NSTL国家科技图书文献中心

1. Histone deacetylase inhibiting nanoprodrugs for enhanced chemodynamic therapy through multistage downregulating glutathione NSTL国家科技图书文献中心

Liu, Yongxin | Zhang, Xinlu ... - 《International Journal of Biological Macromolecules》 - 2025,305(Pt.2) - 共9页

摘要： release histone* deacetylase (HDAC) inhibitors for* | propose a HDAC* inhibiting nanoprodrug consisting of an* | inhibiting HDAC, thereby suppressing GSH synthesis by | HDAC-inhibiting strategy to achieve GSH depletion for | The unique redox homeostasis in tumor cells

关键词： Reactive oxygen species | Histone deacetylase | Glutathione

2. Multicomponent syntheses enable the discovery of novel quisinostat-derived chemotypes as histone deacetylase inhibitors NSTL国家科技图书文献中心

Stopper, Daniel | Buntrock, Susanna ... - 《European Journal of Medicinal Chemistry》 - 2025,281 - 117045～117045 - 共17页

摘要： novel histone* deacetylase (HDAC) inhibitors derived* | compounds caused hyperacetylation of histone* H3 and alpha* | parasite selectivity (SIMRC-5/Pf3D7 > 2174). HDAC | . Overall, in this work we have identified the HDAC | In this study, we synthesized and evaluated

关键词： Histone deacetylase | HDAC inhibitor | Malaria | Cancer | Multicomponent reaction

3. Histone Deacetylase 9 Deletion Inhibits Hepatic Steatosis and Adipose Tissue Inflammation in Male Diet-Induced Obese Mice NSTL国家科技图书文献中心

Hu, Siqi | Kang, Hyunju ... - 《Journal of gastroenterology and hepatology》 - 2025,40(3) - 741～749 - 共9页

摘要： role of histone* deacetylase 9 (HDAC9) in the* | AimThe goal of this study was to determine the | development of diet-induced metabolic dysfunction-associated | steatohepatitis (MASH) and white adipose tissue (WAT | ) dysfunctions.MethodsWe fed male and female mice with global Hdac9

关键词： fibrosis | histone deacetylase 9 | inflammation | obesity | steatosis

4. Development of Ethyl-Hydrazide-Based Selective Histone Deacetylase 6 (HDAC6) PROTACs NSTL国家科技图书文献中心

Stopper, Daniel | Honin, Irina ... - 《ACS medicinal chemistry letters》 - 2025,16(3) - 487～495 - 共9页

摘要：Histone deacetylases (HDACs) are promising | selective HDAC6 degradation over other HDAC* isoforms.* | targets for epigenetic drug discovery. Additionally | , targeted degradation of HDACs has emerged as a novel | approach in medicinal chemistry and chemical biology

关键词： histone deacetylase (HDAC) | HDAC degradation | proteolysis targeting chimeras (PROTACs) | targeted proteindegradation (TPD) | zinc-binding group (ZBG)

5. Histone Deacetylase 2 Stabilizes SPARC-related Modular Calcium Binding 2 to Promote Metastasis and Stemness in Gallbladder Cancer NSTL国家科技图书文献中心

Feng, Ji | Zheng, Xueyong - 《Current molecular medicine》 - 2025,25(1) - 56～68 - 共13页

摘要： relationship between histone* deacetylase 2 (HDAC2) and SPARC* | Background We aimed to investigate the | -related modular calcium binding 2 (SMOC2) and the role | of SMOC2 in gallbladder cancer (GBC).Methods The | expression of HDAC2 and SMOC2 in GBC and normal cells was

关键词： Histone deacetylase 2 | SPARC-related modular calcium binding 2 | deacetylation | metastasis | stemness | gallbladder c & aacute;ncer

6. Development of an 18 F-labeled 5-aroylindole derivative for histone deacetylase 6 imaging in spinocerebellar ataxia NSTL国家科技图书文献中心

Yu, Hung-Man | Lin, Kun-Liang ... - 《Applied radiation and isotopes》 - 2025,217 - 共6页

摘要：Histone deacetylase 6 (HDAC6) is an enzyme | crucial in epigenetic regulation and protein degradation | , with implications in various cancers and | neurodegenerative disorders. While HDAC6 is recognized as a | promising therapeutic target for Parkinson's and

关键词： Histone deacetylase 6 | Spinocerebellar ataxia | Positron emission tomography | Epigenetic | Fluorine-18

7. Histone deacetylase MdHDT3 suppresses ethylene biosynthesis by deacetylating MdACS1 and MdACO1 during apple fruit ripening NSTL国家科技图书文献中心

Wang, Yuqing | Sun, Jiamao ... - 《Postharvest Biology and Technology》 - 2025,219 - 共10页

摘要： histone deacetylase inhibitor sodium butyrate to | the effects of a specific histone* deacetylase on* | mechanism by which the histone* deacetylase MdHDT3 inhibits* | identify histone* deacetylases. Additionally, we examined* | six histone* deacetylases identified in the apple*

关键词： Histone deacetylate | MdHDT3 | Ethylene | Fruit ripening | MdACS1 | MdACO1

8. Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotection NSTL国家科技图书文献中心

Park, Yeongwon | Yu, Shangfei ... - 《Molecular & Cellular Toxicology》 - 2025,21(1) - 1～9 - 共9页

摘要： vulnerable to progressive neurodegeneration. Histone | from histones or non-histone* proteins for the* | deacetylases (HDAC) are the enzymes that remove acetyl group | transcriptional control. Thus, HDAC* inhibitors (HDACi) have been* | BackgroundNeurodegenerative diseases show

关键词： HDAC inhibitors | Bioenergetics | Neuroinflammation | Neurodegeneration | Neuroprotection

9. Protective effects of ginsenoside Rd on inflammation and mitochondrial dysfunction in lipopolysaccharide-induced microglial activation through histone deacetylase 5-mediated signaling NSTL国家科技图书文献中心

Park, Jimin | Moon, Chae Young ... - 《Food Bioscience》 - 2025,66 - 共9页

摘要：) phosphorylation, thereby enhancing histone* deacetylase 5 (HDAC5* | Neuroinflammation and mitochondrial | dysfunction are key drivers of neurodegenerative diseases | , often orchestrated by epigenetic modifications. This | study investigated the protective effects of

关键词： Ginsenoside Rd | Microglia | Neuroinflammation | Mitochondrial function | Histone deacetylase 5 | AMP-activated protein kinase

10. The Impact of the Histone Deacetylase Inhibitor-Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia-Ischemia NSTL国家科技图书文献中心

Ziabska, Karolina | Gewartowska, Magdale...... - 《Molecular Neurobiology》 - 2025,62(4) - 5216～5233 - 共18页

摘要： histone deacetylase inhibitor (HDACi)-sodium butyrate | Perinatal asphyxia is one of the most | important causes of morbidity and mortality in newborns | . One of the key pathogenic factors in hypoxic | -ischemic (HI) brain injury is the inflammatory reaction

摘要： release histone* deacetylase (HDAC) inhibitors for* | propose a HDAC* inhibiting nanoprodrug consisting of an* | inhibiting HDAC, thereby suppressing GSH synthesis by | HDAC-inhibiting strategy to achieve GSH depletion for | The unique redox homeostasis in tumor cells

关键词： Reactive oxygen species | Histone deacetylase | Glutathione

摘要： novel histone* deacetylase (HDAC) inhibitors derived* | compounds caused hyperacetylation of histone* H3 and alpha* | parasite selectivity (SIMRC-5/Pf3D7 > 2174). HDAC | . Overall, in this work we have identified the HDAC | In this study, we synthesized and evaluated

关键词： Histone deacetylase | HDAC inhibitor | Malaria | Cancer | Multicomponent reaction

摘要： role of histone* deacetylase 9 (HDAC9) in the* | AimThe goal of this study was to determine the | development of diet-induced metabolic dysfunction-associated | steatohepatitis (MASH) and white adipose tissue (WAT | ) dysfunctions.MethodsWe fed male and female mice with global Hdac9

关键词： fibrosis | histone deacetylase 9 | inflammation | obesity | steatosis

摘要：Histone deacetylases (HDACs) are promising | selective HDAC6 degradation over other HDAC* isoforms.* | targets for epigenetic drug discovery. Additionally | , targeted degradation of HDACs has emerged as a novel | approach in medicinal chemistry and chemical biology

关键词： histone deacetylase (HDAC) | HDAC degradation | proteolysis targeting chimeras (PROTACs) | targeted proteindegradation (TPD) | zinc-binding group (ZBG)

摘要： relationship between histone* deacetylase 2 (HDAC2) and SPARC* | Background We aimed to investigate the | -related modular calcium binding 2 (SMOC2) and the role | of SMOC2 in gallbladder cancer (GBC).Methods The | expression of HDAC2 and SMOC2 in GBC and normal cells was

关键词： Histone deacetylase 2 | SPARC-related modular calcium binding 2 | deacetylation | metastasis | stemness | gallbladder c & aacute;ncer

摘要：Histone deacetylase 6 (HDAC6) is an enzyme | crucial in epigenetic regulation and protein degradation | , with implications in various cancers and | neurodegenerative disorders. While HDAC6 is recognized as a | promising therapeutic target for Parkinson's and

关键词： Histone deacetylase 6 | Spinocerebellar ataxia | Positron emission tomography | Epigenetic | Fluorine-18

摘要： histone deacetylase inhibitor sodium butyrate to | the effects of a specific histone* deacetylase on* | mechanism by which the histone* deacetylase MdHDT3 inhibits* | identify histone* deacetylases. Additionally, we examined* | six histone* deacetylases identified in the apple*

关键词： Histone deacetylate | MdHDT3 | Ethylene | Fruit ripening | MdACS1 | MdACO1

摘要： vulnerable to progressive neurodegeneration. Histone | from histones or non-histone* proteins for the* | deacetylases (HDAC) are the enzymes that remove acetyl group | transcriptional control. Thus, HDAC* inhibitors (HDACi) have been* | BackgroundNeurodegenerative diseases show

关键词： HDAC inhibitors | Bioenergetics | Neuroinflammation | Neurodegeneration | Neuroprotection

摘要：) phosphorylation, thereby enhancing histone* deacetylase 5 (HDAC5* | Neuroinflammation and mitochondrial | dysfunction are key drivers of neurodegenerative diseases | , often orchestrated by epigenetic modifications. This | study investigated the protective effects of

关键词： Ginsenoside Rd | Microglia | Neuroinflammation | Mitochondrial function | Histone deacetylase 5 | AMP-activated protein kinase

摘要： histone deacetylase inhibitor (HDACi)-sodium butyrate | Perinatal asphyxia is one of the most | important causes of morbidity and mortality in newborns | . One of the key pathogenic factors in hypoxic | -ischemic (HI) brain injury is the inflammatory reaction

关键词： Neonatal Hypoxia-Ischemia | Histone Deacetylase Inhibitors | Sodium Butyrate | Complement System | Synaptic Proteins

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： release histone deacetylase (HDAC) inhibitors for | propose a HDAC inhibiting nanoprodrug consisting of an | inhibiting HDAC, thereby suppressing GSH synthesis by | HDAC-inhibiting strategy to achieve GSH depletion for | The unique redox homeostasis in tumor cells

关键词： Reactive oxygen species | Histone deacetylase | Glutathione

摘要： novel histone deacetylase (HDAC) inhibitors derived | compounds caused hyperacetylation of histone H3 and alpha | parasite selectivity (SIMRC-5/Pf3D7 > 2174). HDAC | . Overall, in this work we have identified the HDAC | In this study, we synthesized and evaluated

关键词： Histone deacetylase | HDAC inhibitor | Malaria | Cancer | Multicomponent reaction

摘要： role of histone deacetylase 9 (HDAC9) in the | AimThe goal of this study was to determine the | development of diet-induced metabolic dysfunction-associated | steatohepatitis (MASH) and white adipose tissue (WAT | ) dysfunctions.MethodsWe fed male and female mice with global Hdac9

关键词： fibrosis | histone deacetylase 9 | inflammation | obesity | steatosis

摘要：Histone deacetylases (HDACs) are promising | selective HDAC6 degradation over other HDAC isoforms. | targets for epigenetic drug discovery. Additionally | , targeted degradation of HDACs has emerged as a novel | approach in medicinal chemistry and chemical biology

关键词： histone deacetylase (HDAC) | HDAC degradation | proteolysis targeting chimeras (PROTACs) | targeted proteindegradation (TPD) | zinc-binding group (ZBG)

摘要： relationship between histone deacetylase 2 (HDAC2) and SPARC | Background We aimed to investigate the | -related modular calcium binding 2 (SMOC2) and the role | of SMOC2 in gallbladder cancer (GBC).Methods The | expression of HDAC2 and SMOC2 in GBC and normal cells was

关键词： Histone deacetylase 2 | SPARC-related modular calcium binding 2 | deacetylation | metastasis | stemness | gallbladder c & aacute;ncer

摘要：Histone deacetylase 6 (HDAC6) is an enzyme | crucial in epigenetic regulation and protein degradation | , with implications in various cancers and | neurodegenerative disorders. While HDAC6 is recognized as a | promising therapeutic target for Parkinson's and

关键词： Histone deacetylase 6 | Spinocerebellar ataxia | Positron emission tomography | Epigenetic | Fluorine-18

摘要： histone deacetylase inhibitor sodium butyrate to | the effects of a specific histone deacetylase on | mechanism by which the histone deacetylase MdHDT3 inhibits | identify histone deacetylases. Additionally, we examined | six histone deacetylases identified in the apple

关键词： Histone deacetylate | MdHDT3 | Ethylene | Fruit ripening | MdACS1 | MdACO1

摘要： vulnerable to progressive neurodegeneration. Histone | from histones or non-histone proteins for the | deacetylases (HDAC) are the enzymes that remove acetyl group | transcriptional control. Thus, HDAC inhibitors (HDACi) have been | BackgroundNeurodegenerative diseases show

关键词： HDAC inhibitors | Bioenergetics | Neuroinflammation | Neurodegeneration | Neuroprotection

摘要：) phosphorylation, thereby enhancing histone deacetylase 5 (HDAC5 | Neuroinflammation and mitochondrial | dysfunction are key drivers of neurodegenerative diseases | , often orchestrated by epigenetic modifications. This | study investigated the protective effects of

关键词： Ginsenoside Rd | Microglia | Neuroinflammation | Mitochondrial function | Histone deacetylase 5 | AMP-activated protein kinase

摘要： histone deacetylase inhibitor (HDACi)-sodium butyrate | Perinatal asphyxia is one of the most | important causes of morbidity and mortality in newborns | . One of the key pathogenic factors in hypoxic | -ischemic (HI) brain injury is the inflammatory reaction

关键词： Neonatal Hypoxia-Ischemia | Histone Deacetylase Inhibitors | Sodium Butyrate | Complement System | Synaptic Proteins

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： release histone* deacetylase (HDAC) inhibitors for* | propose a HDAC* inhibiting nanoprodrug consisting of an* | inhibiting HDAC, thereby suppressing GSH synthesis by | HDAC-inhibiting strategy to achieve GSH depletion for | The unique redox homeostasis in tumor cells

摘要： novel histone* deacetylase (HDAC) inhibitors derived* | compounds caused hyperacetylation of histone* H3 and alpha* | parasite selectivity (SIMRC-5/Pf3D7 > 2174). HDAC | . Overall, in this work we have identified the HDAC | In this study, we synthesized and evaluated

摘要： role of histone* deacetylase 9 (HDAC9) in the* | AimThe goal of this study was to determine the | development of diet-induced metabolic dysfunction-associated | steatohepatitis (MASH) and white adipose tissue (WAT | ) dysfunctions.MethodsWe fed male and female mice with global Hdac9

摘要：Histone deacetylases (HDACs) are promising | selective HDAC6 degradation over other HDAC* isoforms.* | targets for epigenetic drug discovery. Additionally | , targeted degradation of HDACs has emerged as a novel | approach in medicinal chemistry and chemical biology

摘要： relationship between histone* deacetylase 2 (HDAC2) and SPARC* | Background We aimed to investigate the | -related modular calcium binding 2 (SMOC2) and the role | of SMOC2 in gallbladder cancer (GBC).Methods The | expression of HDAC2 and SMOC2 in GBC and normal cells was

摘要： histone deacetylase inhibitor sodium butyrate to | the effects of a specific histone* deacetylase on* | mechanism by which the histone* deacetylase MdHDT3 inhibits* | identify histone* deacetylases. Additionally, we examined* | six histone* deacetylases identified in the apple*

摘要： vulnerable to progressive neurodegeneration. Histone | from histones or non-histone* proteins for the* | deacetylases (HDAC) are the enzymes that remove acetyl group | transcriptional control. Thus, HDAC* inhibitors (HDACi) have been* | BackgroundNeurodegenerative diseases show

摘要：) phosphorylation, thereby enhancing histone* deacetylase 5 (HDAC5* | Neuroinflammation and mitochondrial | dysfunction are key drivers of neurodegenerative diseases | , often orchestrated by epigenetic modifications. This | study investigated the protective effects of