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1. Lapatinib: A Potential Therapeutic Agent for Colon Cancer Targeting Ferroptosis NSTL国家科技图书文献中心

Sun, Yue |  Wang, Dan... -  《Anti-cancer agents in medicinal chemistry》 - 2025,25(2) - 114~123 - 共10页

摘要: treatment. Lapatinib, a new generation of targeted anti |  molecular mechanisms through which lapatinib exerts its |  employed to assess whether lapatinib has a potential |  to investigate whether lapatinib regulates the |  lapatinib, aiming to elucidate the precise pattern of cell
关键词: Lapatinib |  colon cancer |  GPX4 |  ferroptosis |  targeted therapy |  ROS

2. Evaluation of Lapatinib Tablets Equivalence in the Comparative Dissolution Kinetics Test NSTL国家科技图书文献中心

Shprakh, Z. S. |  Poskedova, Ya. A.... -  《Pharmaceutical Chemistry Journal》 - 2025,58(10) - 1582~1587 - 共6页

摘要:TABLEts of lapatinib, a tyrosine kinase |  reference lapatinib tablets in the studied media (quality |  inhibitor, are widely used to treat HER2-positive breast |  cancer. When developing a generic drug, a comparative |  dissolution kinetics test is performed to study its
关键词: lapatinib |  comparative dissolution kinetics test |  similarity factor |  dissimilarity factor

3. Development of High-Throughput Quantitative Imaging Mass Spectrometry for Analysis of Drug Distribution in Tissues NSTL国家科技图书文献中心

Tanaka, Yukari -  《Journal of mass spectrometry》 - 2025,60(5) - n/a~n/a - 共11页

摘要: epertinib is superior to lapatinib in penetrating brain |  epertinib or lapatinib brain section samples. Quantitative |  and lapatinib responses were strongly linear, with a |  concentrations. Epertinib and lapatinib were sufficiently | Matrix-assisted laser desorption/ionization
关键词: epertinib |  high-throughput |  lapatinib |  MALDI |  quantitative imaging mass spectrometry |  high‐throughput

4. Targeting AFP-RARβ complex formation: a potential strategy for treating AFP-positive hepatocellular carcinoma NSTL国家科技图书文献中心

Banjan, Bhavya |  Vishwakarma, Riya... -  《Molecular diversity》 - 2025,29(2) - 1337~1352 - 共16页

摘要: revealed Lapatinib as a candidate drug of the AFP-RAR |  abstractBinding of Lapatinib with AFP active sites was found to | Alpha-fetoprotein (AFP) is a glycoprotein |  primarily expressed during embryogenesis, with declining |  levels postnatally. Elevated AFP levels correlate with
关键词: AFP |  HCC |  RAR/RXR |  Lapatinib |  Molecular docking |  Molecular dynamic simulations

5. ErbB2-NOTCH1 axis controls autophagy in cardiac cells NSTL国家科技图书文献中心

Fortini, Francesca |  Vieceli Dalla Sega, ...... -  《BioFactors》 - 2025,51(1) - n/a~n/a - 共22页

摘要:, lapatinib, reduced Notch1 activation. Moreover, incubation |  of H9c2 cells with lapatinib resulted in stalled | Although the epidermal growth factor receptor |  2 (ErbB2) and Notch1 signaling pathways have both |  significant roles in regulating cardiac biology, their
关键词: autophagy |  cardiomyocytes |  ErbB2 |  heart |  Notch

6. Construction of lysosome-related prognostic signature to predict the survival outcomes and selecting suitable drugs for patients with HNSCC NSTL国家科技图书文献中心

Cao, Bing |  Gu, Shanshan... -  《BioFactors》 - 2025,51(1) - n/a~n/a - 共11页

摘要: sensitivity to Lapatinib. GO functional enrichment analysis | Lysosomes are digestive organelles responsible |  for endocytosis and autophagy. Recently, the |  malignancy and invasiveness head and neck squamous cell |  carcinoma (HNSCC) has been increasingly studied with the
关键词: bioinformatics analysis |  HNSCC |  immune microenvironment |  lysosome |  prognosis

7. Tucatinib in the treatment of HER2-overexpressing gastrointestinal cancers: current insights and future prospects NSTL国家科技图书文献中心

Hoyek, Celine |  Zheng-Lin, Binbin... -  《Expert opinion on investigational drugs.》 - 2025,34(3) - 161~168 - 共8页

摘要: and other TKIs like lapatinib will be paramount to | IntroductionOver the past 20 years, the |  treatment landscape of HER2-amplified tumors has |  considerably evolved. Until now, no approved targeted |  therapies were available for patients with HER2-amplified
关键词: Tucatinib |  HER2 |  colorectal cancer |  gastroesophageal cancers |  biliary tract cancer |  resistance

8. Formulation optimization and characterization of Central composite design optimized LAP-loaded calcium pectinate nanoparticles: anticancer activity against MCF-7 cells NSTL国家科技图书文献中心

Chauhan, Abhishek |  Verma, Abhishek... -  《Drug development and industrial pharmacy》 - 2025,51(5) - 478~491 - 共14页

摘要: optimize Lapatinib-loaded calcium pectinate nanoparticles | ObjectiveThe study aimed to formulate and |  (LAP-PEC-NPs) using central composite design (CCD | ), evaluate their physicochemical properties, and compare |  their anticancer efficacy with raw LAP on MCF7 breast
关键词: LAP |  pectin |  ionic gelation |  nanoparticles |  breast cancer |  QbD

9. Prognostic value of residual disease (RD) biology and gene expression changes during the neoadjuvant treatment in patients with HER2-positive early breast cancer (EBC) NSTL国家科技图书文献中心

A Fernandez-Martinez |  M Tanioka... -  《Annals of oncology》 - 2025,36(4) - 403~413 - 共11页

摘要: neoadjuvant studies of trastuzumab with or without lapatinib | Background: In human epidermal growth factor |  receptor 2 (HER2)-positive early breast cancer (EBC), we |  investigated tumor and immune changes during neoadjuvant |  treatment and their impact on residual disease (RD
关键词: HER2-positive early breast cancer; gene expression; genomic biomarkers; post-treatment

10. An efficient methodological approach for synthesis of selenopyridines: generation, reactions, anticancer activity, EGFR inhibitory activity and molecular docking studies NSTL国家科技图书文献中心

Hussein, Bahgat R. M... |  El-Saghier, Sham M. ...... -  《Molecular diversity》 - 2025,29(1) - 519~534 - 共16页

摘要: and 0.123 mu M, respectively, compared to lapatinib | In the present work, we successfully |  synthesized Se-alkyl selenopyridines 1 and 3, selenopheno | [2,3-b]pyridine 2, and bis-selenopyridine 4 |  derivatives using an eco-friendly method by utilizing NaHSe
关键词: Selenopyridine |  Selenopheno[2,3-b]pyridine |  Selenoazo dyes |  Anticancer |  EGFR inhibitor
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