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1. Dissecting the immune response of CD4 + T cells in Alzheimer's disease NSTL国家科技图书文献中心

Kostic, Milos |  Zivkovic, Nikola... -  《Reviews in the neurosciences》 - 2025,36(2) - 139~168 - 共30页

摘要: develop AD. CD4+ T cells are the cornerstone of the |  duality of CD4+ T cells in AD can be simply attributed |  current understanding of the role of CD4+ T cells in the | The formation of amyloid-beta (A beta) plaques |  is a neuropathological hallmark of Alzheimer's
关键词: Alzheimer's disease |  amyloid-beta |  tau |  CD4(+) T cells

2. Original Antigenic Sin in CD4+T Cells NSTL国家科技图书文献中心

Zhang, Mingran |  Ma, Junling... -  《Immunology》 - 2025,175(2) - 165~179 - 共15页

摘要: because CD4+ T cell proliferation and regulation signals |  CD4+ T cells trigger regulatory T cell (Tregs | ) responses, which prematurely suppress the na & iuml;ve CD4 |  in CD4+ T cells. This mechanism is illustrated |  and memory CD4+ T cell proliferation, interleukin-2
关键词: IL-2 |  mathematical model |  parameter estimation |  T cell proliferation |  Tregs |  IL‐2

3. Clinical outcome and peripheral CD4+T profile in impending myasthenic crisis: A prospective cohort study NSTL国家科技图书文献中心

Wang, Yuan |  Huan, Xiao... -  《Journal of Neuroimmunology》 - 2025,402 - 578572~578572 - 共8页

摘要: +/- 71.43 months, P = 0.003). Peripheral CD4+ T profiling | Impending Myasthenic Crisis (MC) is defined as |  a rapid worsening of myasthenia gravis (MG) that |  can progress to respiratory failure within days to |  weeks. The clinical data regarding the outcome and
关键词: Impending crisis |  Myasthenic crisis |  Rescue therapies |  Transformation |  CD4+T

4. Characterization of CD4-2+cell subsets and their responses in pearl gentian grouper (Epinephelus fuscoguttatus x E. lanceolatus) NSTL国家科技图书文献中心

Jiang, Xiaoyu |  Xing, Jing... -  《Aquaculture》 - 2025,600 - 共10页

摘要:CD4+ T cells (T helper cells, Th) are |  molecular number, structure, and expression of the CD4 |  and differentiation of CD4+ T cells in fish is |  currently unclear. Here, we identified a CD4-2+ T cell |  investigated its immune response dynamics. The CD4-2 sequence
关键词: Epinephelus fuscoguttatus x E.Lanceolatus |  Leukocytes |  CD4-2 molecule |  Phagocytosis |  Cross-reactivity |  Nervous necrosis virus (NNV)

5. IL-17 affects the immune regulation of CD4+T cells in dilated cardiomyopathy through JAK/STAT pathway NSTL国家科技图书文献中心

Hao, Jie |  Li, Weiwei... -  《Cardiology in the young.》 - 2025,35(1) - 16~23 - 共8页

摘要: (IL-17) on the mechanism of CD4+ T-cell immune |  cardiomyopathy. Methods: Naive CD4+ T cells were isolated from |  flow cytometry. Results: In CD4+ T cells, IL-17 | . Conclusion: Through regulation of IL-17 expression in CD4 |  matrix metalloproteinases, and apoptosis of CD4+ T
关键词: IL-17 |  JAK/STAT |  CD4+T |  dilated cardiomyopathy

6. Association between a lower T-CD4+/CD8+lymphocyte ratio and cognitive impairment in older persons with HIV NSTL国家科技图书文献中心

Ruiz-Manriquez, Carl... |  Avila-Funes, Jose Al...... -  《European geriatric medicine.》 - 2025,16(1) - 305~313 - 共9页

摘要: the LT-CD4 + /CD8 + ratio and cognitive impairment |  performed to determine the association between T-CD4 |  regression analyses showed that the lowest LT-CD4 + /CD8 |  LT-CD4 + /CD8 + ratios are independently associated | Purpose To ascertain the association between
关键词: CD4+/CD8+ratio |  HIV |  Cognitive impairment |  Older adults

7. Peripheral CD4+T Cells Predict T Cell Immunity in Lung Tissues of Non-small Cell Lung Cancer Patients NSTL国家科技图书文献中心

Tone, Mari |  Isono, Tomomi... -  《Anticancer Research》 - 2025,45(3) - 909~920 - 共12页

摘要: a high percentage of a peripheral CD4' T cell |  peripheral CD4' T cell subset and T cell immunity in the |  CD4' T cell subset (CD45RA'CD25'CD4' T cells), non | -tumor lung tissues had a high percentage of PD-1'CD4 |  production by CD4' T cells in the lung tissues of patients
关键词: Non-small cell lung cancer |  peripheral CD4' T cells |  PD-1 |  regulatory T cells

8. Safety, pharmacokinetics, and biological activity of CD4-mimetic BNM-III-170 in SHIV-infected rhesus macaques NSTL国家科技图书文献中心

Viox, Elise G. |  Richard, Jonathan... -  《Journal of Virology》 - 2025,99(5) - e0006225~e0006225 - 共25页

摘要:-1 and preferentially target the "open," CD4-bound |  CD4-mimetic compound that binds the Phe43 cavity of | ," thus exposing epitopes targeted by CD4-induced (CD4i |  small-molecule CD4-mimetic compound BNM-III-170 has | Anti-HIV-1 antibodies capable of mediating
关键词: human immunodeficiency virus |  nonhuman primate |  ADCC |  CD4 mimetic |  in vivo therapeutic strategies

9. Immunometabolic profiling related with gestational diabetes mellitus: a nested case-control study of CD4 + T cell phenotypes and glycemic traits NSTL国家科技图书文献中心

Wei, Xiaohui |  Sun, Zhuo... -  《Acta diabetologica.》 - 2025,62(1) - 77~85 - 共9页

摘要: associations of CD4(+) T cell phenotypes with gestational | . Metabolomic signatures related to both CD4(+) T cell |  models were used to explore the associations of CD4 |  relationship between CD4(+) T cell phenotypes and glycemic | Aims To investigate immunometabolic
关键词: CD4(+) T cells |  Metabolome |  Gestational diabetes mellitus |  Nested case-control study

10. Imbalance of human CD4 + T lymphocyte subsets following atrazine treatment NSTL国家科技图书文献中心

Alhosseini, Mahdieh ... |  Maddalon, Ambra... -  《Archives of Toxicology》 - 2025,99(4) - 1455~1469 - 共15页

摘要: on CD4+ T cells and decreases their activation | , including the percentage of cytokine-producing CD4+ T | )-gamma- and interleukin (IL)-22-producing CD4+ T cells |  decreased within total CD4+ T cells. Moreover, IL-4-, IL | -10- and IL-17-producing CD4+ T cells decreased
关键词: Endocrine disruptor |  Atrazine |  T cell differentiation |  Cytokines |  Human study |  In vitro study
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