NSTL国家科技图书文献中心

1. Targeted Colon Cancer and Chemotherapeutic Through Metal Glycoconjugates:Design,Synthesis,Molecular Docking,and DFT Investigations NSTL国家科技图书文献中心

Waad A.Al-Otaibi | Sahar M.Al Motwaa ... - 《Applied Organometallic Chemistry》 - 2025,39(3) - e70000～33 - 共33页

摘要： against two colon cell lines(HCT-116* and Caco-2 | /mL against HCT-116 and 49.53 μg/mL against Caco-2* | in combating colon cancer(HCT-116)through | recognition binding site and* enhance the effectiveness of* | effect.Newly synthesized complexes with the formulae Zn(HL)2

关键词： glucose transporter | HCT-116 and Caco-2 | metal glycoconjugates | microbiological screening | molecular docking

2. 6-Paradol enhances sorafenib's effects against colorectal cancer and promotes active metabolite formation NSTL国家科技图书文献中心

Mehanna, Mohamed G. | El-Halawany, Ali M.... - 《Pathology Research and Practice》 - 2025,269 - Article 155876～Article 155876 - 共10页

摘要： accumulation in CaCo-2, HCT-116, and* HT-29. Co-incubation* | (HT-29, HCT-116, LS-174T, CaCo-2). Result: Sorafenib | enhanced its effect in HT-29 and* HCT-116 cells, reducing* | colorectal cancer (CRC) cell lines (HT-29, HCT-116, LS-174T | , CaCo-2) through its effects on cellular processes

关键词： Colorectal cancer | Cell line | 6-Paradol | Sorafenib

3. Synthesis of novel benzimidazole-based retrochalcones and their anticancer activity against breast and colon cancer NSTL国家科技图书文献中心

Kone, Aboudramane | Souleymane, Coulibal...... - 《Synthetic Communications》 - 2025,55(1/4) - 175～182 - 共8页

摘要：) and* human colon (Caco-2, HCT-116) cancer cell lines | , compound 6e was inactive against both Caco-2 and MDA-MB* | retrochalcones (6a-g) was synthesized and* evaluated for their* | A series of novel 3-benzimidazolyl | anticancer activities against breast (MDA-MB-231, MCF-7

关键词： Benzimidazole retrochalcones | anticancer activity | breast cancer | colon cancer | drug resistance

4. The m6A methyltransferase METTL3 modifies Kcnk6 promoting on inflammation associated carcinogenesis is essential for colon homeostasis and defense system through histone lactylation dependent YTHDF2 binding NSTL国家科技图书文献中心

Yuan, Xiaolong | Wang, Qiong ... - 《International reviews of immunology》 - 2025,44(1) - 1～16 - 共16页

摘要： viability and* proliferation in HCT-116 or Caco-2 cells* | Inflammation induces tumor formation and* plays* | a crucial role in tumor progression and* prognosis* | study aims to elucidate the effects and* biological* | and the defense system. To induce colitis, mice were

关键词： Inflammation associated carcinogenesis | KCNK6 | lactylation | METTL3 | YTHDF2

5. Modulation of autophagy and apoptosis can contribute to the anticancer effect of Abemaciclib/Celecoxib combination in colon cancer cells NSTL国家科技图书文献中心

Alian, Dalia Mohamed... | Helmy, Maged W.... - 《Medical oncology.》 - 2024,41(2) - Article 43～Article 43 - 共6页 - 被引量：4

摘要： interplay between them in HCT-116* and Caco-2 cell lines | -116 and Caco-2 cells with Abemaciclib, Celecoxib | and 92.67 mu M, respectively, while for Caco-2 cells | of Beclin-1, LC3, Cox-2, and Bcl-2. Active Caspase* | assessed by quantitative real-time PCR. In HCT-116* cells*

关键词： Colon Cancer | Abemaciclib | Celecoxib | Autophagy | Apoptosis | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | EPITHELIAL-MESENCHYMAL TRANSITION | NF-KAPPA-B | COLORECTAL-CANCER | CELECOXIB SUPPRESSES...

6. 6-Shogaol improves sorafenib efficacy in colorectal cancer cells by modulating its cellular accumulation and metabolism NSTL国家科技图书文献中心

Mehanna M.G. | El-Halawany A.M.... - 《Pathology Research and Practice》 - 2024,262 - 155520～155520 - 共6页

摘要： lines (HT-29, HCT-116, CaCo-2, and* LS174T) through its* | increased c-PARP and pro-caspase-3 concentrations in HCT | CaCo-2 cells compared to alone. Sorafenib | ? 2024 Elsevier GmbHCarcinoma of the colon and | against Raf, VEGF, and* PDGF pathways in hepatocellular*

关键词： 6-Shogaol | Apoptosis | Cancer cell line | Colorectal cancer | Sorafenib

7. Design, semi-synthesis and bioevaluation of koumine-like derivatives as potential antitumor agents in vitro and in vivo NSTL国家科技图书文献中心

Xu, Xingjun | Yu, Yan ... - 《Future medicinal chemistry》 - 2024,16(14) - 1413～1428 - 共16页

摘要：, HCT-116, HCT-15 and* Caco-2. Results: Most compounds* | compounds were designed, semi-synthesized and | and C5 showed comparable antitumor effects to 5-FU | studies suggested that A4 and* C5 could arrest HT-29 cell* | cycle in G2 phase and* raise reactive oxygen species*

关键词： antitumor | Koumine | structural modification | structure and activity relationship | INDOLE ALKALOIDS | GELSEMIUM | MECHANISM | PATHWAY

8. Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome NSTL国家科技图书文献中心

El Hindi K. | Brachtendorf S.... - 《Biochimica et biophysica acta. Molecular basis of disease: BBA》 - 2024,1870(1) - 166906～166906 - 共6页 - 被引量：2

摘要： cancer (CRC) cells (HCT-116, SW620) but not in non | -metastatic CRC cells (SW480, Caco-2). Downregulation of | Caco-2 cells reduced tumor growth in vivo. Lipidomic | membranes and* deregulated in tumors. In human colon cancer* | tissue ceramide synthase (CerS) 4 and* CerS5 are reduced*

关键词： Biomarker | Lipidomic | Metabolism | Oxidative consumption rate | hypoxia | Proteomic

9. Functional nanoemulsion and nanocomposite microparticles as an anticolorectal cancer and antimicrobial agent: applied in yogurt NSTL国家科技图书文献中心

Hashim, Ayat F. | Abd-Rabou, Ahmed A.... - 《Biomass Conversion and Biorefinery》 - 2024,14(12) - 13233～13249 - 共17页 - 被引量：5

摘要： values against human colorectal cancerous Caco-2 and | HCT 116 cell lines: 1.10 mu g/mL and 15.34 mu g/mL | . Microparticles based on nanoemulsions (M1) and* nanocomposites* | colorectal cancer and* microbial infection. The functional* | (EVOO), probiotics, and* fig leaves extract with sodium*

关键词： Nanoemulsion | Nanocomposite | Microparticles | Anticolorectal cancer | Antimicrobial | VIRGIN OLIVE OIL | ENCAPSULATION EFFICIENCY | OXIDATIVE STABILITY | MICROENCAPSULATION | EXTRACTS...

10. Potential of Nanomedicines as an Alternative for the Treatment of Colorectal Cancer - A Review NSTL国家科技图书文献中心

Costa, Kammila Marti... | Barros, Larissa Alve...... - 《Anti-cancer agents in medicinal chemistry》 - 2024,24(7) - 477～487 - 共11页

摘要： cell lines, such as HCT-116, HT-29, and* CaCo-2* | cancer and* the second in cases of cancer-related death* | of polymeric, lipid, and* inorganic nanoparticles* | ", "SciELO" and* "PubMed/Medline" was performed, resulting* | neoplasms," and "chemotherapy." After inclusion and

关键词： Nanoparticles | drug delivery system | chemotherapy | cancer treatment | 5-fluorouracil | resistance mechanisms | POLYMERIC NANOPARTICLES | CHEMOTHERAPY | NANOTECHNOLOGY | 5-FLUOROURACIL...

摘要： against two colon cell lines(HCT-116 and Caco-2 | /mL against HCT-116 and 49.53 μg/mL against Caco-2 | in combating colon cancer(HCT-116)through | recognition binding site and enhance the effectiveness of | effect.Newly synthesized complexes with the formulae Zn(HL)2

关键词： glucose transporter | HCT-116 and Caco-2 | metal glycoconjugates | microbiological screening | molecular docking

摘要： accumulation in CaCo-2, HCT-116, and HT-29. Co-incubation | (HT-29, HCT-116, LS-174T, CaCo-2). Result: Sorafenib | enhanced its effect in HT-29 and HCT-116 cells, reducing | colorectal cancer (CRC) cell lines (HT-29, HCT-116, LS-174T | , CaCo-2) through its effects on cellular processes

关键词： Colorectal cancer | Cell line | 6-Paradol | Sorafenib

摘要：) and human colon (Caco-2, HCT-116) cancer cell lines | , compound 6e was inactive against both Caco-2 and MDA-MB | retrochalcones (6a-g) was synthesized and evaluated for their | A series of novel 3-benzimidazolyl | anticancer activities against breast (MDA-MB-231, MCF-7

关键词： Benzimidazole retrochalcones | anticancer activity | breast cancer | colon cancer | drug resistance

摘要： viability and proliferation in HCT-116 or Caco-2 cells | Inflammation induces tumor formation and plays | a crucial role in tumor progression and prognosis | study aims to elucidate the effects and biological | and the defense system. To induce colitis, mice were

关键词： Inflammation associated carcinogenesis | KCNK6 | lactylation | METTL3 | YTHDF2

摘要： interplay between them in HCT-116 and Caco-2 cell lines | -116 and Caco-2 cells with Abemaciclib, Celecoxib | and 92.67 mu M, respectively, while for Caco-2 cells | of Beclin-1, LC3, Cox-2, and Bcl-2. Active Caspase | assessed by quantitative real-time PCR. In HCT-116 cells

关键词： Colon Cancer | Abemaciclib | Celecoxib | Autophagy | Apoptosis | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | EPITHELIAL-MESENCHYMAL TRANSITION | NF-KAPPA-B | COLORECTAL-CANCER | CELECOXIB SUPPRESSES...

摘要： lines (HT-29, HCT-116, CaCo-2, and LS174T) through its | increased c-PARP and pro-caspase-3 concentrations in HCT | CaCo-2 cells compared to alone. Sorafenib | ? 2024 Elsevier GmbHCarcinoma of the colon and | against Raf, VEGF, and PDGF pathways in hepatocellular

关键词： 6-Shogaol | Apoptosis | Cancer cell line | Colorectal cancer | Sorafenib

摘要：, HCT-116, HCT-15 and Caco-2. Results: Most compounds | compounds were designed, semi-synthesized and | and C5 showed comparable antitumor effects to 5-FU | studies suggested that A4 and C5 could arrest HT-29 cell | cycle in G2 phase and raise reactive oxygen species