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1. Lapatinib: A Potential Therapeutic Agent for Colon Cancer Targeting Ferroptosis NSTL国家科技图书文献中心

Sun, Yue |  Wang, Dan... -  《Anti-cancer agents in medicinal chemistry》 - 2025,25(2) - 114~123 - 共10页

摘要: treatment. Lapatinib, a new generation of targeted anti |  molecular mechanisms through which lapatinib exerts its |  employed to assess whether lapatinib has a potential |  to investigate whether lapatinib regulates the |  lapatinib, aiming to elucidate the precise pattern of cell
关键词: Lapatinib |  colon cancer |  GPX4 |  ferroptosis |  targeted therapy |  ROS

2. Evaluation of Lapatinib Tablets Equivalence in the Comparative Dissolution Kinetics Test NSTL国家科技图书文献中心

Shprakh, Z. S. |  Poskedova, Ya. A.... -  《Pharmaceutical Chemistry Journal》 - 2025,58(10) - 1582~1587 - 共6页

摘要:TABLEts of lapatinib, a tyrosine kinase |  reference lapatinib tablets in the studied media (quality |  inhibitor, are widely used to treat HER2-positive breast |  cancer. When developing a generic drug, a comparative |  dissolution kinetics test is performed to study its
关键词: lapatinib |  comparative dissolution kinetics test |  similarity factor |  dissimilarity factor

3. Nanocrystalline solid dispersions: an emerging approach for oral bioavailability enhancement of anticancer drugs using lapatinib ditosylate as the case drug NSTL国家科技图书文献中心

Mane, Preeti |  Wakure, Balaji... -  《Journal of Dispersion Science and Technology》 - 2025,46(1/4) - 199~213 - 共15页

摘要:The bioavailability of lapatinib ditosylate |  crystals of lapatinib ditosylate. The molecular-level |  aqueous solubility of lapatinib ditosylate, by 3.68 |  respectively for lapatinib ditosylate. All these |  of anticancer drug, lapatinib ditosylate through
关键词: Lapatinib ditosylate |  nanocrystalline solid dispersion |  breast cancer |  bioavailability |  anti-cancer activity

4. Targeted nanoparticle delivery of lapatinib for cancer therapy: Progress, challenges, and future directions NSTL国家科技图书文献中心

Abad, Fateme Rezaei ... |  Pourmadadi, Mehrab... -  《Journal of drug delivery science and technology》 - 2025,108 - 106902~106902 - 共16页

摘要:Lapatinib (LPT), a tyrosine kinase inhibitor |  with therapeutic efficacy against HER2-positive |  cancers, faces clinical limitations due to its poor |  aqueous solubility, systemic toxicity, and multidrug |  resistance (MDR). Nanoparticle-based delivery systems offer
关键词: Lapatinib |  Nanoparticle drug delivery |  Lipid nanoparticles |  Polymer nanoparticles |  Cancer therapy |  Multidrug resistance |  Targeted therapy

5. Combined PET and near-infrared fluorescence probe based on lapatinib targeting HER2 for in vivo tumor imaging NSTL国家科技图书文献中心

Gong, Jingyao |  Li, Yunlong... -  《Bioorganic chemistry》 - 2025,161 - 共10页

摘要: combined two lapatinib-based molecular probes for | -lapatinib demonstrated superior imaging performance in | Combination of PET and optical imaging |  techniques holds significant potential for complete tumor |  resection to optimize patient outcomes. In this study, we
关键词: Dual imaging |  Fluorescence imaging |  Her2 |  PET/CT |  Diagnostic

6. Development of High-Throughput Quantitative Imaging Mass Spectrometry for Analysis of Drug Distribution in Tissues NSTL国家科技图书文献中心

Tanaka, Yukari -  《Journal of mass spectrometry》 - 2025,60(5) - n/a~n/a - 共11页

摘要: epertinib is superior to lapatinib in penetrating brain |  epertinib or lapatinib brain section samples. Quantitative |  and lapatinib responses were strongly linear, with a |  concentrations. Epertinib and lapatinib were sufficiently | Matrix-assisted laser desorption/ionization
关键词: epertinib |  high-throughput |  lapatinib |  MALDI |  quantitative imaging mass spectrometry |  high‐throughput

7. Targeting AFP-RARβ complex formation: a potential strategy for treating AFP-positive hepatocellular carcinoma NSTL国家科技图书文献中心

Banjan, Bhavya |  Vishwakarma, Riya... -  《Molecular diversity》 - 2025,29(2) - 1337~1352 - 共16页

摘要: revealed Lapatinib as a candidate drug of the AFP-RAR |  abstractBinding of Lapatinib with AFP active sites was found to | Alpha-fetoprotein (AFP) is a glycoprotein |  primarily expressed during embryogenesis, with declining |  levels postnatally. Elevated AFP levels correlate with
关键词: AFP |  HCC |  RAR/RXR |  Lapatinib |  Molecular docking |  Molecular dynamic simulations

8. ErbB2-NOTCH1 axis controls autophagy in cardiac cells NSTL国家科技图书文献中心

Fortini, Francesca |  Vieceli Dalla Sega, ...... -  《BioFactors》 - 2025,51(1) - n/a~n/a - 共22页 - 被引量:1

摘要:, lapatinib, reduced Notch1 activation. Moreover, incubation |  of H9c2 cells with lapatinib resulted in stalled | Although the epidermal growth factor receptor |  2 (ErbB2) and Notch1 signaling pathways have both |  significant roles in regulating cardiac biology, their
关键词: autophagy |  cardiomyocytes |  ErbB2 |  heart |  Notch

9. Construction of lysosome-related prognostic signature to predict the survival outcomes and selecting suitable drugs for patients with HNSCC NSTL国家科技图书文献中心

Cao, Bing |  Gu, Shanshan... -  《BioFactors》 - 2025,51(1) - n/a~n/a - 共11页

摘要: sensitivity to Lapatinib. GO functional enrichment analysis | Lysosomes are digestive organelles responsible |  for endocytosis and autophagy. Recently, the |  malignancy and invasiveness head and neck squamous cell |  carcinoma (HNSCC) has been increasingly studied with the
关键词: bioinformatics analysis |  HNSCC |  immune microenvironment |  lysosome |  prognosis

10. Tucatinib in the treatment of HER2-overexpressing gastrointestinal cancers: current insights and future prospects NSTL国家科技图书文献中心

Hoyek, Celine |  Zheng-Lin, Binbin... -  《Expert opinion on investigational drugs.》 - 2025,34(3) - 161~168 - 共8页

摘要: and other TKIs like lapatinib will be paramount to | IntroductionOver the past 20 years, the |  treatment landscape of HER2-amplified tumors has |  considerably evolved. Until now, no approved targeted |  therapies were available for patients with HER2-amplified
关键词: Tucatinib |  HER2 |  colorectal cancer |  gastroesophageal cancers |  biliary tract cancer |  resistance
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