NSTL国家科技图书文献中心

1. Cryo‐EM structures of the full‐length human contactin‐2 NSTL国家科技图书文献中心

Zhenzhen Zhang | Wei Chen ... - 《The FEBS journal》 - 2025,292(3) - 602～618 - 共17页

摘要：. We further determined the cryo‐EM structures* of the* | Contactin‐2 (CNTN2), an immunoglobulin cell | adhesion molecule (IgCAM) expressed on the neural cell | surface, regulates the formation of myelin sheaths | , facilitates communication between neurons and axoglial cells

关键词： cell adhesion | contactin‐2 | cryo‐EM | dimerization | full‐length

2. Cryo-EM Structures of Native Chromatin Units From Human Cells NSTL国家科技图书文献中心

Suguru Hatazawa | Yoshiyuki Fukuda ... - 《Genes to cells》 - 2025,30(3) - e70019～e70019 - 共10页

摘要： nucleus. To study the structures* of chromatin units in* | gradient ultracentrifugation, and their structures* were* | analyzed by cryo-electron microscopy. Cryo-electron | microscopy single particle analysis and cryo-electron | In eukaryotic cells, genomic DNA is compacted

关键词： chromatin; cryo‐EM; cryo‐electron tomography; nucleosome; single particle analysis.

3. Cryo‐EM structures of apo and atorvastatin‐bound human 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase NSTL国家科技图书文献中心

Manikandan Karuppasa... | Jason van Rooyen - 《Acta crystallographica,Structural biology communications.Section F》 - 2025,81(3) - 118～122 - 共5页

摘要： report the cryo‐EM structure of the catalytic part of | , respectively. In the cryo‐EM maps, part of the N‐domain | the structures* of pharmaceutical target compounds* | The enzyme 3‐hydroxy‐3‐methylglutaryl‐coenzyme | A reductase (HMGR) regulates the level of

关键词： SPA cryo‐EM | HMGR | atorvastatin | graphene oxide

4. Cryo-EM structures of the zinc transporters ZnT3 and ZnT4 provide insights into their transport mechanisms NSTL国家科技图书文献中心

Ishida, Hanako | Yo, Riri ... - 《FEBS letters.》 - 2025,599(1) - 41～52 - 共12页

摘要：. Despite their importance, the structures* and Zn2* | three-dimensional structures* of human ZnT3 (inward* | -facing) and ZnT4 (outward-facing) using cryo-electron | microscopy. By combining these structures, we assessed the | Zinc transporters (ZnTs) act as H+/Zn2

关键词： cryo-electron microscopy | membrane protein | three-dimensional structure | zinc transporter | ZnT | cryo‐electron microscopy | three‐dimensional structure

5. DiffFit: Visually-Guided Differentiable Fitting of Molecule Structures to a Cryo-EM Map NSTL国家科技图书文献中心

Deng Luo | Zainab Alsuwaykit ... - 《IEEE transactions on visualization and computer graphics》 - 2025,31(1) - 558～568 - 共11页

摘要： cellular structures* that are based on measured cryo-EM* | experimental reconstructed Cryo-Electron Microscopy (cryo-EM | cryo-EM volume. To ensure a meaningful correlation | algorithm for fitting protein atomistic structures* into an* | approximately aligned structures* followed by an automated fine*

关键词： Fitting | Proteins | Biology | Three-dimensional displays | Image registration | Accuracy | Manuals

6. Cryo‐EM SPR structures of Salmonella typhimurium ArnC; the key enzyme in lipid‐A modification conferring polymyxin resistance NSTL国家科技图书文献中心

Dhruvin H. Patel | Elina Karimullina ... - 《Protein science :》 - 2025,34(2) - e70037～e70037 - 共11页

摘要：. Here, we report the cryo‐EM SPR structures* of* | ArnC structures* to their homologs GtrB and DPMS* | Abstract Polymyxins are last‐resort | antimicrobial peptides administered clinically against multi | ‐drug resistant bacteria, specifically in the case of

关键词： ArnC | Cryo‐EM | GT‐2 | lipid‐A modifications | polymyxin resistance | Salmonella typhimurium

7. Identical Seeding Characteristics and Cryo-EM Filament Structures in FTLD-Synuclein and Typical Multiple System Atrophy NSTL国家科技图书文献中心

Cullinane, Patrick W... | Yang, Yang ... - 《Neuropathology and applied neurobiology.》 - 2025,51(2) - e70013～e70013 - 共10页

摘要： electron cryo-microscopy (cryo-EM) filament structure in | determined by cryo-EM. Results: We identified 283 cases of | were identified by cryo-EM. Conclusions: FTD/CBS is | characteristics and cryo-EM findings support the classification | Aims: The aim of this study is to identify the

关键词： cell-based seeding | cryo-EM | frontotemporal lobar degeneration | multiple system atrophy | alpha-synuclein

8. Errata to “DiffFit: Visually-Guided Differentiable Fitting of Molecule Structures to a Cryo-EM Map” NSTL国家科技图书文献中心

Deng Luo | Zainab Alsuwaykit ... - 《IEEE transactions on visualization and computer graphics》 - 2025,31(2) - 1645～1646 - 共2页

摘要：The authors would like to make the following | errata after correcting the initialization related bugs | in the associated program.

关键词： Fitting

9. CryoCrane : an open-source GUI for analyzing cryo-EM screening data sets NSTL国家科技图书文献中心

Ruickoldt, Jakob | Wendler, Petra - 《Acta crystallographica,Structural biology communications.Section F》 - 2025,81(2) - 62～65 - 共4页

摘要： the generation of high-resolution cryo-EM structures | Screening of cryo-EM samples is essential for | tool for cryo-EM screening data, is presented. It | . Often, it is cumbersome to correlate the appearance of | specific grid squares and micrograph quality. Here

关键词： cryo-EM | sample optimization | grid screening | cryo-EM data collection

10. A structural snapshot of the multiple working states of the Mpox virus helicase-primase D5 NSTL国家科技图书文献中心

Guo, Yingying | Yan, Renhong - 《The FEBS journal》 - 2025,292(3) - 510～518 - 共9页

摘要：-electron microscopy (cryo-EM) structures* of D5 in* | and genome uncoating process. Recently, cryo | multiple states have been determined. These structures | The Mpox virus (or Monkeypox virus, MPXV) uses | its own encoded proteins to form a replication

关键词： cryo-EM structure | D5 helicase-primase | Double-strand DNA unwinding | Mpox virus | Viral DNA replication | cryo‐EM structure | D5 helicase–primase | Double‐strand DNA unwinding

摘要：. We further determined the cryo‐EM structures of the | Contactin‐2 (CNTN2), an immunoglobulin cell | adhesion molecule (IgCAM) expressed on the neural cell | surface, regulates the formation of myelin sheaths | , facilitates communication between neurons and axoglial cells