NSTL国家科技图书文献中心

1. Unsaturated Fatty Acids Are Decreased in Aβ Plaques in Alzheimer's Disease NSTL国家科技图书文献中心

Roehr, Dominik | Helfrich, Melina ... - 《Journal of neurochemistry.》 - 2025,169(1) - e16306～e16306 - 共14页

摘要： the accumulation of amyloid-beta* (A beta) plaques in* | lipidomic analysis of chemically unaltered A beta plaques | fatty acids (UFAs) in A beta* plaques, suggesting a* | understanding of the molecular landscape of A beta* plaques and* | plaques using a novel, label-free, multimodal approach

关键词： Alzheimer's disease | amyloid‐beta plaques | fatty acids | infrared spectroscopy | laser microdissection | lipidomics | mass spectrometry | neural networks | neurodegeneration | oxidative stress...

2. Diverse role of S100 calcium-binding protein B in alzheimer's disease: pathological mechanisms and therapeutic implications NSTL国家科技图书文献中心

Sarkar, Sampriti | Porel, Pratyush ... - 《Inflammopharmacology》 - 2025,33(4) - 1803～1816 - 共14页

摘要： by amyloid-beta* plaques, neurofibrillary tangles* | and amyloid-beta* deposition effectively. This review* | S100 calcium-binding protein B, a member of | the S100 protein family, plays an important role in | the pathogenesis of Alzheimer's disease. Alzheimer's

关键词： S100B | Alzheimer's disease | A beta plaques | RAGE | Neuroinflammation

3. Targeting Neuroinflammation and Apoptosis: Cardamonin's Cognitive Benefits in Alzheimer's 5XFAD Mice NSTL国家科技图书文献中心

Smail, Shukur Wasman - 《Neurochemical research》 - 2025,50(1) - Article: 57～Article: 57 - 共12页

摘要： amyloid-beta* (A beta) levels, neuroinflammation markers* | , cardamonin reduced soluble and insoluble A beta* levels in* | markers, with IL-1 beta, IL-6, and TNF-alpha levels | This study aimed to evaluate the cognitive | -enhancing and neuroprotective effects of cardamonin in the

关键词： Alzheimer's disease | Cardamonin | A beta plaques | Memory | 5XFAD mice | Neuroinflammation

4. Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer's Pathogenesis NSTL国家科技图书文献中心

Almeida, Zaida L. | Vaz, Daniela C.... - 《Molecular Neurobiology》 - 2025,62(4) - 4391～4419 - 共29页

摘要： involvement with A beta* plaques and cell death are discussed* | , and classification of amyloid plaques* (diffuse, non* | -pathways) are described. A beta* 42/A beta 40 monomers* | , dimers, trimers, A beta-derived diffusible ligands | aggregates, protofibrils, fibrils, and plaques* are*

关键词： Alzheimer's disease (AD) | Amyloid-beta (A beta) peptide | Tau protein | Protein aggregation | Amyloid plaques | A beta-based therapies

5. Preferential clustering of microglia and astrocytes around neuritic plaques during progression of Alzheimer's disease neuropathological changes NSTL国家科技图书文献中心

Tsering, Wangchen | de la Rosa, Ana ... - 《Journal of neurochemistry.》 - 2025,169(1) - e16275～e16275 - 共15页 - 被引量：1

摘要： (A beta) plaques* and intracellular aggregates of* | immune activation is centered around A beta plaques | beta plaques. Glial fibrillary acidic protein | ) along with aggregation of extracellular amyloid-beta | brains a diversity of A beta* plaque morphologies is*

关键词： Alzheimer's disease | dystrophic neurite | microglial clustering | neuritic plaque

6. An Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: The Role of Therapeutic Interventions on Neurotransmission NSTL国家科技图书文献中心

Akyuz, Enes | Arulsamy, Alina ... - 《Molecular Neurobiology》 - 2025,62(2) - 1631～1674 - 共44页

摘要： beta) plaques and tau neurofibrillary tangles are the | disease. The accumulation of A beta* plaques and tau* | . In the presence of A beta* plaques and* | neurodegenerative disease. The accumulation of amyloid-beta* (A* | enhancing cognitive function and preventing A beta

关键词： Alzheimer's disease | Neurotransmitters | Glutamate | Acetylcholine | Amyloid-beta | Neurodegeneration

7. Olfactory deprivation promotes amyloid β deposition in a mouse model of Alzheimer's disease NSTL国家科技图书文献中心

Zhao, Xirun | Zhou, Qing ... - 《Brain research》 - 2025,1851 - Article 149500～Article 149500 - 共12页

摘要： in WT or AD mice. Densitometry of A beta plaques | difference in the plaque area. Given that A beta plaques | stained with 6E10 and anti-A beta* 42 antibodies was* | exacerbate A beta pathology at the early phase of A beta | pathogenesis. The accelerated A beta* plaque formation by OBX*

关键词： Alzheimer's disease | Model mice | Olfactory bulb | Smell loss | Amyloid plaques | Microglia

8. Novel insights into Cntnap4 in Alzheimer's disease: Intestinal flora interaction NSTL国家科技图书文献中心

Xiao, Xiaodan | Guan, Yanfei ... - 《International Journal of Biological Macromolecules》 - 2025,285 - 共15页

摘要： amyloid-beta* plaques, and increased neuronal counts* | increased Tau protein phosphorylation, amyloid-beta* plaque* | - /- mice showed impaired amyloid-beta* processing. 16 s* | Alzheimer's disease (AD) is a | neurodegenerative disorder with unclear etiology. This study

关键词： Alzheimer's disease | Cntnap4 gene | Intestinal flora | Pathological mechanisms | GABAergic synapse | Therapeutic target

9. Apolipoprotein E in Alzheimer's Disease: Focus on Synaptic Function and Therapeutic Strategy NSTL国家科技图书文献中心

Qu, Longjie | Xu, Shuai ... - 《Molecular Neurobiology》 - 2025,62(3) - 3040～3052 - 共13页

摘要：, including beta-amyloid (A beta) plaques* and* | accelerates the development of A beta* and tau pathology in* | Synaptic dysfunction is a critical | pathological feature in the early phase of Alzheimer's | disease (AD) that precedes typical hallmarks of AD

关键词： Alzheimer's disease | Apolipoprotein E | Synaptic function

10. Emerging advances in nano-biomaterial assisted amyloid beta chimeric antigen receptor macrophages (CAR-M) therapy: reducing plaque burden in Alzheimer's disease NSTL国家科技图书文献中心

Kushwaha, Nishabh | Panjwani, Drishti ... - 《Journal of drug targeting》 - 2025,33(2) - 185～205 - 共21页

摘要： beta) have demonstrated that reducing amyloid plaques | (Hp-Hb/mannose) to bind and take up A beta plaques | antibodies targeting aggregated forms of beta* amyloid (A* | Alzheimer's disease is the most common form | , accounting for 60-70% of 55 million dementia cases. Even

关键词： Alzheimer's disease | amyloid‐beta plaques | fatty acids | infrared spectroscopy | laser microdissection | lipidomics | mass spectrometry | neural networks | neurodegeneration | oxidative stress...

摘要： by amyloid-beta* plaques, neurofibrillary tangles* | and amyloid-beta* deposition effectively. This review* | S100 calcium-binding protein B, a member of | the S100 protein family, plays an important role in | the pathogenesis of Alzheimer's disease. Alzheimer's

关键词： S100B | Alzheimer's disease | A beta plaques | RAGE | Neuroinflammation

摘要： amyloid-beta* (A beta) levels, neuroinflammation markers* | , cardamonin reduced soluble and insoluble A beta* levels in* | markers, with IL-1 beta, IL-6, and TNF-alpha levels | This study aimed to evaluate the cognitive | -enhancing and neuroprotective effects of cardamonin in the

关键词： Alzheimer's disease | Cardamonin | A beta plaques | Memory | 5XFAD mice | Neuroinflammation

摘要： involvement with A beta* plaques and cell death are discussed* | , and classification of amyloid plaques* (diffuse, non* | -pathways) are described. A beta* 42/A beta 40 monomers* | , dimers, trimers, A beta-derived diffusible ligands | aggregates, protofibrils, fibrils, and plaques* are*

关键词： Alzheimer's disease (AD) | Amyloid-beta (A beta) peptide | Tau protein | Protein aggregation | Amyloid plaques | A beta-based therapies

摘要： (A beta) plaques* and intracellular aggregates of* | immune activation is centered around A beta plaques | beta plaques. Glial fibrillary acidic protein | ) along with aggregation of extracellular amyloid-beta | brains a diversity of A beta* plaque morphologies is*

关键词： Alzheimer's disease | dystrophic neurite | microglial clustering | neuritic plaque

摘要： beta) plaques and tau neurofibrillary tangles are the | disease. The accumulation of A beta* plaques and tau* | . In the presence of A beta* plaques and* | neurodegenerative disease. The accumulation of amyloid-beta* (A* | enhancing cognitive function and preventing A beta

关键词： Alzheimer's disease | Neurotransmitters | Glutamate | Acetylcholine | Amyloid-beta | Neurodegeneration

摘要： in WT or AD mice. Densitometry of A beta plaques | difference in the plaque area. Given that A beta plaques | stained with 6E10 and anti-A beta* 42 antibodies was* | exacerbate A beta pathology at the early phase of A beta | pathogenesis. The accelerated A beta* plaque formation by OBX*

关键词： Alzheimer's disease | Model mice | Olfactory bulb | Smell loss | Amyloid plaques | Microglia

摘要： amyloid-beta* plaques, and increased neuronal counts* | increased Tau protein phosphorylation, amyloid-beta* plaque* | - /- mice showed impaired amyloid-beta* processing. 16 s* | Alzheimer's disease (AD) is a | neurodegenerative disorder with unclear etiology. This study

关键词： Alzheimer's disease | Cntnap4 gene | Intestinal flora | Pathological mechanisms | GABAergic synapse | Therapeutic target

摘要：, including beta-amyloid (A beta) plaques* and* | accelerates the development of A beta* and tau pathology in* | Synaptic dysfunction is a critical | pathological feature in the early phase of Alzheimer's | disease (AD) that precedes typical hallmarks of AD

关键词： Alzheimer's disease | Apolipoprotein E | Synaptic function

摘要： beta) have demonstrated that reducing amyloid plaques | (Hp-Hb/mannose) to bind and take up A beta plaques | antibodies targeting aggregated forms of beta* amyloid (A* | Alzheimer's disease is the most common form | , accounting for 60-70% of 55 million dementia cases. Even

关键词： Chimeric antigen receptor macrophage | gene delivery | amyloid beta | Alzheimer's disease | iron-oxide nanomaterials | macrophage therapy

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： the accumulation of amyloid-beta (A beta) plaques in | lipidomic analysis of chemically unaltered A beta plaques | fatty acids (UFAs) in A beta plaques, suggesting a | understanding of the molecular landscape of A beta plaques and | plaques using a novel, label-free, multimodal approach

关键词： Alzheimer's disease | amyloid‐beta plaques | fatty acids | infrared spectroscopy | laser microdissection | lipidomics | mass spectrometry | neural networks | neurodegeneration | oxidative stress...

摘要： by amyloid-beta plaques, neurofibrillary tangles | and amyloid-beta deposition effectively. This review | S100 calcium-binding protein B, a member of | the S100 protein family, plays an important role in | the pathogenesis of Alzheimer's disease. Alzheimer's

关键词： S100B | Alzheimer's disease | A beta plaques | RAGE | Neuroinflammation

摘要： amyloid-beta (A beta) levels, neuroinflammation markers | , cardamonin reduced soluble and insoluble A beta levels in | markers, with IL-1 beta, IL-6, and TNF-alpha levels | This study aimed to evaluate the cognitive | -enhancing and neuroprotective effects of cardamonin in the

关键词： Alzheimer's disease | Cardamonin | A beta plaques | Memory | 5XFAD mice | Neuroinflammation

摘要： involvement with A beta plaques and cell death are discussed | , and classification of amyloid plaques (diffuse, non | -pathways) are described. A beta 42/A beta 40 monomers | , dimers, trimers, A beta-derived diffusible ligands | aggregates, protofibrils, fibrils, and plaques are

关键词： Alzheimer's disease (AD) | Amyloid-beta (A beta) peptide | Tau protein | Protein aggregation | Amyloid plaques | A beta-based therapies

摘要： (A beta) plaques and intracellular aggregates of | immune activation is centered around A beta plaques | beta plaques. Glial fibrillary acidic protein | ) along with aggregation of extracellular amyloid-beta | brains a diversity of A beta plaque morphologies is

关键词： Alzheimer's disease | dystrophic neurite | microglial clustering | neuritic plaque

摘要： beta) plaques and tau neurofibrillary tangles are the | disease. The accumulation of A beta plaques and tau | . In the presence of A beta plaques and | neurodegenerative disease. The accumulation of amyloid-beta (A | enhancing cognitive function and preventing A beta

关键词： Alzheimer's disease | Neurotransmitters | Glutamate | Acetylcholine | Amyloid-beta | Neurodegeneration

摘要： in WT or AD mice. Densitometry of A beta plaques | difference in the plaque area. Given that A beta plaques | stained with 6E10 and anti-A beta 42 antibodies was | exacerbate A beta pathology at the early phase of A beta | pathogenesis. The accelerated A beta plaque formation by OBX

关键词： Alzheimer's disease | Model mice | Olfactory bulb | Smell loss | Amyloid plaques | Microglia

摘要： amyloid-beta plaques, and increased neuronal counts | increased Tau protein phosphorylation, amyloid-beta plaque | - /- mice showed impaired amyloid-beta processing. 16 s | Alzheimer's disease (AD) is a | neurodegenerative disorder with unclear etiology. This study

关键词： Alzheimer's disease | Cntnap4 gene | Intestinal flora | Pathological mechanisms | GABAergic synapse | Therapeutic target

摘要：, including beta-amyloid (A beta) plaques and | accelerates the development of A beta and tau pathology in | Synaptic dysfunction is a critical | pathological feature in the early phase of Alzheimer's | disease (AD) that precedes typical hallmarks of AD

关键词： Alzheimer's disease | Apolipoprotein E | Synaptic function

摘要： beta) have demonstrated that reducing amyloid plaques | (Hp-Hb/mannose) to bind and take up A beta plaques | antibodies targeting aggregated forms of beta amyloid (A | Alzheimer's disease is the most common form | , accounting for 60-70% of 55 million dementia cases. Even

关键词： Chimeric antigen receptor macrophage | gene delivery | amyloid beta | Alzheimer's disease | iron-oxide nanomaterials | macrophage therapy

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： by amyloid-beta* plaques, neurofibrillary tangles* | and amyloid-beta* deposition effectively. This review* | S100 calcium-binding protein B, a member of | the S100 protein family, plays an important role in | the pathogenesis of Alzheimer's disease. Alzheimer's

摘要： amyloid-beta* (A beta) levels, neuroinflammation markers* | , cardamonin reduced soluble and insoluble A beta* levels in* | markers, with IL-1 beta, IL-6, and TNF-alpha levels | This study aimed to evaluate the cognitive | -enhancing and neuroprotective effects of cardamonin in the

摘要： involvement with A beta* plaques and cell death are discussed* | , and classification of amyloid plaques* (diffuse, non* | -pathways) are described. A beta* 42/A beta 40 monomers* | , dimers, trimers, A beta-derived diffusible ligands | aggregates, protofibrils, fibrils, and plaques* are*

摘要： (A beta) plaques* and intracellular aggregates of* | immune activation is centered around A beta plaques | beta plaques. Glial fibrillary acidic protein | ) along with aggregation of extracellular amyloid-beta | brains a diversity of A beta* plaque morphologies is*

摘要： beta) plaques and tau neurofibrillary tangles are the | disease. The accumulation of A beta* plaques and tau* | . In the presence of A beta* plaques and* | neurodegenerative disease. The accumulation of amyloid-beta* (A* | enhancing cognitive function and preventing A beta

摘要： in WT or AD mice. Densitometry of A beta plaques | difference in the plaque area. Given that A beta plaques | stained with 6E10 and anti-A beta* 42 antibodies was* | exacerbate A beta pathology at the early phase of A beta | pathogenesis. The accelerated A beta* plaque formation by OBX*

摘要： amyloid-beta* plaques, and increased neuronal counts* | increased Tau protein phosphorylation, amyloid-beta* plaque* | - /- mice showed impaired amyloid-beta* processing. 16 s* | Alzheimer's disease (AD) is a | neurodegenerative disorder with unclear etiology. This study

摘要：, including beta-amyloid (A beta) plaques* and* | accelerates the development of A beta* and tau pathology in* | Synaptic dysfunction is a critical | pathological feature in the early phase of Alzheimer's | disease (AD) that precedes typical hallmarks of AD

摘要： beta) have demonstrated that reducing amyloid plaques | (Hp-Hb/mannose) to bind and take up A beta plaques | antibodies targeting aggregated forms of beta* amyloid (A* | Alzheimer's disease is the most common form | , accounting for 60-70% of 55 million dementia cases. Even