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1. The interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from anti-viral protection to spondyloarthritis SCIE Web of Science核心 SCOPUS Scopus数据库 NSTL国家科技图书文献中心

Vitulano, C. | Tedeschi, V.... - 《Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology》 - 2017,190(3) - 281～290 - 共10页 - 被引量：32

摘要： interaction between HLA-B27 and ERAP1, but not between HLA | observations suggest a paramount centrality for the HLA-B27 | and, as a by-product, elicits HLA-B27* aberrant* | HLA-B27 in autoimmunity and viral protection | The human leukocyte antigen class I gene HLA

关键词： ankylosing spondylitis | autoimmunity | endoplasmic reticulum aminopeptidases | HLA-B27

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2. An HLA-B27 Homodimer Specific Antibody Recognizes a Discontinuous Mixed-Disulfide Epitope as Identified by Affinity-Mass Spectrometry SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Iurascu, Marius-Ionu... | Belaunzanar, Osiris ...... - 《Journal of the American Society for Mass Spectrometry》 - 2016,27(6) - 1105～1112 - 共8页 - 被引量：7

摘要：HLA-B27 homodimer formation is believed to be | a hallmark of HLA-B27* associated* | that HLA-B27* homodimer complexes are present on* | monocytes of healthy HLA-B27* gene carriers at low levels* | between correctly formed HLA-B27* heterotrimers and*

关键词： Affinity mass spectrometry | Proteolytic epitope excision | HLA B27 | Ankylosing Spondylitis | Mixed-disulfide linked epitope | Affinity quantification

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3. HLA-B27 SCOPUS Scopus数据库 SCIE Web of Science核心 NSTL国家科技图书文献中心

Bowness, Paul - 《Annual Review of Immunology》 - 2015,33 - 29～48 - 共20页 - 被引量：144

摘要： explain the role of HLA-B27* in AS pathogenesis. The* | of HLA-B27* of presenting antigenic peptides to* | cytotoxic T cells. Thus, HLA-B27-restricted immune | homodimers (B27(2)) can also be expressed at the cell | describes the natural function of HLA-B27, its disease

关键词： ankylosing spondylitis | spondyloarthritis | arthritogenic peptide | antigen presentation | homodimer

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4. HLA-B27 polymorphism at position 116 critically influences the association with TAP/tapasin, intracellular trafficking and conformational homodimers formation. SCIE Web of Science核心 NSTL国家科技图书文献中心

Blanco-Gelaz MA | Suarez-Alvarez B ... - 《Molecular Immunology》 - 2009,46(7) - 1304～1311 - 共8页

摘要：HLA-B27 confers susceptibility to ankylosing | homodimer formation among HLA-B27* subtypes. We found that* | theabsence of tapasin. This study suggests that HLA-B27 | that of B2705. All B27 subtypes examined were unable* | intracellular maturation and expressions of homodimers.

关键词： tapasin | Intracellular | Molecular Conformation | HLA-B27 Antigen | Relationship by association

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5. HLA-B27 and the pathogenesis of spondyloarthropathies. NSTL国家科技图书文献中心

de-Castro JA - 《Immunology Letters》 - 2007,108(1) - 27～33 - 共7页

摘要：The association of HLA-B27* with ankylosing* | pathogenetic role of HLA-B27* will be discussed. They focus on* | . HLA-B27* misfolding would trigger disease through* | HLA-B27 will eventually be explained through a | covalent heavy chain homodimers* amenable to recognition*

关键词： HLA-B27 Antigen | Pathogenesis | Relationship by association | receptor | Molecule | HLA-B27抗原

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6. Animal models of HLA-B27-associated diseases: new outcomes. SCIE Web of Science核心 NSTL国家科技图书文献中心

Hacquard Bouder C | Ittah M ... - 《Joint, bone, spine: revue du rhumatisme》 - 2006,73(2) - 132～138 - 共7页

摘要：The HLA-B27* molecule is strongly associated* | HLA-B27 likely play an important role. Indeed, APC | linked to HLA-B27* have been developed in mice. The* | frequency in the presence of an HLA-B27 transgene. The HLA | , homodimers* of B27 heavy chains could be implicated in the*

关键词： HLA-B27 Antigen | T-Lymphocytes | APC Gene | Laboratory mice | HLA-B27抗原 | T淋巴细胞

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7. Formation of HLA-B27 homodimers and their relationship to assembly kinetics SCIE Web of Science核心 NSTL国家科技图书文献中心

Antoniou AN. | Ford S.... - 《The Journal of biological chemistry》 - 2004,279(10) - 8895～8902 - 共8页

摘要：The human HLA-B27* class I molecule exhibits a* | characteristic of HLA-B27* is its ability to form heavy chain* | HLA-B27, that homodimer formation involves not only | of HLA-B27. Finally, we report an association | between unfolded HLA-B27* molecules and immunoglobulin*

关键词： Class-i molecules | Unfolded protein response | Cd4(+) t-lymphocytes | Ankylosing-spondylitis | Endoplasmic-reticulum | Cell-surface | Inflammatory disease | Monoclonal-antibody | Heavy-chains | Antigen presentation

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8. The recognition of abnormal forms of HLA-B27 by CD4+ T cells. NSTL国家科技图书文献中心

Boyle LH | Goodall JC ... - 《Current molecular medicine》 - 2004,4(1) - 51～58 - 共8页

摘要：, specifically HLA-B27* homodimers, might mimic MHC class II* | The MHC class I molecule, HLA-B27* can be* | addition to conventional HLA-B27* heterodimers presenting* | . Surprisingly, HLA-B27* transgenic animal models implicated CD4* | is that non-conventional forms of HLA-B27

关键词： HLA-B27 Antigen | T-Lymphocytes | Antigens | CD4 | Myosin Heavy Chains | HLA-B27抗原 | T淋巴细胞 | 抗原 | 肌球蛋白重链

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9. HLA B27 in health and disease: a double-edged sword? SCIE Web of Science核心 NSTL国家科技图书文献中心

Bowness P - 《Rheumatology》 - 2002,41(8) - 857～868 - 共12页

摘要： spondyloarthropathy express a ligand for HLA* B27 homodimers. These | allele HLA B27 with ankylosing spondylitis (AS) has* | pathogenic mechanism linking HLA* B27 with AS and other* | principal natural function of HLA* B27 is an immunologic* | present them to T lymphocytes. I have shown that HLA B27

关键词： HLA-B27 Antigen | Spondylitis | Ankylosing | HLA-B27抗原 | 脊柱炎 | 强直性

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10. Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure. SCIE Web of Science核心 NSTL国家科技图书文献中心

Allen RL | O'Callaghan CA ... - 《The Journal of Immunology: Official Journal of the American Association of Immunologists》 - 1999,162(9) - 5045～5048 - 共4页

摘要：, HLA-B27* heavy chain homodimers (termed HC-B27) were* | HLA-B27 has a striking association with | inflammatory arthritis. We show that free HLA-B27* heavy* | -reactive free heavy chains at the surface of HLA-B27 | explain the ability of HLA-B27* to induce*

关键词： beta 2-Microglobulin | HLA-B27 Antigen | beta-2-Microglobulin | Disulfides | β2微球蛋白 | HLA-B27抗原

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摘要： interaction between HLA-B27 and ERAP1, but not between HLA | observations suggest a paramount centrality for the HLA-B27 | and, as a by-product, elicits HLA-B27 aberrant | HLA-B27 in autoimmunity and viral protection | The human leukocyte antigen class I gene HLA

关键词： ankylosing spondylitis | autoimmunity | endoplasmic reticulum aminopeptidases | HLA-B27

摘要：HLA-B27 homodimer formation is believed to be | a hallmark of HLA-B27 associated | that HLA-B27 homodimer complexes are present on | monocytes of healthy HLA-B27 gene carriers at low levels | between correctly formed HLA-B27 heterotrimers and

关键词： Affinity mass spectrometry | Proteolytic epitope excision | HLA B27 | Ankylosing Spondylitis | Mixed-disulfide linked epitope | Affinity quantification

摘要： explain the role of HLA-B27 in AS pathogenesis. The | of HLA-B27 of presenting antigenic peptides to | cytotoxic T cells. Thus, HLA-B27-restricted immune | homodimers (B27(2)) can also be expressed at the cell | describes the natural function of HLA-B27, its disease

关键词： ankylosing spondylitis | spondyloarthritis | arthritogenic peptide | antigen presentation | homodimer

摘要：HLA-B27 confers susceptibility to ankylosing | homodimer formation among HLA-B27 subtypes. We found that | theabsence of tapasin. This study suggests that HLA-B27 | that of B*2705. All B27 subtypes examined were unable | intracellular maturation and expressions of homodimers.

关键词： tapasin | Intracellular | Molecular Conformation | HLA-B27 Antigen | Relationship by association

摘要：The association of HLA-B27 with ankylosing | pathogenetic role of HLA-B27 will be discussed. They focus on | . HLA-B27 misfolding would trigger disease through | HLA-B27 will eventually be explained through a | covalent heavy chain homodimers amenable to recognition

关键词： HLA-B27 Antigen | Pathogenesis | Relationship by association | receptor | Molecule | HLA-B27抗原

摘要：The HLA-B27 molecule is strongly associated | HLA-B27 likely play an important role. Indeed, APC | linked to HLA-B27 have been developed in mice. The | frequency in the presence of an HLA-B27 transgene. The HLA | , homodimers of B27 heavy chains could be implicated in the

关键词： HLA-B27 Antigen | T-Lymphocytes | APC Gene | Laboratory mice | HLA-B27抗原 | T淋巴细胞

摘要：The human HLA-B27 class I molecule exhibits a | characteristic of HLA-B27 is its ability to form heavy chain | HLA-B27, that homodimer formation involves not only | of HLA-B27. Finally, we report an association | between unfolded HLA-B27 molecules and immunoglobulin

关键词： Class-i molecules | Unfolded protein response | Cd4(+) t-lymphocytes | Ankylosing-spondylitis | Endoplasmic-reticulum | Cell-surface | Inflammatory disease | Monoclonal-antibody | Heavy-chains | Antigen presentation

摘要：, specifically HLA-B27 homodimers, might mimic MHC class II | The MHC class I molecule, HLA-B27 can be | addition to conventional HLA-B27 heterodimers presenting | . Surprisingly, HLA-B27 transgenic animal models implicated CD4 | is that non-conventional forms of HLA-B27

关键词： HLA-B27 Antigen | T-Lymphocytes | Antigens | CD4 | Myosin Heavy Chains | HLA-B27抗原 | T淋巴细胞 | 抗原 | 肌球蛋白重链

关键词： HLA-B27 Antigen | Spondylitis | Ankylosing | HLA-B27抗原 | 脊柱炎 | 强直性

摘要：, HLA-B27 heavy chain homodimers (termed HC-B27) were | HLA-B27 has a striking association with | inflammatory arthritis. We show that free HLA-B27 heavy | -reactive free heavy chains at the surface of HLA-B27 | explain the ability of HLA-B27 to induce

关键词： beta 2-Microglobulin | HLA-B27 Antigen | beta-2-Microglobulin | Disulfides | β2微球蛋白 | HLA-B27抗原

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： interaction between HLA-B27 and ERAP1, but not between HLA | observations suggest a paramount centrality for the HLA-B27 | and, as a by-product, elicits HLA-B27* aberrant* | HLA-B27 in autoimmunity and viral protection | The human leukocyte antigen class I gene HLA

摘要：HLA-B27 homodimer formation is believed to be | a hallmark of HLA-B27* associated* | that HLA-B27* homodimer complexes are present on* | monocytes of healthy HLA-B27* gene carriers at low levels* | between correctly formed HLA-B27* heterotrimers and*

摘要： explain the role of HLA-B27* in AS pathogenesis. The* | of HLA-B27* of presenting antigenic peptides to* | cytotoxic T cells. Thus, HLA-B27-restricted immune | homodimers (B27(2)) can also be expressed at the cell | describes the natural function of HLA-B27, its disease

摘要：HLA-B27 confers susceptibility to ankylosing | homodimer formation among HLA-B27* subtypes. We found that* | theabsence of tapasin. This study suggests that HLA-B27 | that of B2705. All B27 subtypes examined were unable* | intracellular maturation and expressions of homodimers.

摘要：The association of HLA-B27* with ankylosing* | pathogenetic role of HLA-B27* will be discussed. They focus on* | . HLA-B27* misfolding would trigger disease through* | HLA-B27 will eventually be explained through a | covalent heavy chain homodimers* amenable to recognition*

摘要：The HLA-B27* molecule is strongly associated* | HLA-B27 likely play an important role. Indeed, APC | linked to HLA-B27* have been developed in mice. The* | frequency in the presence of an HLA-B27 transgene. The HLA | , homodimers* of B27 heavy chains could be implicated in the*

摘要：The human HLA-B27* class I molecule exhibits a* | characteristic of HLA-B27* is its ability to form heavy chain* | HLA-B27, that homodimer formation involves not only | of HLA-B27. Finally, we report an association | between unfolded HLA-B27* molecules and immunoglobulin*

摘要：, specifically HLA-B27* homodimers, might mimic MHC class II* | The MHC class I molecule, HLA-B27* can be* | addition to conventional HLA-B27* heterodimers presenting* | . Surprisingly, HLA-B27* transgenic animal models implicated CD4* | is that non-conventional forms of HLA-B27

摘要：, HLA-B27* heavy chain homodimers (termed HC-B27) were* | HLA-B27 has a striking association with | inflammatory arthritis. We show that free HLA-B27* heavy* | -reactive free heavy chains at the surface of HLA-B27 | explain the ability of HLA-B27* to induce*