NSTL国家科技图书文献中心

1. Lapatinib: A Potential Therapeutic Agent for Colon Cancer Targeting Ferroptosis NSTL国家科技图书文献中心

Sun, Yue | Wang, Dan ... - 《Anti-cancer agents in medicinal chemistry》 - 2025,25(2) - 114～123 - 共10页

摘要： treatment. Lapatinib, a new generation of targeted anti | molecular mechanisms through which lapatinib* exerts its* | employed to assess whether lapatinib* has a potential* | to investigate whether lapatinib* regulates the* | lapatinib, aiming to elucidate the precise pattern of cell

关键词： Lapatinib | colon cancer | GPX4 | ferroptosis | targeted therapy | ROS

2. Evaluation of Lapatinib Tablets Equivalence in the Comparative Dissolution Kinetics Test NSTL国家科技图书文献中心

Shprakh, Z. S. | Poskedova, Ya. A.... - 《Pharmaceutical Chemistry Journal》 - 2025,58(10) - 1582～1587 - 共6页

摘要：TABLEts of lapatinib, a tyrosine kinase | reference lapatinib* tablets in the studied media (quality* | inhibitor, are widely used to treat HER2-positive breast | cancer. When developing a generic drug, a comparative | dissolution kinetics test is performed to study its

关键词： lapatinib | comparative dissolution kinetics test | similarity factor | dissimilarity factor

3. Nanocrystalline solid dispersions: an emerging approach for oral bioavailability enhancement of anticancer drugs using lapatinib ditosylate as the case drug NSTL国家科技图书文献中心

Mane, Preeti | Wakure, Balaji ... - 《Journal of Dispersion Science and Technology》 - 2025,46(1/4) - 199～213 - 共15页

摘要：The bioavailability of lapatinib* ditosylate* | crystals of lapatinib* ditosylate. The molecular-level* | aqueous solubility of lapatinib* ditosylate, by 3.68* | respectively for lapatinib* ditosylate. All these* | of anticancer drug, lapatinib* ditosylate through*

关键词： Lapatinib ditosylate | nanocrystalline solid dispersion | breast cancer | bioavailability | anti-cancer activity

4. Targeted nanoparticle delivery of lapatinib for cancer therapy: Progress, challenges, and future directions NSTL国家科技图书文献中心

Abad, Fateme Rezaei ... | Pourmadadi, Mehrab ... - 《Journal of drug delivery science and technology》 - 2025,108 - 106902～106902 - 共16页

摘要：Lapatinib (LPT), a tyrosine kinase inhibitor | with therapeutic efficacy against HER2-positive | cancers, faces clinical limitations due to its poor | aqueous solubility, systemic toxicity, and multidrug | resistance (MDR). Nanoparticle-based delivery systems offer

关键词： Lapatinib | Nanoparticle drug delivery | Lipid nanoparticles | Polymer nanoparticles | Cancer therapy | Multidrug resistance | Targeted therapy

5. Combined PET and near-infrared fluorescence probe based on lapatinib targeting HER2 for in vivo tumor imaging NSTL国家科技图书文献中心

Gong, Jingyao | Li, Yunlong ... - 《Bioorganic chemistry》 - 2025,161 - 共10页

摘要： combined two lapatinib-based molecular probes for | -lapatinib* demonstrated superior imaging performance in* | Combination of PET and optical imaging | techniques holds significant potential for complete tumor | resection to optimize patient outcomes. In this study, we

关键词： Dual imaging | Fluorescence imaging | Her2 | PET/CT | Diagnostic

6. Development of High-Throughput Quantitative Imaging Mass Spectrometry for Analysis of Drug Distribution in Tissues NSTL国家科技图书文献中心

Tanaka, Yukari - 《Journal of mass spectrometry》 - 2025,60(5) - n/a～n/a - 共11页

摘要： epertinib is superior to lapatinib* in penetrating brain* | epertinib or lapatinib* brain section samples. Quantitative* | and lapatinib* responses were strongly linear, with a* | concentrations. Epertinib and lapatinib* were sufficiently* | Matrix-assisted laser desorption/ionization

关键词： epertinib | high-throughput | lapatinib | MALDI | quantitative imaging mass spectrometry | high‐throughput

7. Targeting AFP-RARβ complex formation: a potential strategy for treating AFP-positive hepatocellular carcinoma NSTL国家科技图书文献中心

Banjan, Bhavya | Vishwakarma, Riya ... - 《Molecular diversity》 - 2025,29(2) - 1337～1352 - 共16页

摘要： revealed Lapatinib* as a candidate drug of the AFP-RAR* | abstractBinding of Lapatinib* with AFP active sites was found to* | Alpha-fetoprotein (AFP) is a glycoprotein | primarily expressed during embryogenesis, with declining | levels postnatally. Elevated AFP levels correlate with

关键词： AFP | HCC | RAR/RXR | Lapatinib | Molecular docking | Molecular dynamic simulations

8. ErbB2-NOTCH1 axis controls autophagy in cardiac cells NSTL国家科技图书文献中心

Fortini, Francesca | Vieceli Dalla Sega, ...... - 《BioFactors》 - 2025,51(1) - n/a～n/a - 共22页 - 被引量：1

摘要：, lapatinib, reduced Notch1 activation. Moreover, incubation | of H9c2 cells with lapatinib* resulted in stalled* | Although the epidermal growth factor receptor | 2 (ErbB2) and Notch1 signaling pathways have both | significant roles in regulating cardiac biology, their

关键词： autophagy | cardiomyocytes | ErbB2 | heart | Notch

9. Construction of lysosome-related prognostic signature to predict the survival outcomes and selecting suitable drugs for patients with HNSCC NSTL国家科技图书文献中心

Cao, Bing | Gu, Shanshan ... - 《BioFactors》 - 2025,51(1) - n/a～n/a - 共11页

摘要： sensitivity to Lapatinib. GO functional enrichment analysis | Lysosomes are digestive organelles responsible | for endocytosis and autophagy. Recently, the | malignancy and invasiveness head and neck squamous cell | carcinoma (HNSCC) has been increasingly studied with the

关键词： bioinformatics analysis | HNSCC | immune microenvironment | lysosome | prognosis

10. Tucatinib in the treatment of HER2-overexpressing gastrointestinal cancers: current insights and future prospects NSTL国家科技图书文献中心

Hoyek, Celine | Zheng-Lin, Binbin ... - 《Expert opinion on investigational drugs.》 - 2025,34(3) - 161～168 - 共8页

摘要： and other TKIs like lapatinib* will be paramount to* | IntroductionOver the past 20 years, the | treatment landscape of HER2-amplified tumors has | considerably evolved. Until now, no approved targeted | therapies were available for patients with HER2-amplified

摘要： treatment. Lapatinib, a new generation of targeted anti | molecular mechanisms through which lapatinib* exerts its* | employed to assess whether lapatinib* has a potential* | to investigate whether lapatinib* regulates the* | lapatinib, aiming to elucidate the precise pattern of cell

关键词： Lapatinib | colon cancer | GPX4 | ferroptosis | targeted therapy | ROS

摘要：TABLEts of lapatinib, a tyrosine kinase | reference lapatinib* tablets in the studied media (quality* | inhibitor, are widely used to treat HER2-positive breast | cancer. When developing a generic drug, a comparative | dissolution kinetics test is performed to study its

关键词： lapatinib | comparative dissolution kinetics test | similarity factor | dissimilarity factor

摘要：The bioavailability of lapatinib* ditosylate* | crystals of lapatinib* ditosylate. The molecular-level* | aqueous solubility of lapatinib* ditosylate, by 3.68* | respectively for lapatinib* ditosylate. All these* | of anticancer drug, lapatinib* ditosylate through*

关键词： Lapatinib ditosylate | nanocrystalline solid dispersion | breast cancer | bioavailability | anti-cancer activity

摘要：Lapatinib (LPT), a tyrosine kinase inhibitor | with therapeutic efficacy against HER2-positive | cancers, faces clinical limitations due to its poor | aqueous solubility, systemic toxicity, and multidrug | resistance (MDR). Nanoparticle-based delivery systems offer

关键词： Lapatinib | Nanoparticle drug delivery | Lipid nanoparticles | Polymer nanoparticles | Cancer therapy | Multidrug resistance | Targeted therapy

摘要： combined two lapatinib-based molecular probes for | -lapatinib* demonstrated superior imaging performance in* | Combination of PET and optical imaging | techniques holds significant potential for complete tumor | resection to optimize patient outcomes. In this study, we

关键词： Dual imaging | Fluorescence imaging | Her2 | PET/CT | Diagnostic

摘要： epertinib is superior to lapatinib* in penetrating brain* | epertinib or lapatinib* brain section samples. Quantitative* | and lapatinib* responses were strongly linear, with a* | concentrations. Epertinib and lapatinib* were sufficiently* | Matrix-assisted laser desorption/ionization

关键词： epertinib | high-throughput | lapatinib | MALDI | quantitative imaging mass spectrometry | high‐throughput

摘要： revealed Lapatinib* as a candidate drug of the AFP-RAR* | abstractBinding of Lapatinib* with AFP active sites was found to* | Alpha-fetoprotein (AFP) is a glycoprotein | primarily expressed during embryogenesis, with declining | levels postnatally. Elevated AFP levels correlate with

关键词： AFP | HCC | RAR/RXR | Lapatinib | Molecular docking | Molecular dynamic simulations

摘要：, lapatinib, reduced Notch1 activation. Moreover, incubation | of H9c2 cells with lapatinib* resulted in stalled* | Although the epidermal growth factor receptor | 2 (ErbB2) and Notch1 signaling pathways have both | significant roles in regulating cardiac biology, their

关键词： autophagy | cardiomyocytes | ErbB2 | heart | Notch

摘要： sensitivity to Lapatinib. GO functional enrichment analysis | Lysosomes are digestive organelles responsible | for endocytosis and autophagy. Recently, the | malignancy and invasiveness head and neck squamous cell | carcinoma (HNSCC) has been increasingly studied with the

关键词： bioinformatics analysis | HNSCC | immune microenvironment | lysosome | prognosis

摘要： and other TKIs like lapatinib* will be paramount to* | IntroductionOver the past 20 years, the | treatment landscape of HER2-amplified tumors has | considerably evolved. Until now, no approved targeted | therapies were available for patients with HER2-amplified

关键词： Tucatinib | HER2 | colorectal cancer | gastroesophageal cancers | biliary tract cancer | resistance

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： treatment. Lapatinib, a new generation of targeted anti | molecular mechanisms through which lapatinib exerts its | employed to assess whether lapatinib has a potential | to investigate whether lapatinib regulates the | lapatinib, aiming to elucidate the precise pattern of cell

关键词： Lapatinib | colon cancer | GPX4 | ferroptosis | targeted therapy | ROS

摘要：TABLEts of lapatinib, a tyrosine kinase | reference lapatinib tablets in the studied media (quality | inhibitor, are widely used to treat HER2-positive breast | cancer. When developing a generic drug, a comparative | dissolution kinetics test is performed to study its

关键词： lapatinib | comparative dissolution kinetics test | similarity factor | dissimilarity factor

摘要：The bioavailability of lapatinib ditosylate | crystals of lapatinib ditosylate. The molecular-level | aqueous solubility of lapatinib ditosylate, by 3.68 | respectively for lapatinib ditosylate. All these | of anticancer drug, lapatinib ditosylate through

关键词： Lapatinib ditosylate | nanocrystalline solid dispersion | breast cancer | bioavailability | anti-cancer activity

摘要：Lapatinib (LPT), a tyrosine kinase inhibitor | with therapeutic efficacy against HER2-positive | cancers, faces clinical limitations due to its poor | aqueous solubility, systemic toxicity, and multidrug | resistance (MDR). Nanoparticle-based delivery systems offer

关键词： Lapatinib | Nanoparticle drug delivery | Lipid nanoparticles | Polymer nanoparticles | Cancer therapy | Multidrug resistance | Targeted therapy

摘要： combined two lapatinib-based molecular probes for | -lapatinib demonstrated superior imaging performance in | Combination of PET and optical imaging | techniques holds significant potential for complete tumor | resection to optimize patient outcomes. In this study, we

关键词： Dual imaging | Fluorescence imaging | Her2 | PET/CT | Diagnostic

摘要： epertinib is superior to lapatinib in penetrating brain | epertinib or lapatinib brain section samples. Quantitative | and lapatinib responses were strongly linear, with a | concentrations. Epertinib and lapatinib were sufficiently | Matrix-assisted laser desorption/ionization

关键词： epertinib | high-throughput | lapatinib | MALDI | quantitative imaging mass spectrometry | high‐throughput

摘要： revealed Lapatinib as a candidate drug of the AFP-RAR | abstractBinding of Lapatinib with AFP active sites was found to | Alpha-fetoprotein (AFP) is a glycoprotein | primarily expressed during embryogenesis, with declining | levels postnatally. Elevated AFP levels correlate with

关键词： AFP | HCC | RAR/RXR | Lapatinib | Molecular docking | Molecular dynamic simulations

摘要：, lapatinib, reduced Notch1 activation. Moreover, incubation | of H9c2 cells with lapatinib resulted in stalled | Although the epidermal growth factor receptor | 2 (ErbB2) and Notch1 signaling pathways have both | significant roles in regulating cardiac biology, their

关键词： autophagy | cardiomyocytes | ErbB2 | heart | Notch

摘要： sensitivity to Lapatinib. GO functional enrichment analysis | Lysosomes are digestive organelles responsible | for endocytosis and autophagy. Recently, the | malignancy and invasiveness head and neck squamous cell | carcinoma (HNSCC) has been increasingly studied with the

关键词： bioinformatics analysis | HNSCC | immune microenvironment | lysosome | prognosis

摘要： and other TKIs like lapatinib will be paramount to | IntroductionOver the past 20 years, the | treatment landscape of HER2-amplified tumors has | considerably evolved. Until now, no approved targeted | therapies were available for patients with HER2-amplified

关键词： Tucatinib | HER2 | colorectal cancer | gastroesophageal cancers | biliary tract cancer | resistance

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： treatment. Lapatinib, a new generation of targeted anti | molecular mechanisms through which lapatinib* exerts its* | employed to assess whether lapatinib* has a potential* | to investigate whether lapatinib* regulates the* | lapatinib, aiming to elucidate the precise pattern of cell

摘要：TABLEts of lapatinib, a tyrosine kinase | reference lapatinib* tablets in the studied media (quality* | inhibitor, are widely used to treat HER2-positive breast | cancer. When developing a generic drug, a comparative | dissolution kinetics test is performed to study its

摘要：The bioavailability of lapatinib* ditosylate* | crystals of lapatinib* ditosylate. The molecular-level* | aqueous solubility of lapatinib* ditosylate, by 3.68* | respectively for lapatinib* ditosylate. All these* | of anticancer drug, lapatinib* ditosylate through*

摘要： combined two lapatinib-based molecular probes for | -lapatinib* demonstrated superior imaging performance in* | Combination of PET and optical imaging | techniques holds significant potential for complete tumor | resection to optimize patient outcomes. In this study, we

摘要： epertinib is superior to lapatinib* in penetrating brain* | epertinib or lapatinib* brain section samples. Quantitative* | and lapatinib* responses were strongly linear, with a* | concentrations. Epertinib and lapatinib* were sufficiently* | Matrix-assisted laser desorption/ionization

摘要： revealed Lapatinib* as a candidate drug of the AFP-RAR* | abstractBinding of Lapatinib* with AFP active sites was found to* | Alpha-fetoprotein (AFP) is a glycoprotein | primarily expressed during embryogenesis, with declining | levels postnatally. Elevated AFP levels correlate with

摘要：, lapatinib, reduced Notch1 activation. Moreover, incubation | of H9c2 cells with lapatinib* resulted in stalled* | Although the epidermal growth factor receptor | 2 (ErbB2) and Notch1 signaling pathways have both | significant roles in regulating cardiac biology, their

摘要： and other TKIs like lapatinib* will be paramount to* | IntroductionOver the past 20 years, the | treatment landscape of HER2-amplified tumors has | considerably evolved. Until now, no approved targeted | therapies were available for patients with HER2-amplified