NSTL国家科技图书文献中心

1. In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances NSTL国家科技图书文献中心

Luo, Xuan | Chen, Qiaotong ... - 《Archives of Toxicology》 - 2025,99(3) - 1059～1072 - 共14页

摘要： in vitro* metabolism of arolyl-derived F-NPS, and* | this issue, in this study, the in vitro* phase I* | theoretical support for predicting their in vivo metabolism | representative synthetic opioids in third-generation drugs | " fatal dose and parent drug levels in biological

关键词： Arolyl-derived fentanyl-type new psychoactive substances | Human liver microsomes | In vitro metabolism | Metabolic characteristics | Structural effect

2. Elucidating the Phase I metabolism of psilocin in vitro NSTL国家科技图书文献中心

Chen, Junqi | Wang, Ziteng ... - 《Archives of Toxicology》 - 2025,99(3) - 1085～1094 - 共10页

摘要： hepatic and extrahepatic clearances via in vitro* to in* | . However, research gaps remain regarding its metabolism | Phase I metabolism* of psilocin and estimated its* | for 80.9% of the total hepatic metabolism* of* | Phase I metabolism* of psilocin. Total MAO-A-mediated*

关键词： Cytosolic enzyme | In vitro to in vivo extrapolation | Monoamine oxidase | Phase I metabolism | Psilocin | Psilocybin

3. The relationship between CYP2C9 gene polymorphisms and azilsartan metabolism in vitro NSTL国家科技图书文献中心

Bao, Su-Su | Tang, Peng-Fei ... - 《Expert opinion on drug metabolism & toxicology》 - 2025,21(1) - 95～103 - 共9页

摘要： enzyme, result in different clearances for different | , expressed in insect microsomes, were incubated with | underlying changes in enzyme function. Results: Compared | azilsartan metabolism, establishing a theoretical basis for | further in-vivo studies and clinical applications. This

关键词： Genetic polymorphism | Azilsartan | metabolism in vitro | HPLC-MS/MS

4. Effects of CYP3A4 Variants on Methadone Metabolism In Vitro NSTL国家科技图书文献中心

Wang, Chen-chen | Zhang, Ming-lei ... - 《Biomedical Chromatography》 - 2025,39(1) - e6056～e6056 - 共10页

摘要：In hepatic drug metabolism, cytochrome P450 | CYP3A4 allelic variants on the in vitro* oxidative* | metabolism of methadone. We utilized a baculovirus-insect | activity in the N-demethylation of methadone. Of the 23 | demonstrated no significant difference in intrinsic clearance

关键词： CYP3A4 variants | drug‐metabolizing enzyme | genetic polymorphisms | intrinsic clearance | methadone metabolism | drug-metabolizing enzyme

5. Trilobatin regulates glucose metabolism by ameliorating oxidative stress and insulin resistance in vivo and in vitro NSTL国家科技图书文献中心

He, Ming | Zhang, Yuqing ... - 《Journal of Pharmacy and Pharmacology》 - 2025,77(2) - 236～248 - 共13页

摘要： cells and in STZ-induced mice. Furthermore, in vitro | unexplained. Methods: In this investigation, the regulation | of trilobatin on glucose metabolism* of insulin* | , hexokinase (HK), and pyruvate kinase (PK) activity in IR | -HepG2 cells. Among them, the HK and PK activity in IR

关键词： trilobatin | glucose metabolism | insulin resistance | oxidative stress | PI3K/Akt/GSK-3 beta pathway | Nrf2/Keap-1 pathway

6. Light quality affects photosynthesis and antioxidant metabolism of Colletia paradoxa cultivated in-vitro NSTL国家科技图书文献中心

Taques, Rhuann Carlo... | Souza, Rafaela Crist...... - 《Plant Cell, Tissue and Organ Culture》 - 2025,161(1) - 共13页

摘要： plant morphogenesis in tissue culture. In-vitro | . paradoxa cultivated in-vitro. We compared the morphogenic | the photosynthetic and antioxidant metabolism* of C* | fluorescence, and antioxidant enzyme activities in explants | resulted in the highest number (5.44) and average length

关键词： Chlorophyll | Light-emitting diodes | Photosystem | Micropropagation | Rhamnaceae

7. Impact of Hedgehog modulators on signaling pathways in primary murine and human hepatocytes in vitro: insights into liver metabolism NSTL国家科技图书文献中心

Ott, Fritzi | Koerner, Christiane ... - 《Archives of Toxicology》 - 2025,99(3) - 1105～1116 - 共12页

摘要： pathway can affect liver metabolism* in healthy livers* | primary hepatocytes in vitro. We employed toxicological | and in adult tissues. In the liver, dysregulation of | . Recent studies also suggest that disturbances in the Hh | effects of Hh modulators on healthy hepatocytes. In our

关键词： Hedgehog signaling | Hepatocytes | Human | Murine | Modulator | Activator | Inhibitor

8. In vitro stretch modulates mitochondrial dynamics and energy metabolism to induce smooth muscle differentiation in mesenchymal stem cells NSTL国家科技图书文献中心

Liu, Yu | Yang, Zhijie ... - 《The FASEB Journal》 - 2025,39(2) - e70354～e70354 - 共17页

摘要： contractile ability in vitro* and facilitate angiogenesis in* | The smooth muscle cells (SMCs) located in the | crucial role in vascular wall remodeling and blood | markers alpha-SMA and SM22 in MSCs. These cells exhibit | the Matrigel plug assay in vivo. The contraction of

关键词： cyclic stretch | energy metabolism | mesenchymal stem cells | mitochondrial dynamics | smooth muscle cells

9. LCMS Detection and Characterization of In Vitro Metabolites of Isotonitazene, a Targeted Strategy for Novel Psychoactive Substance Control in Camel Racing NSTL国家科技图书文献中心

Nalakath, Jahfar | Thacholil, Rasik P.... - 《Rapid Communications in Mass Spectrometry》 - 2025,39(7) - n/a～n/a - 共12页

摘要： characterization of the metabolites.ResultsThrough in vitro | vitro metabolites of isotonitazene in camels | raising concerns about potential misuse and doping in | metabolism of these substances is critical for developing | animal welfare.MethodsIn vitro* studies were conducted*

关键词： camel racing | doping control | in vitro metabolism | isotonitazene | LC-HRMS | psychoactive substances | LC‐HRMS

10. Assessing the Anti-Obesity Potential of Lactococcus lactis subsp. lactis CAB701: Modulation of Adipocyte Differentiation and Lipid Metabolism in In Vitro and In Vivo Models NSTL国家科技图书文献中心

Jeong, Huijin | Hwang, Un-Sik ... - 《Probiotics and Antimicrobial Proteins》 - 2025,17(3) - 1203～1216 - 共14页

摘要： using in vitro* and in vivo assays. L. lactis subsp* | and proteins involved in lipid metabolism* and* | In this study, the potential anti-obesity | 3T3-L1 cells by 67%. In an in vivo model of high-fat | significantly downregulated in peri-epididymal adipose tissue

摘要： in vitro* metabolism of arolyl-derived F-NPS, and* | this issue, in this study, the in vitro* phase I* | theoretical support for predicting their in vivo metabolism | representative synthetic opioids in third-generation drugs | " fatal dose and parent drug levels in biological

关键词： Arolyl-derived fentanyl-type new psychoactive substances | Human liver microsomes | In vitro metabolism | Metabolic characteristics | Structural effect

摘要： hepatic and extrahepatic clearances via in vitro* to in* | . However, research gaps remain regarding its metabolism | Phase I metabolism* of psilocin and estimated its* | for 80.9% of the total hepatic metabolism* of* | Phase I metabolism* of psilocin. Total MAO-A-mediated*

关键词： Cytosolic enzyme | In vitro to in vivo extrapolation | Monoamine oxidase | Phase I metabolism | Psilocin | Psilocybin

摘要： enzyme, result in different clearances for different | , expressed in insect microsomes, were incubated with | underlying changes in enzyme function. Results: Compared | azilsartan metabolism, establishing a theoretical basis for | further in-vivo studies and clinical applications. This

关键词： Genetic polymorphism | Azilsartan | metabolism in vitro | HPLC-MS/MS

摘要：In hepatic drug metabolism, cytochrome P450 | CYP3A4 allelic variants on the in vitro* oxidative* | metabolism of methadone. We utilized a baculovirus-insect | activity in the N-demethylation of methadone. Of the 23 | demonstrated no significant difference in intrinsic clearance

关键词： CYP3A4 variants | drug‐metabolizing enzyme | genetic polymorphisms | intrinsic clearance | methadone metabolism | drug-metabolizing enzyme

摘要： cells and in STZ-induced mice. Furthermore, in vitro | unexplained. Methods: In this investigation, the regulation | of trilobatin on glucose metabolism* of insulin* | , hexokinase (HK), and pyruvate kinase (PK) activity in IR | -HepG2 cells. Among them, the HK and PK activity in IR

关键词： trilobatin | glucose metabolism | insulin resistance | oxidative stress | PI3K/Akt/GSK-3 beta pathway | Nrf2/Keap-1 pathway

摘要： plant morphogenesis in tissue culture. In-vitro | . paradoxa cultivated in-vitro. We compared the morphogenic | the photosynthetic and antioxidant metabolism* of C* | fluorescence, and antioxidant enzyme activities in explants | resulted in the highest number (5.44) and average length

关键词： Chlorophyll | Light-emitting diodes | Photosystem | Micropropagation | Rhamnaceae

摘要： pathway can affect liver metabolism* in healthy livers* | primary hepatocytes in vitro. We employed toxicological | and in adult tissues. In the liver, dysregulation of | . Recent studies also suggest that disturbances in the Hh | effects of Hh modulators on healthy hepatocytes. In our

关键词： Hedgehog signaling | Hepatocytes | Human | Murine | Modulator | Activator | Inhibitor

摘要： contractile ability in vitro* and facilitate angiogenesis in* | The smooth muscle cells (SMCs) located in the | crucial role in vascular wall remodeling and blood | markers alpha-SMA and SM22 in MSCs. These cells exhibit | the Matrigel plug assay in vivo. The contraction of

关键词： cyclic stretch | energy metabolism | mesenchymal stem cells | mitochondrial dynamics | smooth muscle cells

摘要： characterization of the metabolites.ResultsThrough in vitro | vitro metabolites of isotonitazene in camels | raising concerns about potential misuse and doping in | metabolism of these substances is critical for developing | animal welfare.MethodsIn vitro* studies were conducted*

关键词： camel racing | doping control | in vitro metabolism | isotonitazene | LC-HRMS | psychoactive substances | LC‐HRMS

摘要： using in vitro* and in vivo assays. L. lactis subsp* | and proteins involved in lipid metabolism* and* | In this study, the potential anti-obesity | 3T3-L1 cells by 67%. In an in vivo model of high-fat | significantly downregulated in peri-epididymal adipose tissue

关键词： Probiotics | Anti-obesity | Body weight | High-fat diet | Adipocyte differentiation

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： in vitro metabolism of arolyl-derived F-NPS, and | this issue, in this study, the in vitro phase I | theoretical support for predicting their in vivo metabolism | representative synthetic opioids in third-generation drugs | " fatal dose and parent drug levels in biological

关键词： Arolyl-derived fentanyl-type new psychoactive substances | Human liver microsomes | In vitro metabolism | Metabolic characteristics | Structural effect

摘要： hepatic and extrahepatic clearances via in vitro to in | . However, research gaps remain regarding its metabolism | Phase I metabolism of psilocin and estimated its | for 80.9% of the total hepatic metabolism of | Phase I metabolism of psilocin. Total MAO-A-mediated

关键词： Cytosolic enzyme | In vitro to in vivo extrapolation | Monoamine oxidase | Phase I metabolism | Psilocin | Psilocybin

摘要： enzyme, result in different clearances for different | , expressed in insect microsomes, were incubated with | underlying changes in enzyme function. Results: Compared | azilsartan metabolism, establishing a theoretical basis for | further in-vivo studies and clinical applications. This

关键词： Genetic polymorphism | Azilsartan | metabolism in vitro | HPLC-MS/MS

摘要：In hepatic drug metabolism, cytochrome P450 | CYP3A4 allelic variants on the in vitro oxidative | metabolism of methadone. We utilized a baculovirus-insect | activity in the N-demethylation of methadone. Of the 23 | demonstrated no significant difference in intrinsic clearance

关键词： CYP3A4 variants | drug‐metabolizing enzyme | genetic polymorphisms | intrinsic clearance | methadone metabolism | drug-metabolizing enzyme

摘要： cells and in STZ-induced mice. Furthermore, in vitro | unexplained. Methods: In this investigation, the regulation | of trilobatin on glucose metabolism of insulin | , hexokinase (HK), and pyruvate kinase (PK) activity in IR | -HepG2 cells. Among them, the HK and PK activity in IR

关键词： trilobatin | glucose metabolism | insulin resistance | oxidative stress | PI3K/Akt/GSK-3 beta pathway | Nrf2/Keap-1 pathway

摘要： plant morphogenesis in tissue culture. In-vitro | . paradoxa cultivated in-vitro. We compared the morphogenic | the photosynthetic and antioxidant metabolism of C | fluorescence, and antioxidant enzyme activities in explants | resulted in the highest number (5.44) and average length

关键词： Chlorophyll | Light-emitting diodes | Photosystem | Micropropagation | Rhamnaceae

摘要： pathway can affect liver metabolism in healthy livers | primary hepatocytes in vitro. We employed toxicological | and in adult tissues. In the liver, dysregulation of | . Recent studies also suggest that disturbances in the Hh | effects of Hh modulators on healthy hepatocytes. In our

关键词： Hedgehog signaling | Hepatocytes | Human | Murine | Modulator | Activator | Inhibitor

摘要： contractile ability in vitro and facilitate angiogenesis in | The smooth muscle cells (SMCs) located in the | crucial role in vascular wall remodeling and blood | markers alpha-SMA and SM22 in MSCs. These cells exhibit | the Matrigel plug assay in vivo. The contraction of

关键词： cyclic stretch | energy metabolism | mesenchymal stem cells | mitochondrial dynamics | smooth muscle cells

摘要： characterization of the metabolites.ResultsThrough in vitro | vitro metabolites of isotonitazene in camels | raising concerns about potential misuse and doping in | metabolism of these substances is critical for developing | animal welfare.MethodsIn vitro studies were conducted

关键词： camel racing | doping control | in vitro metabolism | isotonitazene | LC-HRMS | psychoactive substances | LC‐HRMS

摘要： using in vitro and in vivo assays. L. lactis subsp | and proteins involved in lipid metabolism and | In this study, the potential anti-obesity | 3T3-L1 cells by 67%. In an in vivo model of high-fat | significantly downregulated in peri-epididymal adipose tissue

关键词： Probiotics | Anti-obesity | Body weight | High-fat diet | Adipocyte differentiation

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： in vitro* metabolism of arolyl-derived F-NPS, and* | this issue, in this study, the in vitro* phase I* | theoretical support for predicting their in vivo metabolism | representative synthetic opioids in third-generation drugs | " fatal dose and parent drug levels in biological

摘要： hepatic and extrahepatic clearances via in vitro* to in* | . However, research gaps remain regarding its metabolism | Phase I metabolism* of psilocin and estimated its* | for 80.9% of the total hepatic metabolism* of* | Phase I metabolism* of psilocin. Total MAO-A-mediated*

摘要：In hepatic drug metabolism, cytochrome P450 | CYP3A4 allelic variants on the in vitro* oxidative* | metabolism of methadone. We utilized a baculovirus-insect | activity in the N-demethylation of methadone. Of the 23 | demonstrated no significant difference in intrinsic clearance

摘要： cells and in STZ-induced mice. Furthermore, in vitro | unexplained. Methods: In this investigation, the regulation | of trilobatin on glucose metabolism* of insulin* | , hexokinase (HK), and pyruvate kinase (PK) activity in IR | -HepG2 cells. Among them, the HK and PK activity in IR

摘要： plant morphogenesis in tissue culture. In-vitro | . paradoxa cultivated in-vitro. We compared the morphogenic | the photosynthetic and antioxidant metabolism* of C* | fluorescence, and antioxidant enzyme activities in explants | resulted in the highest number (5.44) and average length

摘要： pathway can affect liver metabolism* in healthy livers* | primary hepatocytes in vitro. We employed toxicological | and in adult tissues. In the liver, dysregulation of | . Recent studies also suggest that disturbances in the Hh | effects of Hh modulators on healthy hepatocytes. In our

摘要： contractile ability in vitro* and facilitate angiogenesis in* | The smooth muscle cells (SMCs) located in the | crucial role in vascular wall remodeling and blood | markers alpha-SMA and SM22 in MSCs. These cells exhibit | the Matrigel plug assay in vivo. The contraction of

摘要： characterization of the metabolites.ResultsThrough in vitro | vitro metabolites of isotonitazene in camels | raising concerns about potential misuse and doping in | metabolism of these substances is critical for developing | animal welfare.MethodsIn vitro* studies were conducted*

摘要： using in vitro* and in vivo assays. L. lactis subsp* | and proteins involved in lipid metabolism* and* | In this study, the potential anti-obesity | 3T3-L1 cells by 67%. In an in vivo model of high-fat | significantly downregulated in peri-epididymal adipose tissue