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1. Cytochrome P450-mediated carbon-carbon bond formation in drug metabolism NSTL国家科技图书文献中心

Liu, Joyce |  Zhang, Donglu -  《Drug Metabolism Reviews》 - 2025,57(1) - 51~66 - 共16页

摘要: for the metabolism of numerous drug compounds and | -C bond formation that occur during drug metabolism |  novel drug metabolites that result from these |  metabolite identification and drug design efforts. | Cytochrome P450 (CYPs) enzymes are essential
关键词: Cytochrome P450 |  drug metabolism |  carbon-carbon bond formation |  biotransformation |  enzyme mechanism

2. Therapeutic drug monitoring, liquid biopsies or pharmacogenomics for prediction of human drug metabolism and response NSTL国家科技图书文献中心

Ingelman-Sundberg, M... |  Molden, Espen -  《British Journal of Clinical Pharmacology》 - 2025,91(6) - 1569~1579 - 共11页

摘要: exist in drug metabolism and response. Effectively |  expression, which includes prediction of drug metabolism in |  treatment by predicting drug metabolism and response |  drug monitoring (TDM) and liquid biopsy-based | Pharmacokinetics plays a central role in
关键词: ADME |  adverse drug reactions |  exosomes |  missing heritability |  post-translational regulation |  precision medicine

3. A hollow fiber membrane-based liver organoid-on-a-chip model for examining drug metabolism and transport NSTL国家科技图书文献中心

Adam Myszczyszyn |  Anna Muench... -  《Biofabrication》 - 2025,17(2) - A hollow fiber/1~A hollow fiber/22 - 共22页

摘要: metabolism, and blood and canalicular transport of drug | , CYP2D6, CYP2C9) and II (e.g. UGTs, SULTs) drug | -metabolizing enzymes and drug transporters (e.g. MDR1, MRP3 |  displayed phase I and II metabolism of a cocktail of six |  metabolism and transport of drugs, which can be further
关键词: bioengineering |  drug metabolism and transport |  liver |  organoids |  organs-on-a-chip |  pharmacokinetics |  stem cells

4. Genetic determinants of paclitaxel-induced peripheral neuropathy: a review of current literature NSTL国家科技图书文献中心

Sivadas, Swathi Kris... |  Das, Aiswarya... -  《Drug Metabolism Reviews》 - 2025,57(2) - 190~207 - 共18页

摘要: susceptibility to PIPN, influencing both drug metabolism and | , CYP3A4, and CYP2C9 affect drug metabolism, while |  associated with paclitaxel metabolism, transport |  polymorphisms in ABCB1 and SLCO1B1 influence drug transport | Paclitaxel is a widely used chemotherapeutic
关键词: Paclitaxel |  peripheral neuropathy |  neuroinflammation |  genetic risk factors |  drug metabolism |  drug transport |  pharmacogenomics

5. Roles of LncRNA ARSR in tumor proliferation, drug resistance, and lipid and cholesterol metabolism NSTL国家科技图书文献中心

Li, Zhicheng |  Wang, Dan... -  《Clinical & translational oncology》 - 2025,27(4) - 1356~1365 - 共10页

摘要:, delayed treatment, and drug tolerance, indicating that |  proliferation, drug tolerance, and lipid and cholesterol |  metabolism, highlighting the potential of lncARSR as a | Cancer is one of the most serious diseases |  that threaten human life and health. Among all kinds
关键词: Cancer |  LncARSR |  Tumor proliferation |  Drug tolerance |  Lipids and cholesterol metabolism

6. Sex-specific UGT expression and function: prevalence, potential mechanisms and significance NSTL国家科技图书文献中心

Meech, Robyn |  Hu, Dong Gui... -  《Expert opinion on drug metabolism & toxicology》 - 2025,21(5) - 511~518 - 共8页

摘要: processes that control drug disposition such as metabolism |  pharmacotherapy outcomes, including adverse drug effects which |  in drug responses involve factors as diverse as |  the critical phase II drug-metabolizing enzymes, UDP |  evidence for UGT-mediated sex-differences in drug
关键词: drug metabolism |  pharmacokinetics |  gene expression |  sex differences |  glucuronide |  UDP-glucuronosyltransferases |  UGTs |  sex steroids

7. Cytochrome P450 phenotyping using the Geneva cocktail improves metabolic capacity prediction in a hospitalized patient population NSTL国家科技图书文献中心

Gloor, Yvonne S. |  Mouterde, Mederic... -  《British Journal of Clinical Pharmacology》 - 2025,91(5) - 1382~1395 - 共14页

摘要: important role in drug metabolism but display a large |  environmental factors. Most drug dose adjustment guidelines |  drug treatment modifications than healthy volunteers | , but will also be more subject to polypharmacy, drug | -drug interactions, or to suffer from disease or
关键词: cytochrome P450 |  drug metabolism |  genotyping |  phenotyping

8. Scaling factors to inform in vitro - in vivo extrapolation from preclinical and livestock animals: state of the field and recommendations for development of missing data NSTL国家科技图书文献中心

Zimmer, Austin A. |  Collier, Abby C. -  《Drug Metabolism Reviews》 - 2025,57(2) - 91~114 - 共24页

摘要:The use of in-vitro-in-vivo physiologically |  based pharmacokinetic (IVIVE-PBPK) modeling approaches |  assists for prediction of first-in animal or human |  trials. These approaches are underpinned by the scaling |  factors: microsomal protein per gram (MPPG) and
关键词: Pharmacokinetics |  toxicokinetics |  drug metabolism |  modelling |  preclinical animal models |  drug development |  veterinary medicine

9. Enhancing clinical research with pharmacogenomics: a practical perspective NSTL国家科技图书文献中心

Xiaolong Tom Zhang |  Jacob Blacutt... -  《Bioanalysis》 - 2025,17(5/6) - 399~411 - 共13页

摘要: of key genes involved in drug metabolism, transport |  genetic variations influence drug response, safety, and |  across all phases of drug development. This review aims |  integrating PGx into clinical research to enhance drug | Pharmacogenomics (PGx) is transforming
关键词: PGx platform; Pharmacogenomics; drug metabolism; drug target; drug transport; genetic

10. Bioavailability, Metabolism, and Excretion of [14C]‐Tazemetostat in Patients With B‐Cell Lymphomas or Advanced Solid Tumors NSTL国家科技图书文献中心

Yingxue Chen |  Renli Teng... -  《Clinical pharmacology in drug development》 - 2025,14(3) - 231~239 - 共9页

摘要:, characterized the disposition and metabolism, and investigated |  Drug Administration–approved inhibitor of enhancer of |  total drug‐related exposure, respectively. Recovery of | Abstract This open‐label, multicenter study |  (NCT03010982) evaluated the absolute bioavailability
关键词: bioavailability |  drug excretion |  drug metabolism |  pharmacokinetics |  tazemetostat
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