NSTL国家科技图书文献中心

1. Role of mitophagy in intervertebral disc degeneration: A narrative review NSTL国家科技图书文献中心

Wu, Zuo-long | Liu, Yong ... - 《Osteoarthritis and cartilage》 - 2025,33(1) - 27～41 - 共15页

摘要： disc (IVD) degeneration (IDD) has become increasingly | the initiation and progression of intervertebral | Objective: The pivotal role of mitophagy in | apparent due to a growing body of research on its | pathogenesis. This review summarizes the role of mitophagy in

关键词： Mitophagy | Intervertebral disc degeneration | Intervertebral disc | Autophagy lysosomes | Nucleus pulposus

2. 3D printed PGCL@PLA/10CSPL composite scaffolds loaded with fibronectin 1 for intervertebral disc degeneration treatment NSTL国家科技图书文献中心

Zhang, Weilin | Chen, Siyuan ... - 《Biofabrication》 - 2025,17(1) - 共14页

摘要： function is essential for intervertebral disc | Restoration of disc* height and biomechanical* | degeneration (IDD) treatment. Removing abnormal nucleus | associated with NP degeneration. A novel poly(glycolide-co | the abnormal NP degeneration. In vitro and in vivo

关键词： intervertebral disc degeneration | fibronectin 1 | poly(glycolide-co-caprolactone)

3. Causal effects of plasma proteome on intervertebral disc degeneration: a comprehensive mendelian randomization study NSTL国家科技图书文献中心

Bo-Wen,Ren | Yi-Hao,Liu ... - 《European spine journal》 - 2025,34(1) - 316～325 - 共10页 - 被引量：1

摘要：Abstract Purpose Intervertebral disc | degeneration (IVDD) considerably impacts global disability | and quality of life. Although potential links | between plasma proteins and IVDD exist, their causal | correlation remains undefined. This study explored the

关键词： Plasma proteome | Mendelian randomization | Intervertebral disc degeneration | Causal association

4. Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration NSTL国家科技图书文献中心

Cheng, Zhangrong | Gan, Weikang ... - 《Autophagy》 - 2025,21(2) - 352～373 - 共22页

摘要： intervertebral disc degeneration. Based on structural and | : intervertebral* disc; IVDD: intervertebral disc degeneration; KD* | -induced disc* degeneration in rats was inhibited by* | common features of disc* degeneration and other age* | was associated with disc* senescence, and the TNF*

关键词： Calcium overload | chaperone-mediated autophagy | intervertebral disc degeneration | senescence | nucleus pulposus

5. Machine learning-based analysis of programmed cell death types and key genes in intervertebral disc degeneration NSTL国家科技图书文献中心

Lv, Yigang | Du, Jiawei ... - 《Apoptosis》 - 2025,30(1/2) - 250～266 - 共17页

摘要：Intervertebral disc degeneration (IVDD) is | contributing to disc* degeneration. Core genes were identified* | correlation with the severity of disc degeneration | reduced apoptosis and delayed disc degeneration | molecular pathology of disc* degeneration and suggest*

关键词： Intervertebral disc degeneration | Programmed cell death | Bioinformatics | Therapeutic targets | Machine learning

6. Implications of circadian disruption on intervertebral disc degeneration: The mediating role of sympathetic nervous system NSTL国家科技图书文献中心

Song, Zongmian | Yan, Miaoheng ... - 《Ageing Research Reviews》 - 2025,104 - 102633～102633 - 共16页

摘要： ascribed to intervertebral* disc degeneration (IVDD). The* | intervertebral disc (IVD) exhibits rhythmic physiological | The circadian clock orchestrates a broad | spectrum of physiological processes, crucially modulating | human biology across an approximate 24-hour cycle. The

关键词： Intervertebral disc degeneration | Circadian rhythm | Circadian clock | Sympathetic nervous system | Chronotherapy

7. Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence-Associated Intervertebral Disc Degeneration NSTL国家科技图书文献中心

Da-wang Zhao | Jing Zhang ... - 《Advanced Materials》 - 2025,37(7) - 2409979.1～2409979.15 - 共15页

摘要： to resist intervertebral* disc degeneration (IVDD* | of degenerated intervertebral* discs. In summary* | The decreased regeneration potential of aging | nucleus pulposus resident progenitor cells (NPPCs) fails | ), and strategies to remodel the regeneration capacity

关键词： -Klotho | aging cell reinvigoration | circRNA | intervertebral disc degeneration | nucleus pulposus progenitor cells

8. Potential causal association between serum vitamin D levels and intervertebral disc degeneration: A mendelian randomization study NSTL国家科技图书文献中心

Libangxi Liu | Chao Sun ... - 《Journal of orthopaedic science》 - 2025,30(3) - 433～439 - 共7页

摘要：Objectives: Intervertebral disc degeneration | (IDD) is a prevalent musculoskeletal disorder with | substantial implications for disability and healthcare | expenditures. The role of serum vitamin D (25-Hydroxyvitamin | D, 25(OH)D) levels in the pathogenesis of various

关键词： 25-Hydroxyvitamin D; Genome-wide association studies; Intervertebral disc degeneration

9. Application of Self-Healing Hydrogels in the Treatment of Intervertebral Disc Degeneration NSTL国家科技图书文献中心

Guo, Cunliang | Jiao, Xinyi ... - 《Journal of biomedical materials research.,Part B,.Applied biomaterials.》 - 2025,113(2) - e35532～e35532 - 共20页

摘要：Intervertebral disc degeneration (IDD) is one | , offering new hope for disc* repair due to their* | , intervertebral* discs are often damaged by trauma or* | the mechanical properties of natural intervertebral | of the leading causes of chronic pain and

关键词： cell delivery | drug delivery systems | exosomes | intervertebral disc degeneration | self-healing hydrogels | tissue engineering | self‐healing hydrogels

10. Integration of bioinformatics and multi-layered experimental validation reveals novel functions of acetylation-related genes in intervertebral disc degeneration NSTL国家科技图书文献中心

Zhu, Jun | Song, Tongqu ... - 《Gene》 - 2025,933 - 148974～148974 - 共23页

摘要： underlying intervertebral* disc degeneration (IDD) remain* | degrees of degeneration* were collected to corroborate* | Background: The molecular mechanisms | poorly understood. The purpose of this work is to | elucidate key molecules and investigate the roles of

摘要： disc (IVD) degeneration (IDD) has become increasingly | the initiation and progression of intervertebral | Objective: The pivotal role of mitophagy in | apparent due to a growing body of research on its | pathogenesis. This review summarizes the role of mitophagy in

关键词： Mitophagy | Intervertebral disc degeneration | Intervertebral disc | Autophagy lysosomes | Nucleus pulposus

摘要： function is essential for intervertebral disc | Restoration of disc* height and biomechanical* | degeneration (IDD) treatment. Removing abnormal nucleus | associated with NP degeneration. A novel poly(glycolide-co | the abnormal NP degeneration. In vitro and in vivo

关键词： intervertebral disc degeneration | fibronectin 1 | poly(glycolide-co-caprolactone)

摘要：Abstract Purpose Intervertebral disc | degeneration (IVDD) considerably impacts global disability | and quality of life. Although potential links | between plasma proteins and IVDD exist, their causal | correlation remains undefined. This study explored the

关键词： Plasma proteome | Mendelian randomization | Intervertebral disc degeneration | Causal association

关键词： Calcium overload | chaperone-mediated autophagy | intervertebral disc degeneration | senescence | nucleus pulposus

摘要：Intervertebral disc degeneration (IVDD) is | contributing to disc* degeneration. Core genes were identified* | correlation with the severity of disc degeneration | reduced apoptosis and delayed disc degeneration | molecular pathology of disc* degeneration and suggest*

关键词： Intervertebral disc degeneration | Programmed cell death | Bioinformatics | Therapeutic targets | Machine learning

摘要： ascribed to intervertebral* disc degeneration (IVDD). The* | intervertebral disc (IVD) exhibits rhythmic physiological | The circadian clock orchestrates a broad | spectrum of physiological processes, crucially modulating | human biology across an approximate 24-hour cycle. The

关键词： Intervertebral disc degeneration | Circadian rhythm | Circadian clock | Sympathetic nervous system | Chronotherapy

摘要： to resist intervertebral* disc degeneration (IVDD* | of degenerated intervertebral* discs. In summary* | The decreased regeneration potential of aging | nucleus pulposus resident progenitor cells (NPPCs) fails | ), and strategies to remodel the regeneration capacity

关键词： -Klotho | aging cell reinvigoration | circRNA | intervertebral disc degeneration | nucleus pulposus progenitor cells

摘要：Objectives: Intervertebral disc degeneration | (IDD) is a prevalent musculoskeletal disorder with | substantial implications for disability and healthcare | expenditures. The role of serum vitamin D (25-Hydroxyvitamin | D, 25(OH)D) levels in the pathogenesis of various

关键词： 25-Hydroxyvitamin D; Genome-wide association studies; Intervertebral disc degeneration

摘要：Intervertebral disc degeneration (IDD) is one | , offering new hope for disc* repair due to their* | , intervertebral* discs are often damaged by trauma or* | the mechanical properties of natural intervertebral | of the leading causes of chronic pain and

关键词： cell delivery | drug delivery systems | exosomes | intervertebral disc degeneration | self-healing hydrogels | tissue engineering | self‐healing hydrogels

摘要： underlying intervertebral* disc degeneration (IDD) remain* | degrees of degeneration* were collected to corroborate* | Background: The molecular mechanisms | poorly understood. The purpose of this work is to | elucidate key molecules and investigate the roles of

关键词： Intervertebral disc degeneration | Acetylation | Immune infiltration | Hub gene | Bioinformatics analysis

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： disc (IVD) degeneration (IDD) has become increasingly | the initiation and progression of intervertebral | Objective: The pivotal role of mitophagy in | apparent due to a growing body of research on its | pathogenesis. This review summarizes the role of mitophagy in

关键词： Mitophagy | Intervertebral disc degeneration | Intervertebral disc | Autophagy lysosomes | Nucleus pulposus

摘要： function is essential for intervertebral disc | Restoration of disc height and biomechanical | degeneration (IDD) treatment. Removing abnormal nucleus | associated with NP degeneration. A novel poly(glycolide-co | the abnormal NP degeneration. In vitro and in vivo

关键词： intervertebral disc degeneration | fibronectin 1 | poly(glycolide-co-caprolactone)

摘要：Abstract Purpose Intervertebral disc | degeneration (IVDD) considerably impacts global disability | and quality of life. Although potential links | between plasma proteins and IVDD exist, their causal | correlation remains undefined. This study explored the

关键词： Plasma proteome | Mendelian randomization | Intervertebral disc degeneration | Causal association

摘要： intervertebral disc degeneration. Based on structural and | : intervertebral disc; IVDD: intervertebral disc degeneration; KD | -induced disc degeneration in rats was inhibited by | common features of disc degeneration and other age | was associated with disc senescence, and the TNF

关键词： Calcium overload | chaperone-mediated autophagy | intervertebral disc degeneration | senescence | nucleus pulposus

摘要：Intervertebral disc degeneration (IVDD) is | contributing to disc degeneration. Core genes were identified | correlation with the severity of disc degeneration | reduced apoptosis and delayed disc degeneration | molecular pathology of disc degeneration and suggest

关键词： Intervertebral disc degeneration | Programmed cell death | Bioinformatics | Therapeutic targets | Machine learning

摘要： ascribed to intervertebral disc degeneration (IVDD). The | intervertebral disc (IVD) exhibits rhythmic physiological | The circadian clock orchestrates a broad | spectrum of physiological processes, crucially modulating | human biology across an approximate 24-hour cycle. The

关键词： Intervertebral disc degeneration | Circadian rhythm | Circadian clock | Sympathetic nervous system | Chronotherapy

摘要： to resist intervertebral disc degeneration (IVDD | of degenerated intervertebral discs. In summary | The decreased regeneration potential of aging | nucleus pulposus resident progenitor cells (NPPCs) fails | ), and strategies to remodel the regeneration capacity

关键词： -Klotho | aging cell reinvigoration | circRNA | intervertebral disc degeneration | nucleus pulposus progenitor cells

摘要：Objectives: Intervertebral disc degeneration | (IDD) is a prevalent musculoskeletal disorder with | substantial implications for disability and healthcare | expenditures. The role of serum vitamin D (25-Hydroxyvitamin | D, 25(OH)D) levels in the pathogenesis of various

关键词： 25-Hydroxyvitamin D; Genome-wide association studies; Intervertebral disc degeneration

摘要：Intervertebral disc degeneration (IDD) is one | , offering new hope for disc repair due to their | , intervertebral discs are often damaged by trauma or | the mechanical properties of natural intervertebral | of the leading causes of chronic pain and

关键词： cell delivery | drug delivery systems | exosomes | intervertebral disc degeneration | self-healing hydrogels | tissue engineering | self‐healing hydrogels

摘要： underlying intervertebral disc degeneration (IDD) remain | degrees of degeneration were collected to corroborate | Background: The molecular mechanisms | poorly understood. The purpose of this work is to | elucidate key molecules and investigate the roles of

关键词： Intervertebral disc degeneration | Acetylation | Immune infiltration | Hub gene | Bioinformatics analysis

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： function is essential for intervertebral disc | Restoration of disc* height and biomechanical* | degeneration (IDD) treatment. Removing abnormal nucleus | associated with NP degeneration. A novel poly(glycolide-co | the abnormal NP degeneration. In vitro and in vivo

摘要：Intervertebral disc degeneration (IVDD) is | contributing to disc* degeneration. Core genes were identified* | correlation with the severity of disc degeneration | reduced apoptosis and delayed disc degeneration | molecular pathology of disc* degeneration and suggest*

摘要： ascribed to intervertebral* disc degeneration (IVDD). The* | intervertebral disc (IVD) exhibits rhythmic physiological | The circadian clock orchestrates a broad | spectrum of physiological processes, crucially modulating | human biology across an approximate 24-hour cycle. The

摘要： to resist intervertebral* disc degeneration (IVDD* | of degenerated intervertebral* discs. In summary* | The decreased regeneration potential of aging | nucleus pulposus resident progenitor cells (NPPCs) fails | ), and strategies to remodel the regeneration capacity

摘要：Intervertebral disc degeneration (IDD) is one | , offering new hope for disc* repair due to their* | , intervertebral* discs are often damaged by trauma or* | the mechanical properties of natural intervertebral | of the leading causes of chronic pain and

摘要： underlying intervertebral* disc degeneration (IDD) remain* | degrees of degeneration* were collected to corroborate* | Background: The molecular mechanisms | poorly understood. The purpose of this work is to | elucidate key molecules and investigate the roles of