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1. β-Glucuronidase-Responsive Albumin-Binding Prodrug of Colchicine-Site Binders for Selective Cancer Therapy NSTL国家科技图书文献中心

Bordes, Alexandra |  Opalinski, Isabelle... -  《ChemMedChem》 - 2025,20(9) - n/a~n/a - 共8页

摘要: albumin-binding prodrug programmed to release a potent |  orthotopic triple-negative mammary tumors, this prodrug | The development of novel therapeutic |  strategies enabling the selective destruction of tumors |  while sparing healthy tissues is of great interest to
关键词: Prodrugs |  Drug delivery systems |  beta-glucuronidase |  Antiangiogenic agent |  Cancer |  β-glucuronidase

2. An albumin-binding lidamycin prodrug for efficient targeted cancer therapy NSTL国家科技图书文献中心

Hong, Han-Yu |  Zheng, Yi-Jia... -  《Journal of drug delivery science and technology》 - 2024,91 - 105213~105213 - 共6页

摘要:-binding LDM prodrug for efficient targeted cancer |  limited their developments. Here, we report an albumin | -rLDP bound to albumin quickly in vitro and in vivo |  demonstrate that Mal-LDM is a promising prodrug which could | As a radiomimetic antitumor antibiotic
关键词: Lidamycin |  Prodrug |  Mal-LDM |  Mal-rLDP |  Albumin |  Antitumor |  FUSION PROTEIN |  ANTITUMOR |  C-1027 |  DRUG...

3. A responsive disulfide bond switch aptamer prodrug exhibiting enhanced stability and anticancer efficacy NSTL国家科技图书文献中心

Dong, Xiao |  Zhang, Zhe... -  《Bioorganic and Medicinal Chemistry Letters》 - 2024,104 - 129729~129729 - 共6页

摘要: prodrug-type aptamers for tumor treatment was introduced |  against nuclease activity but also facilitated binding |  to serum albumin. Furthermore, in the reducing | Aptamers have shown significant potential in |  treating diverse diseases. However, challenges such as
关键词: Aptamer |  Prodrug |  Stability |  Antitumor |  Disulfide bond switch |  DNA |  OLIGONUCLEOTIDES |  AS1411 |  MACROPINOCYTOSIS |  MOLECULES...

4. A dual-prodrug nanogel combining Vorinostat and Pyropheophorbide a for a high efficient photochemotherapy NSTL国家科技图书文献中心

Jiang W. |  Cheng Y.... -  《International Journal of Pharmaceutics》 - 2024,661 - 124422~124422 - 共6页 - 被引量:1

摘要:. Overall, our dual-prodrug nanogel, formed by the binding |  developed a dual-prodrug nanogel (PVBN) consisting of Pyro |  Serum Albumin), which facilitates synchronous and | ? 2024 Elsevier B.V.The challenges posed by |  intractable relapse and metastasis in cancer treatment have
关键词: Histone deacetylase |  Histone deacetylase inhibitors |  Nano Hydrogel |  Photodynamic therapy |  Pyropheophorbide a

5. Acid-sensitive prodrugs; a promising approach for site-specific and targeted drug release NSTL国家科技图书文献中心

Nazli A. |  Irshad Khan M.Z.... -  《European Journal of Medicinal Chemistry: Chimie Therapeutique》 - 2024,276 - 116699~116699 - 共6页 - 被引量:3

摘要: undergoing clinical trials. These prodrugs include albumin | -binding prodrugs (Aldoxorubicin and DK049), polymeric |  challenges associated with the acid-sensitive prodrug | ? 2024 The AuthorsDrugs administered through |  conventional formulations are devoid of targeting and often
关键词: Cancer |  Challenges |  Clinical trials |  Infection |  Inflammation |  On-demand drug delivery

6. Antiproliferative activity of platinum(II) and copper(II) complexes containing novel biquinoxaline ligands NSTL国家科技图书文献中心

El-Beshti, Hager Sad... |  Gercek, Zuhal... -  《Metallomics. integrated biometal science》 - 2024,16(2) - ARTN mfae001~ - 共19页

摘要: platinum(II) compounds as prodrug candidates. The binding | ) and human serum albumin were assessed with UV |  temperature-dependent binding constant (KMODIFIER LETTER | Nowadays, cancer represents one of the major |  causes of death in humans worldwide, which renders the
关键词: Cu(II) and Pt(II) biquinoxalines |  DNA/HSA binding |  DNA cleavage |  Apoptosis |  Invasion/migration assay |  ROS generation |  BOVINE SERUM-ALBUMIN |  DNA-BINDING |  METAL-COMPLEXES |  PALLADIUM(II) COMPLEXES...

7. Combination of Targeted Therapies for Colorectal Cancer Treatment NSTL国家科技图书文献中心

Peraudeau, Elodie |  Renoux, Brigitte... -  《Molecular pharmaceutics》 - 2023,20(9) - 4537~4545 - 共9页 - 被引量:5

摘要:-binding prodrug of monomethyl auristatin E (MMAE), is |  (Bev), and a beta-glucuronidase-responsive albumin |  glucuronide prodrug in the tumor microenvironment. Since | The design of innovative therapeutic |  strategies enabling the selective destruction of tumor
关键词: targeted polytherapy |  beta-glucuronidase-responsive albumin-binding prodrug |  tumor microenvironment |  antiangiogenic therapy |  colon cancer |  ALBUMIN-BINDING PRODRUG |  BETA-GLUCURONIDASE |  TUMOR MICROENVIRONMENT |  DRUG-DELIVERY |  ANTITUMOR...

8. A boronic acid conjugation integrates antitumor drugs into albumin-binding prodrugs-based nanoparticles with robust efficiency for cancer therapy NSTL国家科技图书文献中心

Ban, Weiyue |  Luo, Qiuhua... -  《Nano Research》 - 2023,16(5) - 7422~7430 - 共9页 - 被引量:2

摘要:). Herein, we reported that an albumin-binding prodrug |  albumin-based paclitaxel (PTX) nanoparticles (NPs |  help of albumin via simple one-step nano | -precipitation method. The albumin-based nanomedicines were |  intermolecular interactions. We found that albumin-based P-PTX
关键词: drug delivery |  Abraxane (R) |  albumin-based paclitaxel nanoparticles |  phenylboronic acid group |  antitumor nanomedicines |  COORDINATION |  CHEMISTRY |  DELIVERY

9. Structure–Activity Relationship of pH-Sensitive Doxorubicin-Fatty Acid Prodrug Albumin Nanoparticles EI 工程索引 NSTL国家科技图书文献中心

Yang Yinxian |  Li Xiuhong... -  《Nano letters》 - 2023,23(4) - 1530~1538 - 共9页 - 被引量:13

摘要: acid (LA) as the albumin-binding motif, respectively | Albumin has emerged as a versatile drug |  carrier. To harness albumin as a carrier for doxorubicin | . Different from conventional albumin nanodrugs (such as |  assembled albumin nanoparticles (NPs) have an ultrahigh
关键词: Albumin |  Fatty acid prodrug |  pH-sensitive |  Nanomedicine |  Antitumor

10. Albumin-Hitchhiking Drug Delivery to Tumor-Draining Lymph Nodes Precisely Boosts Tumor-Specific Immunity through Autophagy Modulation of Immune Cells EI 工程索引 NSTL国家科技图书文献中心

Xuhui Wang |  Dong Chen... -  《Advanced Materials》 - 2023,35(29) - 2211055.1~2211055.9 - 共9页 - 被引量:8

摘要: TDLNs. A tumor-microenvironment-responsive “albumin | -targeting oxaliplatin prodrug and lipophilized trehalose |  prodrug. This demonstrates that lipophilic modification |  exposure in the tumor site enhances its binding to |  endogenous albumin and realizes TDLNs-selective reflux
关键词: antitumor immunity |  autophagy activation |  chemoimmunotherapy |  dendritic cells |  micelles |  tumor-draining lymph nodes
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