NSTL国家科技图书文献中心

1. Advances in reversible covalent kinase inhibitors NSTL国家科技图书文献中心

Zheng Zhao | Philip E. Bourne - 《Medicinal research reviews》 - 2025,45(2) - 629～653 - 共25页

摘要：Abstract Reversible covalent kinase inhibitors | (RCKIs) are a class of novel kinase inhibitors | show the selectivity of covalent kinase inhibitors | attracting increasing attention because they simultaneously | yet avoid permanent protein‐modification‐induced

关键词： binding modes | drug discovery | kinase inhibitors | privileged warheads | reversible‐covalent kinase inhibitors

2. Therapeutic Insights of Indole Scaffold-Based Compounds as Protein Kinase Inhibitors NSTL国家科技图书文献中心

Dina H.Dawood - 《Chemistry Select》 - 2025,10(5) - e202404767～22 - 共22页

摘要： indole-based anticancer agents as kinase* inhibitors in* | cancerous tissues.Thus,the suppression of the kinase | -kinase* suppression effect.This review presents various* | Cancer is deemed to be one of the most severe | diseases,which is accountable for the elevated mortality

关键词： Anticancer | Indole | Kinase inhibitors

3. Significance of phosphoinositide 3-kinase inhibitors in advanced breast cancer: a systematic review and meta-analysis NSTL国家科技图书文献中心

Naqi, Asma | Khan, Mohammad Ahmed ... - 《Clinical & translational oncology》 - 2025,27(3) - 950～959 - 共10页 - 被引量：1

摘要：BackgroundThe Phosphoinositide 3-kinase* (PI3K* | ) inhibitors* may be used in cancer progression and mortality* | inhibitors in ABC.MethodsThe electronic databases were | co- administration of PI3K inhibitors* with standard* | increased.ConclusionsThe addition of PI3K inhibitors* decreased the risk*

关键词： Advanced Breast Cancer | Phosphoinositide 3-Kinase Pathway | Phosphoinositide 3-Kinase Inhibitors | Randomised Controlled Trial

4. Efficacy and safety of Janus kinase inhibitors in patients with difficult-to-treat rheumatoid arthritis NSTL国家科技图书文献中心

Anno, Shohei | Okano, Tadashi ... - 《Modern rheumatology》 - 2025,35(2) - 225～233 - 共9页

摘要： effectiveness of Janus kinase* inhibitors (JAKi) in patients* | Objectives: This study evaluated the | with difficult-to-treat rheumatoid arthritis (D2T RA | ). Methods: This study included 220 patients with RA who | were treated with JAKi. Sixty-two patients were na

关键词： Difficult-to-treat rheumatoid arthritis | Janus kinase inhibitors | drug retention rate | effectiveness | safety

5. Advances in the design, discovery, and optimization of aurora kinase inhibitors as anticancer agents NSTL国家科技图书文献中心

Verma, Anubhav | Bharatiya, Pradhuman ... - 《Expert opinion on drug discovery》 - 2025,20(4) - 475～497 - 共23页

摘要：, discovery, and development of Aurora kinase inhibitors | IntroductionAurora kinases (AKs) play key | roles during carcinogenesis and show a close | relationship with many cellular effects including mitotic | entry, spindle assembly and chromosomal alignment

关键词： Aurora kinases | Aurora kinase inhibitors | AURK-A | AURK-B | AURK-C | mitosis | combination therapy | anticancer

6. Understanding and overcoming resistance to tyrosine kinase inhibitors (TKIs) in Chronic myeloid leukemia (CML) NSTL国家科技图书文献中心

Lagana, Alessandro | Scalzulli, Emilia ... - 《Expert review of hematology》 - 2025,18(1) - 65～79 - 共15页

摘要： pathogenesis was successfully unraveled, with tyrosine kinase | inhibitors (TKIs) representing one of the first-targeted | Introduction: Chronic myeloid leukemia (CML | ) represents one of the first neoplasms whose molecular | therapies. TKIs have revolutionized long-term outcomes of

关键词： Chronic myeloid leukemia | tyrosine kinase inhibitors | TKI resistance | BCR::ABL1 mutations | asciminib | ponatinib | allogeneic hematopoietic stem cell transplant | allo-HSCT

7. Emerging Trends in Quinoxaline‐Based Analogs as Protein Kinase Inhibitors: Structural Developments and SAR Insights NSTL国家科技图书文献中心

Amol T. Mahajan | Sandeep Chaudhary - 《ChemMedChem》 - 2025,20(4) - n/a～n/a - 共21页

摘要： through protein kinase* inhibition. Quinoxaline* | kinase inhibition. This review aims to elucidate recent | kinase along with structural developments and structure | Abstract Cancer remains a leading cause of | mortality and has been recognized as a significant global

关键词： Anticancer Agents | Phosphorylation | Protein kinase inhibitors | Structure-Activity Relationship | Quinoxaline

8. PD-1 inhibitors improve the efficacy of tyrosine kinase inhibitors combined with transcatheter arterial chemoembolization in advanced hepatocellular carcinoma: a meta-analysis and trial sequential analysis NSTL国家科技图书文献中心

Jiahui Yu | Yong Li ... - 《Scandinavian journal of gastroenterology.》 - 2025,60(5) - 472～484 - 共13页

摘要： and safety of triple therapy with tyrosine kinase | inhibitors (TKIs) combined with transcatheter arterial | chemoembolization (TACE) plus programmed death 1 (PD-1) inhibitors | inhibitors in uHCC was searched using the Embase, PubMed | Background: This meta-analysis and trial

关键词： PD-1 inhibitors; Tyrosine kinase inhibitors; hepatocellular carcinoma; meta-analysis

9. Head-to-head comparison of tyrosine kinase inhibitors in renal cell carcinoma using patient-derived cell culture NSTL国家科技图书文献中心

Urquhart, Aaron J. | Glass, Christian H.... - 《Personalized medicine》 - 2025,22(2) - 83～91 - 共9页

摘要： immunotherapy and tyrosine kinase* inhibitors (TKIs). Patient* | Background Metastatic renal cell carcinoma | (RCC) is often treated with a combination of | -derived RCC cells were cultured and inter-individual | differences to treatment with a panel of TKIs were evaluated

关键词： Renal cell carcinoma | patient-derived cell culture | tyrosine kinase inhibitors | sunitinib | cabozantinib | pazopanib | axitinib

10. Mortality and medical utilization in rheumatoid arthritis associated interstitial lung disease: A real-world, large-scale retrospective study comparing Janus kinase inhibitors and tumor necrosis factor inhibitors NSTL国家科技图书文献中心

Shih, Po-Cheng | Zou, Qing-Hua ... - 《Seminars in Arthritis and Rheumatism》 - 2025,71 - 152636～152636 - 共7页 - 被引量：1

摘要： the effectiveness of Janus kinase* inhibitors (JAKi* | inhibitors (TNFi). Methods: We applied a retrospective | Objective: The study is aimed to investigate | ) on rheumatoid arthritis associated interstitial | lung disease (RA-ILD) compared to tumor necrosis

摘要：Abstract Reversible covalent kinase inhibitors | (RCKIs) are a class of novel kinase inhibitors | show the selectivity of covalent kinase inhibitors | attracting increasing attention because they simultaneously | yet avoid permanent protein‐modification‐induced

关键词： binding modes | drug discovery | kinase inhibitors | privileged warheads | reversible‐covalent kinase inhibitors

摘要： indole-based anticancer agents as kinase* inhibitors in* | cancerous tissues.Thus,the suppression of the kinase | -kinase* suppression effect.This review presents various* | Cancer is deemed to be one of the most severe | diseases,which is accountable for the elevated mortality

关键词： Anticancer | Indole | Kinase inhibitors

关键词： Advanced Breast Cancer | Phosphoinositide 3-Kinase Pathway | Phosphoinositide 3-Kinase Inhibitors | Randomised Controlled Trial

摘要： effectiveness of Janus kinase* inhibitors (JAKi) in patients* | Objectives: This study evaluated the | with difficult-to-treat rheumatoid arthritis (D2T RA | ). Methods: This study included 220 patients with RA who | were treated with JAKi. Sixty-two patients were na

关键词： Difficult-to-treat rheumatoid arthritis | Janus kinase inhibitors | drug retention rate | effectiveness | safety

摘要：, discovery, and development of Aurora kinase inhibitors | IntroductionAurora kinases (AKs) play key | roles during carcinogenesis and show a close | relationship with many cellular effects including mitotic | entry, spindle assembly and chromosomal alignment

关键词： Aurora kinases | Aurora kinase inhibitors | AURK-A | AURK-B | AURK-C | mitosis | combination therapy | anticancer

摘要： pathogenesis was successfully unraveled, with tyrosine kinase | inhibitors (TKIs) representing one of the first-targeted | Introduction: Chronic myeloid leukemia (CML | ) represents one of the first neoplasms whose molecular | therapies. TKIs have revolutionized long-term outcomes of

关键词： Chronic myeloid leukemia | tyrosine kinase inhibitors | TKI resistance | BCR::ABL1 mutations | asciminib | ponatinib | allogeneic hematopoietic stem cell transplant | allo-HSCT

摘要： through protein kinase* inhibition. Quinoxaline* | kinase inhibition. This review aims to elucidate recent | kinase along with structural developments and structure | Abstract Cancer remains a leading cause of | mortality and has been recognized as a significant global

关键词： Anticancer Agents | Phosphorylation | Protein kinase inhibitors | Structure-Activity Relationship | Quinoxaline

摘要： and safety of triple therapy with tyrosine kinase | inhibitors (TKIs) combined with transcatheter arterial | chemoembolization (TACE) plus programmed death 1 (PD-1) inhibitors | inhibitors in uHCC was searched using the Embase, PubMed | Background: This meta-analysis and trial

关键词： PD-1 inhibitors; Tyrosine kinase inhibitors; hepatocellular carcinoma; meta-analysis

摘要： immunotherapy and tyrosine kinase* inhibitors (TKIs). Patient* | Background Metastatic renal cell carcinoma | (RCC) is often treated with a combination of | -derived RCC cells were cultured and inter-individual | differences to treatment with a panel of TKIs were evaluated

关键词： Renal cell carcinoma | patient-derived cell culture | tyrosine kinase inhibitors | sunitinib | cabozantinib | pazopanib | axitinib

摘要： the effectiveness of Janus kinase* inhibitors (JAKi* | inhibitors (TNFi). Methods: We applied a retrospective | Objective: The study is aimed to investigate | ) on rheumatoid arthritis associated interstitial | lung disease (RA-ILD) compared to tumor necrosis

关键词： Mortality | Medical utilization | Tumor necrosis factor inhibitors | Janus kinase inhibitors | Rheumatoid arthritis | Interstitial lung disease

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：Abstract Reversible covalent kinase inhibitors | (RCKIs) are a class of novel kinase inhibitors | show the selectivity of covalent kinase inhibitors | attracting increasing attention because they simultaneously | yet avoid permanent protein‐modification‐induced

关键词： binding modes | drug discovery | kinase inhibitors | privileged warheads | reversible‐covalent kinase inhibitors

摘要： indole-based anticancer agents as kinase inhibitors in | cancerous tissues.Thus,the suppression of the kinase | -kinase suppression effect.This review presents various | Cancer is deemed to be one of the most severe | diseases,which is accountable for the elevated mortality

关键词： Anticancer | Indole | Kinase inhibitors

关键词： Advanced Breast Cancer | Phosphoinositide 3-Kinase Pathway | Phosphoinositide 3-Kinase Inhibitors | Randomised Controlled Trial

摘要： effectiveness of Janus kinase inhibitors (JAKi) in patients | Objectives: This study evaluated the | with difficult-to-treat rheumatoid arthritis (D2T RA | ). Methods: This study included 220 patients with RA who | were treated with JAKi. Sixty-two patients were na

关键词： Difficult-to-treat rheumatoid arthritis | Janus kinase inhibitors | drug retention rate | effectiveness | safety

摘要：, discovery, and development of Aurora kinase inhibitors | IntroductionAurora kinases (AKs) play key | roles during carcinogenesis and show a close | relationship with many cellular effects including mitotic | entry, spindle assembly and chromosomal alignment

关键词： Aurora kinases | Aurora kinase inhibitors | AURK-A | AURK-B | AURK-C | mitosis | combination therapy | anticancer

摘要： pathogenesis was successfully unraveled, with tyrosine kinase | inhibitors (TKIs) representing one of the first-targeted | Introduction: Chronic myeloid leukemia (CML | ) represents one of the first neoplasms whose molecular | therapies. TKIs have revolutionized long-term outcomes of

关键词： Chronic myeloid leukemia | tyrosine kinase inhibitors | TKI resistance | BCR::ABL1 mutations | asciminib | ponatinib | allogeneic hematopoietic stem cell transplant | allo-HSCT

摘要： through protein kinase inhibition. Quinoxaline | kinase inhibition. This review aims to elucidate recent | kinase along with structural developments and structure | Abstract Cancer remains a leading cause of | mortality and has been recognized as a significant global

关键词： Anticancer Agents | Phosphorylation | Protein kinase inhibitors | Structure-Activity Relationship | Quinoxaline

摘要： and safety of triple therapy with tyrosine kinase | inhibitors (TKIs) combined with transcatheter arterial | chemoembolization (TACE) plus programmed death 1 (PD-1) inhibitors | inhibitors in uHCC was searched using the Embase, PubMed | Background: This meta-analysis and trial

关键词： PD-1 inhibitors; Tyrosine kinase inhibitors; hepatocellular carcinoma; meta-analysis

摘要： immunotherapy and tyrosine kinase inhibitors (TKIs). Patient | Background Metastatic renal cell carcinoma | (RCC) is often treated with a combination of | -derived RCC cells were cultured and inter-individual | differences to treatment with a panel of TKIs were evaluated

关键词： Renal cell carcinoma | patient-derived cell culture | tyrosine kinase inhibitors | sunitinib | cabozantinib | pazopanib | axitinib

摘要： the effectiveness of Janus kinase inhibitors (JAKi | inhibitors (TNFi). Methods: We applied a retrospective | Objective: The study is aimed to investigate | ) on rheumatoid arthritis associated interstitial | lung disease (RA-ILD) compared to tumor necrosis

关键词： Mortality | Medical utilization | Tumor necrosis factor inhibitors | Janus kinase inhibitors | Rheumatoid arthritis | Interstitial lung disease

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： indole-based anticancer agents as kinase* inhibitors in* | cancerous tissues.Thus,the suppression of the kinase | -kinase* suppression effect.This review presents various* | Cancer is deemed to be one of the most severe | diseases,which is accountable for the elevated mortality

摘要： effectiveness of Janus kinase* inhibitors (JAKi) in patients* | Objectives: This study evaluated the | with difficult-to-treat rheumatoid arthritis (D2T RA | ). Methods: This study included 220 patients with RA who | were treated with JAKi. Sixty-two patients were na

摘要： through protein kinase* inhibition. Quinoxaline* | kinase inhibition. This review aims to elucidate recent | kinase along with structural developments and structure | Abstract Cancer remains a leading cause of | mortality and has been recognized as a significant global

摘要： immunotherapy and tyrosine kinase* inhibitors (TKIs). Patient* | Background Metastatic renal cell carcinoma | (RCC) is often treated with a combination of | -derived RCC cells were cultured and inter-individual | differences to treatment with a panel of TKIs were evaluated

摘要： the effectiveness of Janus kinase* inhibitors (JAKi* | inhibitors (TNFi). Methods: We applied a retrospective | Objective: The study is aimed to investigate | ) on rheumatoid arthritis associated interstitial | lung disease (RA-ILD) compared to tumor necrosis