NSTL国家科技图书文献中心

1. Learning personalized drug features and differentiated drug-pair interaction information for drug-drug interaction prediction NSTL国家科技图书文献中心

Meng, Li | He, Yunfei ... - 《Neural Networks》 - 2025,181 - Article 106828～Article 106828 - 共10页

摘要： especially prominent in drug* interaction graphs with long* | differentiated Drug-Pair interaction information for drug-drug | harmful drug interactions. Effective drug-drug | Multi-drug* combination therapies are* | interaction prediction (DDIP) is essential for assessing

关键词： Drug-drug interaction prediction | Mutual information | Graph neural networks | Long-tailed graph | Contrastive learning

2. A Molecular Fragment Representation Learning Framework for Drug-Drug Interaction Prediction NSTL国家科技图书文献中心

He, Jiaxi | Sun, Yuping ... - 《Interdisciplinary Sciences: Computational Life Sciences》 - 2025,17(1) - 42～58 - 共17页

摘要： representation learning framework for drug-drug interaction | effectively integrated, enabling drug-drug interaction | enhances the performance of drug-drug interaction | result in drug-drug* interactions, increasing the risk* | identifying unknown drug-drug* interactions, which is of*

关键词： Drug | Drug-drug interaction | Molecular fragment | Molecular hierarchical information

3. Clinical Assessment of the Drug-Drug Interaction Potential of Omaveloxolone in Healthy Adult Participants NSTL国家科技图书文献中心

Zahir, Hamim | Murai, Masako ... - 《Journal of clinical pharmacology.》 - 2025,65(6) - 715～730 - 共16页 - 被引量：1

摘要：-drug* interaction studies (NCT04008186 and NCT05909644* | metabolized by cytochrome P450 (CYP) 3A4 in vitro. Two drug | ) were performed to evaluate (1) the effect of drug | -metabolizing enzymes (DMEs) and drug* transporter (DT* | Omaveloxolone is approved in the United States

关键词： drug-drug interaction | Friedreich ataxia | omaveloxolone | pharmacokinetics

4. Drug–Drug Interaction Potential of Mavacamten with Midazolam: Combined Results from Clinical and Model‐Based Studies NSTL国家科技图书文献中心

Samira Merali | Caroline Sychterz ... - 《Journal of clinical pharmacology.》 - 2025,65(5) - 598～606 - 共9页

摘要： the drug* concentration‐time curve (AUC) from time* | Abstract Mavacamten is a potential inducer of | cytochrome P450 (CYP) 3A4 and could reduce the | effectiveness of concomitant drugs that are metabolized by | CYP3A4, such as midazolam. This study aimed to

关键词： drug–drug interaction | hypertrophic cardiomyopathy | mavacamten | midazolam

5. PBPK modelling for the evaluation of drug-drug interaction between meropenem and valproic acid NSTL国家科技图书文献中心

Liu, Hongrui | Yu, Yiqun ... - 《British Journal of Clinical Pharmacology》 - 2025,91(4) - 1198～1207 - 共10页

摘要： investigate the potential drug-drug* interaction (DDI* | AimsThe present study aimed to quantitatively | ) mechanism between meropenem (MEPM) and valproic acid (VPA | ).MethodsIn the present study, we firstly developed a | physiologically based pharmacokinetic (PBPK) model of MEPM and

关键词： acylpeptide hydrolase (APEH) | drug-drug interaction (DDI) | meropenem (MEPM) | physiologically based pharmacokinetic (PBPK) modelling | polymorphisms | valproic acid (VPA)

6. Severe Impact of Omeprazole Timing on pH‐Sensitive Dasatinib Absorption: Unveiling Substantial Drug–Drug Interaction NSTL国家科技图书文献中心

Per Andersson | Magnus Brisander ... - 《Journal of clinical pharmacology.》 - 2025,65(5) - 588～597 - 共10页

摘要： inhibitors (PPIs) should be avoided. Drug–drug interaction | Abstract The absorption and bioavailability of | most tyrosine kinase inhibitors are affected by | gastrointestinal pH as they are weak basic lipophilic drugs | . Hence, concomitant use of acid reducing agents (ARAs

关键词： acid reducing agent (ARA) | bioavailability | chronic myeloid leukemia (CML) | crystalline dasatinib | drug–drug interaction (DDI) | omeprazole | pharmacokinetics | proton‐pump inhibitors (PPI)

7. A phase I, single-center, randomized, open-label, three-period crossover study to evaluate the drug-drug interaction between ZSP1273 and oseltamivir in healthy Chinese subjects NSTL国家科技图书文献中心

Pang, Yanqing | Li, Haijun ... - 《Antimicrobial agents and chemotherapy.》 - 2025,69(4) - e0172924～e0172924 - 共11页

摘要： drug-drug interaction between ZSP1273 and oseltamivir | no drug-drug* interaction occurs with ZSP1273. After* | -influenza drug* that targets the RNA polymerase PB2 subunit* | drug administration to measure the plasma | believed that no clinically significant drug-drug

关键词： drug-drug interaction | ZSP1273 | oseltamivir | pharmacokinetics | safety

8. A systematic review of molecular structures, knowledge graphs, and cold-start scenario in drug-drug interaction prediction NSTL国家科技图书文献中心

Mir Mansoor Ahmad | Zuraini Binti Ali Sh...... - 《Computers in Biology and Medicine》 - 2025,190 - Article 110122～Article 110122 - 共16页

摘要： Drug-Drug Interactions (DDIs). Adverse DDIs are a | challenges when dealing with drugs with limited interaction | Drugs are essential chemical substances used | to treat, prevent, or diagnose diseases. However | , the co-administration or simultaneous use of

关键词： Cold-start scenario; Drug-drug interaction; Generalization; Knowledge graph; Molecular

9. Drug-drug interaction extraction-based system: An natural language processing approach NSTL国家科技图书文献中心

Jose Machado | Carla Rodrigues ... - 《Expert systems》 - 2025,42(1) - e13303.1～e13303.12 - 共12页 - 被引量：1

摘要： architecture outlined for the drug-drug interaction | inappropriate prescribing increase drug-drug interactions | for drug-drug* interactions from unstructured data* | 65, have increased. Multiple drug* use and* | , adverse drug* reactions, morbidity, and mortality. This*

关键词： drug-drug interactions | information extraction | machine learning | natural language processing | text mining

10. The European Drug-Drug Interaction (EuroDDI) Study Protocol: A Cross-Country Comparison of Drug-Drug Interaction Prevalence in the Older Community-Dwelling Population NSTL国家科技图书文献中心

Hughes, John E. | Menditto, Enrica ... - 《Pharmacoepidemiology and drug safety》 - 2025,34(1) - e70092～e70092 - 共8页

摘要：BackgroundDrug-drug* interactions (DDIs* | Stockley's Drug* Interactions. Two separate lists of 'severe* | ), highly prevalent amongst the elderly, can lead to | avoidable medication-related harm. Cardiovascular and | central nervous system (CNS) drugs are commonly

关键词： adverse drug reactions | cardiovascular | common data model | drug interactions | elderly | medication safety | nervous system | pharmacoepidemiology | polypharmacy | protocol

摘要： especially prominent in drug interaction graphs with long | differentiated Drug-Pair interaction information for drug-drug | harmful drug interactions. Effective drug-drug | Multi-drug combination therapies are | interaction prediction (DDIP) is essential for assessing

关键词： Drug-drug interaction prediction | Mutual information | Graph neural networks | Long-tailed graph | Contrastive learning

摘要： representation learning framework for drug-drug interaction | effectively integrated, enabling drug-drug interaction | enhances the performance of drug-drug interaction | result in drug-drug interactions, increasing the risk | identifying unknown drug-drug interactions, which is of