NSTL国家科技图书文献中心

1. A Retrospective Cohort Analysis of Analgosedation Requirements in COVID-19 Compared to Non-COVID-19 Extracorporeal Membrane Oxygenation Patients NSTL国家科技图书文献中心

Schaller, Alyssa M. | Feih, Joel T.... - 《Journal of intensive care medicine》 - 2025,40(1) - 32～39 - 共8页

摘要：Background: Reports have described increased | sedation requirements in patients with acute respiratory | distress syndrome (ARDS) while on extracorporeal membrane | oxygenation (ECMO) and for intubated COVID-19 patients. Thus | , the objective of this study was to assess the

关键词： analgesia | sedation | ECMO | COVID-19 | ARDS

2. The O -GlcNAc database: introducing new features and tools developed from community feedback NSTL国家科技图书文献中心

Malard, Florian | Massman, Lilyanna ... - 《Analytical and bioanalytical chemistry》 - 2025,417(5) - 879～884 - 共6页

摘要：O-GlcNAc is a reversible post-translational | modification found on serine and threonine residues of | nucleocytoplasmic proteins. Four years ago, we released the O | -GlcNAc Database (oglcnac.mcw.edu), a comprehensive | catalog of O-GlcNAcylated proteins that has become one

关键词： O-GlcNAc | Database | Mass spectrometry | Subcellular localization

3. KIF11 Variants Associated With Novel Renal System Involvement-Two Cases That Expand the Phenotypic Spectrum of Microcephaly With or Without Chorioretinopathy, Lymphedema, or Impaired Intellectual Development NSTL国家科技图书文献中心

Gonzalez, Tessa | Tyler, Rebecca C.... - 《American journal of medical genetics,Part A》 - 2025,197A(2) - e63903～e63903 - 共5页

摘要：Pathogenic variants in KIF11 are linked to | microcephaly with or without chorioretinopathy, lymphedema | , or impaired intellectual development (MCLMR). To | our knowledge, renal phenotypes have not been | described in the literature in association with KIF11

关键词： heterozygous variants | KIF11-related disorders | renal system involvement | KIF11–related disorders

4. Completion of Distress Screening and Correlates of Distress Score in Patients With Multiple Myeloma at Initial Evaluation at a Transplant Center NSTL国家科技图书文献中心

Estrada-Merly, Noel | Wu, James F.... - 《European Journal of Haematology》 - 2025,114(5) - 890～899 - 共10页

摘要：Objectives We describe the completion of the | National Comprehensive Care Network's distress | thermometer (DT) survey for multiple myeloma (MM), quantify | , and identify factors influencing distress score | . Methods We assessed DT completion for MM patients' first

关键词： disparities | distress | multiple myeloma | social vulnerability | survey completion

5. Ends of the spectrum best practices for early detection and multidisciplinary management of acromegaly NSTL国家科技图书文献中心

Cheok, Stephanie Kim | Tavakoli-Sabour, Sam...... - 《Journal of neuro-oncology.》 - 2025,171(1) - 1～9 - 共9页

摘要：PurposeAcromegaly is characterized by an | insidious clinical presentation and delayed diagnosis | . Longer delays are associated with more comorbidities | which can persist after treatment of the growth | hormone-secreting pituitary adenoma (GH-PA). Surgery is

关键词： Acromegaly | GH-secreting adenoma | Somatotroph | Pituitary adenoma | Somatostatin receptor ligands | Headache | Transsphenoidal surgery | Remission | Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)

6. Promoting Resiliency to Stress in the Vascular Endothelium NSTL国家科技图书文献中心

Jaramillo-Torres, Ma... | Limpert, Rachel H.... - 《Basic & clinical pharmacology & toxicology.》 - 2025,136(3) - e70001～e70001 - 共13页

摘要：By 2050, roughly 60% of the population will | have cardiovascular disease. While a substantial | amount of data has been generated over the last few | decades that has aided in our understanding of | cardiovascular disease pathology, less is known about how to

关键词： endothelial dysfunction | resilience, cardiovascular disease | stress

7. The effective multiplicity of infection for HCMV depends on the activity of the cellular 20S proteasome NSTL国家科技图书文献中心

Cataldo, Katie M. | Roche, Kathryn L.... - 《Journal of Virology》 - 2025,99(1) - e01751-24～e01751-24 - 共19页

摘要：Human cytomegalovirus (HCMV) infection and | reactivation continues to contribute to morbidity and | mortality around the world. Antiviral compounds are | available but have limitations. Here, we have defined the | impact of the proteasome inhibitor bortezomib on HCMV

关键词： cytomegalovirus | proteasome inhibitors | bortezomib | maribavir | cell cycle | cyclin-dependent kinase inhibitor p21

8. The triple code model for advancing research in rare and undiagnosed diseases beyond the base pairs NSTL国家科技图书文献中心

Lomberk, Gwen | Urrutia, Raul - 《Epigenomics》 - 2025,17(2/3) - 115～124 - 共10页

摘要：Rare and undiagnosed diseases pose significant | challenges for understanding their mechanisms, diagnosis | , and treatment. The Triple Code Model, an integrative | paradigm described here, considers the combined influence | of the genetic code, epigenetic code, and nuclear

关键词： Rare diseases | undiagnosed diseases | genetics | epigenome | histone modifications | nuclear organization | chromatin structure and dynamics | multi-omics

9. Elevated frequencies of activated memory B cells in multiple sclerosis are reset to healthy control levels after B cell depletion with Ocrelizumab NSTL国家科技图书文献中心

Gurski, Cody J. | Hajiyeva, Zivar ... - 《Journal of Neuroimmunology》 - 2025,399 - 578502～578502 - 共10页

摘要：In multiple sclerosis (MS) the B cell | depleting drug ocrelizumab has shown high efficacy in | reducing inflammatory activity. Its mechanism of action | is unclear due to B cell subset complexity and | unknown roles in pathogenesis. Here, we comprehensively

关键词： Multiple sclerosis | B cell depletion | Memory B cells | Flow cytometry

10. Emergent properties of the lysine methylome reveal regulatory roles via protein interactions and histone mimicry NSTL国家科技图书文献中心

Pollin, Gareth | Chi, Young-In ... - 《Epigenomics》 - 2025,17(1) - 5～20 - 共16页

摘要：AimsEpigenomics has significantly advanced | through the incorporation of Systems Biology approaches | . This study aims to investigate the human lysine | methylome as a system, using a data-science approach to | reveal its emergent properties, particularly focusing