NSTL国家科技图书文献中心

1. Haloperidol dopamine receptor occupancy and antagonism correspond to delirium agitation scores and EPS risk: A PBPK-PD modeling analysis NSTL国家科技图书文献中心

Burkat, Paul M. - 《Journal of psychopharmacology》 - 2025,39(3) - 244～253 - 共10页

摘要： dopamine receptor occupancy and antagonism* under these* | 70%-83% and D2LR antagonism* is 1%-10%. Variations* | ratio of developing EPS and peak D2LR antagonism* as* | antagonism parallel RASS score changes and EPS risk | Background: Delirium is a severe

关键词： Antagonism | delirium | haloperidol | occupancy | RASS

2. Fluorine at the Forefront: Transforming Opioid Antagonism with C(20)-Modified Orvinols NSTL国家科技图书文献中心

Dirk Trauner | Kamara Holmes - 《Synfacts》 - 2025,21(3) - 307～307 - 共1页

摘要： antagonism Publication HistoryArticle published online:25 | Keywords orvinols - morphinans | - trifluoromethylation - fluorine functionalization - opioid receptor | February 2025© 2025. Thieme. All rights reserved.Georg | Thieme Verlag KGOswald-Hesse-Straße 50, 70469 Stuttgart

关键词： orvinols | morphinans | trifluoromethylation | fluorine functionalization | opioid receptor antagonism

3. Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts NSTL国家科技图书文献中心

Larrous, Pauline | Garnier, Cassandre ... - 《Journal of Virology》 - 2025,99(5) - e0019825～e0019825 - 共20页

摘要： antiviral proteins. While the antagonism* of SAMHD1 has* | molecular determinants of the antagonism* against HUSH are* | HUSH antagonism. We also found that Vpx proteins of | SAMHD1 and the HUSH complex constitute two | blocks during primate lentivirus infection, the first

关键词： HIV | SIV | restriction factors | coevolution | HUSH | SAMHD1 | viral antagonism

4. Human coronaviruses: activation and antagonism of innate immune responses NSTL国家科技图书文献中心

Tanneti, Nikhila S. | Stillwell, Helen A.... - 《Microbiology and molecular biology reviews》 - 2025,89(1) - e00016-23～e00016-23 - 共29页

摘要： pathways, and viral antagonism* of innate immune responses* | Human coronaviruses cause a range of | respiratory diseases, from the common cold (HCoV-229E, HCoV | -NL63, HCoV-OC43, and SARS-CoV-2) to lethal pneumonia | (SARS-CoV, SARS-CoV-2, and MERS-CoV). Coronavirus

关键词： coronavirus | innate immune response | IFN signaling | PKR | OAS-RNase L

5. GIP Receptor Antagonism Eliminates Paradoxical Growth Hormone Secretion in Some Patients With Acromegaly NSTL国家科技图书文献中心

Jensen, Mette H. | Gasbjerg, Laerke S.... - 《The Journal of Clinical Endocrinology and Metabolism》 - 2025,110(3) - 715～729 - 共15页

摘要：Context About 30% of patients with active | acromegaly experience paradoxically increased growth | hormone (GH) secretion during the diagnostic oral | glucose tolerance test (OGTT). Endogenous glucose | -dependent insulinotropic polypeptide (GIP) is implicated

关键词： glucose-dependent insulinotropic polypeptide (GIP) | GIP receptor antagonism | acromegaly | growth hormone (GH) | paradoxical GH secretion

6. Insurmountable antagonism of human mu opioid receptors by buprenorphine is due to hemi-equilibrium NSTL国家科技图书文献中心

Wedemeyer M.J. | Chavera T.S.... - 《European Journal of Pharmacology》 - 2025,987 - 177192～177192 - 共11页

摘要： antagonist naloxone prevented buprenorphine antagonism | could account for both effects of antagonism. In | antagonism became surmountable with additional agonist | © 2024 Elsevier B.V.Buprenorphine is an FDA | approved drug for the treatment of opioid use disorder

关键词： Buprenorphine | Hemi-equilibrium | Mu opioid receptor | Opioids | Pain | Substance use disorder

7. Critical Insights Into LEAP2 Biology and Physiological Functions: Potential Roles Beyond Ghrelin Antagonism NSTL国家科技图书文献中心

Perello, Mario - 《Endocrinology》 - 2025,166(2) - bqaf011～bqaf011 - 共9页

摘要： ghrelin antagonism* and being crucial for the long-term* | Liver-expressed antimicrobial peptide 2 (LEAP2 | ) has recently emerged as a novel hormone that reduces | food intake and glycemia by acting through the growth | hormone secretagogue receptor (GHSR), also known as the

关键词： GHSR | hepatokine | energy balance | food intake

8. Structural and Functional Effects of C5aR1 Antagonism in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy NSTL国家科技图书文献中心

Saadat, Angela | Pallera, Haree ... - 《Developmental Neuroscience》 - 2025,47(2) - 112～126 - 共15页

摘要： injury and neuronal death. Reasoning C5aR1 antagonism | of treatment, suggesting C5aR1 antagonism* beyond* | Introduction: The complement response | activates upon reperfusion in neonatal hypoxic-ischemic | encephalopathy (HIE) and contributes to excessive

关键词： Neonatal brain injury | Animal model | Hypoxia-ischemia | Complement | Inflammation | Reperfusion injury

9. CD131 antagonism blocks inflammation, emphysema and fibrosis in an asthma‐COPD overlap mouse model originating in early life NSTL国家科技图书文献中心

Hao Wang | Nok Him Fung ... - 《Respirology》 - 2025,30(4) - 303～316 - 共14页

摘要： affected by the treatment. Consistently, CD131 antagonism | antagonism represents a novel approach to combating the | Abstract Background and Objective Asthma‐COPD | overlap (ACO) is characterized by patients exhibiting | features of both asthma and COPD. Currently, there is no

关键词： ACO | asthma‐COPD overlap | beta common receptor (βc) | macrophage | rhinovirus

10. Mineralocorticoid receptor antagonism partially prevents dysfunction of T cell maturation in rats chronically treated with ethanol NSTL国家科技图书文献中心

Dourado, Thales M. H... | Nascimento, Daniele ...... - 《Naunyn-Schmiedeberg's Archives of Pharmacology》 - 2025,398(2) - 1707～1720 - 共14页

摘要：Ethanol consumption induces thymic atrophy and | affects T cell maturation in the thymus. However, the | mechanisms underlying such effects still need to be fully | understood. We attempted to investigate the role of | mineralocorticoid receptors (MR) on ethanol-induced thymic atrophy

摘要： dopamine receptor occupancy and antagonism* under these* | 70%-83% and D2LR antagonism* is 1%-10%. Variations* | ratio of developing EPS and peak D2LR antagonism* as* | antagonism parallel RASS score changes and EPS risk | Background: Delirium is a severe

关键词： Antagonism | delirium | haloperidol | occupancy | RASS

摘要： antagonism Publication HistoryArticle published online:25 | Keywords orvinols - morphinans | - trifluoromethylation - fluorine functionalization - opioid receptor | February 2025© 2025. Thieme. All rights reserved.Georg | Thieme Verlag KGOswald-Hesse-Straße 50, 70469 Stuttgart

关键词： orvinols | morphinans | trifluoromethylation | fluorine functionalization | opioid receptor antagonism

摘要： antiviral proteins. While the antagonism* of SAMHD1 has* | molecular determinants of the antagonism* against HUSH are* | HUSH antagonism. We also found that Vpx proteins of | SAMHD1 and the HUSH complex constitute two | blocks during primate lentivirus infection, the first

关键词： HIV | SIV | restriction factors | coevolution | HUSH | SAMHD1 | viral antagonism

摘要： pathways, and viral antagonism* of innate immune responses* | Human coronaviruses cause a range of | respiratory diseases, from the common cold (HCoV-229E, HCoV | -NL63, HCoV-OC43, and SARS-CoV-2) to lethal pneumonia | (SARS-CoV, SARS-CoV-2, and MERS-CoV). Coronavirus

关键词： coronavirus | innate immune response | IFN signaling | PKR | OAS-RNase L

摘要：Context About 30% of patients with active | acromegaly experience paradoxically increased growth | hormone (GH) secretion during the diagnostic oral | glucose tolerance test (OGTT). Endogenous glucose | -dependent insulinotropic polypeptide (GIP) is implicated

关键词： glucose-dependent insulinotropic polypeptide (GIP) | GIP receptor antagonism | acromegaly | growth hormone (GH) | paradoxical GH secretion

摘要： antagonist naloxone prevented buprenorphine antagonism | could account for both effects of antagonism. In | antagonism became surmountable with additional agonist | © 2024 Elsevier B.V.Buprenorphine is an FDA | approved drug for the treatment of opioid use disorder

关键词： Buprenorphine | Hemi-equilibrium | Mu opioid receptor | Opioids | Pain | Substance use disorder

摘要： ghrelin antagonism* and being crucial for the long-term* | Liver-expressed antimicrobial peptide 2 (LEAP2 | ) has recently emerged as a novel hormone that reduces | food intake and glycemia by acting through the growth | hormone secretagogue receptor (GHSR), also known as the

关键词： GHSR | hepatokine | energy balance | food intake

摘要： injury and neuronal death. Reasoning C5aR1 antagonism | of treatment, suggesting C5aR1 antagonism* beyond* | Introduction: The complement response | activates upon reperfusion in neonatal hypoxic-ischemic | encephalopathy (HIE) and contributes to excessive

关键词： Neonatal brain injury | Animal model | Hypoxia-ischemia | Complement | Inflammation | Reperfusion injury

摘要： affected by the treatment. Consistently, CD131 antagonism | antagonism represents a novel approach to combating the | Abstract Background and Objective Asthma‐COPD | overlap (ACO) is characterized by patients exhibiting | features of both asthma and COPD. Currently, there is no

关键词： ACO | asthma‐COPD overlap | beta common receptor (βc) | macrophage | rhinovirus

摘要：Ethanol consumption induces thymic atrophy and | affects T cell maturation in the thymus. However, the | mechanisms underlying such effects still need to be fully | understood. We attempted to investigate the role of | mineralocorticoid receptors (MR) on ethanol-induced thymic atrophy

关键词： Ethanol | Thymus | Atrophy | T cell maturation | Mineralocorticoid receptors

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： dopamine receptor occupancy and antagonism under these | 70%-83% and D2LR antagonism is 1%-10%. Variations | ratio of developing EPS and peak D2LR antagonism as | antagonism parallel RASS score changes and EPS risk | Background: Delirium is a severe

关键词： Antagonism | delirium | haloperidol | occupancy | RASS

摘要： antagonism Publication HistoryArticle published online:25 | Keywords orvinols - morphinans | - trifluoromethylation - fluorine functionalization - opioid receptor | February 2025© 2025. Thieme. All rights reserved.Georg | Thieme Verlag KGOswald-Hesse-Straße 50, 70469 Stuttgart

关键词： orvinols | morphinans | trifluoromethylation | fluorine functionalization | opioid receptor antagonism

摘要： antiviral proteins. While the antagonism of SAMHD1 has | molecular determinants of the antagonism against HUSH are | HUSH antagonism. We also found that Vpx proteins of | SAMHD1 and the HUSH complex constitute two | blocks during primate lentivirus infection, the first

关键词： HIV | SIV | restriction factors | coevolution | HUSH | SAMHD1 | viral antagonism

摘要： pathways, and viral antagonism of innate immune responses | Human coronaviruses cause a range of | respiratory diseases, from the common cold (HCoV-229E, HCoV | -NL63, HCoV-OC43, and SARS-CoV-2) to lethal pneumonia | (SARS-CoV, SARS-CoV-2, and MERS-CoV). Coronavirus

关键词： coronavirus | innate immune response | IFN signaling | PKR | OAS-RNase L

摘要：Context About 30% of patients with active | acromegaly experience paradoxically increased growth | hormone (GH) secretion during the diagnostic oral | glucose tolerance test (OGTT). Endogenous glucose | -dependent insulinotropic polypeptide (GIP) is implicated

关键词： glucose-dependent insulinotropic polypeptide (GIP) | GIP receptor antagonism | acromegaly | growth hormone (GH) | paradoxical GH secretion

摘要： antagonist naloxone prevented buprenorphine antagonism | could account for both effects of antagonism. In | antagonism became surmountable with additional agonist | © 2024 Elsevier B.V.Buprenorphine is an FDA | approved drug for the treatment of opioid use disorder

关键词： Buprenorphine | Hemi-equilibrium | Mu opioid receptor | Opioids | Pain | Substance use disorder

摘要： ghrelin antagonism and being crucial for the long-term | Liver-expressed antimicrobial peptide 2 (LEAP2 | ) has recently emerged as a novel hormone that reduces | food intake and glycemia by acting through the growth | hormone secretagogue receptor (GHSR), also known as the

关键词： GHSR | hepatokine | energy balance | food intake

摘要： injury and neuronal death. Reasoning C5aR1 antagonism | of treatment, suggesting C5aR1 antagonism beyond | Introduction: The complement response | activates upon reperfusion in neonatal hypoxic-ischemic | encephalopathy (HIE) and contributes to excessive

关键词： Neonatal brain injury | Animal model | Hypoxia-ischemia | Complement | Inflammation | Reperfusion injury

摘要： affected by the treatment. Consistently, CD131 antagonism | antagonism represents a novel approach to combating the | Abstract Background and Objective Asthma‐COPD | overlap (ACO) is characterized by patients exhibiting | features of both asthma and COPD. Currently, there is no

关键词： ACO | asthma‐COPD overlap | beta common receptor (βc) | macrophage | rhinovirus

摘要：Ethanol consumption induces thymic atrophy and | affects T cell maturation in the thymus. However, the | mechanisms underlying such effects still need to be fully | understood. We attempted to investigate the role of | mineralocorticoid receptors (MR) on ethanol-induced thymic atrophy

关键词： Ethanol | Thymus | Atrophy | T cell maturation | Mineralocorticoid receptors

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： dopamine receptor occupancy and antagonism* under these* | 70%-83% and D2LR antagonism* is 1%-10%. Variations* | ratio of developing EPS and peak D2LR antagonism* as* | antagonism parallel RASS score changes and EPS risk | Background: Delirium is a severe

摘要： antiviral proteins. While the antagonism* of SAMHD1 has* | molecular determinants of the antagonism* against HUSH are* | HUSH antagonism. We also found that Vpx proteins of | SAMHD1 and the HUSH complex constitute two | blocks during primate lentivirus infection, the first

摘要： pathways, and viral antagonism* of innate immune responses* | Human coronaviruses cause a range of | respiratory diseases, from the common cold (HCoV-229E, HCoV | -NL63, HCoV-OC43, and SARS-CoV-2) to lethal pneumonia | (SARS-CoV, SARS-CoV-2, and MERS-CoV). Coronavirus

摘要： ghrelin antagonism* and being crucial for the long-term* | Liver-expressed antimicrobial peptide 2 (LEAP2 | ) has recently emerged as a novel hormone that reduces | food intake and glycemia by acting through the growth | hormone secretagogue receptor (GHSR), also known as the

摘要： injury and neuronal death. Reasoning C5aR1 antagonism | of treatment, suggesting C5aR1 antagonism* beyond* | Introduction: The complement response | activates upon reperfusion in neonatal hypoxic-ischemic | encephalopathy (HIE) and contributes to excessive