NSTL国家科技图书文献中心

1. Synthesis and Imaging of Novel CDK19-Targeted Tracers Incorporating an Albumin-Binding Moiety NSTL国家科技图书文献中心

Li, Panfeng | Yang, Zhao ... - 《Journal of labelled compounds & radiopharmaceuticals.》 - 2025,68(3) - e4130～e4130 - 共10页

摘要：Cyclin-dependent kinase 19 (CDK19) is a | CDK19-targeted PET tracers, but in-depth drug | potential target for the diagnosis and treatment of | prostate cancer. We have previously studied a series of | optimization is needed to improve the physiochemical

关键词： albumin binder | CDK19 | PET imaging | prostate cancer | radiotraces

2. Zinc finger protein 169 promotes tumor progress of hepatocellular cancer via up-regulating cyclin-dependent kinase 19 NSTL国家科技图书文献中心

Hu, Chaoquan | Ainiwaer, Aizier ... - 《IUBMB life》 - 2025,77(1) - 共12页

摘要： showed that cyclin-dependent* kinase 19 (CDK19) was* | interaction between ZNF169 and CDK19* promoter. Additionally* | , our data showed that CDK19* expression levels were* | elevated in HCC tissues, and patients with higher CDK19 | experiments demonstrated that CDK19* could reverse the impact*

关键词： cyclin‐dependent kinase 19 (CDK19) | hepatocellular cancer | malignancy | overall survival | zinc finger protein 169 (ZNF169) | cyclin-dependent kinase 19 (CDK19)

3. Novel CDK19-Targeted Radiotracers: A Potential Design Strategy to Improve the Pharmacokinetics and Tumor Uptake NSTL国家科技图书文献中心

Dai, Dong | Yu, Jiang ... - 《Journal of Medicinal Chemistry》 - 2024,67(8) - 6726～6737 - 共12页 - 被引量：2

摘要：Cyclin-dependent kinase 19 (CDK19) is | optimization strategy is well suited for CDK19* and provides a* | overexpressed in prostate cancer, making it an attractive | target for both imaging and therapy. Since little is | known about the optimized approach for radioligands of

关键词： RADIOTHERANOSTICS | RADIOLIGAND | CDK19

4. CDK8/19 inhibition triggers a switch from mitosis to endomitosis in cord blood megakaryocytes NSTL国家科技图书文献中心

Liu, Zhi-Jian | Thom, Christopher ... - 《British Journal of Haematology》 - 2024,205(6) - 2481～2486 - 共6页

摘要： differences are incompletely understood. CDK8 and CDK19* are* | inhibitor of CDK8/CDK19, significantly reduced cell | Neonatal and adult megakaryocytes differ in | proliferative capacity and ploidy levels, and neonatal and | adult platelets differ in function, gene expression

关键词： cord blood | megakaryocytes | neonatal haematology | transcription

5. Discovery of a Novel and Potent Cyclin-Dependent Kinase 8/19 (CDK8/19) Inhibitor for the Treatment of Cancer NSTL国家科技图书文献中心

Xu, Jianyu | Qi, Hongyun ... - 《Journal of Medicinal Chemistry》 - 2024,67(10) - 8161～8171 - 共11页 - 被引量：2

摘要：The mediator kinases CDK8 and CDK19* control* | the dynamic transcription of selected genes in | response to various signals and have been shown to be | hijacked to sustain hyperproliferation by various solid | and liquid tumors. CDK8/19 is emerging as a

关键词： IDENTIFICATION | TRANSCRIPTION | GENES | CELLS | STAT1 | AML

6. Cip1, a CDK regulator, determines heterothallic mating or homothallic selfing in a protist NSTL国家科技图书文献中心

Yang Ma | Guanxiong Yan ... - 《Proceedings of the National Academy of Sciences of the United States of America.》 - 2024,121(13) - e2315531121～e2315531121 - 共6页

摘要： revealed that Cip1 is a regulatory subunit of the Cdk19 | Mating type (sex) plays a crucial role in | regulating sexual reproduction in most extant eukaryotes | . One of the functions of mating types is ensuring | self-incompatibility to some extent, thereby

关键词： self-incompatibility | sexual reproduction initiation | mating-type recognition | ancestral eukaryotic sex | Tetrahymena

7. Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting "block and lock" treatment strategies NSTL国家科技图书文献中心

Horvath, Riley M. | Brumme, Zabrina L.... - 《Antimicrobial agents and chemotherapy.》 - 2024,68(3) - e0107223～e0107223 - 共6页

摘要： CDK8/CDK19* as potential "block and lock" targets for* | Current antiretroviral therapy for HIV-1 | infection does not represent a cure for infection as viral | rebound inevitably occurs following discontinuation of | treatment. The "block and lock" therapeutic strategy is

关键词： CDK7 | CDK8 | CDK9 | CDK19 | YKL-5-124 | LDC000067 | Senexin A | HIV-1 | latency | transcription...

8. MED12 and CDK8/19 Modulate Androgen Receptor Activity and Enzalutamide Response in Prostate Cancer NSTL国家科技图书文献中心

Andolfi, Chiara | Bartolini, Caterina ... - 《Endocrinology》 - 2024,165(10) - bqae114～bqae114 - 共6页 - 被引量：2

摘要： paralog CDK19, are components of the kinase module that | Prostate cancer progression is driven by | androgen receptor (AR) activity, which is a target for | therapeutic approaches. Enzalutamide is an AR inhibitor that | prolongs the survival of patients with advanced prostate

关键词： prostate cancer | Mediator complex | androgen receptor | enzalutamide | MEDIATOR COMPLEX | KINASE | PHOSPHORYLATION | SUBCOMPLEX | CELLS

9. PET imaging of new target CDK19 in prostate cancer NSTL国家科技图书文献中心

Dong,Dai | Jiang,Yu ... - 《European Journal of Nuclear Medicine and Molecular Imaging》 - 2023,50(11) - 3452～3464 - 共13页 - 被引量：6

摘要： cancer were used to identify CDK19* and PSMA expression* | vitro. To evaluate in vivo CDK19-specific uptake of | novel tissue-specific gene CDK19* in high-risk* | metastatic prostate cancer and CDK19* expression correlated* | molecules targeting CDK19* labeled with Ga-68 (68Ga-IRM-015*

关键词： Metastatic prostate cancer | PET imaging | PSMA | CDK19 | Neuroendocrine prostate cancer (NEPC)

10. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins NSTL国家科技图书文献中心

Chen, Mengqian | Li, Jing ... - 《Nucleic Acids Research》 - 2023,51(14) - 7288～7313 - 共26页 - 被引量：10

摘要： paralog CDK19, alternative enzymatic components of the | CDK8 and CDK19, selective CDK8/19 small molecule | isogenic cell populations expressing CDK8, CDK19* or their* | kinase-inactive mutants revealed that CDK8 and CDK19 | CDK19 knockouts were attributable to quantitative

摘要：Cyclin-dependent kinase 19 (CDK19) is a | CDK19-targeted PET tracers, but in-depth drug | potential target for the diagnosis and treatment of | prostate cancer. We have previously studied a series of | optimization is needed to improve the physiochemical

关键词： albumin binder | CDK19 | PET imaging | prostate cancer | radiotraces

关键词： cyclin‐dependent kinase 19 (CDK19) | hepatocellular cancer | malignancy | overall survival | zinc finger protein 169 (ZNF169) | cyclin-dependent kinase 19 (CDK19)

摘要：Cyclin-dependent kinase 19 (CDK19) is | optimization strategy is well suited for CDK19* and provides a* | overexpressed in prostate cancer, making it an attractive | target for both imaging and therapy. Since little is | known about the optimized approach for radioligands of

关键词： RADIOTHERANOSTICS | RADIOLIGAND | CDK19

摘要： differences are incompletely understood. CDK8 and CDK19* are* | inhibitor of CDK8/CDK19, significantly reduced cell | Neonatal and adult megakaryocytes differ in | proliferative capacity and ploidy levels, and neonatal and | adult platelets differ in function, gene expression

关键词： cord blood | megakaryocytes | neonatal haematology | transcription

摘要：The mediator kinases CDK8 and CDK19* control* | the dynamic transcription of selected genes in | response to various signals and have been shown to be | hijacked to sustain hyperproliferation by various solid | and liquid tumors. CDK8/19 is emerging as a

关键词： IDENTIFICATION | TRANSCRIPTION | GENES | CELLS | STAT1 | AML

摘要： revealed that Cip1 is a regulatory subunit of the Cdk19 | Mating type (sex) plays a crucial role in | regulating sexual reproduction in most extant eukaryotes | . One of the functions of mating types is ensuring | self-incompatibility to some extent, thereby

关键词： self-incompatibility | sexual reproduction initiation | mating-type recognition | ancestral eukaryotic sex | Tetrahymena

摘要： CDK8/CDK19* as potential "block and lock" targets for* | Current antiretroviral therapy for HIV-1 | infection does not represent a cure for infection as viral | rebound inevitably occurs following discontinuation of | treatment. The "block and lock" therapeutic strategy is

关键词： CDK7 | CDK8 | CDK9 | CDK19 | YKL-5-124 | LDC000067 | Senexin A | HIV-1 | latency | transcription...

摘要： paralog CDK19, are components of the kinase module that | Prostate cancer progression is driven by | androgen receptor (AR) activity, which is a target for | therapeutic approaches. Enzalutamide is an AR inhibitor that | prolongs the survival of patients with advanced prostate

关键词： prostate cancer | Mediator complex | androgen receptor | enzalutamide | MEDIATOR COMPLEX | KINASE | PHOSPHORYLATION | SUBCOMPLEX | CELLS

摘要： cancer were used to identify CDK19* and PSMA expression* | vitro. To evaluate in vivo CDK19-specific uptake of | novel tissue-specific gene CDK19* in high-risk* | metastatic prostate cancer and CDK19* expression correlated* | molecules targeting CDK19* labeled with Ga-68 (68Ga-IRM-015*

关键词： Metastatic prostate cancer | PET imaging | PSMA | CDK19 | Neuroendocrine prostate cancer (NEPC)

摘要： paralog CDK19, alternative enzymatic components of the | CDK8 and CDK19, selective CDK8/19 small molecule | isogenic cell populations expressing CDK8, CDK19* or their* | kinase-inactive mutants revealed that CDK8 and CDK19 | CDK19 knockouts were attributable to quantitative

关键词： DEPENDENT KINASE 8 | IDENTIFICATION | CORTISTATIN | ELONGATION | SUBUNITS | GROWTH | GENES | STAT1

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：Cyclin-dependent kinase 19 (CDK19) is a | CDK19-targeted PET tracers, but in-depth drug | potential target for the diagnosis and treatment of | prostate cancer. We have previously studied a series of | optimization is needed to improve the physiochemical

关键词： albumin binder | CDK19 | PET imaging | prostate cancer | radiotraces

摘要： showed that cyclin-dependent kinase 19 (CDK19) was | interaction between ZNF169 and CDK19 promoter. Additionally | , our data showed that CDK19 expression levels were | elevated in HCC tissues, and patients with higher CDK19 | experiments demonstrated that CDK19 could reverse the impact

关键词： cyclin‐dependent kinase 19 (CDK19) | hepatocellular cancer | malignancy | overall survival | zinc finger protein 169 (ZNF169) | cyclin-dependent kinase 19 (CDK19)

摘要：Cyclin-dependent kinase 19 (CDK19) is | optimization strategy is well suited for CDK19 and provides a | overexpressed in prostate cancer, making it an attractive | target for both imaging and therapy. Since little is | known about the optimized approach for radioligands of

关键词： RADIOTHERANOSTICS | RADIOLIGAND | CDK19

摘要： differences are incompletely understood. CDK8 and CDK19 are | inhibitor of CDK8/CDK19, significantly reduced cell | Neonatal and adult megakaryocytes differ in | proliferative capacity and ploidy levels, and neonatal and | adult platelets differ in function, gene expression

关键词： cord blood | megakaryocytes | neonatal haematology | transcription

摘要：The mediator kinases CDK8 and CDK19 control | the dynamic transcription of selected genes in | response to various signals and have been shown to be | hijacked to sustain hyperproliferation by various solid | and liquid tumors. CDK8/19 is emerging as a

关键词： IDENTIFICATION | TRANSCRIPTION | GENES | CELLS | STAT1 | AML

摘要： revealed that Cip1 is a regulatory subunit of the Cdk19 | Mating type (sex) plays a crucial role in | regulating sexual reproduction in most extant eukaryotes | . One of the functions of mating types is ensuring | self-incompatibility to some extent, thereby

关键词： self-incompatibility | sexual reproduction initiation | mating-type recognition | ancestral eukaryotic sex | Tetrahymena

摘要： CDK8/CDK19 as potential "block and lock" targets for | Current antiretroviral therapy for HIV-1 | infection does not represent a cure for infection as viral | rebound inevitably occurs following discontinuation of | treatment. The "block and lock" therapeutic strategy is

关键词： CDK7 | CDK8 | CDK9 | CDK19 | YKL-5-124 | LDC000067 | Senexin A | HIV-1 | latency | transcription...

摘要： paralog CDK19, are components of the kinase module that | Prostate cancer progression is driven by | androgen receptor (AR) activity, which is a target for | therapeutic approaches. Enzalutamide is an AR inhibitor that | prolongs the survival of patients with advanced prostate

关键词： prostate cancer | Mediator complex | androgen receptor | enzalutamide | MEDIATOR COMPLEX | KINASE | PHOSPHORYLATION | SUBCOMPLEX | CELLS

摘要： cancer were used to identify CDK19 and PSMA expression | vitro. To evaluate in vivo CDK19-specific uptake of | novel tissue-specific gene CDK19 in high-risk | metastatic prostate cancer and CDK19 expression correlated | molecules targeting CDK19 labeled with Ga-68 (68Ga-IRM-015

关键词： Metastatic prostate cancer | PET imaging | PSMA | CDK19 | Neuroendocrine prostate cancer (NEPC)

摘要： paralog CDK19, alternative enzymatic components of the | CDK8 and CDK19, selective CDK8/19 small molecule | isogenic cell populations expressing CDK8, CDK19 or their | kinase-inactive mutants revealed that CDK8 and CDK19 | CDK19 knockouts were attributable to quantitative

关键词： DEPENDENT KINASE 8 | IDENTIFICATION | CORTISTATIN | ELONGATION | SUBUNITS | GROWTH | GENES | STAT1

4008-161-200 800-990-8900

国家科技图书文献中心

摘要：Cyclin-dependent kinase 19 (CDK19) is | optimization strategy is well suited for CDK19* and provides a* | overexpressed in prostate cancer, making it an attractive | target for both imaging and therapy. Since little is | known about the optimized approach for radioligands of

摘要： differences are incompletely understood. CDK8 and CDK19* are* | inhibitor of CDK8/CDK19, significantly reduced cell | Neonatal and adult megakaryocytes differ in | proliferative capacity and ploidy levels, and neonatal and | adult platelets differ in function, gene expression

摘要：The mediator kinases CDK8 and CDK19* control* | the dynamic transcription of selected genes in | response to various signals and have been shown to be | hijacked to sustain hyperproliferation by various solid | and liquid tumors. CDK8/19 is emerging as a

摘要： CDK8/CDK19* as potential "block and lock" targets for* | Current antiretroviral therapy for HIV-1 | infection does not represent a cure for infection as viral | rebound inevitably occurs following discontinuation of | treatment. The "block and lock" therapeutic strategy is

摘要： cancer were used to identify CDK19* and PSMA expression* | vitro. To evaluate in vivo CDK19-specific uptake of | novel tissue-specific gene CDK19* in high-risk* | metastatic prostate cancer and CDK19* expression correlated* | molecules targeting CDK19* labeled with Ga-68 (68Ga-IRM-015*

摘要： paralog CDK19, alternative enzymatic components of the | CDK8 and CDK19, selective CDK8/19 small molecule | isogenic cell populations expressing CDK8, CDK19* or their* | kinase-inactive mutants revealed that CDK8 and CDK19 | CDK19 knockouts were attributable to quantitative