NSTL国家科技图书文献中心

1. Preclinical Evidence for a Drug-Drug Interaction Between Cannabinol and Melatonin NSTL国家科技图书文献中心

Anderson, Lyndsey L. | Hawkins, Nicole A.... - 《Basic & clinical pharmacology & toxicology.》 - 2025,136(1) - e14120～e14120 - 共5页 - 被引量：1

摘要： recently reported that CBN potently inhibited the CYP1A2 | -mediated metabolism of caffeine. CYP1A2* is the major* | inhibited CYP1A2-mediated metabolism of melatonin in vitro | and in vivo. We found CBN potently inhibited CYP1A2 | The worldwide legalization of medicinal

关键词： cannabinoid | cannabinol | CYP1A2 | melatonin | metabolism

2. In Vitro Evaluation of CYP-Mediated Metabolism of Fezolinetant and Pharmacokinetic Interaction Between Fezolinetant and Fluvoxamine in Healthy Postmenopausal Smokers and Nonsmokers NSTL国家科技图书文献中心

Iwai, Megumi | Nielsen, Jace ... - 《Journal of clinical pharmacology.》 - 2025,65(4) - 508～519 - 共12页

摘要： through CYP1A2, with minor contributions from CYP2C9 and | CYP2C19. The clinical impact of CYP1A2* inhibition and* | the impact of fluvoxamine, a strong CYP1A2* inhibitor* | , and smoking, a moderate CYP1A2* inducer, were* | Fezolinetant is an oral, nonhormonal

关键词： drug-drug interaction | fezolinetant | induction | inhibition | smoking | CYP1A2 | drug–drug interaction

3. Habitual caffeine intake, genetics and cognitive performance NSTL国家科技图书文献中心

Kapellou, Angeliki | Pilic, Leta ... - 《Journal of psychopharmacology》 - 2025,39(3) - 233～243 - 共11页

摘要： CYP1A2, AHR and ADORA2A may account for variable | rs6968554, CYP1A2* rs2472297, ADORA2A rs5751876, ADA* | Background: Research on caffeine and cognitive | performance remains controversial. Variations in genes | associated with caffeine metabolism and response such as

关键词： Attention | coffee | cognition | memory | polymorphism

4. Phase 1 Studies to Assess Inhaled Seralutinib as a Perpetrator or a Victim of Drug‐Drug Interactions in Healthy Participants NSTL国家科技图书文献中心

Jianke Li | Ed Parsley ... - 《Clinical pharmacology in drug development》 - 2025,14(2) - 91～104 - 共14页

摘要： substrates: caffeine (CYP1A2), montelukast (CYP2C8 | weak CYP1A2* inhibitor; it slightly inhibits P‐gp* | Abstract Seralutinib, an inhaled, small | ‐molecule tyrosine kinase inhibitor in clinical | development for the treatment of pulmonary arterial

关键词： cytochrome P450 | drug interactions | P‐glycoprotein | pharmacokinetics | seralutinib

5. Determination of Vatiquinone Drug‐Drug Interactions, as CYP450 Perpetrator and Victim, Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation NSTL国家科技图书文献中心

Lucy Lee | Noriko Okudaira ... - 《Journal of clinical pharmacology.》 - 2025,65(2) - 160～169 - 共10页

摘要： significantly alter the drug exposures of CYP3A4 and CYP1A2 | and CYP1A2* substrates and that moderate CYP3A4* | Abstract Vatiquinone, a 15‐lipoxygenase | inhibitor, is in development for patients with | Friedreich's ataxia. Physiologically based pharmacokinetic

关键词： drug‐drug interaction | PBPK modeling | rare disease | vatiquinone

6. Metabolic activation and hepatic cytotoxicity of osthole mediated by cytochrome P450 enzymes NSTL国家科技图书文献中心

Liu, Siyu | Zhao, Guode ... - 《Toxicology Letters》 - 2025,404 - 1～8 - 共8页

摘要： chemical analysis. CYP3A4 and CYP1A2* were the major* | Osthole (OST), a coumarin derivative, is one | of the major components of Cnidium monnieri (L | .) Cussion. OST was reported to induce apoptosis in | hepatocytes. Elevated serum ALT and AST were documented in

关键词： Osthole | Metabolic activity | Hepatotoxicity | Cytochrome P450

7. Illustrating the distribution and metabolic regulatory effects of nuciferine by mass spectrometry imaging and spatial metabolomics NSTL国家科技图书文献中心

Liu, Guangyuan | Wu, Yiying ... - 《Neurochemistry International》 - 2025,186 - Article 105977～Article 105977 - 共11页

摘要： the CYP1A2* enzyme. Metabolomic analysis revealed* | Nuciferine has been widely used in traditional | Chinese medicine compound preparations and natural | edible resources. Most current studies have | concentrated on its lipid-lowering and weight-loss effects

关键词： Nuciferine | Nuciferine metabolism | Mass spectrometry imaging | Neuropharmacological effects | Purine metabolic pathway | Adenosine

8. Pre-ADMET studies of 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone, the bioactive intestinal metabolite of proanthocyanidins NSTL国家科技图书文献中心

Della Vedova, Lariss... | Husain, Islam ... - 《Archiv der Pharmazie》 - 2025,358(1) - e2400575～e2400575 - 共17页

摘要： (CYP3A4) and Cytochrome P1A2 (CYP1A2) enzymes | 5-(3 ',4 '-Dihydroxyphenyl)-gamma | -valerolactone (VL) is a bioactive metabolite resulting from | the gut microbial metabolism of proanthocyanidins | and flavonoids, known for its health-promoting

关键词： 5-(3 ',4 '-dihydroxyphenyl)-gamma-valerolactone | HDI | pre-ADMET

9. Toxicokinetics and analytical toxicology of the phenmetrazine-derived new psychoactive substance 3,4-methylenedioxyphenmetrazine studied by means of in vitro systems NSTL国家科技图书文献中心

Kroesen, Matthias D. | Gampfer, Tanja M.... - 《Archives of Toxicology》 - 2025,99(4) - 1407～1416 - 共10页

摘要： of CYP2D6 and moderate inhibition of CYP1A2* and* | Compounds derived from known drugs are usually | brought on the new psychoactive substance (NPS) market | without any previous toxicological risk assessment. The | European Union Drugs Agency issued an EU early

关键词： 3,4-methylenedioxyphenmetrazine | Analytical toxicology | Toxicokinetics | New psychoactive substance

10. Botanical sources, biopharmaceutical profile, anticancer effects with mechanistic insight, toxicological and clinical evidence of prunetin: a literature review NSTL国家科技图书文献中心

Bithi, Sumaya Akter | Al Hasan, Md. Sakib ... - 《Medical oncology.》 - 2025,42(4) - Article: 87～Article: 87 - 共17页

摘要：, and metabolism via CYP1A2, CYP2C19, CYP2C9, and | Prunetin (PRU), a naturally occurring | flavonoid, has gained recognition for its wide-ranging | therapeutic benefits, though its anticancer properties have | yet to be extensively reviewed. This study explores

摘要： recently reported that CBN potently inhibited the CYP1A2 | -mediated metabolism of caffeine. CYP1A2* is the major* | inhibited CYP1A2-mediated metabolism of melatonin in vitro | and in vivo. We found CBN potently inhibited CYP1A2 | The worldwide legalization of medicinal

关键词： cannabinoid | cannabinol | CYP1A2 | melatonin | metabolism

摘要： through CYP1A2, with minor contributions from CYP2C9 and | CYP2C19. The clinical impact of CYP1A2* inhibition and* | the impact of fluvoxamine, a strong CYP1A2* inhibitor* | , and smoking, a moderate CYP1A2* inducer, were* | Fezolinetant is an oral, nonhormonal

关键词： drug-drug interaction | fezolinetant | induction | inhibition | smoking | CYP1A2 | drug–drug interaction

摘要： CYP1A2, AHR and ADORA2A may account for variable | rs6968554, CYP1A2* rs2472297, ADORA2A rs5751876, ADA* | Background: Research on caffeine and cognitive | performance remains controversial. Variations in genes | associated with caffeine metabolism and response such as

关键词： Attention | coffee | cognition | memory | polymorphism

摘要： substrates: caffeine (CYP1A2), montelukast (CYP2C8 | weak CYP1A2* inhibitor; it slightly inhibits P‐gp* | Abstract Seralutinib, an inhaled, small | ‐molecule tyrosine kinase inhibitor in clinical | development for the treatment of pulmonary arterial

关键词： cytochrome P450 | drug interactions | P‐glycoprotein | pharmacokinetics | seralutinib

摘要： significantly alter the drug exposures of CYP3A4 and CYP1A2 | and CYP1A2* substrates and that moderate CYP3A4* | Abstract Vatiquinone, a 15‐lipoxygenase | inhibitor, is in development for patients with | Friedreich's ataxia. Physiologically based pharmacokinetic

关键词： drug‐drug interaction | PBPK modeling | rare disease | vatiquinone

摘要： chemical analysis. CYP3A4 and CYP1A2* were the major* | Osthole (OST), a coumarin derivative, is one | of the major components of Cnidium monnieri (L | .) Cussion. OST was reported to induce apoptosis in | hepatocytes. Elevated serum ALT and AST were documented in

关键词： Osthole | Metabolic activity | Hepatotoxicity | Cytochrome P450

摘要： the CYP1A2* enzyme. Metabolomic analysis revealed* | Nuciferine has been widely used in traditional | Chinese medicine compound preparations and natural | edible resources. Most current studies have | concentrated on its lipid-lowering and weight-loss effects

关键词： Nuciferine | Nuciferine metabolism | Mass spectrometry imaging | Neuropharmacological effects | Purine metabolic pathway | Adenosine

摘要： (CYP3A4) and Cytochrome P1A2 (CYP1A2) enzymes | 5-(3 ',4 '-Dihydroxyphenyl)-gamma | -valerolactone (VL) is a bioactive metabolite resulting from | the gut microbial metabolism of proanthocyanidins | and flavonoids, known for its health-promoting

关键词： 5-(3 ',4 '-dihydroxyphenyl)-gamma-valerolactone | HDI | pre-ADMET

摘要： of CYP2D6 and moderate inhibition of CYP1A2* and* | Compounds derived from known drugs are usually | brought on the new psychoactive substance (NPS) market | without any previous toxicological risk assessment. The | European Union Drugs Agency issued an EU early

关键词： 3,4-methylenedioxyphenmetrazine | Analytical toxicology | Toxicokinetics | New psychoactive substance

摘要：, and metabolism via CYP1A2, CYP2C19, CYP2C9, and | Prunetin (PRU), a naturally occurring | flavonoid, has gained recognition for its wide-ranging | therapeutic benefits, though its anticancer properties have | yet to be extensively reviewed. This study explores

关键词： Prunetin | Flavonoid | Cancer review | Cytotoxicity | Oxidative stress | Botanical sources

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： recently reported that CBN potently inhibited the CYP1A2 | -mediated metabolism of caffeine. CYP1A2 is the major | inhibited CYP1A2-mediated metabolism of melatonin in vitro | and in vivo. We found CBN potently inhibited CYP1A2 | The worldwide legalization of medicinal

关键词： cannabinoid | cannabinol | CYP1A2 | melatonin | metabolism

摘要： through CYP1A2, with minor contributions from CYP2C9 and | CYP2C19. The clinical impact of CYP1A2 inhibition and | the impact of fluvoxamine, a strong CYP1A2 inhibitor | , and smoking, a moderate CYP1A2 inducer, were | Fezolinetant is an oral, nonhormonal

关键词： drug-drug interaction | fezolinetant | induction | inhibition | smoking | CYP1A2 | drug–drug interaction

摘要： CYP1A2, AHR and ADORA2A may account for variable | rs6968554, CYP1A2 rs2472297, ADORA2A rs5751876, ADA | Background: Research on caffeine and cognitive | performance remains controversial. Variations in genes | associated with caffeine metabolism and response such as

关键词： Attention | coffee | cognition | memory | polymorphism

摘要： substrates: caffeine (CYP1A2), montelukast (CYP2C8 | weak CYP1A2 inhibitor; it slightly inhibits P‐gp | Abstract Seralutinib, an inhaled, small | ‐molecule tyrosine kinase inhibitor in clinical | development for the treatment of pulmonary arterial

关键词： cytochrome P450 | drug interactions | P‐glycoprotein | pharmacokinetics | seralutinib

摘要： significantly alter the drug exposures of CYP3A4 and CYP1A2 | and CYP1A2 substrates and that moderate CYP3A4 | Abstract Vatiquinone, a 15‐lipoxygenase | inhibitor, is in development for patients with | Friedreich's ataxia. Physiologically based pharmacokinetic

关键词： drug‐drug interaction | PBPK modeling | rare disease | vatiquinone

摘要： chemical analysis. CYP3A4 and CYP1A2 were the major | Osthole (OST), a coumarin derivative, is one | of the major components of Cnidium monnieri (L | .) Cussion. OST was reported to induce apoptosis in | hepatocytes. Elevated serum ALT and AST were documented in

关键词： Osthole | Metabolic activity | Hepatotoxicity | Cytochrome P450

摘要： the CYP1A2 enzyme. Metabolomic analysis revealed | Nuciferine has been widely used in traditional | Chinese medicine compound preparations and natural | edible resources. Most current studies have | concentrated on its lipid-lowering and weight-loss effects

关键词： Nuciferine | Nuciferine metabolism | Mass spectrometry imaging | Neuropharmacological effects | Purine metabolic pathway | Adenosine

摘要： (CYP3A4) and Cytochrome P1A2 (CYP1A2) enzymes | 5-(3 ',4 '-Dihydroxyphenyl)-gamma | -valerolactone (VL) is a bioactive metabolite resulting from | the gut microbial metabolism of proanthocyanidins | and flavonoids, known for its health-promoting

关键词： 5-(3 ',4 '-dihydroxyphenyl)-gamma-valerolactone | HDI | pre-ADMET

摘要： of CYP2D6 and moderate inhibition of CYP1A2 and | Compounds derived from known drugs are usually | brought on the new psychoactive substance (NPS) market | without any previous toxicological risk assessment. The | European Union Drugs Agency issued an EU early

关键词： 3,4-methylenedioxyphenmetrazine | Analytical toxicology | Toxicokinetics | New psychoactive substance

摘要：, and metabolism via CYP1A2, CYP2C19, CYP2C9, and | Prunetin (PRU), a naturally occurring | flavonoid, has gained recognition for its wide-ranging | therapeutic benefits, though its anticancer properties have | yet to be extensively reviewed. This study explores

关键词： Prunetin | Flavonoid | Cancer review | Cytotoxicity | Oxidative stress | Botanical sources

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： recently reported that CBN potently inhibited the CYP1A2 | -mediated metabolism of caffeine. CYP1A2* is the major* | inhibited CYP1A2-mediated metabolism of melatonin in vitro | and in vivo. We found CBN potently inhibited CYP1A2 | The worldwide legalization of medicinal

摘要： through CYP1A2, with minor contributions from CYP2C9 and | CYP2C19. The clinical impact of CYP1A2* inhibition and* | the impact of fluvoxamine, a strong CYP1A2* inhibitor* | , and smoking, a moderate CYP1A2* inducer, were* | Fezolinetant is an oral, nonhormonal

摘要： CYP1A2, AHR and ADORA2A may account for variable | rs6968554, CYP1A2* rs2472297, ADORA2A rs5751876, ADA* | Background: Research on caffeine and cognitive | performance remains controversial. Variations in genes | associated with caffeine metabolism and response such as

摘要： substrates: caffeine (CYP1A2), montelukast (CYP2C8 | weak CYP1A2* inhibitor; it slightly inhibits P‐gp* | Abstract Seralutinib, an inhaled, small | ‐molecule tyrosine kinase inhibitor in clinical | development for the treatment of pulmonary arterial

摘要： significantly alter the drug exposures of CYP3A4 and CYP1A2 | and CYP1A2* substrates and that moderate CYP3A4* | Abstract Vatiquinone, a 15‐lipoxygenase | inhibitor, is in development for patients with | Friedreich's ataxia. Physiologically based pharmacokinetic

摘要： chemical analysis. CYP3A4 and CYP1A2* were the major* | Osthole (OST), a coumarin derivative, is one | of the major components of Cnidium monnieri (L | .) Cussion. OST was reported to induce apoptosis in | hepatocytes. Elevated serum ALT and AST were documented in

摘要： the CYP1A2* enzyme. Metabolomic analysis revealed* | Nuciferine has been widely used in traditional | Chinese medicine compound preparations and natural | edible resources. Most current studies have | concentrated on its lipid-lowering and weight-loss effects

摘要： of CYP2D6 and moderate inhibition of CYP1A2* and* | Compounds derived from known drugs are usually | brought on the new psychoactive substance (NPS) market | without any previous toxicological risk assessment. The | European Union Drugs Agency issued an EU early