NSTL国家科技图书文献中心

1. Increased levels of DNA methyltransferases in the placentas of women affected by Placenta Accreta Spectrum lead to aberrant DNA methylation patterns NSTL国家科技图书文献中心

Uysal, Fatma | Bozdemir, Nazlican ... - 《Journal of molecular histology》 - 2025,56(1) - Article: 28～Article: 28 - 共8页

摘要： with tumor-related proteins. While DNA* methylation is* | of PAS on DNA methylation and DNA | methyltransferases (DNMTs). The groups were categorized into three | ) and Western blot (WB) techniques. Global DNA | , global DNA* methylation levels were found to be*

关键词： Placenta Accreta Spectrum | DNA methylation | DNMT | Chorionic villus | Placentas

2. Characterization of Rationally Designed CRISPR/Cas9-Based DNA Methyltransferases with Distinct Methyltransferase and Gene Silencing Activities in Human Cell Lines and Primary Human T Cells NSTL国家科技图书文献中心

Guerra-Resendez, Ros... | Lydon, Samantha LeGo...... - 《ACS Synthetic Biology》 - 2025,14(2) - 384～397 - 共14页

摘要： different forms of dCas-based DNA* methyltransferases (dCas* | mammalian epigenome and transcriptome. DNA* methylation is* | -DNMTs) have been developed for programmable DNA | DNA methylation or gene-silencing performance. We | in DNMT3A alter DNA* methylation profiles at loci*

关键词： CRISPR/Cas systems | DNA methylation | epigeneticediting | human T cells | dCas9 | rationalmutagenesis

3. pH-sensitive liposomal curcumin with good biocompatibility for improving therapeutic efficacy by decreasing DNA methylation level in tumor cells NSTL国家科技图书文献中心

Wang, Wanxue | Shao, Mingzheng ... - 《Chemistry Letters》 - 2025,54(2) - 共5页

摘要： DNA methyltransferases expression in A549 and K562 | A new type of pH-sensitive liposome | nanoparticles encapsulated with curcumin and doxorubicin was | prepared and exhibited high specificity for tumor cells | . The liposomal curcumin enables the endosome escape

关键词： DNA methylation | great therapeutic efficacy | pH-sensitive liposome

4. Enhancing nature's palette through the epigenetic breeding of flower color in chrysanthemum NSTL国家科技图书文献中心

Xueqi Li | Fanqi Bu ... - 《The New Phytologist》 - 2025,245(5) - 2117～2132 - 共16页

摘要： still unknown which DNA* methyltransferases are* | DNA methylation level of this gene. However, it is | involved in modifying the DNA* methylation levels of this* | gene.Here, we used dead Cas9 (dCas9) together with DNA | methyltransferases that methylate cytosine residues in the CHH

关键词： Chrysanthemum | CRISPR-dCas9 | DNA methylation | epigeneticbreeding | 铿俹wer color

5. G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials NSTL国家科技图书文献中心

Bellver-Sanchis, Ain... | Ribalta-Vilella, Mar...... - 《Medicinal research reviews》 - 2025,45(3) - 985～1015 - 共31页

摘要： deacetylases, DNA* methyltransferases, and other lysine* | methyltransferases. Hence, findings offer valuable insights into | This review provides a comprehensive overview | of the role of G9a/EHMT2, focusing on its structure | and exploring the impact of its pharmacological and

关键词： aging | clinical trials | EHMT2 | epigenetics | G9a | neurodegenerative conditions | small-molecules

6. Mesoporous polydopamine nanoparticles coated with metal-polyphenol networks for demethylation therapy of lung cancer NSTL国家科技图书文献中心

Wang, Jingsi | Deng, Xufeng ... - 《Medical oncology.》 - 2025,42(5) - Article: 147～Article: 147 - 共11页

摘要： uptake, and downregulated the expression of DNA | methyltransferases. Moreover, mA@EF demonstrated good biosafety. In | The treatment of lung cancer with azacitidine | (AZA) is urgently in need of a novel delivery | material due to its limitations, including a short half

关键词： Azacitidine | mA@EF | DNA methyltransferase | Biosafety | Tumor targeting

7. Transcriptional regulation of basophil-specific protease genes by C/EBPα, GATA2, TGF-β signaling, and epigenetic mechanisms NSTL国家科技图书文献中心

Tojima, Ryotaro | Nagata, Kazuki ... - 《FEBS letters.》 - 2025,599(5) - 777～786 - 共10页

摘要： deacetylases and downregulated by DNA methyltransferases | Basophils and mast cells (MCs) play an | important role in immune responses against allergens and | parasitic infection. To elucidate the mechanisms that | determine the commitment between basophils and mast cell

关键词： basophil | C/EBP alpha | DNA methylation | GATA2 | HDAC | mast cell | Mcpt11 | Mcpt8 | TGF-beta | C/EBPα...

8. Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming NSTL国家科技图书文献中心

Clement, Kirsten | Nemec-Bakk, Ashley S...... - 《Radiation and Environmental Biophysics》 - 2025,64(1) - 17～27 - 共11页

摘要： of DNA* methyltransferases Dnmt1 and Dnmt3a, and* | alterations. DNA* hypermethylation in the 5'-untranslated* | methyl-binding protein, MecP2. Trends towards DNA | suggests that the DNA* methylation status of LINE-1 can* | Most studies on the effects of galactic cosmic

关键词： DNA methylation | Hind-limb suspension | Galactic cosmic rays | Ionizing radiation | LINE-1 | Microgravity

9. Annonaceous acetogenins as promising DNA methylation inhibitors to prevent and treat leukemogenesis - an in silico approach NSTL国家科技图书文献中心

Subaramaniyam, Udaya... | Ramalingam, Divya ... - 《Journal of Biomolecular Structure and Dynamics》 - 2025,43(6) - 3116～3129 - 共14页

摘要：. DNA* methyltransferases (DNMTs) such as DNMT1, DNMT3A* | other common cancers. DNA* methylation is an epigenetic* | and DNMT3B are the key enzymes catalysing DNA | from medicinal plants helps reverse DNA* methylation* | the potential to inhibit the DNA* methylation process*

关键词： Leukemia | DNMT1 | annonaceous acetogenin | molecular docking | molecular dynamic simulation

10. Epigenetic Modifications as Novel Therapeutic Strategies of Cancer Chemoprevention by Phytochemicals NSTL国家科技图书文献中心

Hsieh, Hui-Hsia | Kuo, Min-Zhan ... - 《Pharmaceutical research》 - 2025,42(1) - 69～78 - 共10页

摘要： can regulate the function of DNA methyltransferases | aberrant DNA* methylation, histone alterations, non-coding* | DNA methylation, throughout the different stages of | using the keywords "epigenetic", or "DNA* methylation* | PurposeEpigenetic modifications, such as

摘要： with tumor-related proteins. While DNA* methylation is* | of PAS on DNA methylation and DNA | methyltransferases (DNMTs). The groups were categorized into three | ) and Western blot (WB) techniques. Global DNA | , global DNA* methylation levels were found to be*

关键词： Placenta Accreta Spectrum | DNA methylation | DNMT | Chorionic villus | Placentas

摘要： different forms of dCas-based DNA* methyltransferases (dCas* | mammalian epigenome and transcriptome. DNA* methylation is* | -DNMTs) have been developed for programmable DNA | DNA methylation or gene-silencing performance. We | in DNMT3A alter DNA* methylation profiles at loci*

关键词： CRISPR/Cas systems | DNA methylation | epigeneticediting | human T cells | dCas9 | rationalmutagenesis

摘要： DNA methyltransferases expression in A549 and K562 | A new type of pH-sensitive liposome | nanoparticles encapsulated with curcumin and doxorubicin was | prepared and exhibited high specificity for tumor cells | . The liposomal curcumin enables the endosome escape

关键词： DNA methylation | great therapeutic efficacy | pH-sensitive liposome

摘要： still unknown which DNA* methyltransferases are* | DNA methylation level of this gene. However, it is | involved in modifying the DNA* methylation levels of this* | gene.Here, we used dead Cas9 (dCas9) together with DNA | methyltransferases that methylate cytosine residues in the CHH

关键词： Chrysanthemum | CRISPR-dCas9 | DNA methylation | epigeneticbreeding | 铿俹wer color

摘要： deacetylases, DNA* methyltransferases, and other lysine* | methyltransferases. Hence, findings offer valuable insights into | This review provides a comprehensive overview | of the role of G9a/EHMT2, focusing on its structure | and exploring the impact of its pharmacological and

关键词： aging | clinical trials | EHMT2 | epigenetics | G9a | neurodegenerative conditions | small-molecules

摘要： uptake, and downregulated the expression of DNA | methyltransferases. Moreover, mA@EF demonstrated good biosafety. In | The treatment of lung cancer with azacitidine | (AZA) is urgently in need of a novel delivery | material due to its limitations, including a short half

关键词： Azacitidine | mA@EF | DNA methyltransferase | Biosafety | Tumor targeting

摘要： deacetylases and downregulated by DNA methyltransferases | Basophils and mast cells (MCs) play an | important role in immune responses against allergens and | parasitic infection. To elucidate the mechanisms that | determine the commitment between basophils and mast cell

关键词： basophil | C/EBP alpha | DNA methylation | GATA2 | HDAC | mast cell | Mcpt11 | Mcpt8 | TGF-beta | C/EBPα...

摘要： of DNA* methyltransferases Dnmt1 and Dnmt3a, and* | alterations. DNA* hypermethylation in the 5'-untranslated* | methyl-binding protein, MecP2. Trends towards DNA | suggests that the DNA* methylation status of LINE-1 can* | Most studies on the effects of galactic cosmic

关键词： DNA methylation | Hind-limb suspension | Galactic cosmic rays | Ionizing radiation | LINE-1 | Microgravity

摘要：. DNA* methyltransferases (DNMTs) such as DNMT1, DNMT3A* | other common cancers. DNA* methylation is an epigenetic* | and DNMT3B are the key enzymes catalysing DNA | from medicinal plants helps reverse DNA* methylation* | the potential to inhibit the DNA* methylation process*

关键词： Leukemia | DNMT1 | annonaceous acetogenin | molecular docking | molecular dynamic simulation

摘要： can regulate the function of DNA methyltransferases | aberrant DNA* methylation, histone alterations, non-coding* | DNA methylation, throughout the different stages of | using the keywords "epigenetic", or "DNA* methylation* | PurposeEpigenetic modifications, such as

关键词： chemoprevention | DNA methylation | epigenetic | phytochemicals

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： with tumor-related proteins. While DNA methylation is | of PAS on DNA methylation and DNA | methyltransferases (DNMTs). The groups were categorized into three | ) and Western blot (WB) techniques. Global DNA | , global DNA methylation levels were found to be

关键词： Placenta Accreta Spectrum | DNA methylation | DNMT | Chorionic villus | Placentas

摘要： different forms of dCas-based DNA methyltransferases (dCas | mammalian epigenome and transcriptome. DNA methylation is | -DNMTs) have been developed for programmable DNA | DNA methylation or gene-silencing performance. We | in DNMT3A alter DNA methylation profiles at loci

关键词： CRISPR/Cas systems | DNA methylation | epigeneticediting | human T cells | dCas9 | rationalmutagenesis

摘要： DNA methyltransferases expression in A549 and K562 | A new type of pH-sensitive liposome | nanoparticles encapsulated with curcumin and doxorubicin was | prepared and exhibited high specificity for tumor cells | . The liposomal curcumin enables the endosome escape

关键词： DNA methylation | great therapeutic efficacy | pH-sensitive liposome

摘要： still unknown which DNA methyltransferases are | DNA methylation level of this gene. However, it is | involved in modifying the DNA methylation levels of this | gene.Here, we used dead Cas9 (dCas9) together with DNA | methyltransferases that methylate cytosine residues in the CHH

关键词： Chrysanthemum | CRISPR-dCas9 | DNA methylation | epigeneticbreeding | 铿俹wer color

摘要： deacetylases, DNA methyltransferases, and other lysine | methyltransferases. Hence, findings offer valuable insights into | This review provides a comprehensive overview | of the role of G9a/EHMT2, focusing on its structure | and exploring the impact of its pharmacological and

关键词： aging | clinical trials | EHMT2 | epigenetics | G9a | neurodegenerative conditions | small-molecules

摘要： uptake, and downregulated the expression of DNA | methyltransferases. Moreover, mA@EF demonstrated good biosafety. In | The treatment of lung cancer with azacitidine | (AZA) is urgently in need of a novel delivery | material due to its limitations, including a short half

关键词： Azacitidine | mA@EF | DNA methyltransferase | Biosafety | Tumor targeting

摘要： deacetylases and downregulated by DNA methyltransferases | Basophils and mast cells (MCs) play an | important role in immune responses against allergens and | parasitic infection. To elucidate the mechanisms that | determine the commitment between basophils and mast cell

关键词： basophil | C/EBP alpha | DNA methylation | GATA2 | HDAC | mast cell | Mcpt11 | Mcpt8 | TGF-beta | C/EBPα...

摘要： of DNA methyltransferases Dnmt1 and Dnmt3a, and | alterations. DNA hypermethylation in the 5'-untranslated | methyl-binding protein, MecP2. Trends towards DNA | suggests that the DNA methylation status of LINE-1 can | Most studies on the effects of galactic cosmic

关键词： DNA methylation | Hind-limb suspension | Galactic cosmic rays | Ionizing radiation | LINE-1 | Microgravity

摘要：. DNA methyltransferases (DNMTs) such as DNMT1, DNMT3A | other common cancers. DNA methylation is an epigenetic | and DNMT3B are the key enzymes catalysing DNA | from medicinal plants helps reverse DNA methylation | the potential to inhibit the DNA methylation process

关键词： Leukemia | DNMT1 | annonaceous acetogenin | molecular docking | molecular dynamic simulation

摘要： can regulate the function of DNA methyltransferases | aberrant DNA methylation, histone alterations, non-coding | DNA methylation, throughout the different stages of | using the keywords "epigenetic", or "DNA methylation | PurposeEpigenetic modifications, such as

关键词： chemoprevention | DNA methylation | epigenetic | phytochemicals

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： with tumor-related proteins. While DNA* methylation is* | of PAS on DNA methylation and DNA | methyltransferases (DNMTs). The groups were categorized into three | ) and Western blot (WB) techniques. Global DNA | , global DNA* methylation levels were found to be*

摘要： different forms of dCas-based DNA* methyltransferases (dCas* | mammalian epigenome and transcriptome. DNA* methylation is* | -DNMTs) have been developed for programmable DNA | DNA methylation or gene-silencing performance. We | in DNMT3A alter DNA* methylation profiles at loci*

摘要： still unknown which DNA* methyltransferases are* | DNA methylation level of this gene. However, it is | involved in modifying the DNA* methylation levels of this* | gene.Here, we used dead Cas9 (dCas9) together with DNA | methyltransferases that methylate cytosine residues in the CHH

摘要： deacetylases, DNA* methyltransferases, and other lysine* | methyltransferases. Hence, findings offer valuable insights into | This review provides a comprehensive overview | of the role of G9a/EHMT2, focusing on its structure | and exploring the impact of its pharmacological and

摘要： of DNA* methyltransferases Dnmt1 and Dnmt3a, and* | alterations. DNA* hypermethylation in the 5'-untranslated* | methyl-binding protein, MecP2. Trends towards DNA | suggests that the DNA* methylation status of LINE-1 can* | Most studies on the effects of galactic cosmic

摘要：. DNA* methyltransferases (DNMTs) such as DNMT1, DNMT3A* | other common cancers. DNA* methylation is an epigenetic* | and DNMT3B are the key enzymes catalysing DNA | from medicinal plants helps reverse DNA* methylation* | the potential to inhibit the DNA* methylation process*

摘要： can regulate the function of DNA methyltransferases | aberrant DNA* methylation, histone alterations, non-coding* | DNA methylation, throughout the different stages of | using the keywords "epigenetic", or "DNA* methylation* | PurposeEpigenetic modifications, such as