC–MS/MS

4. HSP90, a Common Therapeutic Target for Suppressing Skin Injury Caused by Exposure to Chemically Diverse Classes of Blistering Agents NSTL国家科技图书文献中心

Srivastava, Ritesh K... | Muzaffar, Suhail ... - 《The Journal of pharmacology and experimental therapeutics.》 - 2024,388(2) - 546～559 - 共14页 - 被引量：3

摘要：Vesicants such as arsenicals and mustards | mustard surrogates, namely phenylarsine oxide (PAO) and | action by these two distinct classes of vesicants | by these two distinct vesicants* and provide an* | produce highly painful cutaneous inflammatory and

关键词： SULFUR MUSTARD ANALOG | I DOSE-ESCALATION | SHOCK-PROTEIN 90 | DNA-DAMAGE | PHASE-I | HYDROCHLORIDE IPI-504 | EPIDERMAL-CELLS | LEWISITE | INHIBITOR | VESICANT

5. Targeting Tumor Necrosis Factor Alpha to Mitigate Lung Injury Induced by Mustard Vesicants and Radiation NSTL国家科技图书文献中心

Rama Malaviya | Jeffrey D Laskin ... - 《Disaster medicine and public health preparedness.》 - 2023,17(1) - e553～e553 - 共1页 - 被引量：2

摘要：Pulmonary injury induced by mustard vesicants | in pathologies associated with exposure to mustard | vesicants and radiation, with a focus on the therapeutic | and radiation is characterized by DNA damage | , oxidative stress, and inflammation. This is associated

关键词： lung injury | mustard vesicants | radiation | tumor necrosis factor.

6. Cellular senescence implication in mustard keratopathy NSTL国家科技图书文献中心

Soleimani M. | Baharnoori S.M.... - 《Experimental Eye Research》 - 2023,233 - 109565～109565 - 共6页 - 被引量：3

摘要： vesicants that were used in warfare multiple times. They | to mustard* exposure with a wide range of ocular* | surface damage. Three main categories of mustard-related | manifestations. Mustard* keratopathy (MK) is a known* | induction as a new pathological mechanism in mustard

关键词： Aging | Beta-galactosidase | Mustard gas | Mustard keratopathy | Nitrogen mustard | Ocular surface | Senescence

7. Cutaneous Exposure to Arsenicals Is Associated with Development of Constrictive Bronchiolitis in Mice NSTL国家科技图书文献中心

Surolia, Ranu | Li, Fu Jun ... - 《American journal of respiratory cell and molecular biology.》 - 2023,68(5) - 485～497 - 共13页 - 被引量：1

摘要： are reported for the organoarsenical sulfur mustard | vesicants and constrictive bronchiolitis. We developed and | Organoarsenicals, such as lewisite and related | chloroarsine, diphenylchloroarsine (DPCA), are chemical | warfare agents developed during World War I. Stockpiles

关键词： chemical warfare agents | delayed lung injury | constrictive bronchiolitis | CHEMICAL WEAPONS | LUNG | INHALATION | DISEASE | AIRWAYS | COMPLICATIONS | INFLAMMATION...

8. Farnesoid X receptor regulates lung macrophage activation and injury following nitrogen mustard exposure NSTL国家科技图书文献中心

Murray, Alexa | Banota, Tanvi ... - 《Toxicology and Applied Pharmacology》 - 2022,454 - 116208～116208 - 共7页 - 被引量：6

摘要：Nitrogen mustard* (NM) is a cytotoxic vesicant* | mustard lung toxicity. | known to cause acute lung injury which progresses to | fibrosis; this is associated with a sequential | accumulation of pro- and anti-inflammatory macrophages in the

关键词： FXR | Mustard vesicants | Lung toxicity | Macrophages | Oxidative stress | AGONIST OBETICHOLIC ACID | GENDER-DIFFERENCES | PULMONARY INJURY | TISSUE-INJURY | UNITED-STATES...

9. Research models of sulfur mustard- and nitrogen mustard-induced ocular injuries and potential therapeutics NSTL国家科技图书文献中心

Mishra N. | Agarwal R. - 《Experimental Eye Research》 - 2022,223 - 109209～109209 - 共8页 - 被引量：5

摘要：? 2022 Elsevier LtdSulfur mustard* (SM) is a* | accessible analogue, nitrogen mustard* (NM) that mimics SM* | mechanisms underlying mustard-induced ocular injury that | notorious, bifunctional alkylating vesicant that was first | used in warfare during World War I in 1917 and since

关键词： Animal models | Eyes | Human patients | Nitrogen mustard | Pathways | Sulfur mustard | Therapeutics | Vesicants

10. Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes SCIE Web of Science核心 NSTL国家科技图书文献中心

Jan, Yi-Hua | Heck, Diane E.... - 《Chemical research in toxicology》 - 2022,35(4) - 636～650 - 共15页 - 被引量：1

摘要： for mustard* vesicants. Modification of p53 likely* | mustard and nitrogen mustard (HN2) were synthesized for | Cytotoxic blistering agents such as sulfur | chemical warfare. Toxicity is due to reactive chloroethyl | side chains that modify and damage cellular

关键词： REACTIVATES MUTANT P53 | LUNG EPITHELIAL-CELLS | TUMOR-SUPPRESSOR P53 | DNA-DAMAGE | SULFUR MUSTARD | INHIBITION | ACTIVATION | BINDING | PHARMACOLOGY | MECHANISMS

摘要：? 2024Nitrogen mustard (NM) is a toxic | vesicant that causes acute injury to the respiratory | tract. This is accompanied by an accumulation of | activated macrophages in the lung and oxidative stress | which have been implicated in tissue injury. In these