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1. Defining a genetic background for bamboo spine and axial spondyloarthritis NSTL国家科技图书文献中心

Ozkaya, Seyma Colako... |  Abacar, Kerem... -  《Joint, bone, spine》 - 2025,92(3) - 105842~105842 - 共7页

摘要: reticulum aminopeptidase (ERAP)1 and ERAP2 single |  criteria. ERAP1 and ERAP2 polymorphisms were determined |  association between bamboo spine development and ERAP2 SNPs | Objective: Bamboo spine is the most severe |  complication of axial spondyloarthritis (AxSpA). This study
关键词: Axial spondyloarthritis |  ERAP1 |  ERAP2 |  HLA-B27 |  Bamboo spine

2. Mendelian Randomization Estimates the Effects of Plasma and Cerebrospinal Fluid Proteins on Intelligence, Fluid Intelligence Score, and Cognitive Performance NSTL国家科技图书文献中心

Zhao, Wei |  Zhang, Xinyu... -  《Molecular Neurobiology》 - 2025,62(4) - 4922~4934 - 共13页

摘要: aminopeptidase 2 (ERAP2) and secretogranin III (SCG3), while | , negatively associated proteins in plasma include ERAP2 |  proteins in plasma include endoplasmic reticulum | Observational studies have revealed |  associations between levels of plasma and cerebrospinal fluid
关键词: MR |  Intelligence |  Fluid intelligence score |  Cognitive performance |  Peripheral proteins |  CSF proteins |  Genetic variants

3. ERAP1 and ERAP2 gene variants as potential clinical biomarkers of anti-interleukin-17A response in psoriasis vulgaris NSTL国家科技图书文献中心

Kronborg, Lasse |  Hansen, Emma Oxlund... -  《Clinical and experimental dermatology.》 - 2024,49(10) - 1171~1178 - 共8页 - 被引量:1

摘要: ground by identifying distinct ERAP1 and ERAP2 gene |  and ERAP2 gene variants as potential clinical |  ERAP2) have been associated with psoriasis and other |  association between the ERAP1 and ERAP2 genotypes and | , the ERAP2 rs2248374 SNP, and the status of the human
关键词: ASSOCIATION |  HLA-C-ASTERISK-06/02 |  PATHOGENESIS |  SECUKINUMAB |  IMMUNITY |  SHESIS

4. Variation in ERAP2 has opposing effects on severe respiratory infection and autoimmune disease NSTL国家科技图书文献中心

Fergus Hamilton |  Alexander J. Mentzer... -  《The American Journal of Human Genetics》 - 2023,110(4) - 691~702 - 共12页

摘要:ERAP2 is an aminopeptidase involved in |  deleterious during this period, while ERAP2 is also |  association between variation at ERAP2 and (1) infection, (2 |  loci (QTLs) for ERAP2 were used in Mendelian |  with decreased ERAP2 expression and protein levels
关键词: COVID-19 |  ERAP2 |  Mendelian randomization |  balancing selection |  infection |  pneumonia

5. ERAP2 supports TCR recognition of three immunotherapy targeted tumor epitopes NSTL国家科技图书文献中心

Schmidt, Karin |  Leisegang, Matthias... -  《Molecular Immunology》 - 2023,154 - 61~68 - 共8页 - 被引量:3

摘要: aminopeptidases ERAP1 and ERAP2 to TCR recognition of cancer |  cells. We found that ERAP2 on its own, when expressed |  and ERAP2 and thus may serve as potential source for |  the Tyrosinase368-376 epitope. ERAP2 also influenced |  relevance of ERAP2 for tumor epitope presentation and TCR
关键词: ER -resident aminopeptidases |  Antigen processing |  Antigen presentation |  MHC class I |  Adoptive T-cell therapy |  MHC CLASS-I |  ENDOPLASMIC-RETICULUM |  AMINOPEPTIDASE ERAAP |  MELANOMA-CELLS |  PEPTIDE...

6. Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate NSTL国家科技图书文献中心

Nicoletti P. |  Dellinger A.... -  《Gastroenterology》 - 2023,164(3) - 454~466 - 共13页 - 被引量:19

摘要:-DILI risk with reduced liver expression of ERAP2 (P |  risk with ERAP2 low expression and with HLA-B?15:18 | ? 2023 AGA InstituteBackground & Aims: Drug | -induced liver injury (DILI) due to amoxicillin | –clavulanate (AC) has been associated with HLA-A?02:01, HLA
关键词: Amoxicillin-Clavulanate |  DILI |  ERAP2 |  GWAS |  HLA-B?15:18

7. The role of endoplasmic reticulum aminopeptidases in type 1 diabetes mellitus NSTL国家科技图书文献中心

Limanaqi F. |  Vicentini C.... -  《Life sciences》 - 2023,323 - 121701~121701 - 共5页 - 被引量:4

摘要: 1 (ERAP1) and 2 (ERAP2) hold center stage. ERAPs | ? 2023Type-I diabetes mellitus (T1DM) is |  generally considered as a chronic, T-cell mediated |  autoimmune disease. This notwithstanding, both the |  endogenous characteristics of β-cells, and their response
关键词: ER stress |  ERAP1 |  ERAP2 |  MHC-I |  Pancreatic β-cell |  Preproinsulin |  Viral infections

8. M1-aminopeptidase family-beyond antigen-trimming activities NSTL国家科技图书文献中心

Evnouchidou, Irini |  Koumantou, Despoina... -  《Current opinion in immunology》 - 2023,83 - 102337~102337 - 共8页 - 被引量:6

摘要:, less for ERAP2, which is absent in rodents, and |  on IRAP and ERAP2. | Antigen (Ag)-trimming aminopeptidases belong |  to the oxytocinase subfamily of M1 |  metallopeptidases. In humans, this subfamily contains the
关键词: INSULIN-REGULATED AMINOPEPTIDASE |  RECYCLING COMPARTMENT |  STRUCTURAL BASIS |  PEPTIDES |  IDENTIFICATION |  IMMUNE |  ERAP1 |  ER |  RECOGNITION |  ACTIVATION

9. EULAR study group on ‘MHC-I-opathy’: identifying disease-overarching mechanisms across disciplines and borders NSTL国家科技图书文献中心

Jonas JW Kuiper |  J?rg C Prinz... -  《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 - 2023,82(7) - 887~896 - 共10页 - 被引量:18

摘要: ERAP2 that implicates altered MHC-I peptide | The 'MHC-I (major histocompatibility complex |  class I)-opathy' concept describes a family of |  inflammatory conditions with overlapping clinical |  manifestations and a strong genetic link to the MHC-I antigen
关键词: Arthritis |  Psoriatic |  Behcet Syndrome |  Immune System Diseases |  Spondylitis |  Ankylosing.

10. Retina-arrestin specific CD8+T cells are not implicated in HLA-A29-positive birdshot chorioretinitis NSTL国家科技图书文献中心

Venema, W. J. |  Hiddingh, S.... -  《Clinical immunology: The official journal of the Clinical Immunology Society》 - 2023,247 - 109219~109219 - 共9页

摘要: ERAP2. Unex-pectedly, no enhanced antigen engagement | Background: HLA-A29-positive birdshot |  chorioretinitis (BCR) is an inflammatory eye disorder that is |  generally assumed to be caused by an autoimmune response |  to HLA-A29-presented peptides from retinal arrestin
关键词: HUMAN S-ANTIGEN |  CD8(+) T-CELLS |  PATHOPHYSIOLOGICAL CHARACTERISTICS |  DETERMINANT RECOGNITION |  UVEITIS |  IDENTIFICATION |  PREDICTION |  TETRAMERS |  EPITOPES |  SELF
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