NSTL国家科技图书文献中心

1. Amelioration of breast cancer therapies through normalization of tumor vessels and microenvironment: paradigm shift to improve drug perfusion and nanocarrier permeation NSTL国家科技图书文献中心

Famta, Paras | Shah, Saurabh ... - 《Drug delivery and translational research》 - 2025,15(2) - 389～406 - 共18页

摘要：Breast cancer (BC) is the most commonly | diagnosed cancer among women. Chemo-, immune- and | photothermal therapies are employed to manage BC. However | , the tumor microenvironment (TME) prevents free drugs | and nanocarriers (NCs) from entering the tumor

关键词： Angiogenesis | Tumor microenvironment normalization | Mechanotherapeutics | Chemotherapy | Immunotherapy

2. Sonopermeation combined with stroma normalization enables complete cure using nano-immunotherapy in murine breast tumors NSTL国家科技图书文献中心

Neophytou, Constanti... | Charalambous, Antoni...... - 《Journal of Controlled Release》 - 2025,382 - 共16页

摘要：Nano-immunotherapy shows great promise in | improving patient outcomes, as seen in advanced triple | -negative breast cancer, but it does not cure the disease | , with median survival under two years. Therefore | , understanding resistance mechanisms and developing strategies

关键词： Mechanotherapeutics | Ultrasound sonopermeation | Drug delivery | Proteomics | Machine learning | Cancer metastasis

3. From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics NSTL国家科技图书文献中心

Ingber, Donald E. - 《The Biochemical Journal》 - 2023,480(4) - 243～257 - 共15页 - 被引量：6

摘要：The field of mechanobiology, which focuses on | the key role that physical forces play in control of | biological systems, has grown enormously over the past few | decades. Here, I provide a brief personal perspective on | the development of the tensegrity theory that

关键词： EXTRACELLULAR-MATRIX | CELL-SHAPE | LIVING CELLS | ION CHANNELS | CYTOSKELETAL | INTEGRINS | MECHANOTRANSDUCTION | FILAMENTS | GROWTH | VISUALIZATION

4. Pirfenidone-Loaded Polymeric Micelles as an Effective Mechanotherapeutic to Potentiate Immunotherapy in Mouse Tumor Models NSTL国家科技图书文献中心

Mpekris, Fotios | Papaphilippou, Petri...... - 《ACS nano》 - 2023,17(24) - 24654～24667 - 共14页 - 被引量：7

摘要：. Mechanotherapeutics* have formed a recent class of drugs that aim to* | for mechanotherapeutics, and imaging methods, such | Ongoing research is actively exploring the use | of immune checkpoint inhibitors to treat solid | tumors by inhibiting the PD-1/PD-L1 axis and

关键词： nanocarriers | tumor microenvironment | immunecheckpoint inhibition | stroma normalization | drugdelivery | nano-immunotherapy | oncology | SOLID STRESS | MICROENVIRONMENT | IMPROVE...

5. Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy NSTL国家科技图书文献中心

Voutouri, Chrysovala... | Mpekris, Fotios ... - 《Acta biomaterialia》 - 2023,167 - 121～134 - 共14页 - 被引量：15

摘要：. Mechanotherapeutics* combined with ICI are advancing through clinical* | ICI therapy in combination with mechanotherapeutics | . Mechanotherapeutics* is a new class of drugs that target the TME to* | Immunotherapy has revolutionized the treatment | of dozens of cancers and became a standard of care

关键词： Shear wave elastography | Contrast-enhanced ultrasound | Immune checkpoint inhibition | Breast cancer | Sarcoma | Melanoma | CONTRAST-ENHANCED ULTRASOUND | IMMUNE CHECKPOINT INHIBITORS | SHEAR-WAVE ELASTOGRAPHY | SOLID STRESS...

6. Nanomechanical properties of solid tumors as treatment monitoring biomarkers SCIE Web of Science核心 EI 工程索引 NSTL国家科技图书文献中心

Stylianou, Andreas | Mpekris, Fotios ... - 《Acta biomaterialia》 - 2022,154 - 324～334 - 共11页 - 被引量：16

摘要：Many tumors, such as types of sarcoma and | breast cancer, stiffen as they grow in a host healthy | tissue, while individual cancer cells are becoming | softer. Tumor stiffening poses major pathophysiological | barriers to the effective delivery of drugs and

关键词： Atomic force microscopy (AFM) | Sarcoma | Breast cancer | Tumor microenvironment | Mechanotherapeutics | Tranilast | Normalization | PROSTATE-CANCER CELLS | ELASTIC PROPERTIES | MICROENVIRONMENT...

7. Mechanically-regulated bone repair NSTL国家科技图书文献中心

Anani T. | Castillo A.B. - 《Bone》 - 2022,154 - 116223～116223 - 共7页 - 被引量：14

摘要： the need for novel mechanotherapeutics* that can re* | ? 2021 Elsevier Inc.Fracture healing is a | complex, multistep process that is highly sensitive to | mechanical signaling. To optimize repair, surgeons | prescribe immediate weight-bearing as-tolerated within 24

关键词： Bone mechanoadaptation | Bone mechanobiology | Dynamization | Fracture callus | Fracture healing | Mechanical regulation of bone repair | Skeletal stem and progenitor cells

8. Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Samira,Aghlara-Fotov... | Amanda,Nash ... - 《Drug delivery and translational research》 - 2021,11(6) - 2394～2413 - 共20页 - 被引量：5

摘要： therapeutics. b Mechanotherapeutics* can be used to inhibit* | Abstract Host immune cells interact bi | -directionally with their extracellular matrix (ECM) to receive | and deposit molecular signals, which orchestrate | cellular activation, proliferation, differentiation, and

关键词： Extracellular matrix (ECM) | Immune system | Immunomodulation | Drug delivery | Cell therapy

9. Combining microenvironment normalization strategies to improve cancer immunotherapy SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Mpekris, Fotios | Voutouri, Chrysovala...... - 《Proceedings of the National Academy of Sciences of the United States of America.》 - 2020,117(7) - 3728～3737 - 共10页 - 被引量：125

摘要： and/or mechanotherapeutics* can overcome these* |
Advances in | immunotherapy have revolutionized the treatment of multiple | cancers. Unfortunately, tumors usually have impaired | blood perfusion, which limits the delivery of

关键词： immunotherapy | vascular function | normalization | anti-angiogenic therapy | mechanotherapeutics | TUMOR MICROENVIRONMENT | VASCULAR NORMALIZATION | DRUG-DELIVERY | SOLID TUMORS | INHIBITION...

10. Age‐Related Changes in the Mechanical Regulation of Bone Healing Are Explained by Altered Cellular Mechanoresponse SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Borgiani Edoardo | Figge Christine ... - 《Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research》 - 2019,34(10) - 1923～1937 - 共15页 - 被引量：24

摘要： data hint to mechanotherapeutics* as a potential* | ABSTRACT Increasing age is associated with a | reduced bone regeneration potential and increased risk | of morbidities and mortality. A reduced bone | formation response to mechanical loading has been shown

摘要：Breast cancer (BC) is the most commonly | diagnosed cancer among women. Chemo-, immune- and | photothermal therapies are employed to manage BC. However | , the tumor microenvironment (TME) prevents free drugs | and nanocarriers (NCs) from entering the tumor

关键词： Angiogenesis | Tumor microenvironment normalization | Mechanotherapeutics | Chemotherapy | Immunotherapy

摘要：Nano-immunotherapy shows great promise in | improving patient outcomes, as seen in advanced triple | -negative breast cancer, but it does not cure the disease | , with median survival under two years. Therefore | , understanding resistance mechanisms and developing strategies

关键词： Mechanotherapeutics | Ultrasound sonopermeation | Drug delivery | Proteomics | Machine learning | Cancer metastasis

摘要：The field of mechanobiology, which focuses on | the key role that physical forces play in control of | biological systems, has grown enormously over the past few | decades. Here, I provide a brief personal perspective on | the development of the tensegrity theory that

关键词： EXTRACELLULAR-MATRIX | CELL-SHAPE | LIVING CELLS | ION CHANNELS | CYTOSKELETAL | INTEGRINS | MECHANOTRANSDUCTION | FILAMENTS | GROWTH | VISUALIZATION

摘要：. Mechanotherapeutics* have formed a recent class of drugs that aim to* | for mechanotherapeutics, and imaging methods, such | Ongoing research is actively exploring the use | of immune checkpoint inhibitors to treat solid | tumors by inhibiting the PD-1/PD-L1 axis and

关键词： nanocarriers | tumor microenvironment | immunecheckpoint inhibition | stroma normalization | drugdelivery | nano-immunotherapy | oncology | SOLID STRESS | MICROENVIRONMENT | IMPROVE...

关键词： Shear wave elastography | Contrast-enhanced ultrasound | Immune checkpoint inhibition | Breast cancer | Sarcoma | Melanoma | CONTRAST-ENHANCED ULTRASOUND | IMMUNE CHECKPOINT INHIBITORS | SHEAR-WAVE ELASTOGRAPHY | SOLID STRESS...

摘要：Many tumors, such as types of sarcoma and | breast cancer, stiffen as they grow in a host healthy | tissue, while individual cancer cells are becoming | softer. Tumor stiffening poses major pathophysiological | barriers to the effective delivery of drugs and

关键词： Atomic force microscopy (AFM) | Sarcoma | Breast cancer | Tumor microenvironment | Mechanotherapeutics | Tranilast | Normalization | PROSTATE-CANCER CELLS | ELASTIC PROPERTIES | MICROENVIRONMENT...

摘要： the need for novel mechanotherapeutics* that can re* | ? 2021 Elsevier Inc.Fracture healing is a | complex, multistep process that is highly sensitive to | mechanical signaling. To optimize repair, surgeons | prescribe immediate weight-bearing as-tolerated within 24

关键词： Bone mechanoadaptation | Bone mechanobiology | Dynamization | Fracture callus | Fracture healing | Mechanical regulation of bone repair | Skeletal stem and progenitor cells

摘要： therapeutics. b Mechanotherapeutics* can be used to inhibit* | Abstract Host immune cells interact bi | -directionally with their extracellular matrix (ECM) to receive | and deposit molecular signals, which orchestrate | cellular activation, proliferation, differentiation, and

关键词： Extracellular matrix (ECM) | Immune system | Immunomodulation | Drug delivery | Cell therapy

摘要： and/or mechanotherapeutics* can overcome these* |
Advances in | immunotherapy have revolutionized the treatment of multiple | cancers. Unfortunately, tumors usually have impaired | blood perfusion, which limits the delivery of

关键词： immunotherapy | vascular function | normalization | anti-angiogenic therapy | mechanotherapeutics | TUMOR MICROENVIRONMENT | VASCULAR NORMALIZATION | DRUG-DELIVERY | SOLID TUMORS | INHIBITION...

摘要： data hint to mechanotherapeutics* as a potential* | ABSTRACT Increasing age is associated with a | reduced bone regeneration potential and increased risk | of morbidities and mortality. A reduced bone | formation response to mechanical loading has been shown

关键词： BONE HEALING | CELLULAR MECHANORESPONSE | COMPUTER MODELING | AGING

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：Breast cancer (BC) is the most commonly | diagnosed cancer among women. Chemo-, immune- and | photothermal therapies are employed to manage BC. However | , the tumor microenvironment (TME) prevents free drugs | and nanocarriers (NCs) from entering the tumor

关键词： Angiogenesis | Tumor microenvironment normalization | Mechanotherapeutics | Chemotherapy | Immunotherapy

摘要：Nano-immunotherapy shows great promise in | improving patient outcomes, as seen in advanced triple | -negative breast cancer, but it does not cure the disease | , with median survival under two years. Therefore | , understanding resistance mechanisms and developing strategies

关键词： Mechanotherapeutics | Ultrasound sonopermeation | Drug delivery | Proteomics | Machine learning | Cancer metastasis

摘要：The field of mechanobiology, which focuses on | the key role that physical forces play in control of | biological systems, has grown enormously over the past few | decades. Here, I provide a brief personal perspective on | the development of the tensegrity theory that

关键词： EXTRACELLULAR-MATRIX | CELL-SHAPE | LIVING CELLS | ION CHANNELS | CYTOSKELETAL | INTEGRINS | MECHANOTRANSDUCTION | FILAMENTS | GROWTH | VISUALIZATION

摘要：. Mechanotherapeutics have formed a recent class of drugs that aim to | for mechanotherapeutics, and imaging methods, such | Ongoing research is actively exploring the use | of immune checkpoint inhibitors to treat solid | tumors by inhibiting the PD-1/PD-L1 axis and

关键词： nanocarriers | tumor microenvironment | immunecheckpoint inhibition | stroma normalization | drugdelivery | nano-immunotherapy | oncology | SOLID STRESS | MICROENVIRONMENT | IMPROVE...

关键词： Shear wave elastography | Contrast-enhanced ultrasound | Immune checkpoint inhibition | Breast cancer | Sarcoma | Melanoma | CONTRAST-ENHANCED ULTRASOUND | IMMUNE CHECKPOINT INHIBITORS | SHEAR-WAVE ELASTOGRAPHY | SOLID STRESS...

摘要：Many tumors, such as types of sarcoma and | breast cancer, stiffen as they grow in a host healthy | tissue, while individual cancer cells are becoming | softer. Tumor stiffening poses major pathophysiological | barriers to the effective delivery of drugs and

关键词： Atomic force microscopy (AFM) | Sarcoma | Breast cancer | Tumor microenvironment | Mechanotherapeutics | Tranilast | Normalization | PROSTATE-CANCER CELLS | ELASTIC PROPERTIES | MICROENVIRONMENT...

摘要： the need for novel mechanotherapeutics that can re | ? 2021 Elsevier Inc.Fracture healing is a | complex, multistep process that is highly sensitive to | mechanical signaling. To optimize repair, surgeons | prescribe immediate weight-bearing as-tolerated within 24

关键词： Bone mechanoadaptation | Bone mechanobiology | Dynamization | Fracture callus | Fracture healing | Mechanical regulation of bone repair | Skeletal stem and progenitor cells

摘要： therapeutics. b Mechanotherapeutics can be used to inhibit | Abstract Host immune cells interact bi | -directionally with their extracellular matrix (ECM) to receive | and deposit molecular signals, which orchestrate | cellular activation, proliferation, differentiation, and

关键词： Extracellular matrix (ECM) | Immune system | Immunomodulation | Drug delivery | Cell therapy

摘要： and/or mechanotherapeutics can overcome these | Advances in | immunotherapy have revolutionized the treatment of multiple | cancers. Unfortunately, tumors usually have impaired | blood perfusion, which limits the delivery of

关键词： immunotherapy | vascular function | normalization | anti-angiogenic therapy | mechanotherapeutics | TUMOR MICROENVIRONMENT | VASCULAR NORMALIZATION | DRUG-DELIVERY | SOLID TUMORS | INHIBITION...

摘要： data hint to mechanotherapeutics as a potential | ABSTRACT Increasing age is associated with a | reduced bone regeneration potential and increased risk | of morbidities and mortality. A reduced bone | formation response to mechanical loading has been shown

关键词： BONE HEALING | CELLULAR MECHANORESPONSE | COMPUTER MODELING | AGING

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：. Mechanotherapeutics* have formed a recent class of drugs that aim to* | for mechanotherapeutics, and imaging methods, such | Ongoing research is actively exploring the use | of immune checkpoint inhibitors to treat solid | tumors by inhibiting the PD-1/PD-L1 axis and

摘要： the need for novel mechanotherapeutics* that can re* | ? 2021 Elsevier Inc.Fracture healing is a | complex, multistep process that is highly sensitive to | mechanical signaling. To optimize repair, surgeons | prescribe immediate weight-bearing as-tolerated within 24

摘要： therapeutics. b Mechanotherapeutics* can be used to inhibit* | Abstract Host immune cells interact bi | -directionally with their extracellular matrix (ECM) to receive | and deposit molecular signals, which orchestrate | cellular activation, proliferation, differentiation, and

摘要： and/or mechanotherapeutics* can overcome these* |
Advances in | immunotherapy have revolutionized the treatment of multiple | cancers. Unfortunately, tumors usually have impaired | blood perfusion, which limits the delivery of

摘要： data hint to mechanotherapeutics* as a potential* | ABSTRACT Increasing age is associated with a | reduced bone regeneration potential and increased risk | of morbidities and mortality. A reduced bone | formation response to mechanical loading has been shown