NSTL国家科技图书文献中心

1. Modulation of CRISPR-Cas9 Cleavage with an Oligo-Ribonucleoprotein Design NSTL国家科技图书文献中心

Gao, Yahui | Ang, Yan Shan ... - 《Chembiochem》 - 2025,26(4) - n/a～n/a - 共11页

摘要： palindromic repeats (CRISPR) associated protein Cas9* system* | , the editing or cleavage specificity of CRISPR Cas9 | CRISPR Cas9 cleavage include engineering Cas9 protein | to modulate CRISPR* Cas9 cleavage without* | and development of anti-CRISPR* proteins. There are*

关键词： CRISPR Cas9 | modulation of Cas9 | DNA cleavage | DNA | genome editing

2. CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis NSTL国家科技图书文献中心

Gu, Bin | Li, Min ... - 《Journal of cardiovascular translational research.》 - 2025,18(2) - 424～441 - 共18页

摘要：CRISPR-Cas9 gene editing technology, as an | precisely editing key genes such as PCSK9, CRISPR-Cas9 | continued advancement of gene editing technology, CRISPR | -Cas9* may become an important tool for treating* | innovative biomedical tool, holds significant potential in

关键词： Atherosclerosis | PCSK9 | CRISPR-Cas9 | Gene editing | LDL-C | Cardiovascular diseases

3. CRISPR/Cas9 system: a novel approach to overcome chemotherapy and radiotherapy resistance in cancer NSTL国家科技图书文献中心

Noruzi, Somaye | Mohammadi, Rezvan ... - 《Naunyn-Schmiedeberg's Archives of Pharmacology》 - 2025,398(4) - 3373～3408 - 共36页

摘要： protein 9 (CRISPR/Cas9) genome editing has | sequences, and genome-wide screening. CRISPR/Cas9* is an* | CRISPR/Cas9 system in improving the effectiveness of | interspaced short palindromic repeats and CRISPR-associated | Cancer presents a global health challenge with

关键词： CRISPR/Cas9 | Cancer | Chemoresistance | Radioresistance

4. Cell cycle-dependent regulation of CRISPR-Cas9 repetitive activation by anti-CRISPR and Cdt1 fusion in the CRISPRa system NSTL国家科技图书文献中心

Kishi, Kanae | Nigorikawa, Kiyomi ... - 《FEBS letters.》 - 2025,599(6) - 828～837 - 共10页

摘要：CRISPR-Cas9 is a widely used genome-editing | , a Cas9* inhibitor, and Cdt1, which accumulates in* | the G1 phase and activates Cas9* only in the S/G2* | phase. However, it is unknown whether Cas9* inhibition* | interaction between Cas9* and AcrIIA4 + Cdt1 at single-cell*

关键词： cell cycle | CRISPR activation | CRISPR-Cas9 | protein-protein interaction | transcription regulation | CRISPR‐Cas9 | protein–protein interaction

5. Leveraging CRISPR/Cas9 in notable bacteria for the production of industrially valuable compounds NSTL国家科技图书文献中心

Karim, Md Dilshad | Abuhena, Md ... - 《Systems Microbiology and Biomanufacturing》 - 2025,5(2) - 512～530 - 共19页

摘要：. The CRISPR/Cas9* gene editing technique offers more* | the research of natural goods. The CRISPR/Cas9 | article provides an overview of the CRISPR/CRISPR | to highlight and analyze the applications of CRISPR | /Cas, particularly CRISPR/SpCas9, in genome editing

关键词： Bacteria | CRISPR/Cas9 | Genome editing | Natural compounds | Metabolites

6. An undergraduate research experience in CRISPR‐Cas9 mediated eukaryotic genome editing to teach fundamental biochemistry techniques NSTL国家科技图书文献中心

Andrew J. Tonsager | Laurie A. Stargell - 《Biochemistry and molecular biology education》 - 2025,53(1) - 33～45 - 共13页

摘要：Abstract CRISPR‐Cas9* technology is an* | introduction of desired genetic modifications. CRISPR‐Cas9* is* | sciences are educated on CRISPR‐Cas9* technology. To this* | ) designed for students to understand CRISPR‐Cas9* genome* | CRISPR‐Cas9 genome editing, from preparation of genome

关键词： biochemistry education | course‐based undergraduate research experience | CRISPR‐Cas9 | yeast genome engineering

7. The Potential Therapeutic Applications of CRISPR/Cas9 in the Treatment of Gastrointestinal Cancers NSTL国家科技图书文献中心

Mehrabadi, Shima | Izadi, Faezeh Salman...... - 《Current molecular medicine》 - 2025,25(3) - 278～288 - 共11页

摘要： progression cause GI progression. CRISPR/Cas9* technique is a* | . CRISPR/Cas9* can be applied to genome therapy for GI* | multiple genes. The use of CRISPR/ Cas9* gene editing* | on the role of CRISPR/Cas9* in cancer treatment that* | . Here, the use of CRISPR/Cas9-based genome editing in

关键词： CRISPR/Cas9 | Gastrointestinal | Cancer therapy | Cancer research | Diagnosis of cancer | Gene editing technology

8. CRISPR/Cas9-mediated knockout of Tektin 4 -like gene ( TEKT4L ) causes male sterility of Cydia pomonella NSTL国家科技图书文献中心

Wei, Zihan | Wang, Chang ... - 《Insect Biochemistry and Molecular Biology》 - 2025,177 - 共11页 - 被引量：1

摘要： management approach utilizing CRISPR/Cas9* to target these* | reproductive processes. By utilizing CRISPR/Cas9* technology* | The sterile insect technique (SIT) is a well | -established and environmentally benign method for population | control. Identifying genes that regulate insect

关键词： CRISPR/Cas9 | Cydia pomonella | Male sterility | TEKT4L | SIT

9. Generation of viable hypomorphic and null mutant plants via CRISPR-Cas9 targeting mRNA splicing sites NSTL国家科技图书文献中心

Yoshimura, Mika | Ishida, Takashi - 《Journal of Plant Research》 - 2025,138(1) - 189～196 - 共8页

摘要： technologies, particularly CRISPR-Cas9, have revolutionized | CRISPR-Cas9. The Arabidopsis HIGH PLOIDY 2 (HPY2 | HPY2, and demonstrate the usefulness of CRISPR-Cas9 | Genetic analysis is important for modern plant | molecular biology, and in this regard, the existence of

关键词： CRISPR-Cas9 | Genome editing | Hypomorphic allele | Lethal gene

10. CRISPR/Cas9-based editing of NF-YC4 promoters yields high-protein rice and soybean NSTL国家科技图书文献中心

Lei Wang | Seth O'Conner ... - 《The New Phytologist》 - 2025,245(5) - 2103～2116 - 共14页 - 被引量：3

摘要： soybean (Glycine max).Leveraging CRISPR/Cas9* technology* | Genome editing is a revolution in | biotechnology for crop improvement with the final product | lacking transgenes. However, most derived traits have | been generated through edits that create gene

摘要： palindromic repeats (CRISPR) associated protein Cas9* system* | , the editing or cleavage specificity of CRISPR Cas9 | CRISPR Cas9 cleavage include engineering Cas9 protein | to modulate CRISPR* Cas9 cleavage without* | and development of anti-CRISPR* proteins. There are*

关键词： CRISPR Cas9 | modulation of Cas9 | DNA cleavage | DNA | genome editing

摘要：CRISPR-Cas9 gene editing technology, as an | precisely editing key genes such as PCSK9, CRISPR-Cas9 | continued advancement of gene editing technology, CRISPR | -Cas9* may become an important tool for treating* | innovative biomedical tool, holds significant potential in

关键词： Atherosclerosis | PCSK9 | CRISPR-Cas9 | Gene editing | LDL-C | Cardiovascular diseases

摘要： protein 9 (CRISPR/Cas9) genome editing has | sequences, and genome-wide screening. CRISPR/Cas9* is an* | CRISPR/Cas9 system in improving the effectiveness of | interspaced short palindromic repeats and CRISPR-associated | Cancer presents a global health challenge with

关键词： CRISPR/Cas9 | Cancer | Chemoresistance | Radioresistance

摘要：CRISPR-Cas9 is a widely used genome-editing | , a Cas9* inhibitor, and Cdt1, which accumulates in* | the G1 phase and activates Cas9* only in the S/G2* | phase. However, it is unknown whether Cas9* inhibition* | interaction between Cas9* and AcrIIA4 + Cdt1 at single-cell*

关键词： cell cycle | CRISPR activation | CRISPR-Cas9 | protein-protein interaction | transcription regulation | CRISPR‐Cas9 | protein–protein interaction

摘要：. The CRISPR/Cas9* gene editing technique offers more* | the research of natural goods. The CRISPR/Cas9 | article provides an overview of the CRISPR/CRISPR | to highlight and analyze the applications of CRISPR | /Cas, particularly CRISPR/SpCas9, in genome editing

关键词： Bacteria | CRISPR/Cas9 | Genome editing | Natural compounds | Metabolites

关键词： biochemistry education | course‐based undergraduate research experience | CRISPR‐Cas9 | yeast genome engineering

摘要： progression cause GI progression. CRISPR/Cas9* technique is a* | . CRISPR/Cas9* can be applied to genome therapy for GI* | multiple genes. The use of CRISPR/ Cas9* gene editing* | on the role of CRISPR/Cas9* in cancer treatment that* | . Here, the use of CRISPR/Cas9-based genome editing in

关键词： CRISPR/Cas9 | Gastrointestinal | Cancer therapy | Cancer research | Diagnosis of cancer | Gene editing technology

摘要： management approach utilizing CRISPR/Cas9* to target these* | reproductive processes. By utilizing CRISPR/Cas9* technology* | The sterile insect technique (SIT) is a well | -established and environmentally benign method for population | control. Identifying genes that regulate insect

关键词： CRISPR/Cas9 | Cydia pomonella | Male sterility | TEKT4L | SIT

摘要： technologies, particularly CRISPR-Cas9, have revolutionized | CRISPR-Cas9. The Arabidopsis HIGH PLOIDY 2 (HPY2 | HPY2, and demonstrate the usefulness of CRISPR-Cas9 | Genetic analysis is important for modern plant | molecular biology, and in this regard, the existence of

关键词： CRISPR-Cas9 | Genome editing | Hypomorphic allele | Lethal gene

摘要： soybean (Glycine max).Leveraging CRISPR/Cas9* technology* | Genome editing is a revolution in | biotechnology for crop improvement with the final product | lacking transgenes. However, most derived traits have | been generated through edits that create gene

关键词： CRISPR/Cas9 | NF-YC4promoter | protein | rice | soybean

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： palindromic repeats (CRISPR) associated protein Cas9 system | , the editing or cleavage specificity of CRISPR Cas9 | CRISPR Cas9 cleavage include engineering Cas9 protein | to modulate CRISPR Cas9 cleavage without | and development of anti-CRISPR proteins. There are

关键词： CRISPR Cas9 | modulation of Cas9 | DNA cleavage | DNA | genome editing

摘要：CRISPR-Cas9 gene editing technology, as an | precisely editing key genes such as PCSK9, CRISPR-Cas9 | continued advancement of gene editing technology, CRISPR | -Cas9 may become an important tool for treating | innovative biomedical tool, holds significant potential in

关键词： Atherosclerosis | PCSK9 | CRISPR-Cas9 | Gene editing | LDL-C | Cardiovascular diseases

摘要： protein 9 (CRISPR/Cas9) genome editing has | sequences, and genome-wide screening. CRISPR/Cas9 is an | CRISPR/Cas9 system in improving the effectiveness of | interspaced short palindromic repeats and CRISPR-associated | Cancer presents a global health challenge with

关键词： CRISPR/Cas9 | Cancer | Chemoresistance | Radioresistance

摘要：CRISPR-Cas9 is a widely used genome-editing | , a Cas9 inhibitor, and Cdt1, which accumulates in | the G1 phase and activates Cas9 only in the S/G2 | phase. However, it is unknown whether Cas9 inhibition | interaction between Cas9 and AcrIIA4 + Cdt1 at single-cell

关键词： cell cycle | CRISPR activation | CRISPR-Cas9 | protein-protein interaction | transcription regulation | CRISPR‐Cas9 | protein–protein interaction

摘要：. The CRISPR/Cas9 gene editing technique offers more | the research of natural goods. The CRISPR/Cas9 | article provides an overview of the CRISPR/CRISPR | to highlight and analyze the applications of CRISPR | /Cas, particularly CRISPR/SpCas9, in genome editing

关键词： Bacteria | CRISPR/Cas9 | Genome editing | Natural compounds | Metabolites

摘要：Abstract CRISPR‐Cas9 technology is an | introduction of desired genetic modifications. CRISPR‐Cas9 is | sciences are educated on CRISPR‐Cas9 technology. To this | ) designed for students to understand CRISPR‐Cas9 genome | CRISPR‐Cas9 genome editing, from preparation of genome

关键词： biochemistry education | course‐based undergraduate research experience | CRISPR‐Cas9 | yeast genome engineering

摘要： progression cause GI progression. CRISPR/Cas9 technique is a | . CRISPR/Cas9 can be applied to genome therapy for GI | multiple genes. The use of CRISPR/ Cas9 gene editing | on the role of CRISPR/Cas9 in cancer treatment that | . Here, the use of CRISPR/Cas9-based genome editing in

关键词： CRISPR/Cas9 | Gastrointestinal | Cancer therapy | Cancer research | Diagnosis of cancer | Gene editing technology

摘要： management approach utilizing CRISPR/Cas9 to target these | reproductive processes. By utilizing CRISPR/Cas9 technology | The sterile insect technique (SIT) is a well | -established and environmentally benign method for population | control. Identifying genes that regulate insect

关键词： CRISPR/Cas9 | Cydia pomonella | Male sterility | TEKT4L | SIT

摘要： technologies, particularly CRISPR-Cas9, have revolutionized | CRISPR-Cas9. The Arabidopsis HIGH PLOIDY 2 (HPY2 | HPY2, and demonstrate the usefulness of CRISPR-Cas9 | Genetic analysis is important for modern plant | molecular biology, and in this regard, the existence of

关键词： CRISPR-Cas9 | Genome editing | Hypomorphic allele | Lethal gene

摘要： soybean (Glycine max).Leveraging CRISPR/Cas9 technology | Genome editing is a revolution in | biotechnology for crop improvement with the final product | lacking transgenes. However, most derived traits have | been generated through edits that create gene

关键词： CRISPR/Cas9 | NF-YC4promoter | protein | rice | soybean

4008-161-200 800-990-8900

国家科技图书文献中心

摘要： palindromic repeats (CRISPR) associated protein Cas9* system* | , the editing or cleavage specificity of CRISPR Cas9 | CRISPR Cas9 cleavage include engineering Cas9 protein | to modulate CRISPR* Cas9 cleavage without* | and development of anti-CRISPR* proteins. There are*

摘要：CRISPR-Cas9 gene editing technology, as an | precisely editing key genes such as PCSK9, CRISPR-Cas9 | continued advancement of gene editing technology, CRISPR | -Cas9* may become an important tool for treating* | innovative biomedical tool, holds significant potential in

摘要： protein 9 (CRISPR/Cas9) genome editing has | sequences, and genome-wide screening. CRISPR/Cas9* is an* | CRISPR/Cas9 system in improving the effectiveness of | interspaced short palindromic repeats and CRISPR-associated | Cancer presents a global health challenge with

摘要：CRISPR-Cas9 is a widely used genome-editing | , a Cas9* inhibitor, and Cdt1, which accumulates in* | the G1 phase and activates Cas9* only in the S/G2* | phase. However, it is unknown whether Cas9* inhibition* | interaction between Cas9* and AcrIIA4 + Cdt1 at single-cell*

摘要：. The CRISPR/Cas9* gene editing technique offers more* | the research of natural goods. The CRISPR/Cas9 | article provides an overview of the CRISPR/CRISPR | to highlight and analyze the applications of CRISPR | /Cas, particularly CRISPR/SpCas9, in genome editing

摘要： management approach utilizing CRISPR/Cas9* to target these* | reproductive processes. By utilizing CRISPR/Cas9* technology* | The sterile insect technique (SIT) is a well | -established and environmentally benign method for population | control. Identifying genes that regulate insect

摘要： soybean (Glycine max).Leveraging CRISPR/Cas9* technology* | Genome editing is a revolution in | biotechnology for crop improvement with the final product | lacking transgenes. However, most derived traits have | been generated through edits that create gene