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1. Lasmiditan ameliorates serotonergic itch in mice: Possible involvement of 5-HT1F receptors NSTL国家科技图书文献中心

Afrooghe, Arya |  Ahmadi, Elham... -  《Naunyn-Schmiedeberg's Archives of Pharmacology》 - 2025,398(2) - 1535~1543 - 共9页

摘要: agonist of the 5-hydroxytryptamine 1F (5-HT1F) receptor |  levels of TLR-4, IL-31, 5-HT1F receptor, CGRP & TRPV4 |  expression levels of the 5-HT1F receptor significantly |  mice through its interaction with the 5-HT1F receptor |  given intradermal injections of normal saline (2) "5
关键词: Itch |  Lasmiditan |  Serotonin |  5-HT1F receptor |  CGRP |  TRPV4 |  Mice

2. Unmet Needs in the Acute Treatment of Migraine NSTL国家科技图书文献中心

Enrico,Bentivegna |  Silvia,Galastri... -  《Advances in therapy.》 - 2024,41(1) - 1~13 - 共13页

摘要: targeting CGRP, and ditans, 5-HT1F receptor agonists. They |  targeting the calcitonin gene receptor (CGRP) peptide or |  its receptor are the only ones specifically designed | Abstract Migraine represents the most common |  neurologic disorder, ranking second among the world’s
关键词: Migraine |  Acute migraine treatment |  Triptans |  Gepants |  Ditans |  Antimigraine drugs |  Migraine education

3. Neurophysiological and Vascular Mechanisms of Action of Serotoninergic Drugs for Abortive Migraine Treatment NSTL国家科技图书文献中心

Sokolov A. Y. |  Skiba I. B.... -  《Neuroscience and behavioral physiology》 - 2024,54(5) - 707~725 - 共19页

摘要:, serotoninergic agents: triptans (selective 5-HT1B/1D receptor |  agonists), ditans (selective 5-HT1F-mimetics) and ergot |  5-HT receptor). This review presents the currently | Migraine is a form of primary headache that |  affects at least 10% of the world’s population. In
关键词: migraine |  headache |  triptans |  lasmiditan |  ergot alkaloids |  serotonin |  neurophysiology |  mechanism of action |  vasoconstriction

4. Changes in 5-HT1F receptor expression in rats with spasticity following spinal cord injury NSTL国家科技图书文献中心

Zhang C. |  Meng X.... -  《Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences》 - 2023,793 - 136988~136988 - 共9页

摘要: receptor (5-HT1FR) in the spinal cord, especially in |  known about the distribution of the serotonin 1F |  distribution of 5-HT1FR in the spinal cord were analyzed. The |  results showed that the expression of 5-HT1FR (mRNA and |  5 days, respectively. The expression of 5-HT1FR
关键词: 5-HT1FR |  Spasticity |  Spinal cord injury

5. The role of hippocampal 5-HT1D and 5-HT1F receptors on learning and memory in rats NSTL国家科技图书文献中心

Afshar, Simin |  Shahidi, Siamak... -  《Naunyn-Schmiedeberg's Archives of Pharmacology》 - 2023,396(7) - 1451~1460 - 共10页

摘要: receptor antagonist, BRL15572 hydrochloride, and 5-HT1F |  5-HT1F receptor had no effect on cognitive memory |  a 5-HT1D receptor agonist, PNU142633, 5-HT1D |  hippocampal 5-HT1D receptor improved cognition memory but |  involved in memory via its receptors. The 5-HT1D and 5
关键词: 5-HT1D receptor |  5-HT1F receptor |  Memory |  Passive avoidance test |  MEDIAL PREFRONTAL CORTEX |  LONG-TERM POTENTIATION |  SEROTONERGIC MODULATION |  AVOIDANCE MEMORY |  BRAIN |  CONSOLIDATION...

6. Safety profile of lasmiditan in patients with migraine in an Asian population NSTL国家科技图书文献中心

Hirata, Koichi |  Matsumori, Yasuhiko... -  《Expert opinion on drug safety》 - 2023,22(1/6) - 91~101 - 共11页

摘要:Background MONONOFU, a multicenter, randomized | , double-blind, placebo-controlled phase 2 study of |  Japanese patients with migraine, was pivotal for |  lasmiditan approval in Japan. However, treatment-emergent |  adverse events (TEAEs) were more common than in global
关键词: 5-HT1F receptor |  acute treatment |  headache |  Japan |  lasmiditan |  migraine disorders |  phase 2 |  safety |  serotonin agonist |  PREVALENCE

7. Migraine drugs NSTL国家科技图书文献中心

Ramachanderan, Ragha... |  Schramm, Stefan... -  《ChemTexts》 - 2023,9(2) - ARTN 6~ - 共66页

摘要: lasmiditan, a selective 5-HT1F receptor agonist from Eli |  are selective 5-HT1B/1D receptor agonists. Recent |  peptide (CGRP) receptor antagonists discovered at Merck |  & Co and BMS, and anti-CGRP/receptor monoclonal | According to recent studies, migraine affects
关键词: Migraine |  Ergotamine |  Triptans |  Ditans |  Gepants |  Fischer indole synthesis |  Total synthesis |  Biosynthesis |  GENE-RELATED PEPTIDE |  5-SUBSTITUTED INDOLE-DERIVATIVES...

8. Lasmiditan restores mitochondrial quality control mechanisms and accelerates renal recovery after ischemia-reperfusion injury NSTL国家科技图书文献中心

Hurtado, Kevin A. |  Janda, Jaroslav... -  《Biochemical Pharmacology》 - 2023,218 - 115855~115855 - 共6页

摘要:-HT1F) receptor agonism with lasmiditan induces | ). Previously, we identified that 5-hydroxytryptamine 1F (5 | Background: Mitochondrial dysfunction is a |  well-established result of acute kidney injury (AKI |  mitochondrial biogenesis (MB) and improves renal vasculature
关键词: Mitophagy |  Mitochondrial dynamics |  Mitochondrial biogenesis |  Mitochondrial dysfunction |  Acute kidney injury |  ACUTE KIDNEY INJURY |  PROXIMAL TUBULE |  DYNAMICS |  BIOGENESIS |  ACTIVATION...

9. Migraine: from pathophysiology to treatment NSTL国家科技图书文献中心

Francesca,Puledda |  Elisa Martins,Silva... -  《Journal of neurology》 - 2023,270(7) - 3654~3666 - 共13页

摘要:-HT1F receptor agonists (ditans) and non-invasive |  peptide (gepants and monoclonal antibodies), serotonin 5 | Abstract Migraine is an extremely disabling | , common neurological disorder characterized by a complex |  neurobiology, involving a series of central and peripheral
关键词: Migraine |  Pathophysiology |  Treatment |  CGRP |  Neuromodulation

10. Lasmiditan promotes recovery from acute kidney injury through induction of mitochondrial biogenesis NSTL国家科技图书文献中心

Kevin A. Hurtado |  Jaroslav Ja... -  《American Journal of Physiology》 - 2023,324(1 Pt.2) - F56~F63 - 共8页

摘要: 5-HT1F receptor-selective agonist lasmiditan |  group identified that serotonin (5-HT)1F receptor | , claudin-2, and claudin-5 decreased in the I/R group and |  proliferator-activated receptor-γ coactivator-1α and electron | Acute kidney injury (AKI) involves rapid loss
关键词: acute kidney injury |  fibrosis |  microvasculature injury |  mitochondrial biogenesis |  mitochondrial dysfunction
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