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1. Bifunctional Oxaliplatin (IV) Prodrug Based pH-Sensitive PEGylated Liposomes for Synergistic Anticancer Action Against Triple Negative Breast cancer NSTL国家科技图书文献中心

Lavkesh,Bhute |  Sayali,Dighe... -  《AAPS PharmSciTech》 - 2025,26(1) - Article: 2~Article: 2 - 共18页

摘要:) prodrug was developed by using chlorambucil (CBL) as a | Abstract Triple negative breast cancer (TNBC | ) exhibits higher susceptibility towards oxaliplatin (OXA | ) due to a faulty DNA damage repair system. However | , the unfavorable physicochemical properties and risk
关键词: chlorambucil |  oxaliplatin |  pH-sensitive liposomes |  platinum prodrug |  triple negative breast cancer

2. A Universal Single-Activated-Dual-Release Vehicle: Enabling Synergistic Antitumor Therapy NSTL国家科技图书文献中心

Han, Jinliang |  Yang, Mingwang... -  《Small》 - 2025,21(13) - n/a~n/a - 共11页

摘要: photosensitizer (CyI-OH) and DNA alkylating agent chlorambucil | Activatable combined therapeutic strategy |  exhibits significant potential for the management of |  malignant tumors. Ensuring the timely and spatially |  effective release of different therapeutic agents is a
关键词: activatable |  dual-release |  synergistic therapy |  tumor |  various stimulants |  dual‐release

3. Cinnamaldehyde as a Potential Cathepsin-B Inhibitor: A Comparative Investigation with some Commercial Anticancer Drugs NSTL国家科技图书文献中心

Vashisth, Chanchal |  Verma, Nitin Kumar... -  《Chemistry & biodiversity》 - 2025,22(3) - n/a~n/a - 共15页

摘要: chlorambucil (CB), docetaxel (DOC), melphalan (MP | Cancer is a leading cause of death worldwide | , surpassed only by heart disease. Despite improved |  diagnosis and treatment, cancer cells still evade normal |  physiological processes such as apoptosis, metabolism
关键词: Cinnamaldehyde |  Molecular docking |  Cathepsin B

4. Regulating the Cytotoxicity of Anticancer Drugs by Pillar[6]arene-based Host-Guest Complex NSTL国家科技图书文献中心

Jia, Xinyu |  Wei, Haoyu... -  《Chemistry》 - 2025,31(19) - n/a~n/a - 共8页

摘要: chlorambucil (CLB) was developed using the host-guest | Creating molecular-level host-guest complexes |  with properties responsive to endogenous substance |  stimuli-responsive as drug delivery systems, is critical |  for improving drug stability, reducing side effects
关键词: Amino-pillar[6]arene |  Host-guest interaction |  Drug delivery system |  Chemotherapy |  ATP responsiveness

5. Synthesis of water-soluble chlorambucil Janus dendrimers NSTL国家科技图书文献中心

Castillo-Rodriguez, ... |  Rubio-Vigil, Alejand...... -  《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 - 2024,149 - ARTN 155265~ - 共4页

摘要: carboxylate and chlorambucil molecules as the peripheral |  anticancer drug, chlorambucil, by a covalent bond. The |  amounts of chlorambucil molecules. The Janus dendrimers | In this paper we reported a new range of |  amphiphilic Janus dendrimers, which consist of sodium
关键词: Janus dendrimer |  Behera's amine dendrons |  Chlorambucil |  Water soluble conjugated dendrimers |  Anticancer activity |  SURFACE-CHARGE

6. Synthesis of biodegradable Janus dendrimer conjugates with chlorambucil and naproxen NSTL国家科技图书文献中心

Castillo-Rodriguez, ... |  Hernandez-Rioja, Isa...... -  《Tetrahedron》 - 2024,166 - ARTN 134193~ - 共10页

摘要: conjugates with chlorambucil (CLB) and naproxen, which |  chlorambucil and four naproxen moieties. The result indicates | To improve the anticancer activity of |  commercial drugs, a series of well-defined Janus dendrimer |  feature diethanolamine groups and ethylene glycol in the
关键词: Janus dendrimer |  Chlorambucil |  Naproxen |  Diethanolamine |  Ethylene glycol |  Anticancer activity |  CHRONIC LYMPHOCYTIC-LEUKEMIA |  DESIGN |  PLATFORM

7. Janus Dendrimers as Nanocarriers of Ibuprofen, Chlorambucil and their Anticancer Activity NSTL国家科技图书文献中心

Luis Pedro-Hernández |  Israel Barajas-Mendo...... -  《Pharmaceutical Nanotechnology》 - 2024,12(3) - 276~287 - 共12页

摘要: dendron conjugates with chlorambucil, and the other | , attached a chlorambucil- derivative. The IC 50 behavior |  chlorambucil and nonsteroidal antiinflammatory Ibuprofen can |  improve the anticancer activity of chlorambucil with | Background: Janus Dendrimer represents a novel
关键词: Anticancer activity |  click reaction |  Janus dendrimers |  chlorambucil |  Ibuprofen |  dendrons.

8. Enhanced DNA damage and anti-proliferative activity of a novel ruthenium complex with a chlorambucil-decorated ligand NSTL国家科技图书文献中心

Gobbo, Alberto |  Chen, Feihong... -  《Journal of Inorganic Biochemistry》 - 2024,260 - 共10页

摘要: chlorambucil-decorated pyridine ligand PyCA, CA , 3 |  esterification of 4-pyridinemethanol with chlorambucil. The new | Triphenylphosphine substitution reactions of |  [RuCl(PPh3)2(tpm)]Cl, 3 ) 2 (tpm)]Cl, 1 , featuring |  tris(pyrazolyl)methane (tpm) as ligand, with the
关键词: Ruthenium(II) complexes |  Chlorambucil |  Tris-Pyrazolylmethane |  Anticancer activity |  DNA damage

9. Launching triple-hit chemo attack on TNBC through nanoparticle-mediated codelivery of cisplatin-chlorambucil conjugate and venetoclax NSTL国家科技图书文献中心

Date, Tushar |  Katari, Oly... -  《International Journal of Pharmaceutics》 - 2024,667PA - 124890~124890 - 共15页

摘要: cisplatin-chlorambucil (CP-CBL) prodrug and loaded it with |  cisplatin, chlorambucil and venetoclax. The TNPs possessed | The BRCA1 dysfunction and HR deficiency in |  TNBC are responsible for high effectiveness of DNA | -damaging agents in TNBC treatment. Preclinical and
关键词: Chlorambucil |  Cisplatin |  Phenylboronic acid |  TPGS |  Triple-negative breast cancer |  Venetoclax

10. A green route for the synthesis of sponge-like Pr6O11 nanoparticles and their application for the development of chlorambucil sensor NSTL国家科技图书文献中心

Zinatloo-Ajabshir S. |  Mahmoudi-Moghaddam H...... -  《Measurement》 - 2024,235 - 114924.1~114924.8 - 共8页 - 被引量:14

摘要:. Investigation of the electrochemical behavior of chlorambucil | © 2024 Elsevier LtdHerein, to fabricate the |  sponge-like praseodymium oxide nanoparticles (SL | - Pr6O11 NPs), a facile and quick sonochemical route is |  introduced utilizing an environmentally friendly capping
关键词: Anti-cancer |  Chlorambucil |  Modified electrode |  Praseodymium oxide |  Voltammetry
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