NSTL国家科技图书文献中心

1. Advances in bacterial artificial chromosome (BAC) transgenic mice for gene analysis and disease research NSTL国家科技图书文献中心

Mogi, Kazumasa | Tomita, Hiroyuki ... - 《Gene》 - 2025,934 - 149014～149014 - 共12页

摘要：Transgenic mice, including those created using | transgenic mice* offer a solution by incorporating large DNA* | applications of BAC transgenic mice* in various disciplines* | aspects of generating and analyzing BAC transgenic mice | limitations, humanized BAC transgenic mice* have proven to be*

关键词： Genetically modified mice | Bacterial Artificial Chromosome (BAC) | Transgenic mouse technology | Humanized BAC transgenic mice | Pathogenesis | animal model

2. Animal Models for Long COVID: Current Advances, Limitations, and Future Directions NSTL国家科技图书文献中心

Yu Zhang | Huan Chen ... - 《Journal of Medical Virology》 - 2025,97(2) - e70237～e70237 - 共13页

摘要：, including nonhuman primates, genetically modified mice | ABSTRACT Long COVID (LC) represents a chronic | , systemic, and often disabling condition that poses a | significant ongoing threat to public health. Foundational | scientific studies are needed to unravel the underlying

关键词： animal models | COVID‐19 | Long COVID | SARS‐CoV‐2

3. The 129 strain-derived passenger mutations in ACKR1-deficient mice alter the expression of PYHIN and Fc-gamma receptor genes NSTL国家科技图书文献中心

Moeller-Ramon, Zoe | Aslani, Maria ... - 《Journal of Leukocyte Biology》 - 2025,117(2) - qiae208～qiae208 - 共10页

摘要：Most genetically* modified mice have been* | mice have approximately 6 Mb of the 129-derived | Ackr1-/-129ES mice* and underscore the limitations and* | embryonic stem cells.Ackr1 knockout mice* carry a 6-Mb* | produced using 129 strain-derived embryonic stem cells

关键词： 129 embryonic stem cells | ACKR1 | Fc-gamma receptor | knockout mouse | passenger mutations | PYHIN

4. The Evolving Role of PTH Signaling in Osteocytes NSTL国家科技图书文献中心

Kiryaman, Gokce | Enabulele, Irobosa ... - 《Endocrinology》 - 2025,166(4) - bqaf034～bqaf034 - 共7页

摘要： modified mice, in which the PTH receptor is either | targets of PTH, and studies utilizing genetically | Over the past decade, advancements in cell | line development and genetic tools have led to a | wealth of new insights into the effects of parathyroid

关键词： osteocytes | parathyroid hormone | bone metabolism

5. Fertilizable Rat Sperm Is Generated in Mice Using Blastocyst Complementation: An Efficient Method for Producing Rats With ES Cell Traits NSTL国家科技图书文献中心

Rie Natsume | Kosuke Murata ... - 《Genes to cells》 - 2025,30(3) - e70024～e70024 - 共10页

摘要： generating genetically* modified rats, addressing key* | -derived sperm produced in mice* with the blastocyst* | -deficient mice, which resulted in chimeric mice* with the* | cell-deficient mice* as recipients, this approach* | We developed a novel approach for generating

关键词： ES cell; ICSI; blastocyst complementation; mouse; rat.

6. Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response NSTL国家科技图书文献中心

Baquero, Cristina | Iniesta-Gonzalez, Mi...... - 《Journal of Pathology》 - 2025,265(4) - 502～517 - 共16页

摘要： cancer associated with fibrosis using genetically | modified mouse models. We found that while overexpression | response to CCl4 was altered in PF4-C3GKO mice, with a | monocyte-derived macrophages compared to WT mice. On the | other hand, in response to DEN+CCl4, PF4-C3G WT mice

关键词： C3G (RapGEF1) | platelet | liver fibrosis | liver cancer | immune response

7. Utilization of the QuPath open-source software platform for analysis of mammalian spermatogenesis† NSTL国家科技图书文献中心

Niedenberger, Bryan ... | Belcher, Heather A.... - 《Biology of reproduction.》 - 2025,112(3) - 583～599 - 共17页

摘要： mutations, have been genetically* modified (transgenic or* | spermatogenesis. During spermatogenesis in postnatal mice, male | The adult mammalian testis is filled with | seminiferous tubules, which contain somatic Sertoli cells | along with germ cells undergoing all phases of

关键词： spermatogonia | spermatocyte | spermatid | testis | Sertoli cell | software

8. The pulmonary neuroepithelial body microenvironment represents an underestimated multimodal component in airway sensory pathways NSTL国家科技图书文献中心

Brouns, Inge | Adriaensen, Dirk ... - 《The anatomical record》 - 2025,308(4) - 1094～1117 - 共24页

摘要：, combined with state-of-the-art genetically* modified mouse* | microenvironment (NEB ME) in mice, underpinning the role of these | Exciting new imaging and molecular tools | models, have recently boosted interest in pulmonary | (vagal) sensory pathway investigations. In addition to

关键词： airway innervation | Clara-like cell | lung | NEB | pulmonary receptor | Clara‐like cell

9. Generation of albino C57BL/6J mice by CRISPR embryo editing of the mouse tyrosinase locus NSTL国家科技图书文献中心

Diril, M. Kasim | Esmen, Kerem ... - 《Journal of genetics》 - 2025,104(1) - 共10页

摘要： development of genetically* modified mouse models is also* | albino coat-coloured C57BL/6J mice* by targeted* | After the arrival of the CRISPR/Cas9 genome | editing technology, genetic engineering of model | organisms has become much faster and more efficient. The

关键词： CRISPR | Cas9 | tyrosinase | genetically modified mouse models | knockout | knockin | homology-directed repair | nonhomologous end joining.

10. Single nucleotide polymorphism (SNP) characterisation of mouse inbred strains bred at MRC-National Institute for Medical Research NSTL国家科技图书文献中心

Sanchez-Morgado, Jos... - 《Laboratory Animals》 - 2025,59(1) - 83～92 - 共10页

摘要： the many genetically* modified mouse strains made at* | Nomenclature for Mice* umbenannt.Las cepas consangu & iacute* | Standardized Genetic Nomenclature for Mice* (Comit & eacute* | Inbred mouse strains have long proved useful | as tools for biomedical research. They remove the

关键词： Genetically modified mice | Bacterial Artificial Chromosome (BAC) | Transgenic mouse technology | Humanized BAC transgenic mice | Pathogenesis | animal model

摘要：, including nonhuman primates, genetically modified mice | ABSTRACT Long COVID (LC) represents a chronic | , systemic, and often disabling condition that poses a | significant ongoing threat to public health. Foundational | scientific studies are needed to unravel the underlying

关键词： animal models | COVID‐19 | Long COVID | SARS‐CoV‐2

摘要：Most genetically* modified mice have been* | mice have approximately 6 Mb of the 129-derived | Ackr1-/-129ES mice* and underscore the limitations and* | embryonic stem cells.Ackr1 knockout mice* carry a 6-Mb* | produced using 129 strain-derived embryonic stem cells

关键词： 129 embryonic stem cells | ACKR1 | Fc-gamma receptor | knockout mouse | passenger mutations | PYHIN

摘要： modified mice, in which the PTH receptor is either | targets of PTH, and studies utilizing genetically | Over the past decade, advancements in cell | line development and genetic tools have led to a | wealth of new insights into the effects of parathyroid

关键词： osteocytes | parathyroid hormone | bone metabolism

摘要： generating genetically* modified rats, addressing key* | -derived sperm produced in mice* with the blastocyst* | -deficient mice, which resulted in chimeric mice* with the* | cell-deficient mice* as recipients, this approach* | We developed a novel approach for generating

关键词： ES cell; ICSI; blastocyst complementation; mouse; rat.

摘要： cancer associated with fibrosis using genetically | modified mouse models. We found that while overexpression | response to CCl4 was altered in PF4-C3GKO mice, with a | monocyte-derived macrophages compared to WT mice. On the | other hand, in response to DEN+CCl4, PF4-C3G WT mice

关键词： C3G (RapGEF1) | platelet | liver fibrosis | liver cancer | immune response

摘要： mutations, have been genetically* modified (transgenic or* | spermatogenesis. During spermatogenesis in postnatal mice, male | The adult mammalian testis is filled with | seminiferous tubules, which contain somatic Sertoli cells | along with germ cells undergoing all phases of

关键词： spermatogonia | spermatocyte | spermatid | testis | Sertoli cell | software

摘要：, combined with state-of-the-art genetically* modified mouse* | microenvironment (NEB ME) in mice, underpinning the role of these | Exciting new imaging and molecular tools | models, have recently boosted interest in pulmonary | (vagal) sensory pathway investigations. In addition to

关键词： airway innervation | Clara-like cell | lung | NEB | pulmonary receptor | Clara‐like cell

摘要： development of genetically* modified mouse models is also* | albino coat-coloured C57BL/6J mice* by targeted* | After the arrival of the CRISPR/Cas9 genome | editing technology, genetic engineering of model | organisms has become much faster and more efficient. The

关键词： CRISPR | Cas9 | tyrosinase | genetically modified mouse models | knockout | knockin | homology-directed repair | nonhomologous end joining.

摘要： the many genetically* modified mouse strains made at* | Nomenclature for Mice* umbenannt.Las cepas consangu & iacute* | Standardized Genetic Nomenclature for Mice* (Comit & eacute* | Inbred mouse strains have long proved useful | as tools for biomedical research. They remove the

关键词： SNP | genetics | DNA isolation | inbred | mice

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：Transgenic mice, including those created using | transgenic mice offer a solution by incorporating large DNA | applications of BAC transgenic mice in various disciplines | aspects of generating and analyzing BAC transgenic mice | limitations, humanized BAC transgenic mice have proven to be

关键词： Genetically modified mice | Bacterial Artificial Chromosome (BAC) | Transgenic mouse technology | Humanized BAC transgenic mice | Pathogenesis | animal model

摘要：, including nonhuman primates, genetically modified mice | ABSTRACT Long COVID (LC) represents a chronic | , systemic, and often disabling condition that poses a | significant ongoing threat to public health. Foundational | scientific studies are needed to unravel the underlying

关键词： animal models | COVID‐19 | Long COVID | SARS‐CoV‐2

摘要：Most genetically modified mice have been | mice have approximately 6 Mb of the 129-derived | Ackr1-/-129ES mice and underscore the limitations and | embryonic stem cells.Ackr1 knockout mice carry a 6-Mb | produced using 129 strain-derived embryonic stem cells

关键词： 129 embryonic stem cells | ACKR1 | Fc-gamma receptor | knockout mouse | passenger mutations | PYHIN

摘要： modified mice, in which the PTH receptor is either | targets of PTH, and studies utilizing genetically | Over the past decade, advancements in cell | line development and genetic tools have led to a | wealth of new insights into the effects of parathyroid

关键词： osteocytes | parathyroid hormone | bone metabolism

摘要： generating genetically modified rats, addressing key | -derived sperm produced in mice with the blastocyst | -deficient mice, which resulted in chimeric mice with the | cell-deficient mice as recipients, this approach | We developed a novel approach for generating

关键词： ES cell; ICSI; blastocyst complementation; mouse; rat.

摘要： cancer associated with fibrosis using genetically | modified mouse models. We found that while overexpression | response to CCl4 was altered in PF4-C3GKO mice, with a | monocyte-derived macrophages compared to WT mice. On the | other hand, in response to DEN+CCl4, PF4-C3G WT mice

关键词： C3G (RapGEF1) | platelet | liver fibrosis | liver cancer | immune response

摘要： mutations, have been genetically modified (transgenic or | spermatogenesis. During spermatogenesis in postnatal mice, male | The adult mammalian testis is filled with | seminiferous tubules, which contain somatic Sertoli cells | along with germ cells undergoing all phases of

关键词： spermatogonia | spermatocyte | spermatid | testis | Sertoli cell | software

摘要：, combined with state-of-the-art genetically modified mouse | microenvironment (NEB ME) in mice, underpinning the role of these | Exciting new imaging and molecular tools | models, have recently boosted interest in pulmonary | (vagal) sensory pathway investigations. In addition to

关键词： airway innervation | Clara-like cell | lung | NEB | pulmonary receptor | Clara‐like cell

摘要： development of genetically modified mouse models is also | albino coat-coloured C57BL/6J mice by targeted | After the arrival of the CRISPR/Cas9 genome | editing technology, genetic engineering of model | organisms has become much faster and more efficient. The

关键词： CRISPR | Cas9 | tyrosinase | genetically modified mouse models | knockout | knockin | homology-directed repair | nonhomologous end joining.

摘要： the many genetically modified mouse strains made at | Nomenclature for Mice umbenannt.Las cepas consangu & iacute | Standardized Genetic Nomenclature for Mice (Comit & eacute | Inbred mouse strains have long proved useful | as tools for biomedical research. They remove the

关键词： SNP | genetics | DNA isolation | inbred | mice

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：Most genetically* modified mice have been* | mice have approximately 6 Mb of the 129-derived | Ackr1-/-129ES mice* and underscore the limitations and* | embryonic stem cells.Ackr1 knockout mice* carry a 6-Mb* | produced using 129 strain-derived embryonic stem cells

摘要： generating genetically* modified rats, addressing key* | -derived sperm produced in mice* with the blastocyst* | -deficient mice, which resulted in chimeric mice* with the* | cell-deficient mice* as recipients, this approach* | We developed a novel approach for generating

摘要： mutations, have been genetically* modified (transgenic or* | spermatogenesis. During spermatogenesis in postnatal mice, male | The adult mammalian testis is filled with | seminiferous tubules, which contain somatic Sertoli cells | along with germ cells undergoing all phases of

摘要：, combined with state-of-the-art genetically* modified mouse* | microenvironment (NEB ME) in mice, underpinning the role of these | Exciting new imaging and molecular tools | models, have recently boosted interest in pulmonary | (vagal) sensory pathway investigations. In addition to

摘要： development of genetically* modified mouse models is also* | albino coat-coloured C57BL/6J mice* by targeted* | After the arrival of the CRISPR/Cas9 genome | editing technology, genetic engineering of model | organisms has become much faster and more efficient. The

摘要： the many genetically* modified mouse strains made at* | Nomenclature for Mice* umbenannt.Las cepas consangu & iacute* | Standardized Genetic Nomenclature for Mice* (Comit & eacute* | Inbred mouse strains have long proved useful | as tools for biomedical research. They remove the